Abstract Background The aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (SRs) to subcutaneous allergen immunotherapy (SCIT) in ...children and adolescents with asthma in Hangzhou, east China's Zhejiang province. Methods From January 2011 to December 2016, this survey analysed the SCIT-related SRs involving 429 patients (265 children and 134 adolescents) affected by allergic asthma. Recorded data included demographics, diagnosis, patient statuses, pulmonary function testing results before and after each injection, allergen dosage, and details of SRs. Results All patients finished the initial phase and six patients withdrew during the maintenance phase. There were 2.59% (328/12,655) SRs in all injections (3.28% in children and 1.47% in adolescents); 15.62% (67/429) patients experienced SRs (18.49% children and 10.98% adolescents). There were 54.57% SRs of grade 1; 42.37% SRs of grade 2; 3.05% SRs of grade 3; and no grades 4 or grade 5 SRs occurred in patients. Most reactions were mild, and were readily controlled by immediate emergency treatment. There was no need for hospitalisation. The occurrence of SRs was significantly higher in children than that in adolescents ( p < 0.01). A higher ratio of SRs was found among patients with moderate asthma. Conclusion This retrospective survey showed that properly-conducted SCIT was a safe treatment for children and adolescents with asthma in Hangzhou, East China. Children and patients with moderate asthma may be prone to develop SRs.
Vascularization deficiency caused a lot of diseases, such as diabetes ulcer and myocardial infarction. Mesenchymal stem cells (MSCs), with the self-renewal and multipotent differentiation capacities, ...have been used for many diseases treatment through regulation microenvironment. Numerous studies reported that MSCs transplantation could largely improve cutaneous wound healing via paracrine secretion of growth factors. However, whether MSCs take part in the angiogenesis process directly remains elusive. Previous study proved that autophagy inhibited immunosuppressive function of MSCs and prevented the degradation of MSCs function in inflammatory and senescent microenvironment. Here, we proved that autophagy determines the therapeutic effect of MSCs in cutaneous wound healing through promoting endothelial cells angiogenesis and demonstrated that the paracrine of vascular endothelial growth factor (VEGF) in MSCs was required in wound site. We further revealed that autophagy enhanced the VEGF secretion from MSCs through ERK phosphorylation directly. Collectively, we put forward that autophagy mediated paracrine of VEGF plays a central role in MSCs cured cutaneous wound healing and may provide a new therapeutic method for angiogenesis-related diseases.
A
bstract
Using 15
.
6 fb
−
1
of
e
+
e
−
collision data collected at twenty-four center-of-mass energies from 4
.
0 to 4
.
6 GeV with the BESIII detector, the helicity amplitudes of the process
e
+
e
...−
→
π
+
π
−
ω
are analyzed for the first time. Born cross section measurements of two-body intermediate resonance states with statistical significance greater than 5
σ
are presented, such as
f
0
(500),
f
0
(980),
f
2
(1270),
f
0
(1370),
b
1
(1235)
±
, and
ρ
(1450)
±
. In addition, evidence of a resonance state in
e
+
e
−
→
π
+
π
−
ω
production is found. The mass of this state obtained by line shape fitting is about 4
.
2 GeV/
c
2
, which is consistent with the production of
ψ
(4160) or
Y
(4220).
A power ultrasound with different amplitudes was applied during the solidification of ternary Cu-14wt pct Al-4.5 wt pct Ni alloy, which was then quenched to obtain martensite phases. It effectively ...promoted the nucleation of primary austenite
β
(AlCu
3
) phase, thereby reducing its grain size by almost one order of magnitude. This refined austenite structure induced by ultrasound also had influence on the martensite transformation during subsequent quenching. In the coarse
β
grain formed without ultrasound, only very little amount of
β
1
′
martensite phase with 18R structure existed and part of it consisted in the coarse
γ
1
′
martensite phase with 2H structure. As ultrasound amplitude rose up, the martensite phases were both refined and the relative content of
β
1
′
phase increased. This microstructure modification led to the enhancement of mechanical properties of Cu-14 pct Al-4.5 pct Ni alloy as well. The yield strength of the quenched alloy solidified at the maximal ultrasonic amplitude was 1.5 times higher than that without ultrasound. The microhardness and the storage modulus were also enhanced with the increase of ultrasound amplitude.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
All the Li metal anode-based batteries suffer from a high propensity to form Li dendrites. To prevent the formation of dendritic lithium on the electrodes, amorphous carbon coatings are deposited ...onto the surface of metallic lithium foil by magnetron sputtering technique. The electrochemical performances of the amorphous carbon-coated lithium (Li/C) electrodes are investigated by galvanostatic charge/discharge tests, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The compact carbon coatings on the surface of lithium foil can suppress the growth of dendritic lithium during charge–discharge process. The thickness of amorphous carbon coating affects the electrode from two aspects; the thick coating can prevent the formation of dendritic lithium much efficiently, but lead to a large impedance of Li+ transfer.
