This paper investigates the event-based control for network systems. Edge-based approach is utilized to predict the value of edge state between two event instants. Different from the node-based ...approach, it can significantly reduce the communication burden at event instants. Based on the small gain theorem, the closed-loop system is expressed as the feedback interconnection of a linear time-invariant system and an operator. The operator describes the unstable component and has an upper bound in L 2 space and the control gain is designed, such that the feedback interconnection is stable. Furthermore, we adopt the integral quadratic constraints to describe the correlation between output and input of the operator. And the Kalman-Yakubovich-Popov Lemma is adopted to transform the infinite dimensional stability condition into one inequality. The designed event-triggering condition and distributed control law can ensure that a network system achieves synchronization. The effectiveness of the communication protocol and control strategy is illustrated by a numerical example.
On the basis of numerous fluid simulation experiences, researchers have discovered that many common operations can be abstracted to form a general fluid simulation framework. These operations include ...the discretization of equations and variables, the computation of the coefficients, the assembly of the linear or nonlinear systems, the solving of the systems, etc. Furthermore, all of the operations can be attributed to the operations "in the field", which is an abstract concept derived from the equations and variables. Thus, fluid simulations can be performed under a field-based general framework. Moreover, in response to the urgent need for large-scale fluid simulations, parallelism is integrated into the framework. Due to the convenience of the field operations, parallelization of the framework can be realized on both the OpenMP and MPI levels. In other words, because of the newly defined "fields", a series of operations in fluid simulations can be simplified and unified. However, very few studies have noted this advantage, and therefore, this work attempts to fill the void. With the help of a field-based general framework, it is anticipated that the parallel codes of fluid simulations can be generated easily and quickly. As an application of the general framework, a parallel 3D simulator for matrix acidization called Masor is developed. The simulation results are regarded as physically reasonable by many studies, which verifies the correctness and effectiveness of the general framework. In addition, it is noteworthy that the parallel performance of Masor is decided by a solver.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The product of exponential model based robot calibration approach eliminates parameter discontinuity and simplifies coordinate frame setup, but demands extra effort to normalize twist coordinates and ...differentiate parameter-varying exponential maps. In this paper, we show that such an endeavor can be exempted by respecting the nonlinear geometry of the joint axis configuration space (ACS), the set of all possible axis locations. We analyze the geometry of the ACS models for prismatic and revolute joints, and treat the errors as Adjoint transformations on joint twists. We propose a novel robot kinematic calibration algorithm based on the ACS and Adjoint error model. It is geometrically intuitive, computationally efficient, and can easily handle additional assumptions on joint axes relations. We present a comparative study with simulations and experiments to show that our algorithm outperforms the existing ones in various aspects.
This paper is concerned with the consensus of multiagent systems with nonlinear dynamics through the use of aperiodic sampled-data controllers, which are more flexible than classical periodic ...sampled-data controllers. By input delay approach, the resulting sampled-data system is reformulated as a continuous system with time-varying delay in the control input. A continuous Lyapunov functional, which captures the information on sampling pattern, together with the free-weighting matrix method, is then used to establish a sufficient condition for consensusability. For a more general case that the sampled-data controllers are subject to constant input delays, a novel discontinuous Lyapunov functional is introduced on the basis of the vector extension of Wirtinger's inequality. This functional can lead to simplified and efficient stability conditions for computation and optimization. Further results on the estimate of maximal allowable sampling interval upper bound is given as well. Numerical example is provided to show the effectiveness and merits of the proposed protocol.
Just as the 3-D Euclidean space can be inverted through any of its points, the special Euclidean group SE(3) admits an inversion symmetry through any of its elements and is known to be a symmetric ...space. In this paper, we show that the symmetric submanifolds of SE(3) can be systematically exploited to study the kinematics of a variety of kinesiological and mechanical systems and, therefore, have many potential applications in robot kinematics. Unlike Lie subgroups of SE(3), symmetric submanifolds inherit distinct geometric properties from inversion symmetry. They can be generated by kinematic chains with symmetric joint twists. The main contribution of this paper is: 1) to give a complete classification of symmetric submanifolds of SE(3); 2) to investigate their geometric properties for robotics applications; and 3) to develop a generic method for synthesizing their kinematic chains.
