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  • The Two β-Arrestins Regulat... The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models
    Wess, Jürgen International journal of molecular sciences, 01/2022, Volume: 23, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The two β-arrestins (β-arrestin-1 and -2; alternative names: arrestin-2 and -3, respectively) are well known for their ability to inhibit signaling via G protein-coupled receptors. However, ...
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  • Activation and allosteric m... Activation and allosteric modulation of a muscarinic acetylcholine receptor
    Kruse, Andrew C; Ring, Aaron M; Manglik, Aashish ... Nature, 12/2013, Volume: 504, Issue: 7478
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    Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 ...
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  • Muscarinic acetylcholine re... Muscarinic acetylcholine receptor knockout mice: Novel phenotypes and clinical implications
    WESS, Jürgen Annual review of pharmacology and toxicology, 01/2004, Volume: 44, Issue: 1
    Journal Article
    Peer reviewed

    Muscarinic acetylcholine receptors (mAChRs; M1-M5) play key roles in regulating the activity of many important functions of the central and peripheral nervous system. Because of the lack of ligands ...
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4.
  • Lack of beta-arrestin signa... Lack of beta-arrestin signaling in the absence of active G proteins
    Grundmann, Manuel; Merten, Nicole; Malfacini, Davide ... Nature communications, 01/2018, Volume: 9, Issue: 1
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    G protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous biological processes. ...
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  • Clenbuterol exerts antidiab... Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
    Meister, Jaroslawna; Bone, Derek B J; Knudsen, Jonas R ... Nature communications, 01/2022, Volume: 13, Issue: 1
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    Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β adrenergic receptor agonists ...
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  • Muscarinic acetylcholine re... Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
    Wess, Jürgen; Eglen, Richard M; Gautam, Dinesh Nature reviews. Drug discovery, 09/2007, Volume: 6, Issue: 9
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    Muscarinic acetylcholine receptors (mAChRs), M(1)-M(5), regulate the activity of numerous fundamental central and peripheral functions. The lack of small-molecule ligands that can block or activate ...
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  • Structure and dynamics of t... Structure and dynamics of the M3 muscarinic acetylcholine receptor
    KRUSE, Andrew C; JIANXIN HU; SHAW, David E ... Nature, 02/2012, Volume: 482, Issue: 7386
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    Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic ...
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  • Novel metabolic role for BD... Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
    Fulgenzi, Gianluca; Hong, Zhenyi; Tomassoni-Ardori, Francesco ... Nature communications, 04/2020, Volume: 11, Issue: 1
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    BDNF signaling in hypothalamic circuitries regulates mammalian food intake. However, whether BDNF exerts metabolic effects on peripheral organs is currently unknown. Here, we show that the BDNF ...
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  • Accelerated remyelination d... Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery
    Mei, Feng; Lehmann-Horn, Klaus; Shen, Yun-An A ... eLife, 09/2016, Volume: 5
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    Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal ...
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