Although numerous advances have been made in information technology in the past decades, there is still a lack of progress in information systems dynamics (ISD), owing to the lack of a mathematical ...foundation needed to describe information and the lack of an analytical framework to evaluate information systems. The value of ISD lies in its ability to guide the design, development, application, and evaluation of large-scale information system-of-systems (SoSs), just as mechanical dynamics theories guide mechanical systems engineering. This paper reports on a breakthrough in these fundamental challenges by proposing a framework for information space, improving a mathematical theory for information measurement, and proposing a dynamic configuration model for information systems. In this way, it establishes a basic theoretical framework for ISD. The proposed theoretical methodologies have been successfully applied and verified in the Smart Court SoSs Engineering Project of China and have achieved significant improvements in the quality and efficiency of Chinese court informatization. The proposed ISD provides an innovative paradigm for the analysis, design, development, and evaluation of large-scale complex information systems, such as electronic government and smart cities.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
To accurately understand user information needs and provide better search experiences, various methods have been proposed to model user search intent from their search logs. Most traditional methods ...based on query understanding only consider the similarity between the query and documents, while ignoring the user's session interaction sequence. Some researchers also adopt neural network-based methods to model user search intent. However, most of neural network-based models mainly focus on the user's session interaction sequence, without considering the role of topic relevance in modeling user search intent. In this paper, we propose a novel topicality relevance-aware intent model (TRIM) for web search. TRIM consists of a topic relevance predictor and a user short-term intent predictor. The topic relevance predictor utilizes the BERT model to predict the topic relevance between the query and documents. The user short-term search intent predictor utilizes session context information to predict user short-term search intent. We further investigate several fusion strategies to integrate the topic relevance and user short-term search intent for user search intent prediction. We conduct our experiments on two public web search datasets named TianGong-QRef and TianGong-ST. The experiments show that TRIM outperforms all baselines in the document ranking task. On TianGong-QRef dataset, TRIM achieves a 15.19% increase over the best performing baselines M-Match in terms of Mean Average Precision (MAP). On TianGong-ST dataset, TRIM achieves a 5.77% increase over the best performing baselines CARS in terms of MAP. The experimental results indicate that the effectiveness of topic relevance in user search intent modeling.
The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O
2
availability in metazoans. It contributes to physiology and ...pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulation of HIF transcriptional activity by different types of epigenetic regulators.
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EMUNI, FZAB, GEOZS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Background
The treatment strategy for elderly colorectal cancer patients with intestinal obstruction remains controversial. The choice of reasonable treatment and surgical method directly affects ...perioperative safety and prognosis. This study investigated the safety and long-term efficacy of radical surgery in elderly colorectal cancer patients over 80 years old with intestinal obstruction.
Methods
The clinicopathological data of elderly patients over 80 years old with intestinal obstruction who underwent colorectal cancer surgery from January 2012 to December 2021 were retrospectively collected and analysed. Patients were assigned to a radical group and a palliative group according to the surgical method. Propensity score matching (PSM) was performed to match patients in the radical group 1:1 with those in the palliative group. The perioperative-related indexes and prognosis were compared between the two groups.
Results
A total of 187 patients were enrolled in this study. After PSM, 58 matched pairs were selected, and the radical and palliative groups were well balanced in terms of the clinical and surgical characteristics (
P
> 0.05). The proportion of patients transferred to the ICU after surgery in the radical group was significantly higher than that in the palliative group (17.2% vs. 5.2%,
P
= 0.039). In terms of postoperative complications, the incidence of grade 1–5 complications in the radical group was significantly higher than that in the palliative group (37.9% vs. 15.5%,
P
= 0.006); however, there was no significant difference in the incidence of grade 3–5 complications between the two groups (6.9% vs. 1.7%,
P
= 0.364). In addition, the complications were subclassified, and it was found that the incidence of gastrointestinal disorders (20.7% vs. 6.9%,
P
= 0.031) after surgery was significantly higher in the radical group. The 3-year OS rates were 55.2% and 22.6% in the radical and palliative groups, respectively (
P
< 0.001). Multivariate analysis revealed that radical surgery was an independent prognostic factor for OS (HR: 4.32; 95% CI, 1.93–12.45;
P
< 0.001).
Conclusion
Although elderly colorectal cancer patients over 80 years of age with intestinal obstruction are more likely to be admitted to the ICU and develop more postoperative complications after radical surgery, long-term survival benefits can be achieved.
