•Porous carbons prepared by direct carbonization of Cu and Al-based porous frameworks.•Textural properties and morphology of these carbons were investigated.•Al-PCP derived carbon shows high specific ...capacitance of 232.8F/g at 100mA/g.
Three porous carbons were prepared by direct carbonization of HKUST-1, MOF-5 and Al-PCP without additional carbon precursors. The carbon samples obtained by carbonization at 1073K were characterized by XRD, TEM and N2 physisorption techniques followed by testing for electrochemical performance. The BET surface areas of the three carbons were in the range of 50–1103m2/g. As electrode materials for supercapacitor, the MOF-5 and Al-PCP derived carbons displayed the ideal capacitor behavior, whereas the HKUST-1 derived carbon showed poor capacitive behavior at various sweep rates and current densities. Among those carbon samples, Al-PCP derived carbons exhibited highest specific capacitance (232.8F/g) in 30% KOH solution at the current density of 100mA/g.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
•Chemical treatment could improve the CO2 adsorption capacity of HKUST-1.•The chemically treated HKUST-1 exhibits very high CO2 uptake of 11.6mmol/g at 273K.•Chemically treated HKUST-1 shows high ...potential for CO2/N2 and CO2/CH4 separation.
As prepared MOF Cu3(BTC)2 was immersed into different kinds of solvents with or without inorganic salt. The as-treated samples were characterized by XRD, SEM, FT-IR, TG, and N2 physisorption techniques. The results showed that CO2 uptake of the sample treated by ethanol and ammonium chloride at 65°C showed very high CO2 adsorption capacity of 11.6mmol/g at 273K and 1atm CO2 pressure, which is a drastic increase of 61% compared to the original MOF sample. The selectivity of CO2 over N2 and CH4 was also improved after chemical treatment. The sample as a CO2 adsorbent also exhibited good cyclic stabilities.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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► CO2 uptake by SBA-15 with and without framework microporosity or amine was tested. ► The CO2 uptake of SBA-15 silica increased with increasing framework microporosity. ► The CO2 ...uptake of amine-modified SBA-15 samples correlated with surface area.
Mesoporous silica SBA-15 samples with and without controlled framework microporosity were prepared and used directly or impregnated with polymer amine as adsorbent for CO2. These samples were evaluated for their ability to adsorb CO2 by obtaining their equilibrium adsorption isotherms using volumetric adsorption at three different temperatures of 273K, 278K and 283K. The data obtained were analyzed using Freundlich adsorption isotherm model while the isosteric heats of adsorption were estimated by the Clausius–Clapeyron equation. Under comparable conditions, the adsorption performance of silica SBA-15 was found to be strongly dependent upon the framework microporosity. However, the microporosity contribution to CO2 adsorption in amine-modified SBA-15 was not obvious as amine blocked micropores and dominated CO2 adsorption. The SBA-15 sample with higher microporosity displayed higher CO2 uptake and the CO2 uptake by amine-modified SBA-15 samples correlated with their total surface areas, as expected. These findings revealed the importance of surface area in designing an adsorbent for CO2.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Several SBA-15 silica materials with different pore structures were synthesized and functionalized with poly(ethyleneimine) (PEI). The as-prepared materials were characterized by XRD, SEM, TG, FT-IR, ...and N2 physisorption techniques followed by testing for CO2 capture using a N2 stream containing 15.1 v/v% CO2 in the temperature range of 30−75 °C. The results showed that the CO2 adsorption capacity linearly increased with the total pore volume of the SBA-15 phases in the tested temperature range (R 2 > 0.94). Temperature also showed a strong influence on CO2 adsorption capacity. SBA-15 material with the largest pore volume (1.14 cm3 g−1) exhibited the largest CO2 adsorption capacity (105.2 mg g−1 adsorbent) with 15.1 v/v% CO2 in N2 at 75 °C and atmospheric pressure. Pore size was found not to be the main factor influencing the CO2 adsorption capacity of these PEI-modified SBA-15 materials. Adsorption−desorption cycles (12) revealed that the adsorbents with PEI loaded inside the pore channels were found to be quite stable, as they retained their CO2 adsorption capacity with many cycles.
