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1.
  • Defining neonatal sepsis Defining neonatal sepsis
    Wynn, James L Current opinion in pediatrics, 04/2016, Volume: 28, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Although infection rates have modestly decreased in the neonatal intensive care unit (NICU) as a result of ongoing quality improvement measures, neonatal sepsis remains a frequent and devastating ...
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  • Why are preterm newborns at... Why are preterm newborns at increased risk of infection?
    Collins, Amélie; Weitkamp, Jörn-Hendrik; Wynn, James L Archives of disease in childhood. Fetal and neonatal edition, 07/2018, Volume: 103, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    One in 10 newborns will be born before completion of 36 weeks' gestation (premature birth). Infection and sepsis in preterm infants remain a significant clinical problem that represents a substantial ...
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  • A neonatal sequential organ... A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
    Wynn, James L; Polin, Richard A Pediatric research, 07/2020, Volume: 88, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    An operational definition of organ dysfunction applicable to neonates that predicts mortality in the setting of infection is lacking. We determined the utility of an objective, electronic health ...
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  • Application of metabolomics... Application of metabolomics to neonatal meningitis
    Wynn, James L Pediatric research, 08/2020, Volume: 88, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    The risk of infant meningitis has been dramatically reduced by successful vaccination programs over the past several decades.1 A study of 931 infants ≤28 days old (nearly all ≥36 weeks at birth) with ...
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  • Reappraisal of Guidelines f... Reappraisal of Guidelines for Management of Neonates with Suspected Early-Onset Sepsis
    Benitz, William E., MD; Wynn, James L., MD; Polin, Richard A., MD The Journal of pediatrics, 04/2015, Volume: 166, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Since 1992, professional societies or public health agencies in the United States 1 – 12 and elsewhere 13 – 17 have issued several generations of recommendations for prevention or management of ...
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  • Cell-free hemoglobin increa... Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis
    Meegan, Jamie E; Shaver, Ciara M; Putz, Nathan D ... PloS one, 02/2020, Volume: 15, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are ...
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  • Prolonged early antimicrobi... Prolonged early antimicrobials in ELBWs: too much for too little
    Wynn, James L Pediatric research, 06/2019, Volume: 85, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    In this issue of Pediatric Research, Greenberg and colleagues3 examined a cohort of 5730 ELBW, 22–28-week gestation infants cared for in the Eunice Kennedy Shriver NICHD NRN from 2008 to 2014 with ...
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  • Beyond bacteria: a study of... Beyond bacteria: a study of the enteric microbial consortium in extremely low birth weight infants
    LaTuga, Mariam Susan; Ellis, Joseph Christopher; Cotton, Charles Michael ... PloS one, 12/2011, Volume: 6, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Extremely low birth weight (ELBW) infants have high morbidity and mortality, frequently due to invasive infections from bacteria, fungi, and viruses. The microbial communities present in the ...
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