With the development of higher education, the number and scale of college students are expanding, and the new situation poses challenges to the management of college students. This paper proposes a ...comprehensive development evaluation model for college students based on combination assignments and conducts a consistency test for expert ranking using Spearman’s rank correlation coefficient. The indicators are scored using the fuzzy affiliation degree method to eliminate the influence of dimensionlessness and the positive and negative differences between indicators. The correlation coefficient of G1 is corrected by standard deviation to determine the optimal combination of weights for the objective function, and it is dynamically adjusted according to the changes of the data in practice to reflect the degree of deviation and the comparative difference of each single weight. Finally, School C was chosen as the research object to study the timeliness of the comprehensive development teaching model in student management. The results show that among the 650 students in School C, the highest score of student comprehensive development evaluation is 4.083±0.65, which indicates that the comprehensive development evaluation in School C possesses goals and needs with high recognition as the premise of implementation and has strong theoretical and practical significance for the comprehensive development of college students.
Tumor metastasis is not only a sign of disease severity but also a major factor causing treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms of tumor metastasis ...are critical for the development of treatments and for the improvement of survival. The epithelial-mesenchymal transition (EMT) is an orderly, polygenic biological process that plays an important role in tumor cell invasion, metastasis and chemoresistance. The complex, multi-step process of EMT involves multiple regulatory mechanisms. Specifically, the PI3K/Akt signaling pathway can affect the EMT in a variety of ways to influence tumor aggressiveness. A better understanding of the regulatory mechanisms related to the EMT can provide a theoretical basis for the early prediction of tumor progression as well as targeted therapy.
An electrochemical oxidative dehydrogenative C(sp3)–H amination reaction to construct trans-2,3-disubstituted aziridines is reported, which avoids using external oxidants and generates only hydrogen ...gas as the byproduct. With KI as the mediator and electrolyte, the desired aziridines were prepared in good yields in an undivided cell at room temperature. The potential value of this mild electrochemical strategy was further highlighted by the gram-scale synthesis.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Despite the global decline in the incidence and mortality of gastric cancer, it remains one of the most common malignant tumors of the digestive system. Although surgical resection is the preferred ...treatment for gastric cancer, chemotherapy is the preferred treatment for recurrent and advanced gastric cancer patients who are not candidates for reoperation. The short overall survival and lack of a standard chemotherapy regimen make it important to identify novel treatment modalities for gastric cancer. Within the field of tumor biology, molecular targeted therapy has attracted substantial attention to improve the specificity of anti-cancer efficacy and significantly reduce non-selective resistance and toxicity. Multiple clinical studies have confirmed that molecular targeted therapy acts on various mechanisms of gastric cancer, such as the regulation of epidermal growth factor, angiogenesis, immuno-checkpoint blockade, the cell cycle, cell apoptosis, key enzymes, c-Met, mTOR signaling and insulin-like growth factor receptors, to exert a stronger anti-tumor effect. An in-depth understanding of the mechanisms that underlie molecular targeted therapies will provide new insights into gastric cancer treatment.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Despite evidence from experimental grasslands that plant diversity increases biomass production and soil organic carbon (SOC) storage, it remains unclear whether this is true in natural ecosystems, ...especially under climatic variations and human disturbances. Based on field observations from 6,098 forest, shrubland, and grassland sites across China and predictions from an integrative model combining multiple theories, we systematically examined the direct effects of climate, soils, and human impacts on SOC storage versus the indirect effects mediated by species richness (SR), aboveground net primary productivity (ANPP), and belowground biomass (BB). We found that favorable climates (high temperature and precipitation) had a consistent negative effect on SOC storage in forests and shrublands, but not in grasslands. Climate favorability, particularly high precipitation, was associated with both higher SR and higher BB, which had consistent positive effects on SOC storage, thus offsetting the direct negative effect of favorable climate on SOC. The indirect effects of climate on SOC storage depended on the relationships of SR with ANPP and BB, which were consistently positive in all biome types. In addition, human disturbance and soil pH had both direct and indirect effects on SOC storage, with the indirect effects mediated by changes in SR, ANPP, and BB. High soil pH had a consistently negative effect on SOC storage. Our findings have important implications for improving global carbon cycling models and ecosystem management: Maintaining high levels of diversity can enhance soil carbon sequestration and help sustain the benefits of plant diversity and productivity.
