Regional economic inequality is a persistent problem for all nations. Meanwhile, satellite-derived night-time light (NTL) data have been extensively used as an efficient proxy measure for economic ...activity. This study firstly proposes a new method for correction of the NTL data derived from the Visible Infrared Imaging Radiometer Suite (VIIRS) aboard the Suomi National Polar-orbiting Partnership (Suomi-NPP) satellite and then applies the corrected NTL data to estimate gross domestic product (GDP) at a multi-scale level in China from 2014 to 2017. Secondly, incorporating the two-stage nested Theil decomposition method, multi-scale level regional inequalities are investigated. Finally, by using scatter plots, this paper identifies the relationship between the regional inequality and the level of economic development. The results indicate that: (1) after correction, the NPP-VIIRS NTL data show a statistically positive correlation with GDP, which proves that our correction method is scientifically effective; (2) from 2014 to 2017, overall inequality, within-province inequality, and between-region inequality all declined, However, between-province inequality increased slightly. As for the contributions to overall regional inequality, the within-province inequality was the highest, while the between-province inequality was the lowest; (3) further analysis of within-province inequality reveals that economic inequalities in coastal provinces in China are smaller than in inland provinces; (4) China’s economic development plays an important role in affecting regional inequality, and the extent of influence of economic development on regional inequality is varied across provinces.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Environmental process assessment based on the environmental depletion index (EDI) is an important part of the long-term monitoring and early warning mechanism of China's resources and environmental ...carrying capacity. The EDI aims to realize the unified environmental impact assessment of economic and environmental systems through the ratio relationship between economic growth and pollutant emission growth. However, in terms of pollutant emissions, the EDI ignores the environmental capacity (EC), which means that the effectiveness and objectivity of environmental impact assessment must be verified. In this study, with Xinjiang as an example and based on the EDI, Sulfur dioxide (SO2), Nitrogen oxide (NOx), Chemical oxygen demand (COD) and Ammonia nitrogen (NH3-N) were selected for calculation and assessment both without and with consideration of EC and for discussion of the suitability of the environmental depletion method for resources and environmental carrying capacity. The results indicated that ① the percentages of SO2, NOx, COD, NH3-N and CEDI in counties and cities that tend to be poor and lack EC were 32.98%, 29.79%, 30.85%, 28.72% and 38.30%, respectively, while the percentages in counties and cities with EC were 10.64%, 3.19%, 13.83%, 8.51% and 10.64%, respectively. ② When EC was included, the number of counties and cities where changes in SO2, NOx, COD, NH3-N and CEDI tended to be "poor → good" were 23, 26, 17, 21 and 28, respectively, and the number of counties and cities where such changes tended to be "good → poor" were 2, 1, 1, 2 and 2, respectively. ③ EC inclusion corrected overestimated or underestimated EDI results, making the evaluation results more objective and reasonable. This understanding provides a scientific reference for the coordinated development of the regional economy and environment in Xinjiang and worldwide.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Spinal cord injury (SCI) patients display disruption of gut microbiome, and gut dysbiosis exacerbate neurological impairment in SCI models. Cumulative data support an important role of gut microbiome ...in SCI. Here, we investigated the hypothesis that fecal microbiota transplantation (FMT) from healthy uninjured mice into SCI mice may exert a neuroprotective effect.
FMT facilitated functional recovery, promoted neuronal axonal regeneration, improved animal weight gain and metabolic profiling, and enhanced intestinal barrier integrity and GI motility in SCI mice. High-throughput sequencing revealed that levels of phylum Firmicutes, family Christensenellaceae, and genus Butyricimonas were reduced in fecal samples of SCI mice, and FMT remarkably reshaped gut microbiome. Also, FMT-treated SCI mice showed increased amount of fecal short-chain fatty acids (SCFAs), which correlated with alteration of intestinal permeability and locomotor recovery. Furthermore, FMT downregulated IL-1β/NF-κB signaling in spinal cord and NF-κB signaling in gut following SCI.
Our study demonstrates that reprogramming of gut microbiota by FMT improves locomotor and GI functions in SCI mice, possibly through the anti-inflammatory functions of SCFAs. Video Abstract.