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IJS, KILJ, NUK, PNG, UL, UM
Pancreatic cancer (PC) is assumed to be an intimidating and deadly malignancy due to being the leading cause of cancer-led mortality, predominantly affecting males of older age. The overall (5 years) ...survival rate of PC is less than 9% and is anticipated to be aggravated in the future due to the lack of molecular acquaintance and diagnostic tools for its early detection. Multiple factors are involved in the course of PC development, including genetics, cigarette smoking, alcohol, family history, and aberrant epigenetic signatures of the epigenome. In this review, we will mainly focus on the genetic mutations and epigenetic signature of PC. Multiple tumor suppressor and oncogene mutations are involved in PC initiation, including K-RAS, p53, CDKN2A, and SMAD4. The mutational frequency of these genes ranges from 50 to 98% in PC. The nature of mutation diagnosis is mostly homozygous deletion, point mutation, and aberrant methylation. In addition to genetic modification, epigenetic alterations particularly aberrant hypermethylation and hypomethylation also predispose patients to PC. Hypermethylation is mostly involved in the downregulation of tumor suppressor genes and leads to PC, while multiple genes also represent a hypomethylation status in PC. Several renewable drugs and detection tools have been developed to cope with this aggressive malady, but all are futile, and surgical resection remains the only choice for prolonged survival if diagnosed before metastasis. However, the available therapeutic development is insufficient to cure PC. Therefore, novel approaches are a prerequisite to elucidating the genetic and epigenetic mechanisms underlying PC progression for healthier lifelong survival.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression of long ...noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report that HCC-associated mesenchymal stem cells (HCC-MSC) promote epithelial-mesenchymal transition (EMT) and liver tumorigenesis. We identified a novel lncRNA that we termed
(MSC-upregulated factor) that is highly expressed in HCC tissues and correlated with poor prognosis. Depleting
in HCC cells repressed EMT and inhibited their tumorigenic potential. Conversely, lncRNA-MUF overexpression accelerated EMT and malignant capacity. Mechanistic investigations showed that
bound Annexin A2 (ANXA2) and activated Wnt/β-catenin signaling and EMT. Furthermore, lncRNA-MUF acted as a competing endogenous RNA for miR-34a, leading to Snail1 upregulation and EMT activation. Collectively, our findings establish a lncRNA-mediated process in MSC that facilitates hepatocarcinogenesis, with potential implications for therapeutic targeting.
.
Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal reaction. Therefore, a comprehensive ...understanding of cellular diversity and the interplay between malignant cells and niche cells is essential to elucidate the mechanisms driving ICC progression and to develop therapeutic approaches.
Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable cells from 8 human ICCs and adjacent samples to elucidate the comprehensive transcriptomic landscape and intercellular communication network. Additionally, we applied a negative selection strategy to enrich fibroblast populations in 2 other ICC samples to investigate fibroblast diversity. The results of the analyses were validated using multiplex immunofluorescence staining, bulk transcriptomic datasets, and functional in vitro and in vivo experiments.
We sequenced a total of 56,871 single cells derived from human ICC and adjacent tissues and identified diverse tumor, immune, and stromal cells. Malignant cells displayed a high degree of inter-tumor heterogeneity. Moreover, tumor-infiltrating CD4 regulatory T cells exhibited highly immunosuppressive characteristics. We identified 6 distinct fibroblast subsets, of which the majority were CD146-positive vascular cancer-associated fibroblasts (vCAFs), with highly expressed microvasculature signatures and high levels of interleukin (IL)-6. Functional assays indicated that IL-6 secreted by vCAFs induced significant epigenetic alterations in ICC cells, particularly upregulating enhancer of zeste homolog 2 (EZH2) and thereby enhancing malignancy. Furthermore, ICC cell-derived exosomal miR-9-5p elicited high expression of IL-6 in vCAFs to promote tumor progression.
Our single-cell transcriptomic dataset delineates the inter-tumor heterogeneity of human ICCs, underlining the importance of intercellular crosstalk between ICC cells and vCAFs, and revealing potential therapeutic targets.
