Low thermal conductivity is a bottleneck for phase change materials (PCMs), which attracts much attention of the researchers. In this paper, a novel addition agent composed of Al nanoparticle and ...coated C (Al/C hybrid nanoparticles) was developed to improve the thermal conductivity of sodium sulfate decahydrate (Na2SO4⋅10H2O) PCMs. The Al/C hybrid nanoparticles exhibited thorn ball-like structure, in which hydrothermally generated C was well coated on the surface of Al particle to form a spiny spherical outer coating. Adding ~3 wt% Al/C hybrid nanoparticles caused 26.41% increment to the thermal conductivity (at 30 °C) and 5.13% reduction to the solidification latent heat enthalpy, which can be an effective way to improve the thermal conductivity and solidification latent heat enthalpy of the PCMs. Furthermore, the incorporation of Al/C nanoparticles improved the stability of the PCM system.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Peritoneal metastasis often occurs in patients with colorectal cancer peritoneal metastasis, and the prognosis is poor. A large body of evidence highlights the beneficial effects of cytoreductive ...surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on survival, but to date, there is little consensus on the optimal treatment strategy for patients with colorectal cancer peritoneal metastasis. The purpose of this study is to evaluate the impact of CRS + HIPEC on survival and provide reference for the treatment of patients with colorectal cancer peritoneal metastasis.
This systematic review and meta-analysis is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The PubMed, Embase, Cochrane, Web of Knowledge, and ClinicalTrials.gov databases were screened from inception of the review to March 11, 2022. Ten studies were included in qualitative and quantitative analysis.
A total of 3200 patients were enrolled in the study, including 788 patients in the CRS and HIPEC groups and 2412 patients in the control group, of which 3 were randomized controlled trials and 7 were cohort studies. The 3 randomized controlled studies were of high quality, and the quality scores of the 7 cohort studies were all 7 or above, indicating high quality. The results showed that the OS of CRS + HIPEC group was higher than that of control group (HR: 0.53, 95% CI: 0.38-0.73; P < 0.00001, I
= 82.9%); the heterogeneity of the studies was large. The subgroup analysis showed that the OS of CRS and HIPEC group was higher than that of PC group (HR: 0.37, 95% CI: 0.30-0.47; P = 0.215, I
= 31%) and higher than that in CRS group (HR: 0.73, 95% CI: 0.49-1.07; P = 0.163, I
= 44.8%); the heterogeneity of the studies was low. In the OPEN group, the OS of THE CRS and HIPEC groups was higher than that in the control group (HR: 0.51, 95% CI: 0.38-0.70; P = 0.353, I
= 3.9%); OPEN group showed lower heterogeneity. The OS of 60-100-min group was higher than that in the control group (HR: 0.65, 95% CI: 0.49-0.88; P = 0.172, I
= 37.4%); the heterogeneity of the studies was low. Sensitivity analysis showed that there was no significant difference in the results of the combined analysis after each study was deleted. The results of publication bias showed that the P-value of Egger and Begg tests was 0.078 > 0.05, indicating that there is no publication bias.
CRS + HIPEC can improve the survival rate of patients with colorectal cancer peritoneal metastasis.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The Litang fault system that crosses the Litang Plateau, a low relief surface at high elevation (~4200–4800 m above sea level) that is not affected by regional incision, provides the opportunity to ...study exhumation related to tectonics in the SE Tibetan Plateau independently of regional erosion. Combining apatite and zircon fission track with apatite (U‐Th)/He thermochronologic data, we constrain the cooling history of the Litang fault system footwall along two transects. Apatite fission track ages range from 4 to 16 Ma, AHe ages from 2 to 6 Ma, and one zircon fission track age is ~99 Ma. These data imply a tectonic quiet period sustained since at least 100 Ma with a slow denudation rate of ~0.03 km/Ma, interrupted at 7 to 5 Ma by exhumation at a rate between 0.59 and 0.99 km/Ma. We relate that faster exhumation to the onset of motion along the left‐lateral/normal Litang fault system. That onset is linked to a Lower Miocene important kinematic reorganization between the Xianshuihe and the Red River faults, with the eastward propagation of the Xianshuihe fault along the Xiaojiang fault system and the formation of the Zhongdian fault. Such strike‐slip faults allow the sliding to the east of a wide continental block, with the Litang fault system accommodating differential motion between rigid blocks. The regional evolution appears to be guided by the strike‐slip faults, with different phases of deformation, which appears more in agreement with an “hidden plate‐tectonic” model rather than with a “lower channel flow” model.
