Following the publication of this article 1 it was brought to our attention that incorrect funder's number was included for the National Natural Science Foundation of China. The correct number is ...3167131062 instead of the current 81370906.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The aim of this study was to evaluate the association of GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms with the chemotherapy response and overall survival of advanced ...NSCLC. Two hundred and sixty-two patients with histologically confirmed advanced NSCLC (inoperable TNM stages IIIA, IIIB, and IV) were enrolled to this hospital-based study between May 2009 and May 2012. The GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism. A logistic regression analysis revealed a correlation between the null genotype of GSTM1 and improved response to chemotherapy odds ratio = 1.82; 95% confidence interval (CI) = 1.06-3.14. Analyses with the Cox proportional hazards model also indicated that the null genotype of GSTM1 was associated with lower risk of death (hazard ratio = 0.40; 95%CI = 0.23-0.69). In conclusion, the null genotype of GSTM1 was found to be correlated with improved response to chemotherapy and lower risk of death in advanced NSCLC patients.
In fusion welding, variations of cooling rate and microstructure are commonly achieved by changing heat input. Here we show that the cooling rates can be adjusted and microstructural features could ...be refined at constant heat input while changing the pulsing parameters. The temporal variations of cooling rates, solidification growth rate and weld geometry during both single and double pulsed welding of an aluminum alloy are examined. Furthermore, microstructures of both single and double pulsed gas metal arc welding are presented to demonstrate significant microstructural refinement of double pulsed gas metal arc welds for the same heat input.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
To meet the increasing demands for high-performance energy storage devices, an advanced lithium-ion hybrid capacitor (LIHC) has been designed and fabricated, which delivers an ultrahigh energy ...density of 295.1 Wh kg
and a power density of 41 250 W kg
with superior cycling stability. The high-performance LIHC device is based on the uniform porous Nb
N
/rGO nanocomposite, which has an intimate interface between the firmly contacted Nb
N
and rGO through the Nb(Nb
N
)-O(rGO)-C(rGO) bonds, significantly improving the electron transport kinetics. Moreover, the introduction of rGO nanosheets can prevent the Nb
N
nanoparticles from agglomeration, not only resulting in a larger specific surface area to provide more active sites but also accommodating the strain during Li ion insertion/deinsertion. Therefore, the Nb
N
/rGO nanocomposite exhibits a higher reversible specific capacity and better rate and cycling performance than the Nb
N
nanoparticle. In view of the scalable preparation and superior electrochemical characteristics, the Nb
N
/rGO nanocomposite would have great potential practical applications in the future energy storage devices.
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IJS, KILJ, NUK, PNG, UL, UM
The geomagnetic field originates from interior dynamo currents and can be approximated well by a simple dipolar field in the vicinity of Earth's surface. Given that the dipolar field is induced by a ...current loop, it is possible to invert the loop parameters by tracing the sampled magnetic field geometry. Drawing on the analysis of field geometric structure with sampled field dataset, we develop, in this study, a new technique to invert the interior current source, which is based on a single circular current loop model. Unlike previous studies, this technique has the ability to separate and solve the optimal loop parameters successively, including the location of the loop center, the loop axis, the radius, and the carried electric current. Applications to the International Geomagnetic Reference Field and the sampled magnetic field dataset by the spacecraft of the Swarm mission demonstrate that our technique‐derived loop center, loop axis, and magnetic moment are consistent with previous estimations by the eccentric dipole model, which shows the reasonability and effectiveness of this technique. Moreover, our technique can be reduced to fit an eccentric dipole model and is particularly useful for inversions of the geometry of interior current sources. Thus, it could be applied widely in the fields of planetary magnetism and palaeomagnetism. Further applications and constraints are discussed, with some cautions given.
Plain Language Summary
Most planets in our solar system possess a global dipolar magnetic field. The dipolar field can be approximatively generated by a current loop. The loop's parameters, including the location of the loop center, the loop axis, the radius, and the carried electric current, are key to characterizing the geometry and strength of the dipolar field. However, traditional methods that use least‐square fitting of all loop parameters simultaneously result in multiple local solutions, meaning there is no general way to solve it. By analyzing the sampled magnetic field dataset, we present a novel technique that separates and solves the loop parameters successively. Several tests show that our technique is reasonable and able to be applied in the fields of geomagnetism, planetary magnetism, and palaeomagnetism.