Intrahepatic cholangiocarcinoma is an aggressive and chemoresistant malignancy. Better understanding the complex transcriptional architecture and intercellular crosstalk of these tumors will help in the development of more effective therapies. Herein, we have identified important interactions between cancer cells and cancer-associated fibroblasts in the tumor stroma, which could have therapeutic implications.
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•Single cell transcriptomic datasets are a valuable resource to dissect cellular diversity and intercellular crosstalk of human ICCs.•Malignant cells displayed remarkable inter-tumor heterogeneity and Tregs revealed highly immunosuppressive characteristics.•Six distinct fibroblast subsets were defined in ICCs and adjacent tissues.•CD146+ vCAFs, comprising most of the fibroblasts, had tight interactions with malignant cells through IL-6/IL-6R axis.•Tumor exosomal miR-9-5p elicited IL-6 expression in vCAFs, contributing to ICC progression via upregulation of EZH2.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well ...contribute to both of these pathological properties, but the mechanisms underlying their self-renewal and maintenance are poorly understood. Here, using transcriptome microarray analysis, we identified a long noncoding RNA (lncRNA) termed lncTCF7 that is highly expressed in HCC tumors and liver CSCs. LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling. Our data suggest that lncTCF7-mediated Wnt signaling primes liver CSC self-renewal and tumor propagation. In sum, therefore, we have identified an lncRNA-based Wnt signaling regulatory circuit that promotes tumorigenic activity in liver cancer stem cells, highlighting the role that lncRNAs can play in tumor growth and propagation.
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•The long noncoding RNA lncTCF7 is highly expressed in liver cancer tissues and CSCs•LncTCF7 is important for self-renewal of liver CSCs•LncTCF7 activates the Wnt signaling pathway through TCF7 expression•LncTCF7 recruits the SWI/SNF complex to activate the TCF7 promoter
Wang et al. have identified a long noncoding RNA, lncTCF7, that activates Wnt signaling to promote liver cancer stem cell self-renewal and tumor propagation. Targeting this pathway could help address the high recurrence and heterogeneity of liver cancer.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Cu‐catalyzed intramolecular borylation‐cross coupling reaction of alkenes was developed. Racemic and chiral borylated indolines were achieved by borylation‐cross coupling of alkenes with B2pin2 via ...simultaneous construction of C−C and C−B bonds by Cu/phosphine ligand system. With CuOAc and DPPE ligand, a series of 3‐substituted borylated indoline derivatives were concisely synthesized in good to excellent yields in short time under mild conditions. Asymmetric synthesis was investigated by ligand screening, and the chiral 3‐substituted borylated indoline was obtained in 80% yield and 80:20 er with (R, R)‐Me‐Duphos. Application of 3‐substituted borylated indolines has been demonstrated by a gram scale synthesis and further functionalization.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The discharge of dyes from industries to water reservoirs has attracted extensive attention worldwide, and it is of great importance to remove them efficiently. In this study, a series of silica ...nanoparticles with rough surfaces was prepared, and highly dispersed silver nanoparticles were loaded on its surface through a simple wet-impregnation method. The adsorption performance and catalytic activity of the as-prepared Ag/SiO
2
for methylene blue (MB) removal was investigated. The results demonstrated that the Ag/SiO
2
with smaller particle size and higher Ag loading amount shows high adsorption capacity and catalytic activity for MB. The maximum adsorption capacity was found to be ~55 mg/g, which is more than two times of pure silica nanoparticles. Besides, MB could be degraded by more than 99% of the initial concertation (40 mg/L) within 3 min and rate constant of the catalytic reduction achieved as high as 2.128 min
−1
. Moreover, the as-prepared Ag/SiO
2
shows good stability in acidic environment and excellent reusability for at least eight successive cycles of adsorption and four cycles of catalytic reduction.
Highlights
Highly dispersed Ag nanoparticles on rough surface of silica spheres were prepared.
Ag decorated silica shows good adsorption and catalytic capability for MB removal.
MB could be catalytically degraded to < 1% of the initial concentration within 3 min.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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