Patients infected with SARS-CoV-2 may deteriorate rapidly and therefore continuous monitoring is necessary. We conducted an observational study involving patients with mild COVID-19 to explore the ...potentials of wearable biosensors and machine learning-based analysis of physiology parameters to detect clinical deterioration. Thirty-four patients (median age: 32 years; male: 52.9%) with mild COVID-19 from Queen Mary Hospital were recruited. The mean National Early Warning Score 2 (NEWS2) were 0.59 ± 0.7. 1231 manual measurement of physiology parameters were performed during hospital stay (median 15 days). Physiology parameters obtained from wearable biosensors correlated well with manual measurement including pulse rate (r = 0.96, p < 0.0001) and oxygen saturation (r = 0.87, p < 0.0001). A machine learning-derived index reflecting overall health status, Biovitals Index (BI), was generated by autonomous analysis of physiology parameters, symptoms, and other medical data. Daily BI was linearly associated with respiratory tract viral load (p < 0.0001) and NEWS2 (r = 0.75, p < 0.001). BI was superior to NEWS2 in predicting clinical worsening events (sensitivity 94.1% and specificity 88.9%) and prolonged hospitalization (sensitivity 66.7% and specificity 72.7%). Wearable biosensors coupled with machine learning-derived health index allowed automated detection of clinical deterioration.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The research conducted in 2021 aimed to address the limitation on the use of Fish Aggregating Devices (FADs) as one of the management measures in the tuna harvest strategy in Indonesia Archipelagic ...Waters (IAW), specifically in Indonesia FMA 713, 714, and 715. The lack of data on the number and position of FADs posed challenges for effective management. The research utilized Sentinel-1 satellite image data from July and August 2020 to overcome this issue. These images were analyzed using the Constant False Alarm Rate algorithm and a geospatial approach. The research focused on water areas greater than 12 nautical miles from the coastline of IAW. The results estimated the number of FADs in Indonesia FMA 713, 714, and 715 to be 661, 608, and 291 units. The distance between FADs was generally less than ten nautical miles. These findings provide valuable information for managing and implementing FADs in the designated areas. However, it is important to note that the estimates are based on data from 2020, and the actual number and position of FADs may have changed. The research highlights the need for continued monitoring and registration of FADs to ensure accurate and up-to-date information for effective management measures.
Penelitian ini dilatarbelakangi oleh pelaksanaan tugas pegawai di lingkungan PT. Bank Syariah Mandiri Cab. A. Yani Bandung, terdapat beberapa hal yang menentukan tingkat kinerja bagi pegawai yang ...disebabkan antara lain sistem rekrutmen yang selektif bagi pegawai termasuk di dalamnya promosi pegawai dalam suatu jabatan, kemampuan kerja yang dimiliki pegawai, dan perlunya pengalaman pegawai selama ia bekerja serta penempatan pegawai sesuai dengan kemampuan pegawai. Penelitian ini menggunakan metode deskriptif. Adapun objek penelitian ini adalah rekrutmen (X1), penempatan pegawai (X2) dan kinerja pegawai (Y). Sedangkan subjek penelitian ini PT. Bank Syariah Mandiri cab. A. Yani Bandung. Berdasarkan hasil pengolahan data dan interprestasi data terhadap masing-masing variabel dan dimensi pada masing-masing variabel disimpulkan sebagai berikut : (1) rekrutmen berpengaruh positif dan signifikan terhadap kinerja pegawai. Dengan demikian semakin baik pelaksanaan sistem rekruktmen, maka akan semakin tinggi kinerja pegawai; (2) penempatan berpengaruhpositif dan signifikan terhadap kinerja pegawai. Dengan demikian semakin tinggi penempatan, maka akan semakin tinggi pula kinerja pegawai; dan (3) rekrutmen dan penempatan berpengaruhpositif dan signifikan terhadap kinerja pegawai. Dengan demikian semakin baik pelaksanaan rekrutmen dan semakin tinggi penempatan akan semakin meningkat kinerja pegawai. Kata Kunci: Kinerja Pegawai, Rekrutmen, Penempatan Pegawai
The method of angular correlations recovers quantities from diffraction patterns of randomly oriented particles, as expected to be measured with an X-ray free electron laser (XFEL), proportional to ...quadratic functions of the spherical harmonic expansion coefficients of the diffraction volume of a single particle. We have previously shown that it is possible to reconstruct a randomly oriented icosahedral or helical virus from the average over all measured diffraction patterns of such correlations. We point out in this paper that a structure of even simpler particles of 50 Å or so in diameter and consisting of heavier atomic elements (to enhance scattering) that has been used as a test case for reconstructions from XFEL diffraction patterns can also be solved by this technique. Even though there has been earlier work on similar objects (prolate spheroids), one advantage of the present technique is its potential to also work with diffraction patterns not only due to single particles as has been suggested on the basis on nonoverlapping delta functions of angular scattering. Accordingly, we calculated from the diffraction patterns the angular momentum expansions of the pair correlations and triple correlations for general particle images and reconstructed those images in the standard way. Although the images looked pretty much the same, it is not totally clear to us that the angular correlations are exactly the same as different numbers of particles due to the possibility of constructive or destructive interference between the scattered waves from different particles. It is of course known that, for a large number of particles contributing to a diffraction parttern, the correlations converge to that of a single particle. It could be that the lack of perfect agreement between the images reconstructed with one and two particles is due to uncancelling constructive and destructive conditions that are not found in the case of solution scattering.
