The path of integrating red culture into ideological and political education under new media should be more refined and comprehensive. In the innovation of red culture practice, red culture ...propaganda carrier and red culture condition guarantee, further in-depth discussion and research are needed, which provides more space for the research of this paper. In this paper, the FCM-education path model is constructed based on the fuzzy clustering algorithm as the theoretical basis. The calculation and analysis show that the new era background has a heavier share in the basis of ideological and political education in universities, and its comprehensive basis degree is 66%. The extent to which world multipolarity is based on ideological and political education in universities is 64%. The proportion of the basis of economic globalization to the ideological and political education of colleges and universities is 40%, and the difficulty of realizing the path of “three-pronged education” is 60%. The main reason is that the path of “three-pronged education” of ideological and political education culture in colleges and universities is the first experimental path in China, and there are difficulties in the design of class time and the division of objectives. The path of curriculum education is the least difficult to achieve, only 10%.
As an important resource for ideological and political education, red culture has a positive role in promoting college students’ cultivation and practice of socialist core values and enhancing ...cultural self-confidence. In the face of the integration of red culture into ideological and political education in colleges and universities, there are still problems, such as the single way of integration, weak integration content, and poor integration effect. Improving the integration of red culture into the ideology and politics of colleges and universities is an important task of the current ideological and political education work in colleges and universities. This paper uses the fuzzy analysis model to assess the integration of red culture and ideological and political education in colleges and universities and uses questionnaires to investigate the way teachers use red culture resources, the use of red resources in the classroom, student’s understanding of red resources, some problems in integration, and ways to explore the innovation of integration. In the process of integrating red culture with ideology and politics, there are mainly problems such as the low degree of integration of ideology and politics classes with local red cultural resources, the lack of ability of political science teachers to link theory with practice, and the lack of awareness of the importance of red cultural resources among ideology and politics teachers. 23.5% of teachers’ schools’ ideology and politics classes are closely integrated with local red cultural resources, and 50.9% of teachers think the integration is average. Moreover, 35.6% of teachers’ schools’ ideological and political classes are not integrated with local red cultural resources. The degree and depth of integration of red culture and thought politics education are seriously insufficient. In the new media era, we should keep up with the trend of the times and use innovative ways to strengthen the integration of red culture and college thought politics.
Kcnq1 overlapping transcript 1 (kcnq1ot1), an imprinted antisense lncRNA in the kcnq1 locus, acts as a potential contributor to cardiovascular disease, but its role in atherosclerosis remains ...unknown. The aim of this study was to explore the effects of kcnq1ot1 on atherogenesis and the underlying mechanism. Our results showed that kcnq1ot1 expression was significantly increased in mouse aorta with atherosclerosis and lipid-loaded macrophages. Lentivirus-mediated kcnq1ot1 overexpression markedly increased atherosclerotic plaque area and decreased plasma HDL-C levels and RCT efficiency in apoE
mice fed a Western diet. Upregulation of kcnq1ot1 also reduced the expression of miR-452-3p and ABCA1 but increased HDAC3 levels in mouse aorta and THP-1 macrophages. Accordingly, kcnq1ot1 overexpression inhibited cholesterol efflux and promoted lipid accumulation in THP-1 macrophages. In contrast, kcnq1ot1 knockdown protected against atherosclerosis in apoE
mice and suppressed lipid accumulation in THP-1 macrophages. Mechanistically, kcnq1ot1 enhanced HDAC3 expression by competitively binding to miR-452-3p, thereby inhibiting ABCA1 expression and subsequent cholesterol efflux. Taken together, these findings suggest that kcnq1ot1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the miR-452-3p/HDAC3/ABCA1 pathway.
A bottom‐up synthetic strategy is developed to fabricate a highly porous wave‐superposed perchlorate‐doped polypyrrole nanocoating on nickel nanotube arrays. The delicate nanostructure and the unique ...surface chemistry synergistically endow the obtained electrode with revealable pseudocapacitance, large operating potential window, and excellent cycling stability, which are highly promising for both asymmetric and symmetric supercapacitors.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Developing high-efficiency, low-cost and environmental friendly electrode materials for both supercapacitors and overall water splitting are significant for renewable energy storage and conversion. ...Herein, we report a facile consubstantial growth strategy to fabricate subuliform NiCo2S4 nanorod arrays electrode through an in situ growing process, utilizing self-sacrificial Ni foam as substrate and Ni resource. Benefitting from the unique structures, the subuliform NiCo2S4 nanorods can be directly serve as binder-free, trifunctional electrode for overall water splitting with excellent electrocatalytic activity (oxygen evolution reaction with low overpotential of 220 mV at 30 mA cm−2 and hydrogen evolution reaction with low overpotential of 222 mV at 30 mA cm−2) and also as a promising pseudocapacitance electrode with superior electrochemical performance and good stability (high areal capacitance of 8.85 F cm−2 at a current density of 10 mA cm−2 and 94.96% capacitive retention after 10000 cycles). The present work highlights the remarkable advantages of the self-sacrificial strategy for the design of high-performance multifunctional electrode materials.
