Owing to the unique electronic properties, rare‐earth modulations in noble‐metal electrocatalysts emerge as a critical strategy for a broad range of renewable energy solutions such as water‐splitting ...and metal–air batteries. Beyond the typical doping strategy that suffers from synthesis difficulties and concentration limitations, the innovative introduction of rare‐earth is highly desired. Herein, a novel synthesis strategy is presented by introducing CeO2 support for the nickel–iron–chromium hydroxide (NFC) to boost the oxygen evolution reaction (OER) performance, which achieves an ultralow overpotential at 10 mA cm−2 of 230.8 mV, the Tafel slope of 32.7 mV dec−1, as well as the excellent durability in alkaline solution. Density functional theory calculations prove the established d–f electronic ladders, by the interaction between NFC and CeO2, evidently boosts the high‐speed electron transfer. Meanwhile, the stable valence state in CeO2 preserves the high electronic reactivity for OER. This work demonstrates a promising approach in fabricating a nonprecious OER electrocatalyst with the facilitation of rare‐earth oxides to reach both excellent activity and high stability.
A novel and highly efficient hybrid electrocatalyst is synthesized by NiFeCr hydroxide deposited on a porous peapod‐like Cu@CeO2 nanotube array. The introduction of CeO2 supplies abundant d–f orbital ladders to construct a highly efficient electron transfer expressway, leading to superior alkaline oxygen evolution reaction performance.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Layered double hydroxides (LDHs) have been considered as promising electrodes for supercapacitors due to their adjustable composition, designable function and superior high theoretic capacity. ...However, their experimental specific capacity is significantly lower than the theoretical value due to their small interlayer spacing. Therefore, obtaining large interlayer spacing through the intercalation of large‐sized anions is an important means to improve capacity performance. Herein, a metal organic framework derived cobalt‐nickel layered double hydroxide hollowcage intercalated with different concentrations of 1,4‐benzenedicarboxylic acid (H2BDC) through in‐situ cationic etching and organic ligand intercalation method is designed and fabricated. The superior specific capacity and excellent rate performance are benefit from the large specific surface area of the hollow structure and increasing interlayer spacing of LDH after H2BDC intercalation. The sample with the largest layer spacing displays a maximum specific capacity of 229 mA h g−1 at 1 A g−1. In addition, the hybrid supercapacitor assembled from the sample with the largest layer spacing and active carbon electrode has a maximum specific capacity of 158 mA h g−1 at 1 A g−1; the energy density is as high as 126.4 W h kg−1 at 800 W kg−1 and good cycle stability.
CoNi‐BDC hollowcage is obtained by intercalating H2BDC ligand into the CoNi‐LDH nanocage through in‐situ cationic etching and organic ligand intercalation methods for the first time. The structure design and engineering strategies of molecular layer spacing regulation endow larger specific surface areas and increase the interlayer spacing of CoNi‐LDH, thereby evidently boosting their electrochemical performance.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Background and Aims
To clarify high‐risk factors and develop a nomogram model to predict biochemical resolution or biochemical nonresolution (BNR) in patients with chronic DILI.
Approach and Results
...Retrospectively, 3655 of 5326 patients with chronic DILI were enrolled from nine participating hospitals, of whom 2866 underwent liver biopsy. All of these patients were followed up for over 1 year and their clinical characteristics were retrieved from electronic medical records. The endpoint was BNR, defined as alanine aminotransferase or aspartate aminotransferase >1.5× upper limit of normal or alkaline phosphatase >1.1× ULN, at 12 months from chronic DILI diagnosis. The noninvasive high‐risk factors for BNR identified by multivariable logistic regression were used to establish a nomogram, which was validated in an independent external cohort. Finally, 19.3% (707 of 3655) patients presented with BNR. Histologically, with the increase in liver inflammation grades and fibrosis stages, the proportion of BNR significantly increased. The risk of BNR was increased by 21.3‐fold in patients with significant inflammation compared to none or mild inflammation (p < 0.001). Biochemically, aspartate aminotransferase and total bilirubin, platelets, prothrombin time, sex, and age were associated with BNR and incorporated to construct a nomogram model (BNR‐6) with a concordance index of 0.824 (95% CI, 0.798–0.849), which was highly consistent with liver histology. These results were successfully validated both in the internal cohort and external cohort.
