Background: Cement‐retained restorations are commonly used on dental implants. Residual excess cement after placement of fixed partial dentures has been associated with clinical and radiographic ...signs of peri‐implant disease. The purpose of this study was to explore the relationship between excess dental cement and peri‐implant disease using the dental endoscope.
Methods: Thirty‐nine consecutive patients with implants exhibiting clinical and/or radiographic signs of peri‐implant disease were studied. Patients were enrolled in the study during a 5‐year period in a private periodontal practice. Twelve of these patients had similar implants without signs of inflammation; these implants served as controls. There were 20 controls and 42 test implants. All were evaluated using a dental endoscope initially, and all but one implant was evaluated at a 30‐day follow‐up. Results from both groups were assessed by two trained operators and recorded.
Results: None of the controls and all 42 of the test implants had clinical signs of peri‐implant disease at initial treatment. Excess cement was found in none of the controls and 34 of the test sites. Thirty days after cement removal, 25 of 33 test sites from which the cement was removed had no clinical or endoscopic signs of inflammation.
Conclusions: Excess dental cement was associated with signs of peri‐implant disease in the majority (81%) of the cases. Clinical and endoscopic signs of peri‐implant disease were absent in 74% of the test implants after the removal of excess cement.
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BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Most would agree that the etiology of dental implant failure is related to oral biofilm. At present one group of scientists and clinicians feel that biofilm is solely responsible for bone loss around ...the devices. However, there is strong evidence that particles and ions of titanium released into the surrounding tissues by the action of biofilm and/or mechanical forces, a process termed metallosis, can be responsible for bone loss around some dental implants. These findings are reinforced by similar responses found around failed metal on metal joint prostheses. Both possible etiologies are discussed in detail in this commentary.
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BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Abstract Archival data from the WISE satellite reveal infrared flux variations of tens of per cent around numerous dusty white dwarfs. Data spanning more than 7 yr reveal more than half of known ...systems are varying in the 3.4 ${\mu}$m band, while the 4.6 ${\mu}$m data are challenging to interpret due to lower signal-to-noise ratios. The sparsely-sampled data limit interpretation, but the heterogeneous light curves suggest each source may be idiosyncratic, where there may be competing processes operating on different time-scales. Collisions are likely driving the observed decays in flux, and this finding suggests that dust production is operating more often than indicated by previous observations. The observed variation is at odds with the canonical flat disc model in isolation, and underscores the need for infrared monitoring of these evolved planetary systems to inform the next generation of theoretical models.
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory ...cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic fat accumulation and steatosis. We report a close correlation between hepatic fat accumulation and markers of hepatocyte senescence. The elimination of senescent cells by suicide gene-meditated ablation of p16
-expressing senescent cells in INK-ATTAC mice or by treatment with a combination of the senolytic drugs dasatinib and quercetin (D+Q) reduces overall hepatic steatosis. Conversely, inducing hepatocyte senescence promotes fat accumulation in vitro and in vivo. Mechanistically, we show that mitochondria in senescent cells lose the ability to metabolize fatty acids efficiently. Our study demonstrates that cellular senescence drives hepatic steatosis and elimination of senescent cells may be a novel therapeutic strategy to reduce steatosis.
Abstract
This paper presents combined Spitzer IRAC and Hubble COS results for a double-blind survey of 195 single and 22 wide binary white dwarfs for infrared excesses and atmospheric metals. The ...selection criteria include cooling ages in the range 9 to 300 Myr, and hydrogen-rich atmospheres so that the presence of atmospheric metals can be confidently linked to ongoing accretion from a circumstellar disc. The entire sample has infrared photometry, whereas 168 targets have corresponding ultraviolet spectra. Three stars with infrared excesses due to debris discs are recovered, yielding a nominal frequency of $1.5_{-0.5}^{+1.5}$ per cent, while in stark contrast, the fraction of stars with atmospheric metals is 45 ± 4 per cent. Thus, only one out of 30 polluted white dwarfs exhibits an infrared excess at 3–4 $\mu$m in IRAC photometry, which reinforces the fact that atmospheric metal pollution is the most sensitive tracer of white dwarf planetary systems. The corresponding fraction of infrared excesses around white dwarfs with wide binary companions is consistent with zero, using both the infrared survey data and an independent assessment of potential binarity for well-established dusty and polluted stars. In contrast, the frequency of atmospheric pollution among the targets in wide binaries is indistinct from apparently single stars, and moreover the multiplicity of polluted white dwarfs in a complete and volume-limited sample is the same as for field stars. Therefore, it appears that the delivery of planetesimal material on to white dwarfs is ultimately not driven by stellar companions, but by the dynamics of planetary bodies.
