Male care has energetic and opportunity costs, and is more likely to evolve when males gain greater certainty of paternity or when future mating opportunities are scarce. However, little is known ...about the substantial benefits that males may provide to females and offspring. Using phylogenetic comparative methods and a sample of over 500 mammalian species, we show that mammals in which males carry the offspring have shorter lactation periods, which leads to more frequent breeding events. Provisioning the female is associated with larger litters and shorter lactation. Offspring of species with male care have similar weaning mass to those without despite being supported by a shorter lactation period, implying that they grow faster. We propose that males provide an energetic contribution during the most expensive time of female reproduction, lactation, and that different male care behaviours increase female fecundity, which in turn helps males offset the costs of caring.
We present near-UV transmission spectroscopy of the highly irradiated transiting exoplanet WASP-12b, obtained with the Cosmic Origins Spectrograph on the Hubble Space Telescope. The spectra cover ...three distinct wavelength ranges: NUVA (2539-2580 A), NUVB (2655-2696 A), and NUVC (2770-2811 A). Three independent methods all reveal enhanced transit depths attributable to absorption by resonance lines of metals in the exosphere of WASP-12b. Light curves of total counts in the NUVA and NUVC wavelength ranges show a detection at a 2.5{sigma} level. We detect extra absorption in the Mg II {lambda}{lambda}2800 resonance line cores at the 2.8{sigma} level. The NUVA, NUVB, and NUVC light curves imply effective radii of 2.69 {+-} 0.24 R {sub J}, 2.18 {+-} 0.18 R {sub J}, and 2.66 {+-} 0.22 R {sub J} respectively, suggesting the planet is surrounded by an absorbing cloud which overfills the Roche lobe. We detect enhanced transit depths at the wavelengths of resonance lines of neutral sodium, tin, and manganese, and at singly ionized ytterbium, scandium, manganese, aluminum, vanadium, and magnesium. We also find the statistically expected number of anomalous transit depths at wavelengths not associated with any known resonance line. Our data are limited by photon noise, but taken as a whole the results are strong evidence for an extended absorbing exosphere surrounding the planet. The NUVA data exhibit an early ingress, contrary to model expectations; we speculate this could be due to the presence of a disk of previously stripped material.
The WASP Project and the SuperWASP Cameras Pollacco, D. L.; Skillen, I.; Cameron, A. Collier ...
Publications of the Astronomical Society of the Pacific,
10/2006, Volume:
118, Issue:
848
Journal Article
Peer reviewed
Open access
The SuperWASP cameras are wide‐field imaging systems at the Observatorio del Roque de los Muchachos on the island of La Palma in the Canary Islands, and at the Sutherland Station of the South African ...Astronomical Observatory. Each instrument has a field of view of some 482 deg2with an angular scale of 13
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7 pixel−1, and is capable of delivering photometry with accuracy better than 1% for objects having
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. Lower quality data for objects brighter than
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are stored in the project archive. The systems, while designed to monitor fields with high cadence, are capable of surveying the entire visible sky every 40 minutes. Depending on the observational strategy, the data rate can be up to 100 Gbytes per night. We have produced a robust, largely automatic reduction pipeline and advanced archive, which are used to serve the data products to the consortium members. The main science aim of these systems is to search for bright transiting exoplanet systems suitable for spectroscopic follow‐up observations. The first 6 month season of SuperWASP‐North observations produced light curves of ∼6.7 million objects with 12.9 billion data points.
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Inherited or sporadic heterozygous mutations in the transcription factor GATA2 lead to a clinical syndrome characterized by non-tuberculous mycobacterial and other opportunistic infections, a severe ...deficiency in monocytes, B cells and natural killer cells, and progression from a hypocellular myelodysplastic syndrome to myeloid leukemias. To identify acquired somatic mutations associated with myeloid transformation in patients with GATA2 mutations, we sequenced the region of the ASXL1 gene previously associated with transformation from myelodysplasia to myeloid leukemia. Somatic, heterozygous ASXL1 mutations were identified in 14/48 (29%) of patients with GATA2 deficiency, including four out of five patients who developed a proliferative chronic myelomonocytic leukemia. Although patients with GATA2 mutations had a similarly high incidence of myeloid transformation when compared to previously described patients with ASXL1 mutations, GATA2 deficiency patients with acquired ASXL1 mutation were considerably younger, almost exclusively female, and had a high incidence of transformation to a proliferative chronic myelomonocytic leukemia. These patients may benefit from allogeneic hematopoietic stem cell transplantation before the development of acute myeloid leukemia or chronic myelomonocytic leukemia. (ClinicalTrials.gov identifier NCT00018044, NCT00404560, NCT00001467, NCT00923364.).
Extended gas clouds have been previously detected surrounding the brightest known close-in transiting hot Jupiter exoplanets, HD 209458 b and HD 189733 b; we observed the distant but more extreme ...close-in hot Jupiter system, WASP-12, with Hubble Space Telescope (HST). Near-UV (NUV) transits up to three times deeper than the optical transit of WASP-12 b reveal extensive diffuse gas, extending well beyond the Roche lobe. Our spectra reveal significantly enhanced absorption (greater than 3sigma below the median) at ~200 individual wavelengths on each of two HST visits; 65 of these wavelengths are consistent between the two visits, using a strict criterion for velocity matching that excludes matches with velocity shifts exceeding ~20 km s super(-1). Our Visit 2 NUV light curves show evidence for a stellar flare. We show that some of the possible transit detections in resonance lines of rare elements may be due instead to non-resonant transitions in common species. We present optical observations and update the transit ephemeris.