BackgroundPreeclampsia is a major cause of maternal and fetal morbidity and mortality. The imbalance of anti-angiogenic and angiogenic factors plays a role in endothelial dysfunction in preeclampsia. ...L-arginine is expected to improve the process of spiral artery remodeling. This study aims to examine the use of L-arginine to repair endothelial damage by measuring the thickness of uterine spiral arteries in mouse (Mus musculus) models of preeclampsia.MethodsThe researchers carried out an experimental study using 30 sixteen-day old pregnant Swiss mice (in good health, weighing 20-25 grams), which were randomly divided into 3 groups (each consisting of 10 mice). The groups were as follows: 1) normal pregnancy K(-); 2) preeclampsia model K(+); and 3) preeclampsia model receiving L-arginine (P). The authors performed histopathological examination of the mouse placenta, which had been dissected, embedded in paraffin wax and subsequently stained with hematoxylin and eosin (HE). The results were analyzed in SPSS v. 21 for Windows using Anova with Tukey.ResultsThe mean thickness of spiral arteries in group K(-) was 53.95 + 26.96 mm, in K(+) 96.50 + 16.66 mm, and in P 62.79 + 8.04 mm. Statistically, there were significant differences between groups K(-) and K(+) (p=0.001) and between K(+) and P (p=0.000), but non-significant differences between K(-) and P (p=1.000).ConclusionsThe treatment with L-arginine proved to be effective in repairing endothelial damage by reducing intimal hyperplasia and atherosis and, in turn, the thickness of uterine spiral arteries in mouse models of preeclampsia.
This study aims to analyze the effect of training, career development and competencies jointly and partially on the performance of PDAM Tirta Kamuning employees in Kuningan Regency. This study used ...quantitative methods using questionnaires. The population in this study was 161 permanent employees of PDAM Tirta Kamuning, Kuningan Regency. The sampling technique with proportional stratified random sampling and the number of samples determined based on the Slovin formula obtained by 62 respondents. Data analysis uses classical assumptions, multiple linear regression, coefficient of determination and hypothesis tests (t-test and F-test). The results showed that: (1) training had a positive and significant effect on employee performance as evidenced by the calculated tstatistic > ttable, namely 2.107 > 1.671 and the sig value of 0.039 < 0.05, (2) career development had a negative and significant effect on employee performance indicated by the calculated tstatistic < ttable namely -2,070 < 1,671 and sig value 0.043 < 0.05, and (3) competence has a positive and significant effect on employee performance indicated by a calculated tstatistic > ttable which is 3.087 > 1.671 and a sig value of 0.003 < 0.05. Meanwhile, the results of simultaneous tests showed that training, career development and competence had a significant effect on the performance of PDAM Tirta Kamuning employees in Kuningan Regency, which was shown by the calculated Fstatistic > Ftable, namely 7.964 > 2.76 and a sig value of 0.000 < 0.05.
Abstract only
Introduction:
Repeated 6MWT in clinic are inconvenient for patients and disruptive to usual clinic throughput. Digital measures may be a means to overcome these challenges and reliably ...measure functional capacity.
Methods:
As part of an observational clinical trial (NCT04191356), during an 8-week observation period, patients with heart failure (HF) utilize arm-band biosensors (Biofourmis Everion®) for at least 15 hours daily while carrying out daily activities and complete an in-clinic investigator-guided 6MWT on the first and last days of participation. Interim data (N=30, age 56.17 ± 11.26; 24 males; 3 NYHA I, 25 NYHA II, 2 NYHA III) are used for validation, where the distance of baseline 6MWT is used as reference standard.
