BACKGROUNDCutaneous squamous cell carcinoma (cSCC) is a common malignant hyperplasia of the skin epithelium. However, cSCC progressing to giant squamous cell carcinoma of the popliteal fossa skin has ...not been reported. We used full-thickness skin graft from the lower left quadrant of the abdomen to reconstruct the popliteal fossa skin defect in our patient. CASE SUMMARYA 64-year-old woman presented with a 3-year history of a progressively enlarged integumentary tumor located on her left popliteal fossa, which was surgically treated. The resultant defect (15 cm × 25 cm) was repaired using full-thickness skin graft from the lower left quadrant of the abdomen. CONCLUSIONFull-thickness skin graft is a good choice to repair popliteal fossa defect.
Aim： E-cadherin is unusually highly expressed in most ovarian cancers. This study was designed to investigate the roles of E-cadherin in the carcinogenesis and progression of ovarian cancers. ...Methods： Human ovarian adenocarcinoma cell line SKOV-3 was examined. E-cadherin gene CDH1 in SKOV-3 cells was knocked down via RNA interference （RNAi）, and the resultant variation of biological behavior was observed using CCK-8 and colony formation experiment. E-cadherin-mediated Ca2＋-dependent cell-cell adhesion was used to study the mechanisms underlying the effects of E-cadherin on the proliferation and survival of SKOV-3 cells. The expression levels of E-cadherin, extracellular signal-related kinase （ERK）, phosphorylated ERK （P-ERK） were measured using Western blot assays. Results： Transfection with CDHI-siRNA for 24-96 h significantly suppressed the growth and proliferation of SKOV-3 cells. E-cadherinmediated calcium-dependent cell-cell adhesion of SKOV-3 cells resulted in a rapid increase of P-ERK, but did not modify the expression of ERK protein. The phosphorylation of ERK in the cells was blocked by pretreatment with the MEK1 specific inhibitor PD98059 （50 pmol/L）, but not by the PI3K inhibitor wortmannin （1 pmol/L） or PKA inhibitor H89 （10 pmol/L）. Conclusion： E-cadherin may function as a tumor proliferation enhancer via activating the MEK/ERK pathway in development of ovarian epithelial cancers.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Mathematical models of propellers were created that investigate the influence of periodic boundary conditions on predictions of a propeller＇s performance. Thrust and torque coefficients corresponding ...to different advance coefficients of DTMB 4119, 4382, and 4384 propellers were calculated. The pressure coefficient distribution of the DTMB 4119 propeller at different sections was also physically tested. Comparisons indicated good agreement between the results of experiments and the simulation. It showed that the periodic boundary condition can be used to rationally predict the open water performance of a propeller. By analyzing the three established modes for the computation, it was shown that using the spline curve method to divide the grids can meet the calculation＇s demands for precision better than using the rake cutting method.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Plant photoperiodism is an important principle explaining the growth and developmental processes of many plants, including rice (Oryza sativa L.). Most researchers currently believe that the effect ...of photoperiodism in rice plants is restricted to accelerating or delaying heading and flowering. This paper discusses a second effect of photoperiodism on certain lines of rice, the effect of inducing pollen sterility. It summarizes nearly 10 yr of study on photoperiod-sensitive genic male-sterile (PGMS) rice. There are two photoperiodic reactions existing simultaneously in the growth and development of PGMS rice. The first photoperiodic reaction (FPR) accelerates or delays both panicle differentiation and heading and is common to all rice lines. The second photoperiodic reaction (SPR) is novel and determines whether pollen will be sterile or fertile. Results show that FPR can be affected by broad changes in photoperiod, light intensity, and temperature and is controlled by one to two pairs of genes. On the other hand, the SPR requires a more critically timed photoperiod, higher light intensity, and higher temperature than does FPR. The SPR is also controlled by one or two pairs of genes and is inherited independently of the genes that modify the FPR. Several lines of PGMS rice have been produced with Nongken58S as a donor parent. Five growth and development phases comprise the life cycle of PGMS rice. The effects of environment on PGMS rice described in this review may guide the practice of breeding and use of PGMS rice in a newly-developed two-line production system for hybrid rice
Thin oxides thermally grown on the reactive-ion-etched (RIE) silicon substrates in N
2
O and diluted O
2
ambients have been studied. The RIE will strongly affect the silicon surface microroughness ...and lead to poor oxides properties. Using the after-treatment-chamber (ATC) process, CF
4
addition in the O
2
plasma can further improve the time-zero-to-dielectric-breakdown (TZDB) characteristics of the thin oxides as compared with pure O
2
plasma. This is because CF
4
addition in the ATC can remove the damaged silicon layer and smooth the silicon surface since the O
2
plasma can effectively only strip the polymeric layer. In addition, the N
2
O-grown oxides can enlarge the process window of the CF
4
/O
2
ATC treatments with respect to pure oxides.