Key Points
Tectonic quiet period from at least 100 Ma until ~6 Ma of the Litang Plateau
Late Miocene onset of rapid exhumation due to Litang fault activity
Litang fault ensures kinematic compatibility between XSH and Red River faults
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Six undescribed nordrimane sesquiterpene derivatives, salvirrane A-F (1–6), were isolated from the roots and rhizomes of Salvia castanea Diels f. tomentosa Stib. Comprehensive spectral analysis and a ...quantum chemical calculation strategy were employed to determine their structures. These compounds represent four previously unreported nordrimane carbon skeletal types in Salvia genus, including 15-nor-drimane, 11,15-di-nor-drimane, 14,15-di-nor-drimane, and 11,14,15-tri-nor-drimane sesquiterpenes. All compounds were evaluated for their cytotoxic activities against several human cancer cell lines (A549, H460, Hep3B, MCF7, PC3, and HeLa). The results showed that 3 exhibited low activity against MCF7 cells (IC50,72.72 ± 6.95 μM) and moderate activity against HeLa cells (IC50, 9.80 ± 0.64 μM). Moreover, the EdU (5-ethynyl-2′-deoxyuridine) assay demonstrates that 3 displays dose-dependent efficacy in suppressing the proliferation of HeLa cells. Network pharmacology and molecular docking technology implied that 3 may potentially bind to Src (proto-oncogene tyrosine-protein kinase) to exert anti-proliferative activity.
Six undescribed nordrimane sesquiterpenes derivatives were isolated from the roots and rhizomes of Salvia castanea Diels f. tomentosa Stib, and compound 3 may potentially bind to Src to exert anti-proliferative activities on HeLa cells. Display omitted
•Six undescribed nordrimane sesquiterpenes derivatives were isolated from Salvia castanea f. tomentosa.•These compounds represent four unreported nordrimane carbon skeletal types in Salvia.•Compound 3 showed cytotoxic activities and significant anti-proliferation against HeLa cells.•Src may be the key target of compound 3 against cervical cancer.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Objectives
This study sought to compare the efficacy and clinical safety of the LONGTY drug‐coated balloon (DCB) with those of SeQuent Please DCB in patients with in‐stent restenosis (ISR).
...Background
Although DCB technologies have evolved, little is known about the clinical efficacy of the new‐generation LONGTY DCB.
Methods
This was a prospective, multicenter, randomized, noninferiority trial comparing LONGTY DCB with SeQuent Please DCB in patients with ISR. The primary endpoint was target lesion late lumen loss at 9 months' follow‐up.
Results
A total of 211 patients with ISR from 13 Chinese sites were included (LONGTY DCB, n = 105; SeQuent Please DCB, n = 106). Device success was achieved in all patients. At the 9 month angiographic follow‐up, target lesion late lumen loss was 0.35 ± 0.42 mm with LONGTY and 0.38 ± 0.45 mm with SeQuent Please (p for noninferiority <.001). The target lesion revascularization rates at 1 year were similar in both DCB groups (15.24 vs. 13.21%; p = .673). Over an extended follow‐up of 2 years, the clinical endpoints, including cardiac death, myocardial infarction, and thrombus rate, were extremely low and similar in both groups.
