The Natural History of Adolescent Idiopathic Scoliosis Weinstein, Stuart L
Journal of pediatric orthopaedics,
2019-July, 2019-Jul, 2019-07-00, 20190701, Volume:
39, Issue:
Issue 6, Supplement 1 Suppl 1
Journal Article
Peer reviewed
INTRODUCTION:Adolescent idiopathic Scoliosis (AIS) affects 2% to 3% of the population of which only 0.3% to 0.5% of affected patients will have a curvature of >20 degrees, the curve magnitude at ...which treatment is generally recommended. For AIS the current natural history data is limited and most of the information comes from a small body of literature from the University of Iowa.
METHODS:The Iowa natural history studies began as retrospective reviews but beginning in 1976, the cohort was followed prospectively. Outcomes assessed in this group of patients included; mortality, pulmonary function, pregnancy-(effect of pregnancy on scoliosis and the effect of scoliosis on pregnancy), radiographic, curve progression, and osteoarthritis. In addition, validated questionnaires were used to evaluate back pain, pulmonary symptoms, general function, depression, and body image.
RESULTS:Patients with untreated AIS can function well as adults, become employed, get married, have children, and grow to become active older adults. Unfortunately, untreated scoliosis may lead to increased back pain and pulmonary symptoms for patients with large thoracic curves. Patients with untreated AIS can also develop substantial deformity, and the cosmetic aspect of this condition cannot be disregarded.
CONCLUSIONS:The summary findings of this unique lifetime natural history of AIS patients provides patients and parents a solid evidence base upon which to make informed decisions.
Mixing passion and humor, a personal work of literary criticism that demonstrates how the greatest books illuminate our lives Why do we read literature? For Arnold Weinstein, the answer is clear: ...literature allows us to become someone else. Literature changes us by giving us intimate access to an astonishing variety of other lives, experiences, and places across the ages. Reflecting on a lifetime of reading, teaching, and writing, The Lives of Literature explores, with passion, humor, and whirring intellect, a professor's life, the thrills and traps of teaching, and, most of all, the power of literature to lead us to a deeper understanding of ourselves and the worlds we inhabit.As an identical twin, Weinstein experienced early the dislocation of being mistaken for another person—and of feeling that he might be someone other than he had thought. In vivid readings elucidating the classics of authors ranging from Sophocles to James Joyce and Toni Morrison, he explores what we learn by identifying with their protagonists, including those who, undone by wreckage and loss, discover that all their beliefs are illusions. Weinstein masterfully argues that literature's knowing differs entirely from what one ends up knowing when studying mathematics or physics or even history: by entering these characters' lives, readers acquire a unique form of knowledge—and come to understand its cost.In The Lives of Literature, a master writer and teacher shares his love of the books that he has taught and been taught by, showing us that literature matters because we never stop discovering who we are.
While mean-field approximations, such as the nuclear shell model, provide a good description of many bulk nuclear properties, they fail to capture the important effects of nucleon–nucleon ...correlations such as the short-distance and high-momentum components of the nuclear many-body wave function1. Here, we study these components using the effective pair-based generalized contact formalism2,3 and ab initio quantum Monte Carlo calculations of nuclei from deuteron to 40Ca (refs. 4–6). We observe a universal factorization of the many-body nuclear wave function at short distance into a strongly interacting pair and a weakly interacting residual system. The residual system distribution is consistent with that of an uncorrelated system, showing that short-distance correlation effects are predominantly embedded in two-body correlations. Spin- and isospin-dependent ‘nuclear contact terms’ are extracted in both coordinate and momentum space for different realistic nuclear potentials. The contact coefficient ratio between two different nuclei shows very little dependence on the nuclear interaction model. These findings thus allow extending the application of mean-field approximations to short-range correlated pair formation by showing that the relative abundance of short-range pairs in the nucleus is a long-range (that is, mean field) quantity that is insensitive to the short-distance nature of the nuclear force.Effects of nucleon–nucleon correlations are studied with the generalized contact formalism and ab initio quantum Monte Carlo calculations. For nuclei from deuteron to 40Ca, the many-body nuclear wave function is shown to factorize at short distances.
