The Connected Customer Wuyts, Stefan H. K; Dekimpe, Marnik G; Gijsbrechts, Els ...
2010, 20110119, 2010-03-05, 2011-01-19
eBook
In today’s connected consumer environment, customers are better informed and harder to please, but they also leave a more visible evidence trail in the form of improved databases and customer ...information. Consumers are increasingly interconnected through various sorts of social networks, a trend that is facilitated by recent advances in electronic media and telecommunication (i.e., MySpace, Facebook, Twitter and Cyworld). Consumers are also increasingly connected with brands and seek to play a more participative role in their relationship with companies, stimulating companies to reconsider how to connect with consumers.
This book consists of a collection of chapters by thought-leaders in the field of marketing and beyond that deals with the rich facets of connectivity. This edited volume is a great source of research ideas and fresh theory building for academics and students in marketing and related fields who wish to understand this exciting field. It will be a source of inspiration for practitioners who are eager to take up the challenge and adapt their marketing strategies to the changing nature of consumer and business markets.
Stefan Wuyts is associate professor of marketing at Tilburg University, the Netherlands. After studying Business Engineering and Marketing, he joined the Tinbergen Institute (Erasmus University Rotterdam) as a doctoral student. His doctoral dissertation was awarded by the Dutch Royal Society for Economics. Stefan’s research interests include B2B markets, channel management, innovation, and social networks. His work in these areas has appeared in Journal of Marketing, Journal of Marketing Research, and International Journal of Research in Marketin g, among other. In 2007, he was named a MSI (Marketing Science Institute) Young Scholar and published a monograph with Christophe Van den Bulte, ‘Social Networks and Marketing’ (MSI 2007). Stefan serves as area editor for International Journal of Research in Marketing and reviewer for Journal of Marketing, Journal of Marketing Research, Management Science, Journal of Operations Management, and Journal of International Business Studies . He has collaborated with several B2B companies such as ASML and Nexans.
Marnik G. Dekimpe (Ph.D., UCLA) is Research Professor of Marketing at Tilburg University (The Netherlands) and Professor of Marketing at the Catholic University Leuven (Belgium). His work has been published in Marketing Science, Management Science, the Journal of Marketing Research, the Journal of Marketing, the International Journal of Research in Marketing and the Journal of Econometrics , among others. He has won best-paper awards at Marketing Science (1995, 2001), the Journal of Marketing Research (1999), the International Journal of Research in Marketing (1997, 2001, 2002), and Technological Forecasting and Social Change (2000). As of October 2009, he becomes the editor of the International Journal of Research in Marketing . He also serves on the editorial board of Marketing Science , the Journal of Marketing Research, the Journal of Marketing, the Journal of Interactive Marketing, and Marketing Letters . He is an Academic Trustee with both the Marketing Science Institute and AiMark.
Els Gijsbrechts is Professor of Quantitative Marketing at Tilburg University, the Netherlands. She received a PhD in Applied Economic Sciences from the University of Antwerp, and previously held positions at the University of Antwerp, FUCAM and the Catholic University of Leuven. She is Area Editor for the International Journal of Research in Marketing - the official journal of the European Marketing Academy. Her research focuses on modeling consumers' shopping behavior and their responses to retailer and manufacturer decisions such as shelf layout, price (promotions), branding, stock-outs and assortment decisions. She has been involved in research and teaching programs for various companies, such as GfK, Janssen Pharmaceutica, Heineken and Delhaize – to name just a few. Her research has been published in leading journals like the Journal of Marketing Research , the International Journal of Research in Marketing , and the Journal of Retailing , and received several nominations, such as those for the IJRM Best Paper Award , the Davidson Award , and the William O’Dell Award .
Rik Pieters is professor of marketing at Tilburg University and guest professor at the R.H. Smith School at University of Maryland. He holds a PhD in psychology from the University of Leiden. His work has appeared in Journal of Marketing, Journal of Marketing Research, Marketing Science, Management Science, Pint Bulletin, Journal of Personality and Social Psychology, Journal of the American Statistical Association , among others. He is an area editor of Journal of Marketing Research . Together with Michel Wedel he organized the first conference on Visual Marketing at the University of Michigan. His research interests are effectiveness of marketing communication, the social and cognitive psychology of consumer behavior, visual marketing. When not doing research he collects data in various fields.
Preface. Introduction. Part 1. Connectivity and the New Reality of Markets C. Van den Bulte, Opportunities and Challenges in Studying Customer Networks. C.M. Henderson, R.W. Palmatier , Understanding the Relational Ecosystem in a Connected World. S. Wuyts , Connectivity, Control, and Constraint in Business Markets. Part 2. Leveraging Vertical Connectivity with Channel Partners and Brands N. Camacho, V. Landsman, S. Stremersch , The Connected Patient. B. Shiv , Is Mr. Spock a Good Candidate for Being a Connected Customer? The Role of Emotion in Decision Making. A. Rindfleisch, N. Wong, J.E. Burroughs , God and Mammon: The Influence of Religiosity on Brand Connections. R. Srivastava, T. Wiesel , Brand Platforms as Strategic Investments: Leveraging Customer Connections to Manage Profitability, Growth and Risk. Part 3. Leveraging Horizontal Connectivity Among Customers R. Burt , The Shadow of Other People: Socialization and Social Comparison in Marketing. R. van der Lans, G. Verbruggen , Viral Marketing: What is It and What are the Components of Viral Success? J. Goldenberg, S. Han, D.R. Lehmann , Social Connectivity, Opinion Leadership and Diffusion. A. Bonfrer , The Effect of Negative Word of Mouth in Social Networks.