Recently, the Belle and LHCb Collaborations have measured the \(\Lambda^+_c \to p K^- \pi^+\) decay and reported the \(p K^-\) invariant mass distribution, which shows a clear cusp structure around ...the \(\eta \Lambda\) threshold. In this work, we have analyzed this process by considering the triangle mechanism and the \(S\)-wave pseudoscalar meson-octet baryon interactions within the chiral unitary approach, which dynamically generate the \(\Lambda(1670)\). Our results are in good agreement with the Belle measurements, which implies that the cusp structure around \(\eta\Lambda\) threshold could be associated with the \(\Lambda(1670)\) with the molecular nature.
ABSTRACT
Photodynamic therapy (PDT) efficacy is a complex function of tissue sensitivity, photosensitizer (PS) uptake, tissue oxygen concentration, delivered light dose and some other parameters. To ...better understand the mechanisms and optimization of PDT treatment, we assessed two techniques for quantifying tissue PS concentration and two methods for quantifying pathological tumor damage. The two methods used to determine tissue PS concentration kinetic were in vivo fluorescence probe and ex vivo chemical extraction. Both methods show that the highest tumor to normal tissue PS uptake ratio appears 4 h after PS administration. Two different histopathologic techniques were used to quantify tumor and normal tissue damage. A planimetry assessment of regional tumor necrosis demonstrated a linear relationship with increasing light dose. However, in large murine tumors this finding was complicated by the presence of significant spontaneous necrosis. A second method (densitometry) assessed cell death by nuclear size and density. With some exceptions the densitometry method generally supported the planimetry results. Although the densitometry method is potentially more accurate, it has greater potential subjectivity. Finally, our research suggests that the tools or methods we are studying for quantifying PS levels and tissue damage are necessary for the understanding of PDT effect and therapeutic ratio in experimental in vivo tumor research.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
AIM： To study the safety and feasibility of total embolization of the main splenic artery as a supplemental treatment modality for hypersplenism with thrombocy topenia or leukocytopenia accompanying ...liver cirrhosis. METHODS： Fifteen consecutive patients with hyper- splenism due to cirrhosis were enrolled in this study from January 2006 to June 2010. All patients underwent total embolization of the main splenic artery. Clinical symp- toms, white blood cell （WBC） and platelet （PLT） counts, splenic volume, and complications of the patients were recorded. The patients were followed up for 1 and 6 mo, and 1, 2, 3 years, respectively, after operation. RESULTS： Total embolization of the main splenic artery was technically successful in all patients. Minor complications occurred in 13 patients after the procedure, but no major complications were found. The WBC and PLT counts were significantly higher and the residual splenic volume was significantly lower 1 and 6 mo, and 1, 2, 3 years after the procedure than before the procedure （P 〈 0.01）. Moreover, the residual splenic volume increased very slowly with the time after embolization. All patients were alive during the follow-up period. CONCLUSION： Total embolization of the main splenic artery is a safe and feasible procedure and may serve as a supplemental treatment modality for hypersplenism with thrombocytopenia or leukocytopenia accompanying liver cirrhosis.
The collision-energy dependence of the state-resolved differential cross section at a specific backward-scattering angle for the reaction$H + D_{2 \rightarrow D + HD$is measured with the D-atom ...Rydberg "tagging" time-of-flight technique. The reaction was modeled theoretically with converged quantum scattering calculations that provided physical interpretation of the observations. Oscillations in the differential cross sections in the backward-scattering direction are clearly observed and are attributed to the transition-state structures that originate from the interferences of different quantized transition-state pathways.
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BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
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