Results:
Passive 6MWT, which is the maximum 6-minute step count derived from daily accelerometer data (Fig 1), is strongly correlated with the reference standard (R=0.7501, P<0.0001, N=30) (Fig 2). Further analysis (Fig 2) reveals that regardless of the duration of the step count, the digital measures consistently have strong correlations with the reference standard, with the highest correlation obtained by Passive 10MWT (R=0.7746, P<0.0001, N=30).
Conclusions:
Early data highlights that accelerometer data collected during daily activities appears to indicate functional capacity of HF patients. Continued data will validate digital measures against various patient outcomes.
Fig 1
Aggregation of Passive 6MWT from step count recorded during daily activities
Fig 2
Correlation between accelerometer-derived passive step count digital measures and distance manually measured during baseline investigator-guided 6MWT as reference standard (N=30)
The problem of determining the structure of a biomolecule, when all the evidence from experiment consists of individual diffraction patterns from random particle orientations, is the central ...theoretical problem with an XFEL. One of the methods proposed is a calculation over all measured diffraction patterns of the average angular correlations between pairs of points on the diffraction patterns. It is possible to construct from these a matrix B characterized by angular momentum quantum number l, and whose elements are characterized by radii q and q’ of the resolution shells. If matrix B is considered as dot product of vectors, which magnetic quantum number m is the component, singular value of B reveals the number of magnetic quantum numbers in the spherical harmonics expansion. What is shown in this paper is dependency of magnetic quantum number on symmetry can be associated to lowest independent parameter to describe symmetry. At the very least this determines information about particle symmetry from experiment data, independent of any assumed symmetry. An equally important point is that matrix B provides a means of reconstructing diffraction volume. This can be done by formulating intensity and matrix B as linear equation. Lastly, positivity constraint and optimization method is used to construct diffraction volume and phase is determined from phasing algorithm.
Underutilization of guideline-directed heart failure with reduced ejection fraction (HFrEF) medications contributes to poor outcomes.
A pilot study to evaluate the safety and efficacy of a home-based ...remote monitoring system for HFrEF management was performed. The system included wearable armband monitors paired with the smartphone application. An HFrEF medication titration algorithm was used to adjust medication daily. The primary endpoint was HFrEF medication utilization at 120 days. Twenty patients (60.5 ± 8.2 years, men: 85%) with HFrEF were recruited. All received angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB)/angiotensin receptor-neprilysin inhibitor (ARNI) at recruitment; 45% received ≥50% maximal targeted dose (MTD) with % MTD of 44.4 ± 31.7%. At baseline, 90 and 70% received beta-adrenergic blocker and mineralocorticoid receptor antagonist (MRA), 35% received ≥50% MTD beta-adrenergic blocker with % MTD of 34.1 ± 29.6%, and 25% received ≥50% MTD MRA with % MTD of 25.0 ± 19.9%. At 120 days, 70% received ≥50% MTD ACEI/ARB/ARNI (
= 0.110) with % MTD increased to 64.4 ± 33.5% (
= 0.060). The proportion receiving ≥50% MTD ARNI increased from 15 to 55% (
= 0.089) with % MTD ARNI increased from 20.6 ± 30.9 to 53.1 ± 39.5% (
= 0.006*). More patients received ≥50% MTD MRA (65 vs. 25%,
= 0.011*) with % MTD MRA increased from 25.0 ± 19.9 to 46.2 ± 28.8% (
= 0.009*). Ninety-five per cent of patients had reduced NT-proBNP with the percentage reduction of 26.7 ± 19.7%.
Heart failure with reduced ejection fraction medication escalation with remote monitoring appeared feasible.
Limitations of the leader's communication style with work performance, teacher job satisfaction, teacher commitment, and teacher motivation and teacher ability as a positive work culture have yet to ...show collective participation. The existence of harmony between theoretical expectations and reality urges a review to analyze leadership communication styles and teacher work culture towards collaborative management. The research method used is quantitative with a descriptive plan. The subjects were teachers and school leaders, totaling 310 respondents. Supervised data collection techniques by developing instruments based on research indicators. Technical analysis using SPSS Version 26.0 with correlation analysis. The results show that there is a positive and significant relationship between the level of the principal's basic tendency to power, the basis of expert power, the level of the basic tendency of the principal's coercive power, the level of the basic tendency of the principal's legitimate power, the principal's supervisory communication style, the teacher's work culture, the level of teacher competence, an organizational structure with a level of collaborative management at the level. The research conclusions show a negative and significant relationship between the age of leadership in secondary schools, the education level of school principals, and the level of collaborative management. The implications of this research can provide a positive picture and impact for leaders to communicate and collaborate massively and actively with teachers.
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