We have proposed, designed, manufactured and tested low loss dielectric micro-lenses for infrared (IR) radiation based on a dielectric metamaterial layer. This metamaterial layer was created by ...patterning a dielectric surface and etching to sub-micron depths. For a proof-of-concept lens demonstration, we have chosen a fine patterned array of nano-pillars with variable diameters. Gradient index (GRIN) properties were achieved by engineering the nano-pattern characteristics across the lens, so that the effective optical density of the dielectric metamaterial layer peaks around the lens center, and gradually drops at the lens periphery. A set of lens designs with reduced reflection and tailorable phase gradients have been developed and tested, demonstrating focal distances of a few hundred microns, beam area contraction ratio up to three, and insertion losses as low as 11%.
Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than ...non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non- heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.
The Cassini Ultraviolet Imaging Spectrograph (UVIS) observed an occultation of the Sun by the water vapor plume at the south polar region of Saturn's moon Enceladus. The Extreme Ultraviolet (EUV) ...spectrum is dominated by the spectral signature of H2O gas, with a nominal line‐of‐sight column density of 0.90 ± 0.23 × 1016 cm−2 (upper limit of 1.0 × 1016 cm−2). The upper limit for N2 is 5 × 1013 cm−2, or <0.5% in the plume; the lack of N2 has significant implications for models of the geochemistry in Enceladus' interior. The inferred rate of water vapor injection into Saturn's magnetosphere is ∼200 kg/s. The calculated values of H2O flux from three occultations observed by UVIS have a standard deviation of 30 kg/s (15%), providing no evidence for substantial short‐term variability. Collimated gas jets are detected in the plume with Mach numbers of 5–8, implying vertical gas velocities that exceed 1000 m/sec. Observations at higher altitudes with the Cassini Ion Neutral Mass Spectrometer indicate correlated structure in the plume. Our results support the subsurface liquid model, with gas escaping and being accelerated through nozzle‐like channels to the surface, and are consistent with recent particle composition results from the Cassini Cosmic Dust Analyzer.
Key Points
N2 upper limit
Mach number of jets ranges from 5 to 8, more collimated than previous estimate
Flux of water vapor stable over last 6 years at 200 kg/sec
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We report the discovery of a transiting planet with an orbital period of 3.05 days orbiting the star TYC 7247-587-1. The star, WASP-41, is a moderately bright G8
V
V
star (
V = 11.6
V
=
11.6
) with a ...metallicity close to solar (Fe/H = -0.08 ± 0.09
Fe
/
H
=
-
0.08
±
0.09
). The star shows evidence of moderate chromospheric activity, both from emission in the cores of the Ca iiH and K ines and photometric variability with a period of 18.4 days and an amplitude of about 1%. We use a new method to show quantitatively that this periodic signal has a low false-alarm probability. The rotation period of the star implies a gyrochronological age for WASP-41 of 1.8 Gyr with an error of about 15%. We have used a combined analysis of the available photometric and spectroscopic data to derive the mass and radius of the planet (0.92 ± 0.06 M
Jup
0.92
±
0.06
M
Jup
,1.20 ± 0.06 R
Jup
1.20
±
0.06
R
Jup
). Further observations of WASP-41 can be used to explore the connections between the properties of hot Jupiter planets and the level of chromospheric activity in their host stars.
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Background and purpose
Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures.
Methods
To evaluate total tau (t‐tau), glial fibrillary acidic ...protein (GFAP), ubiquitin carboxy‐terminal hydrolase L1 (UCHL1) and neurofilament light‐chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers (n = 143) and controls (n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD‐1 platform. Eleven ATXN3 mutation carrier cerebrospinal fluid samples were analysed for t‐tau and phosphorylated tau (p‐tau181). A transgenic SCA3 mouse model (MJDTg) was used to measure cerebellar t‐tau levels.
Results
Plasma t‐tau levels were higher in mutation carriers below the age of 50 compared to controls, and the Inventory of Non‐Ataxia Signs was associated with t‐tau in ataxic patients (p = 0.004). Pre‐ataxic carriers showed higher cerebrospinal fluid t‐tau and p‐tau181 concentrations compared to ataxic patients (p = 0.025 and p = 0.014, respectively). Cerebellar t‐tau was elevated in MJDTg mice compared to wild‐type (p = 0.033) only in the early stages of the disease. GFAP and UCHL1 did not show higher levels in mutation carriers compared to controls. Plasma NfL concentrations were higher in mutation carriers compared to controls, and differences were greater for younger carriers. The Scale for the Assessment and Rating of Ataxia was the strongest predictor of NfL in ataxic patients (p < 0.001).
Conclusion
Our results suggest that tau might be a marker of early disease stages in SCA3. NfL can discriminate mutation carriers from controls and is associated with different clinical variables. Longitudinal studies are required to confirm their potential role as biomarkers in clinical trials.
Plasma total tau (t‐tau) is elevated in young ATXN3 mutation carriers compared to controls, and cerebrospinal fluid t‐tau and phosphorylated tau181 may be higher in pre‐ataxic subjects compared to ataxic patients. In addition, cerebellar t‐tau levels seem to be increased in early stages of the disease in a transgenic spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) mouse model (MJDTg). Therefore, tau could be a marker of early stages in SCA3/MJD. Plasma neurofilament light‐chain (NfL) concentrations are higher in ATXN3 mutation carriers compared to controls, and such difference is more marked for younger subjects. Plasma NfL concentrations were associated with clinical variables and are a good candidate as a fluid biomarker in SCA3/MJD.
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