Traditionally, online retailers have acted as product resellers. Recently, these retailers have also started to serve as online marketplaces by providing a platform to directly connect sellers with ...buyers. Over and above re‐shaping the traditional e‐commerce market, conventional wisdom suggests that this new format will mitigate the double‐marginalization effect and benefit both the intermediary and suppliers through a revenue sharing scheme. However, we find that upstream competition between suppliers critically moderates this possibility. We also find that the interaction of order‐fulfillment costs and upstream competition intensity moderates the selection of an optimal mode for the intermediary. More specifically, when order‐fulfillment costs are large and when the supplier product offerings are similar (i.e., competition intensity is high), the pure reseller mode is the preferred choice; when order‐fulfillment costs are small and the supplier product offerings are highly differentiated (i.e., low competition intensity), the pure marketplace mode is the preferred choice. Finally, the hybrid mode is preferred when order‐fulfillment costs are moderate and suppliers’ products are somewhat similar (i.e., competition intensity is moderate). The intuition behind these results hinges on the trade‐off between transfer of pricing rights and the responsibility for order fulfillment. Our findings not only complement the emerging online marketplace literature but also provide testable empirical questions concerning the relationship and magnitude of different factors steering the mode choice.
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BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Nonenzymatic DNA catalytic amplification strategies have greatly benefited bioanalysis. However, long period incubation is usually required due to its relatively low reaction rate and efficiency, ...which limits its in vivo application. Here we design a responsive DNA nano string light (DNSL) by interval hybridization of modified hairpin DNA probe pairs to a DNA nanowire generated by rolling circle amplification and realize accelerated DNA cascade reaction (DCR) for fast and highly efficient mRNA imaging in living cells. Target mRNA initiates interval hybridization of two paired hairpin probes sequentially along the DNA nanowire and results in instant lighting up of the whole DNA nanowire with high signal gain due to the fast opening of all the self-quenched hairpins. The reaction time is about 6.7 times shorter compared with a regular DNA cascade reaction due to the acceleration based on domino effect. The cell delivery is achieved by modifying one of the hairpin probes with folic acid, and this intracellular imaging strategy is verified using human HeLa cells and intracellular survivin mRNA with a series of suppressed expressions as model, which provides a useful platform for fast and highly efficient detection of low-abundance nucleic acids in living cells.
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IJS, KILJ, NUK, PNG, UL, UM
Most potassium‐ion battery (PIB) cathode materials have deficient structural stability because of the huge radius of potassium ion, leading to inferior cycling performance. We report the controllable ...synthesis of a novel low‐strain phosphate material K3(VO)(HV2O3)(PO4)2(HPO4) (denoted KVP) nanorulers as an efficient cathode for PIBs. The as‐synthesized KVP nanoruler cathode exhibits an initial reversible capacity of 80.6 mAh g−1 under 20 mA g−1, with a large average working potential of 4.11 V. It also manifests an excellent rate property of 54.4 mAh g−1 under 5 A g−1, with a high capacity preservation of 92.1 % over 2500 cycles. The outstanding potassium storage capability of KVP nanoruler cathode originates from a low‐strain K+ uptake/removal mechanism, inherent semiconductor characteristic, and small K+ migration energy barrier. The high energy density and prolonged cyclic stability of KVP nanorulers//polyaniline‐intercalated layered titanate full battery verifies the superiority of KVP nanoruler cathode in PIBs.
A low‐strain phosphate cathode material K3(VO)(HV2O3)(PO4)2(HPO4) (KVP) nanoruler is synthesized by a facile solvothermal approach. The KVP nanorulers manifest high discharge voltage, superior rate capability, and ultralong cyclic life as a cathode material for potassium‐ion batteries (PIBs). This work would provide guidance to exploit high‐performance PIB cathode materials.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
This article delves into the current popular phenomenon of live streaming e-commerce, with a specific focus on issues related to product quality and after-sales service. It constructs an evolutionary ...game model that encompasses three key stakeholders: e-commerce platforms, consumers, and streamers. The study conducts a thorough analysis of the interactions and strategic choices among these entities, investigating the stability of equilibrium strategy combinations within the game system and the influence of various factors on decision-making behaviors. Furthermore, the validity of the analytical conclusion is corroborated through the application of simulation analysis methods. The study finds that for the consumer, strategies such as reducing losses encountered due to quality issues under strict demands, enhancing compensation in these scenarios, and increasing benefits for maintaining stringent requirements during live streaming sessions can motivate them to adopt more stringent strategies. For the streamer, essential factors in promoting the selection of high-quality products include increasing the benefits associated with such choices and reducing the probability of quality issues, or alternatively, decreasing the gains from lower-quality selections and increasing the likelihood of encountering quality problems with these products. For the e-commerce platform, strategically adjusting the profit-sharing ratio to maintain collaborative momentum and influence the enthusiasm of both consumers and streamers is a critical strategy to avert market scenarios akin to prisoner’s dilemmas and tragic outcomes. Overall, this research offers profound insights into the complex strategic evolution within the live commerce market, providing valuable guidance for interaction strategies among e-commerce platforms, consumers, and streamers. Its implications for practical decision-making optimization and strategic formulation are of significant importance.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Dysbiosis leads to continuous progress of inflammatory bowel disease (IBD). However, current therapeutic approaches for IBD have limited efficacy and are associated with various side effects. This ...study focused on exploring the positive effect of a new Bacillus cereus (B. cereus) strain (HMPM18123) in a colitis mouse model and elucidate the underlying molecular mechanisms. The colitis symptoms were alleviated by the B. cereus administration as evidenced by decreased body weight loss, colon length shortening, disease activity index score, and histopathological score. The B. cereus mitigated intestinal epithelial barrier damage by upregulating tight junction protein expression. Moreover, B. cereus exerted anti-inflammatory effects by regulating macrophage polarization and suppressing the TLR4-NF-κB-NLRP3 inflammasome signaling pathways. B. cereus also rebalanced the damaged gut microbiota. Thus, the molecular mechanism of alleviating colitis by B. cereus treatment involved the regulation of the TLR4-NF-κB-NLRP3 inflammasome signaling pathways in intestinal mucosal barriers by modulating gut microbiota composition.
