The interrupted Passerini reaction of 3-(2-isocyanoethyl)-indole catalysed by 3,5,6-trifluoro-2-pyridone is described. The reaction diastereoselectively provided a tetracyclic furolindoline, which ...proved to be a good substrate for the Joullié-Ugi reaction; therefore, the sequential Passerini/Joullié-Ugi reactions were performed in one-pot to rapidly provide versatile and highly functionalised furoindolines from 3-(2-isocyanoethyl)-indole.
3,5,6-Trifluoro-2-pyridone effectively catalyses interrupted Passerini reaction of 3-(2-isocyanoethyl)-indole as a bifunctional catalyst. The described one-pot four-component coupling reaction afforded highly functionalised tetracyclic furoindolines.
The Manifestation Requirement, advanced by Dummett in his critique of semantic realism, has been criticized for being behavioristic, and the responses have been made that the critics are mistaken. ...However, the dispute has failed to exhibit the point of the Requirement. In this paper, I shall argue (1) that, in the light of Anscombe's theory of practical knowledge, knowledge of linguistic meaning is to be seen as the knowledge-how that forms the basis of the practical knowledge that an agent has of his own intentional actions, (2) that such knowledge of linguistic meaning is to be based on mutual agreements in a community, and (3) that the Manifestation Requirement is a condition for the possibility of such mutual agreements. As a result, the Manifestation Requirement finds its basis on the idea that language and linguistic acts are tools that we use while continually improving them.
The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic ...materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported.
Suppose that two independent sets Ib and Ir of a graph such that |Ib|=|Ir| are given, and a token is placed on each vertex in Ib. The sliding token problem is to determine whether there exists a ...sequence of independent sets which transforms Ib into Ir so that each independent set in the sequence results from the previous one by sliding exactly one token along an edge in the graph. The sliding token problem is one of the reconfiguration problems that attract the attention from the viewpoint of theoretical computer science. Recently, the problems that aim at finding a shortest reconfiguration sequence are investigated. In general, even if it is polynomial time solvable to decide whether two instances are reconfigurable into each other, it can be NP-hard to find a shortest sequence between them. In this paper, we show that the problem for finding a shortest sequence between two independent sets is polynomial time solvable for some graph classes which are subclasses of the class of interval graphs. As far as the authors know, this is the first polynomial time algorithm for the shortest sliding token problem for a graph class that requires detours.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Circular RNAs (circRNAs), are a covalently closed, single-stranded RNA without 5'- and 3'-termini, commonly stem from the exons of precursor mRNAs (pre-mRNAs). They have recently garnered interest, ...with studies uncovering their pivotal roles in regulating various aspects of cell functions and disease progressions. A notable feature of circRNA lies in the mechanism of its biogenesis involving a specialized form of splicing: back-splicing. A splicing process that relies on interactions between introns flanking the circularizing exon to bring the up and downstream splice sites in proximity through the formation of a prerequisite hairpin structure, allowing the spliceosomes to join the two splice sites together to produce a circular RNA molecule. Based on this mechanism, we explored the feasibility of facilitating the formation of such a prerequisite hairpin structure by utilizing a newly designed oligonucleotide, CircuLarIzation Promoting OligoNucleotide (CLIP-ON), to promote the production of circRNA in cells. CLIP-ON was designed to hybridize with and physically bridge two distal sequences in the flanking introns of the circularizing exons. The feasibility of CLIP-ON was confirmed in HeLa cells using a model pre-mRNA, demonstrating the applicability of CLIP-ON as a trans-acting modulator to upregulate the production of circRNAs in a cellular environment.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This concept article provides a brief outline of the concept of flash chemistry for carrying out extremely fast reactions in organic synthesis by using microreactors. Generation of highly reactive ...species is one of the key elements of flash chemistry. Another important element of flash chemistry is the control of extremely fast reactions to obtain the desired products selectively. Fast reactions are usually highly exothermic, and heat removal is an important factor in controlling such reactions. Heat transfer occurs very rapidly in microreactors by virtue of a large surface area per unit volume, making precise temperature control possible. Fast reactions often involve highly unstable intermediates, which decompose very quickly, making reaction control difficult. The residence time can be greatly reduced in microreactors, and this feature is quite effective in controlling such reactions. For extremely fast reactions, kinetics often cannot be used because of the lack of homogeneity of the reaction environment when they are conducted in conventional reactors such as flasks. Fast mixing using micromixers solves such problems. The concept of flash chemistry has been successfully applied to various organic reactions including a) highly exothermic reactions that are difficult to control in conventional reactors, b) reactions in which a reactive intermediate easily decomposes in conventional reactors, c) reactions in which undesired byproducts are produced in the subsequent reactions in conventional reactors, and d) reactions whose products easily decompose in conventional reactors. The concept of flash chemistry can be also applied to polymer synthesis. Cationic polymerization can be conducted with an excellent level of molecular‐weight control and molecular‐weight distribution control.
Speedy reaction: Flash chemistry is defined as a field of chemical synthesis in which extremely fast reactions are conducted in a highly controlled manner to produce desired compounds with high selectivity. This article provides a brief outline of the concept of flash chemistry using microreactors and its applications to organic synthesis and polymer synthesis.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The aim of this study was to evaluate the effect of biologics on the risk of advanced-stage inflammatory bowel disease (IBD)-associated intestinal cancer from a nationwide multicenter data set.
The ...medical records of patients with Crohn's disease (CD) and ulcerative colitis (UC) diagnosed with IBD-associated intestinal neoplasia (dysplasia or cancer) from 1983 to 2020 were included in this study. Therapeutic agents were classified into 3 types: biologics, 5-aminosalicylic acid, and immunomodulators. The pathological cancer stage was compared based on the drug used in both patients with CD and UC.
In total, 1,042 patients (214 CD and 828 UC patients) were included. None of the drugs were significantly associated with cancer stage in the patients with CD. In the patients with UC, an advanced cancer stage was significantly associated with less use of biologics (early stage: 7.7% vs advanced stage: 2.0%, P < 0.001), 5-aminosalicylic acid, and immunomodulators. Biologic use was associated with a lower incidence of advanced-stage cancer in patients diagnosed by regular surveillance (biologics - 24.5% vs + 9.1%, P = 0.043), but this was not the case for the other drugs. Multivariate analysis showed that biologic use was significantly associated with a lower risk of advanced-stage disease (odds ratio = 0.111 95% confidence interval, 0.034-0.356, P < 0.001).
Biologic use was associated with a lower risk of advanced IBD-associated cancer in patients with UC but not with CD. The mechanism of cancer progression between UC and CD may be different and needs to be further investigated.
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