"The mantra of marketing practice today is connectivity--creating deeper connections with customers to enhance brand equity, generate more loyalty, develop new products, and achieve other goals. This book features research by some of the world's best academics on the topic of connectivity. It is a must-read for any academic, student, or practitioner interested in what we know about viral marketing, social networks, emotion, word-of-mouth, and a number of other topics related to how to create and improve customer relationships." - Russell Winer, Chairman, Marketing Department, Stern School of Business, New York University, USA
" This is a timely topic that should find relatively broad interest. Moreover there are no up-to-date competing volumes and the line up of authors is strong." - Norbert Schwarz, University of Michigan, USA
"The focus on how consumers create networks with marketers and other consumers is an important topic. It has significant relevance to scholarship and research in the field. New ideas would be issues pertaining to connections between consumers and their service providers (e.g. doctors and their patients) social capital issues, and issues of how networks can be of strategic importance to both marketers and consumers. These are new and unique ideas." - Cornelia Otnes, University of Illinois, Champaign, USA
"This book offers unique evidence-based insights into a very important and evolving research domain: social networks and consumer connectivity. It is comprised of a well-connected set of scholarly contributions, made by top academic experts in the field. Its three-dimensional structure: overall connectivity, vertical connectivity, and horizontal connectivity, allows for an impressive coverage of what is known as well as what needs to be further researched. It can serve as a very useful guide book for those who want to understand the topic in depth and those interested in adding to the extant knowledge base." - Jehoshua Eliashberg, The Wharton School, University of Pennsylvania, USA
Background and aims:
Endotoxin, derived from intestinal aerobic Gram‐negative bacilli (AGNB), could be an important monocyte activator in chronic heart failure (CHF). The effect of selective ...decontamination of the digestive tract (SDD) on intracellular monocyte cytokine production, monocyte CD14 expression, circulating endotoxin and cytokines, and flow‐mediated dilation (FMD) was studied in patients with severe CHF.
Methods and results:
Ten patients with CHF (NYHA class III–IV) were enrolled in a non‐placebo controlled pilot trial involving the administration of SDD (polymyxin B, tobramycin) for 8 weeks. One patient was later excluded due to cardiac transplantation. Before treatment, after 4 and 8 weeks therapy, and 6 weeks post‐treatment, monocyte CD14 expression, intracellular monocyte production of interleukin‐1β IL‐1β, interleukin‐6 IL‐6, tumour necrosis factor (TNF)‐α with and without lipopolysaccharide (LPS) stimulation were measured. Concentrations of endotoxin and cytokines (IL‐1β, IL‐6, TNF‐α) were also determined. AGNB in faeces, intestinal endotoxin and FMD were assessed at baseline, after 4 weeks of treatment and 6 weeks post‐treatment. SDD eradicated intestinal AGNB (P<0.00001) and decreased faecal endotoxin concentrations (P<0.00001). There was a significant decline in monocyte CD14 expression (P=0.03) and in IL‐1β (P=0.0001), IL‐6 (P=0.02) and TNF‐α (P=0.0002) production after 4 and 8 weeks of treatment in the basal state and for IL‐1β (P=0.008) and IL‐6 (P=0.005) after LPS stimulation. FMD significantly improved at 4 weeks and returned to baseline after treatment discontinuation (P=0.002). Circulating concentrations of endotoxin and cytokines remained unchanged.
Conclusion:
Reduction of the intestinal endotoxin pool led to a decrease in monocyte CD14 expression and intracellular cytokine production in patients with severe CHF. The improvement of peripheral endothelial function could be a marker of the anti‐inflammatory effect of SDD.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Severe acute respiratory syndrome coronavirus-2 infection causes COVID-19, which in severe cases evokes life-threatening acute respiratory distress syndrome (ARDS). Transcriptome signatures and the ...functional relevance of non-vascular cell types (e.g. immune and epithelial cells) in COVID-19 are becoming increasingly evident. However, despite its known contribution to vascular inflammation, recruitment/invasion of immune cells, vascular leakage, and perturbed haemostasis in the lungs of severe COVID-19 patients, an in-depth interrogation of the endothelial cell (EC) compartment in lethal COVID-19 is lacking. Moreover, progressive fibrotic lung disease represents one of the complications of COVID-19 pneumonia and ARDS. Analogous features between idiopathic pulmonary fibrosis (IPF) and COVID-19 suggest partial similarities in their pathophysiology, yet, a head-to-head comparison of pulmonary cell transcriptomes between both conditions has not been implemented to date.
We performed single-nucleus RNA-sequencing on frozen lungs from 7 deceased COVID-19 patients, 6 IPF explant lungs, and 12 controls. The vascular fraction, comprising 38 794 nuclei, could be subclustered into 14 distinct EC subtypes. Non-vascular cell types, comprising 137 746 nuclei, were subclustered and used for EC-interactome analyses. Pulmonary ECs of deceased COVID-19 patients showed an enrichment of genes involved in cellular stress, as well as signatures suggestive of dampened immunomodulation and impaired vessel wall integrity. In addition, increased abundance of a population of systemic capillary and venous ECs was identified in COVID-19 and IPF. COVID-19 systemic ECs closely resembled their IPF counterparts, and a set of 30 genes was found congruently enriched in systemic ECs across studies. Receptor-ligand interaction analysis of ECs with non-vascular cell types in the pulmonary micro-environment revealed numerous previously unknown interactions specifically enriched/depleted in COVID-19 and/or IPF.
This study uncovered novel insights into the abundance, expression patterns, and interactomes of EC subtypes in COVID-19 and IPF, relevant for future investigations into the progression and treatment of both lethal conditions.
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