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IJS, KILJ, NUK, PNG, UL, UM, UPUK
Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including ...immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial-mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.
We present a quantitative model to demonstrate that coclustering multiple enzymes into compact agglomerates accelerates the processing of intermediates, yielding the same efficiency benefits as ...direct channeling, a well-known mechanism in which enzymes are funneled between enzyme active sites through a physical tunnel. The model predicts the separation and size of coclusters that maximize metabolic efficiency, and this prediction is in agreement with previously reported spacings between coclusters in mammalian cells. For direct validation, we study a metabolic branch point in Escherichia coli and experimentally confirm the model prediction that enzyme agglomerates can accelerate the processing of a shared intermediate by one branch, and thus regulate steady-state flux division. Our studies establish a quantitative framework to understand coclustering-mediated metabolic channeling and its application to both efficiency improvement and metabolic regulation.
A Self-Healing Aqueous Lithium-Ion Battery Zhao, Yang; Zhang, Ye; Sun, Hao ...
Angewandte Chemie (International ed.),
November 7, 2016, Volume:
55, Issue:
46
Journal Article
Peer reviewed
Flexible lithium‐ion batteries are critical for the next‐generation electronics. However, during the practical application, they may break under deformations such as twisting and cutting, causing ...their failure to work or even serious safety problems. A new family of all‐solid‐state and flexible aqueous lithium ion batteries that can self‐heal after breaking has been created by designing aligned carbon nanotube sheets loaded with LiMn2O4 and LiTi2(PO4)3 nanoparticles on a self‐healing polymer substrate as electrodes, and a new kind of lithium sulfate/sodium carboxymethylcellulose serves as both gel electrolyte and separator. The specific capacity, rate capability, and cycling performance can be well maintained after repeated cutting and self‐healing. These self‐healing batteries are demonstrated to be promising for wearable devices.
Battery, heal thyself: A new family of solid‐state flexible aqueous lithium‐ion batteries that can self‐heal has been created using aligned carbon nanotube sheets loaded with LiMn2O4 and LiTi2(PO4)3 nanoparticles on a polymer substrate as electrodes and Li2SO4/carboxymethylcellulose as gel electrolyte and separator. The battery performance was well maintained after repeated cycles of cutting and self‐healing.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and ...apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation. Therefore, NSM and ASM have broad prospects in clinical treatments, especially in cancer, cardiovascular diseases (such as atherosclerosis), nervous system diseases (such as Alzheimer's disease), respiratory diseases (such as chronic obstructive pulmonary disease) and the phenotype of dwarfisms in adolescents, playing a complex regulatory role. This review focuses on the physiological functions of NSM and ASM and summarizes their roles in certain diseases and their potential applications in therapy.
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•Neutral sphingomyelinase and acid sphingomyelinase are involved in the hydrolysis of sphingomyelin•Apoptosis, immune function and inflammation can be regulated by sphingomyelinase.•Cardiovascular, neurological, respiratory diseases and tumors are possibly caused by abnormal changes in sphingomyelinase.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•Investigation on gas injection during ACAP process is conducted.•Argon provides a better efficiency of Rhodamine B degradation compared to air.•Hydrogen and oxygen-containing radicals are generated ...in larger amount during argon injection.•Argon dissolves in water that lowers breakdown voltage and improves cavitation treatment.
Underwater plasma has been long recognized as a “green” alternative to conventional chemicals in the wastewater treatment processes. However, practical application of underwater plasma is still challenging due to insufficient treatment performance. Recently, we proposed a novel process named ACAP utilizing acoustic cavitation in order to stabilize the plasma generation and to enlarge the plasma processing region.
This work continues our investigation regarding the ACAP treatment process focusing on effects of gas injection. Experiments were performed using an ultrasonic installation equipped with a specially designed sonotrode (Diam. 48 mm) operated at a frequency of 20 kHz and acoustic power of 120 W. The results revealed that the degradation efficiency of Rhodamine B, which was used as a model wastewater pollutant, remains almost unchangeable in the case of air injection, but it is doubled when argon is injected into the ACAP reactor. It was found that the argon injection enhances the degradation efficiency significantly even without ultrasound irradiation. Results of additional measurements suggest that the effect of argon is attributed to its ability to yield high temperature during cavitation, comparatively good solubility in water and a better ability to reduce the breakdown voltage in water compared to the air case.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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