Abstract A near-infrared spectrum of nova V1716 Scorpii (PNV J17224490-4137160), a recent bright ( V max = 7.3 mag), Fermi-LAT detected γ -ray source, was modeled using the photoionization code ...CLOUDY. Abundances were estimated for He, C, N, O, Si, Al, Mg, Fe, Ne, S, Ca, and P. Notably, P (a factor of 120) and N (a factor of 248) are highly overabundant. It was necessary to assume the ejecta consist of two components (with a cylindrical geometry): a dense component from which the bulk of the H, He, and neutral O i and N emission arises and a more diffuse component from which most of the coronal lines arise. Some of the coronal lines are found to originate from both the dense and diffuse components. The mass of the ejecta, including neutral and ionized gas, is ≃4.19 × 10 −4 M ⊙ . Our analysis indicates that in the case of V1716 Sco (which has a carbon–oxygen white dwarf), a fraction of 25% white dwarf matter rather than 50% is favored for the mixing between a white dwarf and the accreted envelope before the outburst. This mixing ratio is like that found for oxygen–neon novae where a 25% mixing fraction is also indicated. Helium hydride—the first molecule to form after the Big Bang—may have formed in the ejecta of V1716 Sco based on photoionization modeling. This prediction suggests that novae may be potential formation sites of this important molecular ion.
We report 4.5 km luminosities for 27 nearby (D 5 Mpc) dwarf irregular galaxies measured with the Spitzer Infrared Array Camera. We have constructed the 4.5 km luminosity-metallicity (L-Z) relation ...for 25 dwarf galaxies with secure distance and interstellar medium oxygen abundance measurements. The 4.5 km L-Z relation is 12 + log(O/H) = (5.78 c 0.21) + (-0.122c 0.012)M sub(4.5), where M sub(4.5) is the absolute magnitude at 4.5 km. The dispersion in the near-infrared L-Z relation is smaller than the corresponding dispersion in the optical L-Z relation. The subsequently derived stellar mass-metallicity (M*-Z) relation is 12 + log(O/H) = (5.65 c 0.23) + (0.298 c 0.030) log M*, and extends the SDSS M*-Z relation to lower mass by about 2.5 dex. We find that the dispersion in the M*-Z relation is similar over 5 orders of magnitude in stellar mass, and that the relationship between stellar mass and interstellar medium metallicity is similarly tight from high-mass to low-mass systems. We find a larger scatter at low mass in the relation between effective yield and total baryonic mass. In fact, there are a few dwarf galaxies with large yields, which is difficult to explain if galactic winds are ubiquitous in dwarf galaxies. The low scatter in the L-Z and M*-Z relationships are difficult to understand if galactic superwinds or blowout are responsible for the low metallicities at low mass or luminosity. Naively, one would expect an ever increasing scatter at lower masses, which is not observed.
Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's disease (AD). ...Neurodegenerative effects of particulate air pollutants were examined in a US-wide cohort of older women from the Women's Health Initiative Memory Study (WHIMS) and in experimental mouse models. Residing in places with fine PM exceeding EPA standards increased the risks for global cognitive decline and all-cause dementia respectively by 81 and 92%, with stronger adverse effects in APOE ɛ4/4 carriers. Female EFAD transgenic mice (5xFAD
/human APOE ɛ3 or ɛ4
) with 225 h exposure to urban nanosized PM (nPM) over 15 weeks showed increased cerebral β-amyloid by thioflavin S for fibrillary amyloid and by immunocytochemistry for Aβ deposits, both exacerbated by APOE ɛ4. Moreover, nPM exposure increased Aβ oligomers, caused selective atrophy of hippocampal CA1 neurites, and decreased the glutamate GluR1 subunit. Wildtype C57BL/6 female mice also showed nPM-induced CA1 atrophy and GluR1 decrease. In vitro nPM exposure of neuroblastoma cells (N2a-APP/swe) increased the pro-amyloidogenic processing of the amyloid precursor protein (APP). We suggest that airborne PM exposure promotes pathological brain aging in older women, with potentially a greater impact in ɛ4 carriers. The underlying mechanisms may involve increased cerebral Aβ production and selective changes in hippocampal CA1 neurons and glutamate receptor subunits.