Full text
Available for:
BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
Abstract
Many real systems are known to interact with one another, forming networks of networks (NONs). Plenty of attention has been poured into the research on the robustness in NONs in the past ...decade. Previous studies focus on undirected networks, or directed networks under random attacks. While many real networks are directed and how networks of directed networks (NODNs) respond to targeted attacks remains unknown. We thus develop a general analytical tool for analyzing the robustness of NODNs under two kinds of targeted attacks: degree-based attacks and in-degree (out-degree)-based attacks. The analytical tool can perfectly predict the sizes of the final giant strongly connected components and the phase transitions on the NODNs in response to targeted attacks. By applying the tool to synthesis networks, we find that a quadruple point intersected by four different phase regions could appear in the random regular NODNs. To the best of our knowledge, it is the first time that a quadruple point is found in the studies of complex networks. In addition, we find triple points intersected by three phases in networks of directed scale-free networks, and critical points that connect two phases in networks of directed Erdös–Rényi networks. The discovery of these tipping points could help understand network robustness and enable better design of networked systems.
The prevalence of
Helicobacter pylori (H. pylori)
infection has exceeded 50% worldwide, and it is considered a high-risk factor for chronic gastritis, peptic ulcer, gastric adenocarcinoma, ...gastroesophageal reflux disease and functional dyspepsia.
H. pylori
drug resistance is a common problem worldwide. In recent years, the relationship between
H. pylori
infection and gastrointestinal microecology has received much attention.
H. pylori
infection changes the structure and composition of gastrointestinal microflora by regulating the gastrointestinal microecological environment, local pH value, cytokines and antimicrobial peptides, and immune response and then plays a crucial role in the occurrence and development of digestive system tumors, liver metabolism and extragastrointestinal diseases. The quadruple strategy of
H. pylori
eradication can also aggravate gastrointestinal microflora disorder. However, probiotics can reduce intestinal flora changes and imbalances through different mechanisms, thus enhancing the efficacy of
H. pylori
eradication therapy and reducing adverse reactions caused by eradication therapy. Therefore, this paper reviews the relationship between
H. pylori
infection and gastrointestinal microecology and its clinical application, providing a basis for clinical treatment.
In contemporary agronomic research, the focus has increasingly shifted towards non-destructive imaging and precise phenotypic characterization. A photon-counting micro-CT system has been developed, ...which is capable of imaging lychee fruit at the micrometer level and capturing a full energy spectrum, thanks to its advanced photon-counting detectors.
For automatic measurement of phenotypic traits, seven CNN-based deep learning models including AttentionUNet, DeeplabV3+, SegNet, TransUNet, UNet, UNet++, and UNet3+ were developed. Machine learning techniques tailored for small-sample training were employed to identify key characteristics of various lychee species.
These models demonstrate outstanding performance with Dice, Recall, and Precision indices predominantly ranging between 0.90 and 0.99. The Mean Intersection over Union (MIoU) consistently falls between 0.88 and 0.98. This approach served both as a feature selection process and a means of classification, significantly enhancing the study's ability to discern and categorize distinct lychee varieties.
This research not only contributes to the advancement of non-destructive plant analysis but also opens new avenues for exploring the intricate phenotypic variations within plant species.
MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with ...inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Rainfall is one of the primary sources of chemical inputs in forest ecosystems, and the basis of forest nutrient cycling. Mixed evergreen and deciduous broadleaved forests are currently one of the ...most threatened ecosystems due to their sensitivity to anthropogenic climate change. As such, understanding the hydrochemical fluxes of these systems is critical for managing their dynamics in the future. We investigate the chemistry of bulk precipitation, stemflow and throughfall in a mixed evergreen and deciduous broadleaved forest in the Shennongjia region of Central China. Mean nutrient concentrations in throughfall and stemflow were higher than in bulk precipitation. Stemflow ion fluxes from deciduous tree species were greater than those for evergreen tree species because of the differences in bark morphology and branch architecture. Throughfall and stemflow chemistry fluctuated dramatically over the growing season. Nitrate nitrogen and ammonium nitrogen were retained, while other elements and compounds were washed off or leached via throughfall and stemflow pathways. Our findings will facilitate a greater understanding of nutrient balance in canopy water fluxes.
PDF