Conclusions
Significant liver inflammation is a robust predictor associated with biochemical nonresolution. The established BNR‐6 model provides an easy‐to‐use approach to assess the outcome of chronic DILI.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Anti‐counterfeiting techniques have become a global topic since they is correlated to the information and data safety, in which multimodal luminescence is one of the most desirable candidates for ...practical applications. However, it is a long‐standing challenge to actualize robust multimodal luminescence with high thermal stability and humid resistance. Conventionally, the multimodal luminescence is usually achieved by the combination of upconversion and downshifting luminescence, which only responds to the electromagnetic waves in a limited range. Herein, the Yb3+/Er3+/Bi3+ co‐doped Cs2Ag0.6Na0.4InCl6 perovskite material is reported as an efficient multimodal luminescence material. Beyond the excitation of ultraviolet light and near‐infrared laser (980 nm), this work extends multimodal luminescence to the excitation of X‐ray. Besides the flexible excitation sources, this material also shows the exceptional luminescence performance, in which the X‐ray detection limit reaches the level of nGy s−1, indicating a great potential for further application as a colorless pigment in the anti‐counterfeiting field. More importantly, the obtained double perovskite features high stability against both humidity and temperature up to 400 °C. This integrated multifunctional luminescent material provides a new directional solution for the development of multifunctional optical materials and devices.
A Yb3+/Er3+/Bi3+ co‐doped Cs2Ag0.6Na0.4InCl6 double‐perovskite material shows multi‐modal luminescence under excitation by X‐rays, ultraviolet light, and near‐infrared laser light (980 nm), which also features high stability against humidity and high temperature (up to 400 °C). This luminescent material further extends the functionality and potential for future commercial applications in anti‐counterfeiting and X‐ray detection.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to ...increase. Here, we present a mortality risk prediction model for COVID-19 (MRPMC) that uses patients' clinical data on admission to stratify patients by mortality risk, which enables prediction of physiological deterioration and death up to 20 days in advance. This ensemble model is built using four machine learning methods including Logistic Regression, Support Vector Machine, Gradient Boosted Decision Tree, and Neural Network. We validate MRPMC in an internal validation cohort and two external validation cohorts, where it achieves an AUC of 0.9621 (95% CI: 0.9464-0.9778), 0.9760 (0.9613-0.9906), and 0.9246 (0.8763-0.9729), respectively. This model enables expeditious and accurate mortality risk stratification of patients with COVID-19, and potentially facilitates more responsive health systems that are conducive to high risk COVID-19 patients.
Near infrared light photodiodes have been attracting increasing research interest due to their wide application in various fields. In this study, the fabrication of a new n‐type GaAs nanocone ...(GaAsNCs) array/monolayer graphene (MLG) Schottky junction is reported for NIR light detection. The NIR photodetector (NIRPD) shows obvious rectifying behavior with a turn‐on voltage of 0.6 V. Further device analysis reveals that the photovoltaic NIRPDs are highly sensitive to 850 nm light illumination, with a fast response speed and good spectral selectivity at zero bias voltage. It is also revealed that the NIRPD is capable of monitoring high‐switching frequency optical signals (∼2000 Hz) with a high relative balance. Theoretical simulations based on finite difference time domain (FDTD) analysis finds that the high device performance is partially associated with the optical property, which can trap most incident photons in an efficient way. It is expected that such a self‐driven NIRPD will have potential application in future optoelectronic devices.
A new Schottky junction near‐infrared light photodetector is fabricated by coating a GaAs nanocone array with a monolayer graphene film, which shows high sensitivity to near‐infrared light irradiation, with good reproducibility, excellent selectivity, and rapid response speed.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Background and Aims
About 20% of patients receiving nucleos(t)ide analogues treatment experienced low‐level viraemia (LLV), which is associated with progression of liver fibrosis and high risk of ...hepatocellular carcinoma. We aimed to evaluate the effectiveness and safety of switching from entecavir (ETV) to tenofovir alafenamide fumarate (TAF) in ETV‐treated patients with LLV.
Methods
In this prospective study, ETV‐treated patients with LLV, presented to our hospital from December 2018 to October 2019, were enrolled. Switching to TAF or continuing ETV was given. The primary effectiveness endpoint was complete virological response (CVR) at 24 weeks, and the safety endpoint was the first occurrence of any clinical adverse event during the treatment.