Key Points
New technique is developed to diagnose the geomagnetic dipolar field based on a current loop model
Technique is able to separate and solve the loop parameters according to the sampled data set of the magnetic field
Tests and applications show that technology is effective and applicable and could be applied widely in the fields of planetary magnetism
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
•We modeled three sets of light curves and obtained a mass ratio of 0.831.•We detected a periodicity in the O–C curve and provided the possible evidence of the third body.•EP Aur may consist of a ...normal MS star and a cool Roche-lobe filling subgiant, which may be undergoing rapid mass transfer.
We present new observations for the eclipsing binary EP Aurigae, which were performed by using three small telescopes in China from 2003 December to 2014 January. With the updated 2003 version of the Wilson–Devinney code, the photometric elements were deduced from three sets of light curves. Based on all available eclipsing times, the orbital period changes were investigated. It is discovered that the (O–C) curve may show an existence of light-time effect due to an unseen third body, which was weakly identified by the photometric solution. The modulated period and amplitude of the cyclic variation are P3=71.2(±8.0)yr and A=0.0101(±0.0008)day, respectively. In the co-planar orbit with the binary system, the mass of the third body is M3=0.18(±0.02)M⊙. The photometric results imply that EP Aur is an Algol-type binary with a mass ratio of q=0.831(±0.004). Its primary component almost fills its Roche lobe. Therefore, EP Aur may consist of a normal main-sequence star and a cool Roche-lobe filling subgiant, which may be undergoing rapid mass transfer.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Background
Most studies on minimally invasive pancreatoduodenectomy (MIPD) combine patients with pancreatic and periampullary cancers even though there is substantial heterogeneity between these ...tumors. Therefore, this study aimed to evaluate the role of MIPD compared to open pancreatoduodenectomy (OPD) in patients with non-pancreatic periampullary cancer (NPPC).
Methods
A systematic review of Pubmed, Embase, and Cochrane databases was performed by two independent reviewers to identify studies comparing MIPD and OPD for NPPC (ampullary, distal cholangio, and duodenal adenocarcinoma) (01/2015–12/2021). Individual patient data were required from all identified studies. Primary outcomes were (90-day) mortality, and major morbidity (Clavien-Dindo 3a-5). Secondary outcomes were postoperative pancreatic fistula (POPF), delayed gastric emptying (DGE), postpancreatectomy hemorrhage (PPH), blood-loss, length of hospital stay (LOS), and overall survival (OS).
Results
Overall, 16 studies with 1949 patients were included, combining 928 patients with ampullary, 526 with distal cholangio, and 461 with duodenal cancer. In total, 902 (46.3%) patients underwent MIPD, and 1047 (53.7%) patients underwent OPD. The rates of 90-day mortality, major morbidity, POPF, DGE, PPH, blood-loss, and length of hospital stay did not differ between MIPD and OPD. Operation time was 67 min longer in the MIPD group (
P
= 0.009). A decrease in DFS for ampullary (HR 2.27,
P
= 0.019) and distal cholangio (HR 1.84,
P
= 0.025) cancer, as well as a decrease in OS for distal cholangio (HR 1.71,
P
= 0.045) and duodenal cancer (HR 4.59,
P
< 0.001) was found in the MIPD group.
Conclusions
This individual patient data meta-analysis of MIPD versus OPD in patients with NPPC suggests that MIPD is not inferior in terms of short-term morbidity and mortality. Several major limitations in long-term data highlight a research gap that should be studied in prospective maintained international registries or randomized studies for ampullary, distal cholangio, and duodenum cancer separately.
Protocol registration
PROSPERO (CRD42021277495) on the 25th of October 2021.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Initially developed for high-speed optical communication, optical time stretch has recently been adopted for ultrafast and sensitive optical imaging at an unprecedented speed. In this paper, we ...highlight the essential concepts as well as the enabling elements of this ultrafast technology. More importantly, we review the recent developments of optical time-stretch imaging, especially in the context of 1) quantitative optofluidic microscopy for high-content single-cell phenotyping at an imaging throughput ~100 000 cells/s; 2) all-optical multi-MHz (>10 MHz) swept-source optical coherence tomography (OCT) for high-speed in vivo anatomical and functional 3-D tissue imaging. We also discuss the current technological challenges in time-stretch imaging. In particular, generating the enormous data in real time, this technology could uniquely create new insights of data-driven science in clinical diagnostics and basic biological research.
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