Object detection is one of the most widespread applications for numerous Unmanned Aerial Vehicle (UAV) tasks. Due to the shooting angle and flying height of the UAV, compared with general scenarios, ...small objects account for a large proportion of aerial images, and common object detectors are not extremely effective in aerial images. Moreover, since the computing resources of UAV platforms are generally limited, the deployment of common detectors with a large number of parameters on UAV platforms is difficult. This paper proposes a lightweight object detector YOLO-UAVlite for aerial images. Firstly, the spatial attention module and coordinate attention module are modified and combined to form a novel Spatial-Coordinate Self-Attention (SCSA) module, which integrates spatial, location, and channel information to enhance object representation. On this basis, we construct a lightweight backbone, named SCSAshufflenet, which combines the Enhanced ShuffleNet (ES) network with the proposed SCSA module to improve feature extraction and reduce model size. Secondly, we propose an improved feature pyramid model, namely Slim-BiFPN, where we construct new lightweight convolutional blocks to reduce the information loss during the feature map fusion process while reducing the model weights. Finally, the localization loss function is modified to increase the bounding box regression rate while improving the localization accuracy. Extensive experiments conducted on the VisDrone-DET2021 dataset indicate that, compared with the YOLOv5-N baseline, the proposed YOLO-UAVlite reduces the number of parameters by 25.8% and achieves gains of 10.9% in mAP0.50. Compared with other lightweight detectors, both the mAP and the number of parameters are improved.
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Abstract
Neurogenic bowel dysfunction, including hyperreflexic and areflexic bowel, is a common complication in patients with spinal cord injury (SCI). We hypothesized that removing part of the ...colonic sympathetic innervation can alleviate the hyperreflexic bowel, and investigated the effect of sympathectomy on the hyperreflexic bowel of SCI rats. The peri-arterial sympathectomy of the inferior mesenteric artery (PSIMA) was performed in T8 SCI rats. The defecation habits of rats, the water content of fresh faeces, the intestinal transmission function, the defecation pressure of the distal colon, and the down-regulation of Alpha-2 adrenergic receptors in colon secondary to PSIMA were evaluated. The incidence of typical hyperreflexic bowel was 95% in SCI rats. Compared to SCI control rats, PSIMA increased the faecal water content of SCI rats by 5–13% (P < 0.05), the emptying rate of the faeces in colon within 24 h by 14–40% (P < 0.05), and the defecation pressure of colon by 10–11 mmHg (P < 0.05). These effects lasted for at least 12 weeks after PSIMA. Immunofluorescence label showed the secondary down-regulation of Alpha-2 adrenergic receptors after PSIMA occurred mainly in rats’ distal colon. PSIMA mainly removes the sympathetic innervation of the distal colon, and can relieve the hyperreflexic bowel in rats with SCI. The possible mechanism is to reduce the inhibitory effect of sympathetic activity, and enhance the regulatory effect of parasympathetic activity on the colon. This procedure could potentially be used for hyperreflexic bowel in patients with SCI.
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Based on the framework of signed graphs, we investigate finite-time bipartite synchronization (FTBS) of delayed complex-valued complex networks (DCVCN) in this paper. Several control strategies with ...quantizer are designed, which can save communication resources. 1-norm analytical techniques are used and developed to present strict proof of theoretical results. Some FTBS criteria are established by use of multiple Lyapunov functions, and the settling time is estimated by means of control parameters and initial values. Numerical simulation results are given to verify the validity of theoretical analysis.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), and gut dysbiosis is commonly occurs in SCI. Here, we document neurogenic ...bowel management of male patients with chronic traumatic complete SCI in our centre and perform comparative analysis of the gut microbiota between our patients and healthy males.
A total of 43 male patients with chronic traumatic complete SCI (20 with quadriplegia and 23 with paraplegia) and 23 healthy male adults were enrolled. Clinical data and fresh stool specimens were collected from all participants. Face-to-face interviews were conducted to survey the neurogenic bowel management of 43 patients with SCI. Gut microbiomes were analysed by sequencing of the V3-V4 region of the 16S rRNA gene.
NBD was common in adult male patients with chronic traumatic complete SCI. Patients with quadriplegia exhibited a longer time to defecate than did those with paraplegia and had higher NBD scores and heavier neurogenic bowel symptoms. The diversity of the gut microbiota in the SCI group was reduced, and the structural composition was different from that of the healthy adult male group. The abundance of Veillonellaceae and Prevotellaceae increased, while Bacteroidaceae and Bacteroides decreased in the SCI group. The abundance of Bacteroidaceae and Bacteroides in the quadriplegia group and Acidaminococcaceae, Blautia, Porphyromonadaceae, and Lachnoclostridium in the paraplegia group were significantly higher than those in the healthy male group. Serum biomarkers (GLU, HDL, CR, and CRP), NBD defecation time and COURSE had significant correlations with microbial community structure. Microbial community structure was significantly associated with serum biomarkers (GLU, HDL, CR, and CRP), NBD defecation time, and COURSE.