Context. Classical novae are the product of thermonuclear runaway-initiated explosions occurring on accreting white dwarfs. Aims. V339 Del (Nova Delphinus 2013) was one of the brightest classical ...novae of the last hundred years. Spectroscopy and photometry are available from γ-rays through infrared at stages that have frequently not been observed well. The complete data set is intended to provide a benchmark for comparison with modeling and for understanding more sparsely monitored historical classical and recurrent novae. This paper is the first in the series of reports on the development of the nova. We report here on the early stages of the outburst, through the X-ray active stage. Methods. A time sequence of optical, flux calibrated high resolution spectra was obtained with the Nordic Optical Telescope (NOT) using FIES simultaneously, or contemporaneously, with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope during the early stages of the outburst. These were supplemented with Mercator/HERMES optical spectra. High resolution IUE ultraviolet spectra of OS And 1986, taken during the Fe curtain phase, served as a template for the distance determination. We used standard plasma diagnostics (e.g., O III and N II line ratios, and the Hβ line flux) to constrain electron densities and temperatures of the ejecta. Using Monte Carlo modeling of the ejecta, we derived the structure, filling factor, and mass from comparisons of the optical and ultraviolet line profiles. Results. We derive an extinction of E(B − V) = 0.23 ± 0.05 from the spectral energy distribution, the interstellar absorption, and H I emission lines. The distance, about 4−4.5 kpc, is in agreement with the inferred distance from near infrared interferometry. The maximum velocity was about 2500 km s-1, measured from the UV resonance and optical profiles. The ejecta showed considerable fine structure in all transitions, much of which persisted as emission knots. The line profiles were modeled using a bipolar conical structure for the ejecta within a relatively restricted range of parameters. For V339 Del, we find that an inclination to the line of sight of about 35°−55°, an opening angle of 60°−80°, and an inner radius ΔR/R(t) ≈ 0.3 based on vrad,max matches the permitted and intercombination lines. The filling factor is f ≈ 0.1, and the derived range in the ejecta mass is (2−3) × 10-5M⊙.
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Continental shelf sediments are globally important for biogeochemical activity. Quantification of shelf-scale stocks and fluxes of carbon and nutrients requires the extrapolation of observations made ...at limited points in space and time. The procedure for selecting exemplar sites to form the basis of this upscaling is discussed in relation to a UK-funded research programme investigating biogeochemistry in shelf seas. A three-step selection process is proposed in which (1) a target area representative of UK shelf sediment heterogeneity is selected, (2) the target area is assessed for spatial heterogeneity in sediment and habitat type, bed and water column structure and hydrodynamic forcing, and (3) study sites are selected within this target area encompassing the range of spatial heterogeneity required to address key scientific questions regarding shelf scale biogeochemistry, and minimise confounding variables. This led to the selection of four sites within the Celtic Sea that are significantly different in terms of their sediment, bed structure, and macrofaunal, meiofaunal and microbial community structures and diversity, but have minimal variations in water depth, tidal and wave magnitudes and directions, temperature and salinity. They form the basis of a research cruise programme of observation, sampling and experimentation encompassing the spring bloom cycle. Typical variation in key biogeochemical, sediment, biological and hydrodynamic parameters over a pre to post bloom period are presented, with a discussion of anthropogenic influences in the region. This methodology ensures the best likelihood of site-specific work being useful for up-scaling activities, increasing our understanding of benthic biogeochemistry at the UK-shelf scale.
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BFBNIB, DOBA, EMUNI, FZAB, GEOZS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NMLJ, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering ...21,500 square kilometres surrounding a much cooler central 'island'. The temperature gradient seen across areas of the patera indicates a systematic resurfacing process, which has been seen to occur typically every one to three years since the 1980s. Analysis of past data has indicated that the resurfacing progressed around the patera in an anti-clockwise direction at a rate of one to two kilometres per day, and that it is caused either by episodic eruptions that emplace voluminous lava flows or by a cyclically overturning lava lake contained within the patera. However, spacecraft and telescope observations have been unable to map the emission from the entire patera floor at sufficient spatial resolution to establish the physical processes at play. Here we report temperature and lava cooling age maps of the entire patera floor at a spatial sampling of about two kilometres, derived from ground-based interferometric imaging of thermal emission from Loki Patera obtained on 8 March 2015 ut as the limb of Europa occulted Io. Our results indicate that Loki Patera is resurfaced by a multi-phase process in which two waves propagate and converge around the central island. The different velocities and start times of the waves indicate a non-uniformity in the lava gas content and/or crust bulk density across the patera.