Conclusions
In this multicenter, head‐to‐head, randomized trial, the new‐generation LONGTY DCB was noninferior to the SeQuent Please DCB for the primary endpoint of target lesion late lumen loss at 9 months.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
A new species of Dalyelliidae,
Wang and You, is described based on material collected in southern China through an integrative approach combining morphological, histological, and molecular (18S and ...28S rDNA) data.
sp. nov. is morphologically characterized by a fan-shaped (about 270° when pressed) stylet, consisting of 13 similar distal spines and a broad girdle without fenestrae region. This stylet is distinct from that of any other similar species in the Aequales group to which this species belongs. In addition, specimens identifiable as
Van Steenkiste, Van Mulken, and Artois, 2012 were discovered from the same location as
sp. nov.
has previously been known only from India; the present study thus represents the first record of the species from China.
This paper is concerned with the radial stationary problem of a flux‐limited Keller–Segel model derived in a multidimensional bounded domain with Neumann boundary conditions. With the global ...bifurcation theory and Helly compactness theorem by treating the chemotactic coefficient as a bifurcation parameter, we establish the existence of nonconstant monotone radial stationary solutions and further show that the radial stationary solution will tend to a Dirac delta mass as the chemotactic coefficient tends to infinity. By using the stability criterion of Crandall and Rabinnowitz, we prove the linearized stability of bifurcating stationary solutions near the bifurcation points.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, ODKLJ, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Abstract
This paper considers the stationary problem of density-suppressed motility models proposed in Fu et al. (2012) and Liu et al. (2011) in one dimension with Neumman boundary conditions. The ...models consist of parabolic equations with cross-diffusion and degeneracy. We employ the global bifurcation theory and Helly compactness theorem to explore the conditions under which non-constant stationary (pattern) solutions exist and asymptotic profiles of solutions as some parameter value is small. When the cell growth is not considered, we are able to show the monotonicity of solutions and hence achieve a global bifurcation diagram by treating the chemical diffusion rate as a bifurcation parameter. Furthermore, we show that the solutions have boundary spikes as the chemical diffusion rate tends to zero and identify the conditions for the non-existence of non-constant solutions. When transformed to specific motility functions, our results indeed give sharp conditions on the existence of non-constant stationary solutions. While with the cell growth, the structure of global bifurcation diagram is much more complicated and in particular the solution loses the monotonicity property. By treating the growth rate as a bifurcation parameter, we identify a minimum range of growth rate in which non-constant stationary solutions are warranted, while a global bifurcation diagram can still be attained in a special situation. We use numerical simulations to test our analytical results and illustrate that patterns can be very intricate and stable stationary solutions may not exist when the parameter value is outside the minimal range identified in our paper.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
•A series of laboratory tests were performed to explore mechanical properties of rock salt subjected to triaxial cyclic loading.•A new theoretical approach to calculate the Young’s modulus and ...Poisson’s ratio was proposed.•The Young’s modulus decreases with loading cycles nonlinearly and drives to a constant after 50–100 loading cycles.•The two-stage evolution law in both the axial and lateral deformation of salt increases with an increase in the maximum applied stress or with a decrease in the minimum applied stress.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Lithium–sulfur (Li–S) battery can satisfy the need of the future power battery market because of its high energy density, but the hidden dangers caused by lithium anode have seriously hindered their ...commercialization. Herein, an innovative gel polymer electrolyte (GPE) composed of polyvinylidene fluoride (PVDF) and organo-polysulfide polymer (PSPEG) is proposed, which could be used in semi-solid-state Li–S batteries for protection of Li anodes. Particularly, organo-polysulfide polymer could chemically/electrochemically generate both inorganic and organic components simultaneously in-situ once contacting fresh Li metal surface and/or during discharging processes. And these inorganic/organic components could participate in the formation of the SEI layer and finally constitute a stable and flexible hybrid SEI layer on the surface of Li metal anode. Moreover, the organic components were permselective to lithium ions against anions. Therefore, PVDF/PSPEG GPE ensures the ideal chemical and electrochemical properties for Li–S batteries. Our work demonstrates an effective solution to solve the problems about Li anodes and contributes to the development of the safe Li metal batteries.
A PVDF-based GPE modified by organo-polysulfide polymer (PSPEG) with a large number of -Sx- bonds promotes lithium ion transport and enables stable lithium anode for lithium–sulfur batteries. Display omitted
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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