This study presents a comprehensive landscape of the gut microbiota in adult male patients with chronic traumatic complete SCI and documents their neurogenic bowel management. Gut microbiota dysbiosis in SCI patients was correlated with serum biomarkers and NBD symptoms.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The Chinese Dietary Guidelines propose a balanced diet for healthy living, but the affordability of this diet needs to be considered, especially for low-income households. To investigate the ...affordability of a healthy diet, this study analyzes the daily retail prices of 46 food items in 36 Chinese cities from 2016 to 2021. This study compares expenditure, diet composition, and nutritional status in two scenarios aligned with the guidelines. The results show that the mean minimum cost of a balanced diet exceeds the current per capita food expenditure for at least 182.85 million urban households. This suggests that low-income people would need to increase their expenditure by at least 20-121% to achieve the recommended diets. This study also identifies affordable and nutrient-dense foods such as standard flour, eggs, black beans, and cabbage, which policymakers should focus on when monitoring food prices. The findings recommend a combination of social and food system policies to reduce prices and make healthy diets accessible. This study identifies the gaps in the Chinese Dietary Guidelines for ensuring accessibility for vulnerable groups and provides a template for policymakers and researchers to track diet affordability using available food price data in China, contributing to China's 2030 Health Plan and the UN's Sustainable Development Goals.
With the vigorous development of mobile Internet technology and the popularization of smart devices, while the amount of multimedia data has exploded, its forms have become more and more diversified. ...People’s demand for information is no longer satisfied with single-modal data retrieval, and cross-modal retrieval has become a research hotspot in recent years. Due to the strong feature learning ability of deep learning, cross-modal deep hashing has been extensively studied. However, the similarity of different modalities is difficult to measure directly because of the different distribution and representation of cross-modal. Therefore, it is urgent to eliminate the modal gap and improve retrieval accuracy. Some previous research work has introduced GANs in cross-modal hashing to reduce semantic differences between different modalities. However, most of the existing GAN-based cross-modal hashing methods have some issues such as network training is unstable and gradient disappears, which affect the elimination of modal differences. To solve this issue, this paper proposed a novel Semantic-guided Autoencoder Adversarial Hashing method for cross-modal retrieval (SAAH). First of all, two kinds of adversarial autoencoder networks, under the guidance of semantic multi-labels, maximize the semantic relevance of instances and maintain the immutability of cross-modal. Secondly, under the supervision of semantics, the adversarial module guides the feature learning process and maintains the modality relations. In addition, to maintain the inter-modal correlation of all similar pairs, this paper use two types of loss functions to maintain the similarity. To verify the effectiveness of our proposed method, sufficient experiments were conducted on three widely used cross-modal datasets (MIRFLICKR, NUS-WIDE and MS COCO), and compared with several representatives advanced cross-modal retrieval methods, SAAH achieved leading retrieval performance.
Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray ...dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melanoma metastasis and 31 biopsy specimens from patients with primary melanoma, differentially expressed genes (DEGs) were identified, subsequent to data preprocessing with the affy package, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. A protein‑protein interaction (PPI) network was constructed. Mutated genes were analyzed with 80 mutated cases with melanoma from The Cancer Genome Atlas. The overall survival of key candidate DEGs, which were within a filtering of degree >30 criteria in the PPI network and involved three or more KEGG signaling pathways, and genes with a high mutation frequency were delineated. The expression analysis of key candidate DEGs, mutant genes and their associated genes were performed on UALCAN. Of the 1,187 DEGs obtained, 505 were upregulated and 682 were downregulated. 'Extracellular exosome' processes, the 'amoebiasis' pathway, the 'ECM‑receptor interaction' pathway and the 'focal adhesion' signaling pathway were significantly enriched and identified as important processes or signaling pathways. The overall survival analysis of phosphoinositide‑3‑kinase regulator subunit 3 (PIK3R3), centromere protein M (CENPM), aurora kinase A (AURKA), laminin subunit α 1 (LAMA1), proliferating cell nuclear antigen (PCNA), adenylate cyclase 1 (ADCY1), BUB1 mitotic checkpoint serine/threonine kinase (BUB1), NDC80 kinetochore complex component (NDC80) and protein kinase C α (PRKCA) in DEGs was statistically significant. Mutation gene analysis identified that BRCA1‑associated protein 1 (BAP1) had a higher mutation frequency and survival analysis, and its associated genes in the BAP1‑associated PPI network, including ASXL transcriptional regulator 1 (ASXL1), proteasome 26S subunit, non‑ATPase 3 (PSMD3), proteasome 26S subunit, non ATPase 11 (PSMD11) and ubiquitin C (UBC), were statistically significantly associated with the overall survival of patients with melanoma. The expression levels of PRKCA, BUB1, BAP1 and ASXL1 were significantly different between primary melanoma and metastatic melanoma. Based on the present study, 'extracellular exosome' processes, 'amoebiasis' pathways, 'ECM‑receptor interaction' pathways and 'focal adhesion' signaling pathways may be important in the formation of metastases from melanoma. The involved genes, including PIK3R3, CENPM, AURKA, LAMA1, PCNA, ADCY1, BUB1, NDC80 and PRKCA, and mutation associated genes, including BAP1, ASXL1, PSMD3, PSMD11 and UBC, may serve important roles in metastases of melanoma.
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