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The extraction of neutrino mixing parameters from accelerator-based neutrino-oscillation experiments relies on proper modeling of neutrino-nucleus scattering processes using neutrino interaction ...event generators. Experimental tests of these generators are difficult due to the broad range of neutrino energies produced in accelerator-based beams and the low statistics of current experiments. Here we overcome these difficulties by exploiting the similarity of neutrino and electron interactions with nuclei to test neutrino event generators using high-precision inclusive electron-scattering data. To this end, we revised the electron-scattering mode of the genie event generator (e-genie) to include electron-nucleus bremsstrahlung radiation effects and to use, when relevant, the exact same physics models and model parameters, as the standard neutrino-scattering version. We also implemented new models for quasielastic (QE) scattering and meson exchange currents (MECs) based on the theory-inspired super scaling approach SuSAv2. Comparing the new e-genie predictions with inclusive electron-scattering data, we find an overall adequate description of the data in the QE- and MEC-dominated lower energy transfer regime, especially when using the SuSAv2 models. Higher energy transfer interactions, which are dominated by resonance production, are still not well modeled by e-genie.
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Mechanisms of spin-flavor SU(6) symmetry breaking in quantum chromodynamics (QCD) are studied via an extraction of the free neutron structure function from a global analysis of deep inelastic ...scattering (DIS) data on the proton and on nuclei from A=2 (deuterium) to 208 (lead). Modification of the structure function of nucleons bound in atomic nuclei (known as the EMC effect) are consistently accounted for within the framework of a universal modification of nucleons in short-range correlated (SRC) pairs. Our extracted neutron-to-proton structure function ratio F_{2}^{n}/F_{2}^{p} becomes constant for x_{B}≥0.6, equaling 0.47±0.04 as x_{B}→1, in agreement with theoretical predictions of perturbative QCD and the Dyson-Schwinger equation, and in disagreement with predictions of the scalar diquark dominance model. We also predict F_{2}^{^{3}He}/F_{2}^{^{3}H}, recently measured, as yet unpublished, by the MARATHON Collaboration, the nuclear correction function that is needed to extract F_{2}^{n}/F_{2}^{p} from F_{2}^{^{3}He}/F_{2}^{^{3}H}, and the theoretical uncertainty associated with this extraction.
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Adolescent idiopathic scoliosis Weinstein, Stuart L, Dr; Dolan, Lori A, PhD; Cheng, Jack CY, MD ...
The Lancet (British edition),
05/2008, Volume:
371, Issue:
9623
Journal Article
Peer reviewed
Summary Adolescent idiopathic scoliosis (AIS) affects 1–3% of children in the at-risk population of those aged 10–16 years. The aetiopathogensis of this disorder remains unknown, with misinformation ...about its natural history. Non-surgical treatments are aimed to reduce the number of operations by preventing curve progression. Although bracing and physiotherapy are common treatments in much of the world, their effectiveness has never been rigorously assessed. Technological advances have much improved the ability of surgeons to safely correct the deformity while maintaining sagittal and coronal balance. However, we do not have long-term results of these changing surgical treatments. Much has yet to be learned about the general health, quality of life, and self-image of both treated and untreated patients with AIS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
A cantilevered piezoelectric beam is excited in a heating, ventilation and air conditioning (HVAC) flow. This excitation is amplified by the interactions between (a) an aerodynamic fin attached at ...the end of the piezoelectric cantilever and (b) the vortex shedding downstream from a bluff body placed in the air flow ahead of the fin/cantilever assembly. The positioning of small weights along the fin enables tuning of the energy harvester to operate at resonance for flow velocities from 2 to 5 m s−1, which are characteristic of HVAC ducts. In a 15 cm diameter air duct, power generation of 200 μW for a flow speed of 2.5 m s−1 and power generation of 3 mW for a flow speed of 5 m s−1 was achieved. These power outputs are sufficient to power a wireless sensor node for HVAC monitoring systems or other sensors for smart building technology.
This Letter shows quantitatively that the magnitude of the EMC effect measured in electron deep inelastic scattering at intermediate x(B), 0.35≤x(B)≤0.7, is linearly related to the short range ...correlation (SRC) scale factor obtained from electron inclusive scattering at x(B)≥1. The observed phenomenological relationship is used to extract the ratio of the deuteron to the free pn pair cross sections and F(2)(n)/F(2)(p), the ratio of the free neutron to free proton structure functions. We speculate that the observed correlation is because both the EMC effect and SRC are dominated by the high virtuality (high momentum) nucleons in the nucleus.
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