We report here the genome sequence of an ancient human. Obtained from approximately 4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to ...settle in Greenland. Sequenced to an average depth of 20x, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background: Peri‐implantitis is an inflammatory condition that can lead to implant loss. The aim of this descriptive retrospective study is to describe the histopathologic findings in soft tissue ...biopsies of implants with peri‐implantitis.
Methods: Thirty‐six human peri‐implantitis biopsies were analyzed using light microscopy (LM) and scanning electron microscopy (SEM). The composition of foreign materials found in the tissues was assessed using an energy dispersive x‐ray spectrometer.
Results: At the LM level, the inflammatory lesion of peri‐implantitis was in most cases a mixture of subacute and chronic inflammation dominated by plasma cells. At the SEM level, radiopaque foreign bodies were identified in 34 of the 36 biopsies. The predominant foreign bodies found were titanium and dental cement. These foreign materials were surrounded by inflammatory cells.
Conclusions: At present, the exact mechanism for introduction of these materials and their role in peri‐implantitis is unknown. Further research is warranted to determine their etiology and potential role in pathogenesis.
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BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Background
There is growing concern that titanium particles may play a role in peri‐implant breakdown. Ultrasonic scalers are routinely used in the debridement of peri‐implant lesions. This in vitro ...study is designed to evaluate if titanium particles are produced when an ultrasonic scaler is used on an implant.
Methods
New sandblasted, large grit, acid etched (SLA) coated implants were subjected to ultrasonic scaling with stainless steel, titanium, and PEEK plastic tips. The implants were placed in a holding device and the ultrasonic scaler was positioned on the SLA surface under 25 grams of pressure. The implants were subjected to 30 scaling motions. The ultrasonic coolant water was collected and the number of metallic particles were counted under a light microscope. The particles were confirmed to be titanium via elemental analysis. The implants were visually evaluated for damage to the SLA coating.
Results
No metallic particles were detected in the water supplied to the ultrasonic scalers (passive control). Metallic particles were detected when implants were subjected to the ultrasonic coolant water only without the scaler tip touching the implant (active control). All implants that were scaled produced metallic particles and showed easily detectable damage to the SLA layer.
Conclusions
All ultrasonic scaling caused the production of titanium particles and caused damage to the SLA coating of the implant. Ultrasonic scalers should be used with great caution in the treatment of peri‐implant conditions and care should be taken to not touch the SLA surface of the implant.
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BFBNIB, CMK, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
ABSTRACT
Multi-epoch infrared photometry from Spitzer is used to monitor circumstellar discs at white dwarfs, which are consistent with disrupted minor planets whose debris is accreted and chemically ...reflected by their host stars. Widespread infrared variability is found across the population of 37 stars with two or more epochs. Larger flux changes occur on longer time-scales, reaching several tens of per cent over baselines of a few years. The canonical model of a geometrically thin, optically thick disc is thus insufficient, as it cannot give rise to the observed behaviour. Optically thin dust best accounts for the variability, where collisions drive dust production and destruction. Notably, the highest infrared variations are seen in systems that show Ca ii emission, supporting planetesimal collisions for all known debris discs, with the most energetic occurring in those with detected gaseous debris. The sample includes the only polluted white dwarf with a circumbinary disc, where the signal of the day–night cycle of its irradiated substellar companion appears diluted by dust emission.
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