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IJS, KISLJ, NUK, SBMB, UL, UM, UPUK
Exposure to traffic-related air pollution (TRAP) is associated with a range of neurodevelopmental disorders in human populations. In rodent models, prenatal TRAP exposure increased depressive ...behaviors and increased brain microglial activity. To identify cellular mechanisms, we examined adult neurogenesis and the blood-brain barrier (BBB) in relation to cognition and motivated behaviors in rats that were exposed to a nano-sized TRAP subfraction from gestation into adulthood. At age 5 months, exposed male rats had 70% fewer newly generated neurons in the dentate gyrus (DG) of the hippocampus. Microglia were activated in DG and CA1 subfields (35% more Iba1). The BBB was altered, with a 75% decrease of the tight junction protein ZO-1 in the CA1 layer, and twofold more iron deposits, a marker of microhemorrhages. The exposed rats had impaired contextual memory (novel object in context), reduced food-seeking behavior, and increased depressive behaviors (forced swim). Deficits of de novo neurogenesis were inversely correlated with depressive behavior, whereas increased microbleeds were inversely correlated with deficits in contextual memory. These findings give the first evidence that prenatal and early life exposure to TRAP impairs adult hippocampal neurogenesis and increases microbleeds in association with behavioral deficits.
Aim
To investigate early medical and family factors associated with later feeding risk in preterm infants.
Methods
For this longitudinal study, 136 infants born ≤30 weeks gestation were enrolled. ...Medical and social background factors were assessed at term equivalent age. Infants underwent magnetic resonance imaging, neurobehavioral evaluation and feeding assessment. Parent involvement in the neonatal intensive care unit was tracked, and maternal mental health was assessed at neonatal intensive care unit discharge. At age 2 years, feeding outcome was assessed using the Eating Subscale of the Infant‐Toddler Social Emotional Assessment (n = 80). Associations between feeding problems at age 2 years and (i) early medical factors, (ii) neurobehavioral functioning and feeding at term equivalent age, (iii) cerebral structure and (iv) maternal mental health were investigated using regression.
Results
Eighteen (23%) children had feeding problems at age 2 years. Feeding problems were associated with early hypotonia (p = 0.03; β = 0.29) and lower socio‐economic status (p = 0.046; β = −0.22). No associations were observed between early medical factors, early feeding performance, cerebral structure alterations or maternal well‐being and feeding outcome.
Conclusion
Early hypotonia may disrupt the development of oral‐motor skills. Hypotonia and poor feeding also may share a common aetiology. Associations with lower socio‐economic status highlight the potential influence of family background factors in feeding problems in the preterm infant.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Contents
In the horse, breeding induces a transient endometrial inflammation. A subset of mares are unable to resolve this inflammation, and they are considered susceptible to persistent ...mating‐induced endometritis PMIE Select seminal plasma proteins cysteine‐rich secretory protein‐3 (CRISP‐3) and lactoferrin have been shown to affect the innate immune response to sperm in vitro. The objective of this study was to determine whether the addition of CRISP‐3 and lactoferrin at the time of insemination had an effect on the mRNA expression of endometrial cytokines in susceptible mares after breeding. Six mares classified as susceptible to PMIE were inseminated during four consecutive oestrous cycles with treatments in randomized order of: 1 mg/ml CRISP‐3, 150 μg/ml lactoferrin, seminal plasma (positive control) or lactated Ringer's solution (LRS; negative control) to a total volume of 10 ml combined with 1 × 109 spermatozoa pooled from two stallions. Six hours after treatment, an endometrial biopsy was obtained for qPCR analysis of selected genes associated with inflammation (pro‐inflammatory cytokines interleukin (IL)‐1β, IL‐8, tumour necrosis factor (TNF)‐α, interferon (INF)‐γ, anti‐inflammatory cytokines IL‐1RN and IL‐10, and inflammatory‐modulating cytokine IL‐6). Seminal plasma treatment increased the mRNA expression of IL‐1β (p = .019) and IL‐8 (p = .0068), while suppressing the mRNA expression of TNF (p = .0013). Lactoferrin also suppressed the mRNA expression of TNF (p = .0013). In conclusion, exogenous lactoferrin may be considered as one modulator of the complex series of events resulting in the poorly regulated pro‐inflammatory response seen in susceptible mares.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
We report second- and third-harmonic generation in monolayer MoS2 as a tool for imaging and accurately characterizing the material's nonlinear optical properties under 1560 nm excitation. Using a ...surface nonlinear optics treatment, we derive expressions relating experimental measurements to second- and third-order nonlinear sheet susceptibility magnitudes, obtaining values of χ s ( 2 ) = 2.0 × 10 − 20 m2 V−1 and, for the first time for monolayer MoS2, χ s ( 3 ) = 1.7 × 10 − 28 m3 V−2. These sheet susceptibilities correspond to effective bulk nonlinear susceptibility values of χ b ( 2 ) = 2.9 × 10 − 11 m V−1 and χ b ( 3 ) = 2.4 × 10 − 19 m2 V−2, accounting for the sheet thickness. Experimental comparisons between MoS2 and graphene are also performed, demonstrating ∼3.4 times stronger third-order sheet nonlinearity in monolayer MoS2, highlighting the material's potential for nonlinear photonics in the telecommunications C band.
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