Information is the core of Air traffic control system (ATCS). In this paper, objective information theory is extended to depict, model and measure the information exemplified in ATCS. The sextuple ...model is presented with information ontology, state occurrence time, state set, carrier, reflection time, and reflection set. The metric system is given to quantitively measure the information with extensity, detailedness, continuity, richness, containability, delay, pervasiveness, authenticity, and adaptability. The results show that the proposed method is potential to find out actual indexes in ATCS for flight safety.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Endogenous biomolecules in cells are the basis of all life activities. Directly visualizing the structural characteristics and dynamic behaviors of cellular biomolecules is significant for ...understanding the molecular mechanisms in various biological processes. Single-molecule localization microscopy (SMLM) can circumvent the optical diffraction limit, achieving analysis of the fine structures and biological processes in living cells with nanoscale resolution. However, the large size of traditional imaging probes prevents SMLM from accurately locating fine structures and densely distributed biomolecules within cells. In recent years, nucleic acid probes have emerged as potential tools to replace conventional SMLM probes by virtue of their small size and high specificity. In addition, due to their programmability, nucleic acid probes with different conformations can be constructed via sequence design, further extending the application of SMLM in bioanalysis. Here, we discuss the design concepts of different conformational nucleic acid probes for SMLM and summarize the application of SMLM based on nucleic acid probes in the field of biomolecules. Furthermore, we provide a summary and future perspectives of the nucleic acid probe-based SMLM technology, aiming to provide guidance for the acquisition of nanoscale information about cellular biological processes.
J. Neurochem. (2011) 117, 71-81. ABSTRACT: We recently characterized the proteinase-activated receptor (PAR)-2, a G protein-coupled receptor (GPCR), as the first cargo protein recognized by p24A. ...Here, we demonstrate that p24A binds to several other GPCRs, including PAR-1, the nucleotide receptors P2Y₁, P2Y₂, P2Y₄, and P2Y₁₁, as well as the μ-opioid receptor 1B. The acidic amino acid residues Glu and Asp at the second extracellular loop of GPCRs are essential for interaction with p24A. p23, another member of the p24 family, also interacts with GPCRs, similar to p24A. However, p23 shows a delayed dissociation from PAR-2 after activation of PAR-2, compared to the dissociation between PAR-2 and p24A. p24A and p23 arrest both P2Y₄ receptor and μ-opioid receptor 1B at the intracellular compartments, as observed for PAR-2. A comparable result was obtained when we studied primary rat astrocytes in culture. Over-expression of the N-terminal p24A fragment impairs PAR-2 resensitization in astrocytes that extends our findings to a native system. In summary, we demonstrate that p24A and p23 are specific cargo receptors of GPCRs and differentially control GPCR trafficking in the biosynthetic pathway, and thereby, p24A and p23 regulate GPCR signaling in astrocytes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Developing large-scale complex information systems, such as the Smart Court system-of-systems (SoSs) of China, is a worldwide engineering challenge. This paper, from a methodological perspective, ...aims to expound the theoretical construction and practical progress of Smart Court system-of-systems engineering (SoSE) of China. The concept and key task requirements of SoSE are explored, technical difficulties faced by the Smart Court SoSE are analyzed, and a “two-track parallel, six-ring linkage” pattern framework is proposed for the progressive collaboration SoSE of large-scale autonomous information systems. Based on the theories including a universal information model, information metric system, and dynamic configurations of information systems, a key evaluation indicator system for an information SoSs is proposed. To satisfy the SoSE design requirements, an overall design method based on information relationships and its enabling tool are proposed, and a reference model of the Smart Court SoSs is designed to
Apoptosis-inducing factor (AIF) is critical for poly(ADP-ribose) polymerase-1 (PARP-1)-dependent cell death (parthanatos). The molecular mechanism of mitochondrial AIF release to the nucleus remains ...obscure, although a possible role of calpain I has been suggested. Here we show that calpain is not required for mitochondrial AIF release in parthanatos. Although calpain I cleaved recombinant AIF in a cell-free system in intact cells under conditions where endogenous calpain was activated by either NMDA or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) administration, AIF was not cleaved, and it was released from mitochondria to the nucleus in its 62-kDa uncleaved form. Moreover, NMDA administration under conditions that failed to activate calpain still robustly induced AIF nuclear translocation. Inhibition of calpain with calpastatin or genetic knockout of the regulatory subunit of calpain failed to prevent NMDA- or MNNG-induced AIF nuclear translocation and subsequent cell death, respectively, which was markedly prevented by the PARP-1 inhibitor, 3,4-dihydro-5-4-(1-piperidinyl)butoxyl-1(2H)-iso-quinolinone. Our study clearly shows that calpain activation is not required for AIF release during parthanatos, suggesting that other mechanisms rather than calpain are involved in mitochondrial AIF release in parthanatos.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
•Dual autofocusing circular Airy beams (CAB) in free space are proposed, which would be helpful for constructing dual optical tweezers or other fields.•Various modulation methods for two focal ...positions and focal intensities are theoretically studied.•The dual autofocusing CAB are generated in experiment and the dual autofocusing property is demonstrated.
Dual autofocusing circular Airy beams (CAB) are proposed by introducing two different initial launch angles into the phase of light fields. Appropriate values of two launch angle parameters are chosen to enhance dual focusing property and reduce the interference effect. The relation between this dual autofocusing property and corresponding parameters are investigated. Our theoretical results show that, launch angle and initial radius of this beam have much influence on dual focal positions; decaying parameter and angle range parameter could only influence the focal intensities or relative intensity. Finally, dual autofocusing CAB is generated and the dual focusing property is demonstrated in experiment.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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