•Amorphous carbon coatings were deposited onto the surface of metallic lithium.•The formation of dendritic can be prevented according to the SEM photograph.•The electrochemical performance is promoted due to the existence of a-C coating.•The thickness of a-C coating affects the electrode performance from two aspects.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The enhancer of zeste homolog 2 (EZH2) is upregulated and has an oncogenic role in several types of human cancer. However, the abnormalities of EZH2 and its underlying mechanisms in the pathogenesis ...of nasopharyngeal carcinoma (NPC) remain unknown. In this study, we found that high expression of EZH2 in NPC was associated closely with an aggressive and/or poor prognostic phenotype (P<0.05). In NPC cell lines, knockdown of EZH2 by short hairpin RNA was sufficient to inhibit cell invasiveness/metastasis both in vitro and in vivo, whereas ectopic overexpression of EZH2 supported NPC cell invasive capacity with a decreased expression of E-cadherin. In addition, ablation of endogenous Snail in NPC cells virtually totally prevented the repressive activity of EZH2 to E-cadherin, indicating that Snail might be a predominant mediator of EZH2 to suppress E-cadherin. Furthermore, co-immunoprecipitation (IP), chromatin IP and luciferase reporter assays demonstrated that in NPC cells, (1) EZH2 interacted with HDAC1/HDAC2 and Snail to form a repressive complex; (2) these components interact in a linear fashion, not in a triangular fashion, that is, HDAC1 or HDAC2 bridge the interaction between EZH2 and Snail; and (3) the EZH2/HDAC1/2/Snail complex could closely bind to the E-cadherin promoter by Snail, but not YY1, to repress E-cadherin. The data provided in this report suggest a critical role of EZH2 in the control of cell invasion and/or metastasis by forming a co-repressor complex with HDAC1/HDAC2/Snail to repress E-cadherin, an activity that might be responsible, at least in part, for the development and/or progression of human NPCs.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Because of the lack of long-term pulsed emission in quiescence and the strong timing noise, it is impossible to directly measure the braking index n of a magnetar. Based on the estimated ages of ...their potentially associated supernova remnants (SNRs), we estimate the values of the mean braking indices of eight magnetars with SNRs, and find that they cluster in the range of 1–42. Five magnetars have smaller mean braking indices of 1 < n < 3, and we interpret them within a combination of magneto-dipole radiation and wind-aided braking. The larger mean braking indices of n > 3 for the other three magnetars are attributed to the decay of external braking torque, which might be caused by magnetic field decay. We estimate the possible wind luminosities for the magnetars with 1 < n < 3, and the dipolar magnetic field decay rates for the magnetars with n > 3, within the updated magneto-thermal evolution models. Although the constrained range of the magnetars’ braking indices is tentative, as a result of the uncertainties in the SNR ages due to distance uncertainties and the unknown conditions of the expanding shells, our method provides an effective way to constrain the magnetars’ braking indices if the measurements of the SNR ages are reliable, which can be improved by future observations.
Aim
The study aimed to determine whether nonalcoholic fatty liver disease (NAFLD) is an independent risk factor of adenoma after negative baseline colonoscopy.
Method
A retrospective cohort study was ...conducted on 1522 health‐check individuals who underwent two consecutive colonoscopies at Taipei Veterans General Hospital between 2003 and 2010. Those developing an adenoma after an initial negative baseline colonoscopy (adenoma group) were compared with those in whom the second colonoscopy was negative (nonadenoma group). Anthropometric measurements, biochemical tests and the presence of NAFLD were compared between the two groups.
Results
The adenoma group had a higher prevalence of NAFLD than the nonadenoma group (55.6% vs 38.8%; P < 0.05). On multivariate logistic regression analysis, NAFLD was an independent risk factor (OR = 1.45, 95% CI: 1.07–1.98) for adenoma formation after a negative baseline colonoscopy. The risk of colorectal adenoma increased when NAFLD patients had other morbidities including metabolic syndrome, hypertension or smoking (OR = 2.85, 4.03 and 4.17).
Conclusion
NAFLD is an independent risk factor for colorectal adenoma formation after a negative baseline colonoscopy. The risk is higher in individuals with NAFLD and other comorbidities, such as hypertension, smoking or metabolic syndrome.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
You have reached the maximum number of search results that are displayed.
For better performance, the search offers a maximum of 1,000 results per query (or 50 pages if the option 10/page is selected).
Consider using result filters or changing the sort order to explore your results further.
PDF