Results
Totally, 211 patients were recruited and propensity score matching (PSM) generated 75 patients in either TAF or ETV group. After PSM, baseline characteristics were balanced in two groups. After 24‐week treatment, the CVR and ALT normalization in TAF group were 62.7% and 47.6%, which were higher than 9.3% and 10.5% in ETV group (OR 16.4, 95% CI 6.6‐40.0, P < .001) respectively. Subgroup analysis showed that switching to TAF achieved favours CVR regardless of the status of sex, age, CHB family history, HBV DNA, HBeAg and cirrhosis, whereas alcohol consumption and diabetes mellitus might compromise the CVR of switching to TAF. Both therapies were well tolerated and had satisfying renal safety.
Conclusions
For ETV‐treated patients with LLV, switching to TAF is safe enough and superior compared with continuing ETV monotherapy regarding both virological and biochemical benefits.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Background
The low-density lipoprotein receptor-related protein 6 (
LRP6
) gene is a recently defined gene that is associated with the autosomal-dominant inherited tooth agenesis (TA). In the present ...study, a family of four generations having TA was recruited and subjected to a series of clinical, genetic,
in silico
, and
in vitro
investigations.
Methods
After routine clinical evaluation, the proband was subjected to whole-exome sequencing (WES) to detect the diagnostic variant. Next,
in silico
structural and molecular dynamics (MD) analysis was conducted on the identified novel missense variant for predicting its intramolecular impact. Subsequently, an
in vitro
study was performed to further explore the effect of this variant on protein maturation and phosphorylation.
Results
WES identified a novel variant, designated as
LRP6
: c.2570G > A (p.R857H), harbored by six members of the concerned family, four of whom exhibited varied TA symptoms. The
in silico
analysis suggested that this novel variant could probably damage the Wnt bonding function of the LRP6 protein. The experimental study demonstrated that although this novel variant did not affect the
LRP6
gene transcription, it caused a impairment in the maturation and phosphorylation of LRP6 protein, suggesting the possibility of the disruption of the Wnt signaling.
Conclusion
The present study expanded the mutation spectrum of human TA in the
LRP6
gene. The findings of the present study are insightful and conducive to understanding the functional significance of specific
LRP6
variants.
The herbicide diuron is hardly soluble in water and most organic solvents and is usually made into a wettable powder or mixed with soil when used, which causes environmental risk and a reduction in ...herbicidal efficacy. In this study, the physicochemical properties were changed by using
-cyclodextrin (
-CD) to encapsulate diuron to form an inclusion complex. Some key technologies, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (
H NMR), were used to characterize the inclusion complex. The stoichiometry of the inclusion complex was determined by recording the
H NMR spectrum or by using a diagram of inclusion ratios. A phase solubility study proved that the formed inclusion complex exhibited higher water solubility. Thermogravimetric analysis (TGA) demonstrated that the formed inclusion complex exhibited better thermal stability. Biological activity studies indicated that the herbicidal activity, in terms of herbicide removal, of the formed inclusion complex was higher than that of the original diuron. In general, the formation of the inclusion complex could reduce the environmental damage caused by diuron and enhance its herbicidal activity, providing an environmentally friendly method for using diuron.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Cellular senescence severely limits the research and the application of dental pulp stem cells (DPSCs). A previous study conducted by our research group revealed a close implication of ROR2 in DPSC ...senescence, although the mechanism underlying the regulation of ROR2 in DPSCs remains poorly understood so far. In the present study, it was revealed that the expression of the ROR2-interacting transcription factor MSX2 was increased in aging DPSCs. It was demonstrated that the depletion of MSX2 inhibits the senescence of DPSCs and restores their self-renewal capacity, and the simultaneous overexpression of ROR2 enhanced this effect. Moreover, MSX2 knockdown suppressed the transcription of NOP2/Sun domain family member 2 (NSUN2), which regulates the expression of p21 by binding to and causing the 5-methylcytidine methylation of the 3'- untranslated region of p21 mRNA. Interestingly, ROR2 downregulation elevated the levels of MSX2 protein, and not the MSX2 mRNA expression, by reducing the phosphorylation level of MSX2 and inhibiting the RNF34-mediated MSX2 ubiquitination degradation. The results of the present study demonstrated the vital role of the ROR2/MSX2/NSUN2 axis in the regulation of DPSC senescence, thereby revealing a potential target for antagonizing DPSC aging.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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