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1.
  • Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
    Hyde, Craig L; Nagle, Michael W; Tian, Chao ... Nature genetics, 09/2016, Volume: 48, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Despite strong evidence supporting the heritability of major depressive disorder (MDD), previous genome-wide studies were unable to identify risk loci among individuals of European descent. We used ...
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2.
  • Contribution of Common Gene... Contribution of Common Genetic Variants to Antidepressant Response
    Tansey, Katherine E; Guipponi, Michel; Hu, Xiaolan ... Biological psychiatry (1969), 04/2013, Volume: 73, Issue: 7
    Journal Article
    Peer reviewed

    Background Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling ...
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3.
  • Translating Human Genetics ... Translating Human Genetics into Novel Treatment Targets for Schizophrenia
    Schubert, Christian R.; Xi, Hualin S.; Wendland, Jens R. ... Neuron (Cambridge, Mass.), 11/2014, Volume: 84, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Human genetics is a rational starting point for target identification in drug discovery, yet this approach has found little application in neuroscience. Recent large-scale analyses have begun to ...
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4.
  • Genetic predictors of respo... Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis
    Tansey, Katherine E; Guipponi, Michel; Perroud, Nader ... PLoS medicine, 10/2012, Volume: 9, Issue: 10
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    Open access

    It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test ...
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  • The D-amino acid oxidase in... The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial
    O'Donnell, Patricio; Dong, Cheng; Murthy, Venkatesha ... Neuropsychopharmacology (New York, N.Y.), 06/2023, Volume: 48, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid oxidase (DAAO) inhibitor ...
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6.
  • Safety, pharmacokinetics an... Safety, pharmacokinetics and pharmacodynamics of TAK‐418, a novel inhibitor of the epigenetic modulator lysine‐specific demethylase 1A
    Yin, Wei; Arkilo, Dimitrios; Khudyakov, Polyna ... British journal of clinical pharmacology, December 2021, Volume: 87, Issue: 12
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    Aims Dysregulation of histone methylation epigenetic marks may result in intellectual and developmental disability, as seen in Kabuki syndrome. Animal data suggest that increasing histone methylation ...
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7.
  • An Integrative Genomic Stud... An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar Disorder
    Akula, Nirmala; Wendland, Jens R; Choi, Kwang H ... Neuropsychopharmacology (New York, N.Y.), 02/2016, Volume: 41, Issue: 3
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    Genome-wide association studies (GWAS) have identified several common variants associated with bipolar disorder (BD), but the biological meaning of these findings remains unclear. Integrative ...
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8.
  • Anxiety and affective disor... Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive–compulsive disorder as an example of overlapping clinical and genetic heterogeneity
    Murphy, Dennis L.; Moya, Pablo R.; Fox, Meredith A. ... Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 04/2013, Volume: 368, Issue: 1615
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    Individuals with obsessive–compulsive disorder (OCD) have also been shown to have comorbid lifetime diagnoses of major depressive disorder (MDD; rates greater than 70%), bipolar disorder (rates ...
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  • Valproic acid induces funct... Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation
    Marinova, Zoya; Ren, Ming; Wendland, Jens R ... Journal of neurochemistry, November 2009, Volume: 111, Issue: 4
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    Neuroprotective properties of the mood stabilizer valproic acid (VPA) are implicated in its therapeutic efficacy. Heat-shock protein 70 (HSP70) is a molecular chaperone, neuroprotective and ...
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10.
  • Characterizing the genetic ... Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes
    Kim, Sarah; Becker, Jessica; Bechheim, Matthias ... Nature communications, 10/2014, Volume: 5, Issue: 1
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    Open access

    Toll-like receptors (TLRs) play a key role in innate immunity. Apart from their function in host defense, dysregulation in TLR signalling can confer risk to autoimmune diseases, septic shock or ...
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