Trajectory planning is a core technology for autonomous vehicle directlyreflecting the driving safety and efficiency. In this paper, a spatial‐speed decoupled planning method is studied for real‐time ...trajectory generation in the on‐road environment. The proposed approach mainly includes two parts: optimization‐based lateral planning and selection‐based longitudinal speed planning. The optimization‐based lateral planning is employed to generate an optimal collision‐free and smooth path by solving a quadratic programming problem. Specifically, the lateral planning first constructs a safe corridor by integrating obstacles and initial risky corridor together in the Frénet frame. The safe corridor is useful for quadratic programming problem formulation. The selecting‐based longitudinal speed planning is proposed to generate a suitable and continuous velocity trajectory. The novel speed selector considering four cases is designed to select a more suitable reference velocity in different lane situations. The continuous velocity trajectory is obtained by solving piecewise continuous quartic polynomial. As a result, the combination of the spatial path and the velocity trajectory is the final planning result. The proposed algorithm is tested extensively in a simulation environment. Experimental results demonstrate that the proposed algorithm has good real‐time property and practical validity.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to ...study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had more mutations than did HPV-positive tumors. Six of the genes that were mutated in multiple tumors were assessed in up to 88 additional HNSCCs. In addition to previously described mutations in TP53, CDKN2A, PIK3CA, and HRAS, we identified mutations in FBXW7 and NOTCH1. Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
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Nasopharyngeal carcinoma (NPC) is a type of head and neck tumor with noticeable regional and ethnic differences. It is associated with Epstein-Barr virus infection and has a tendency for local and ...distant metastasis. NPC is also highly sensitive to radiotherapy and chemotherapy. Over 70% of patients present with locoregionally advanced disease, and distant metastasis is the primary reason for treatment failure. A signal transducer and activator of transcription 3 (STAT3) promotes NPC oncogenesis through mechanisms within cancerous cells and their interactions with the tumor microenvironment, which is critical in the initiation, progression, and metastasis of NPC. Further, p-STAT3 is strongly associated with advanced NPC. Recent research on STAT3 has focused on its expression at the center of various oncogenic pathways. Here, we discuss the role of STAT3 in NPC and its potential therapeutic inhibitors and analogs for the treatment and control of NPC.
Purpose
Migraine is often accompanied with chronic tinnitus that will affect the cerebral blood flow (CBF) and exacerbate the tinnitus distress. However, the potential relationship between migraine ...and tinnitus remains unclear. This study will investigate whether aberrant CBF patterns exist in migraine patients with tinnitus and examine the influence of migraine on CBF alterations in chronic tinnitus.
Materials and methods
Participants included chronic tinnitus patients (
n
= 45) and non-tinnitus controls (
n
= 50), matched for age, sex, education, and hearing thresholds. CBF images were collected and analyzed using arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI). Regions with major CBF differences between tinnitus patients and non-tinnitus controls were first detected. The effects of migraine on tinnitus for CBF alterations were further examined. Correlation analyses illustrated the association between CBF values and tinnitus severity as well as between CBF and severity of migraine.
Results
Compared with non-tinnitus controls, chronic tinnitus patients without migraine exhibited decreased CBF, primarily in right superior temporal gyrus (STG), bilateral middle frontal gyrus (MFG), and left superior frontal gyrus (SFG); decreased CBF in these regions was correlated with tinnitus distress. There was a significant effect of migraine on tinnitus for CBF in right STG and MFG. Moreover, the severity of migraine correlated negatively with CBF in tinnitus patients.
Conclusions
Chronic tinnitus patients exhibited reduced CBF in the auditory and prefrontal cortex. Migraine may facilitate a CBF decrease in the setting of tinnitus, which may underlie the neuropathological mechanisms of chronic tinnitus comorbid with migraine.
Matrix acidization simulation is a challenging task in the study of flows in porous media due to the changing porosity in the procedure. The improved Darcy–Brinkman–Forchheimer framework is one model ...to do this simulation. In this framework, the mass and momentum conservation equations are discretized to form a pressure–velocity linear system. However, the coefficient matrix of the linear system has a large condition number, and solving the linear system belongs to the saddle point problem. As a result of that, convergence is hard to achieve when solving it with iterative solvers. It is well known that the scale of the linear systems in matrix acidization simulation is large, and therefore, the usage of iterative solvers is required. Thus, a decoupled scheme is proposed in this work to decouple the pressure–velocity linear system into two independent linear systems: one is to solve for pressure, and the other one is to solve for velocity. It is emphasized that both of the linear systems are discretized from the elliptical partial differential equations, which guarantees fast convergence can be achieved by iterative solvers. A numerical experiment is carried out to demonstrate the correctness of the decoupled scheme and its higher computing efficiency. After that, the decoupled scheme is applied in investigating the factors that cannot change the optimal injected velocity and the dissolution pattern in matrix acidization.
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