•The NiCo2S4 nanorod arrays are fabricated by an in situ hydrothermal process.•The integrated configuration of NiCo2S4 can greatly facilitate electron transfer.•The obtained NiCo2S4 electrode exhibit excellent electrochemical performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute ...respiratory syndrome coronavirus (SARS‐CoV) in 2003. Epidemiology studies found males although only slightly more likely to be infected than females account for the majority of the severely ill and fatality, which also bias for people older than 60 years or with metabolic and cardiovascular diseases. Here by analyzing GTEx and other public data in 30 tissues across thousands of individuals, we found a significantly higher level in Asian females, an age‐dependent decrease in all ethnic groups, and a highly significant decrease in type II diabetic patients of ACE2 expression. Consistently, the most significant expression quantitative loci (eQTLs) contributing to high ACE2 expression are close to 100% in East Asians, >30% higher than other ethnic groups. A shockingly common enrichment of viral infection pathways was found among ACE2 anti‐expressed genes, and multiple binding sites of virus infection related transcription factors and sex hormone receptors locate at ACE2 regulatory regions. Human and mice data analysis further revealed ACE2 expression is reduced in T2D patients and with inflammatory cytokine treatment and upregulated by estrogen and androgen (both decrease with age). Our findings revealed a negative correlation between ACE2 expression and COVID‐19 fatality at both population and molecular levels. These results will be instrumental when designing potential prevention and treatment strategies for ACE2 binding coronaviruses in general.
This study revealed the negative correlation of high basal ACE2 level with CoVID‐19 severity/fatality at the population level and its anticorrelation with virus infection pathway expression levels, upregulation by sex hormones and suppression by inflammatory cytokine at the molecular level.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of ...linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Damages caused by the effects of cyclic loading (fatigue) and high temperature (creep and oxidation) have been considered critical and need to be appropriately evaluated. A series of ...strain‐controlled fatigue and creep‐fatigue tests are performed on P92 at 873 K under oxygen‐containing environment. The creep‐fatigue life prediction results are summarized using models based on strain‐range partition, Manson–Coffin equation and linear damage summation (LDS) rule. Obviously, the models based on the LDS rule show relatively good performance with an error band of ±2.5. In view of the adverse effects of oxidation on creep‐fatigue endurance, this paper further develops a physically‐based oxidation damage equation, which is incorporated into LDS rule for the improvement of life assessment. The predicted and experimental results falling into ±1.5 error band proved the accuracy of the proposed oxidation damage equation in the LDS rule. Additionally, model selection criteria are recommended to evaluate the model prediction capabilities.
Highlights
A series of fatigue, creep‐fatigue, and oxidation tests are performed on P92 at 873 K.
Oxidation damage equation based on kinetics and concentration distribution is proposed.
Error band is reduced from ±2.5 to ±1.5 by using the proposed oxidation damage equation.
W‐SEDE‐O model performs best with the minimum error band & best statistical indicators.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
In this study, we identified a defense-related major latex protein （MLP） from upland cotton （designated GhMLP28） and investigated its functional mechanism. GhMLP28 transcripts were ubiquitously ...present in cotton plants, with higher accumulation in the root. Expression of the GhMLP28 gene was induced by Verticillium dahliae inoculation and was responsive to defense signaling molecules, including ethylene, jas- monic acid, and salicylic acid. Knockdown of GhMLP28 expression by virus-induced gene silencing re- sulted in increased susceptibility of cotton plants to V. dahliae infection, while ectopic overexpression of GhMLP28 in tobacco improved the disease tolerance of the transgenic plants. Further analysis revealed that GhMLP28 interacted with cotton ethylene response factor 6 （GhERF6） and facilitated the binding of GhERF6 to GCC-box element. Transient expression assay demonstrated that GhMLP28 enhanced the tran- scription factor activity of GhERF6, which led to the augmented expression of some GCC-box genes. GhMLP28 proteins were located in both the nucleus and cytoplasm and their nuclear distribution was dependent on the presence of GhERF6. Collectively, these results demonstrate that GhMLP28 acts as a positive regulator of GhERF6, and synergetic actions of the two proteins may contribute substantially to protection against V. dahliae infection in cotton plants.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Summary
Salicylic acid (SA) signalling plays an essential role in plant innate immunity. In this study, we identified a component in the SA signaling pathway in potato (Solanum tuberosum), the ...transcription factor StbZIP61, and characterized its function in defence against Phytophthora infestans. Expression of StbZIP61 was induced upon P. infestans infection and following exposure to the defense signaling hormones SA, ethylene and jasmonic acid. Overexpression of StbZIP61 increased the tolerance of potato plants to P. infestans while RNA interference (RNAi) increased susceptibility. Yeast two‐hybrid and pull down experiments revealed that StbZIP61 could interact with an NPR3‐like protein (StNPR3L) that inhibited its DNA‐binding and transcriptional activation activities. Moreover, StNPR3L interacted with StbZIP61 in an SA‐dependent manner. Among candidate genes involved in SA‐regulated defense responses, StbZIP61 had a significant impact on expression of StICS1, which encodes a key enzyme for SA biosynthesis. StICS1 transcription was induced upon P. infestans infection and this responsive expression to the pathogen was reduced in StbZIP61 RNAi plants. Accordingly, StICS1 expression was remarkably enhanced in StbZIP61‐overexpressing plants. Together, our data demonstrate that StbZIP61 functions in concert with StNPR3L to regulate the temporal activation of SA biosynthesis, which contributes to SA‐mediated immunity against P. infestans infection in potato.
Significance statement
The regulatory mechanism for dynamic biosynthesis of SA in plant immunity remains largely unknown. Here, we show that potato transcription factor StbZIP61 participates in defense against P. infestans by regulating SA biosynthesis. In response to pathogen infection, StbZIP61 promotes SA synthesis by inducing StICS1 expression and this activity is repressed by the NPR3‐like protein StNPR3L. Our results demonstrate that StbZIP61 functions in concert with StNPR3L to establish a temporal SA accumulation in immune responses.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
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