In this study, we designed and synthesized three conformation-adaptive Pd
2
L
4
- and Pd
3
L
6
-type coordination cages based on three dihydrophenazine-based ligands with different lengths. ...Interestingly, the shorter ligands
L1
and
L2
self-assembled into Pd
2
L
4
-type coordination cages while the longer ligand
L3
formed Pd
3
L
6
-type one, mainly driven by the anion template effect. All coordination cages were confirmed through single-crystal X-ray diffraction, and their structural conformations underwent great changes compared with those of their corresponding ligands. Moreover, the conformational changes also significantly affected their photophysical and electrochemical properties which were distinct from their parent ligands.
This work investigates how dihydrophenazine ligands and their conformational changes affect the assembly of coordination cages. Self-assembly, in turn, can tune the conformation of dihydrophenazine units and their photophysical and redox properties.
Objectives
We aim to compare the diagnostic performance to assess thyroid nodules and reliability for recommending fine needle aspiration biopsy (FNAB) between American College of Radiology thyroid ...image reporting and data system (ACR TI-RADS) and American Thyroid Association (ATA) guidelines.
Methods
In total, this retrospective study included 1001 consecutive thyroid nodules in 918 patients from May 2016 to December 2017. US features of the thyroid nodules, including composition, echogenicity, shape, margins, echogenic foci, and size, were reviewed and were classified according to ACR TI-RADS and ATA guidelines, respectively. The diagnostic performance to assess thyroid nodules and reliability for recommending fine needle aspiration biopsy were compared between ACR TI-RADS and ATA guidelines.
Results
Of the 1001 thyroid nodules, 609 (60.8%) were benign and 392 (39.2%) were malignant. The sensitivity, specificity, PPV, NPV, and accuracy were 96.7%, 77.3%, 73.3%, 97.3%, and 84.9%, respectively, for ACR TI-RADS and 99.2%, 16.1%, 43.2%, 97.0%, and 48.7%, respectively, for ATA guidelines. AUC of ACR TI-RADS was significantly greater than ATA guidelines (0.935 (0.918, 0.949) vs 0.884 (0.862, 0.903),
p
< 0.001). Biopsy yield of malignancy, biopsy rate of malignancy, and unnecessary FNAB rate were 59.5%, 91.3%, and 40.5%, respectively, for ACR TI-RDS and 38.5%, 97.4%, and 61.5%, respectively, for ATA guidelines.
Conclusions
ACR TI-RADS was more accurate than ATA guidelines for differentiating malignant thyroid nodules from benign nodules and more reliable than ATA guidelines for recommending thyroid nodules for FNAB.
Key Points
•
Malignant risk of thyroid nodules can be stratified by ultrasound.
• American College of Radiology guidelines were more accurate for differentiating malignant thyroid nodules from benign nodules.
• American College of Radiology guidelines were more reliable for recommending thyroid nodules for biopsy.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Diacylglycerol kinase (DGK) is an enzyme that plays a pivotal role in abiotic and biotic stress responses in plants by transforming the diacylglycerol into phosphatidic acid. However, there is no ...report on the characterization of soybean
genes in spite of the availability of the soybean genome sequence. In this study, we performed genome-wide analysis and expression profiling of the
gene family in the soybean genome. We identified 12
genes (namely
) which all contained conserved catalytic domains with protein lengths and molecular weights ranging from 436 to 727 amino acids (aa) and 48.62 to 80.93 kDa, respectively. Phylogenetic analyses grouped
genes into three clusters-cluster I, cluster II, and cluster III-which had three, four, and five genes, respectively. The qRT-PCR analysis revealed significant
gene expression levels in both leaves and roots coping with polyethylene glycol (PEG), salt, alkali, and salt/alkali treatments. This work provides the first characterization of the
gene family in soybean and suggests their importance in soybean response to abiotic stress. These results can serve as a guide for future studies on the understanding and functional characterization of this gene family.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Traffic congestion and emissions are two main types of social cost, and their minimization sometimes conflicts with each other. In this paper we seek nonnegative link toll schemes and/or link toll ...cum rebate schemes for Pareto-efficient control and management of both vehicular congestion and emissions on road networks using a bi-objective optimization approach. We provide necessary and sufficient conditions for the existence of such schemes to decentralize a given target link flow pattern. Then, we investigate the possibility of introducing such schemes to obtain specific Pareto system optimum target link flow patterns with two types of link emission function: increasing functions and non-monotonic functions, respectively.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
495.
Revisiting charmless hadronic B decays to scalar mesons Cheng, Hai-Yang; Chua, Chun-Khiang; Yang, Kwei-Chou ...
Physical review. D, Particles, fields, gravitation, and cosmology,
06/2013, Volume:
87, Issue:
11
Journal Article
Peer reviewed
(ProQuest: ... denotes formulae and/or non-USASCII text omitted)Hadronic charmless B decays to scalar mesons are studied within the framework of QCD factorization (QCDF). Considering two different ...scenarios for scalar mesons above 1 GeV, we find that the data favor the scenario in which the scalars ... and ... are the lowest ... lying bound states. This in turn implies a preferred four-quark nature for light scalars below 1 GeV. In principle, the data of ... modes can be explained if penguin annihilation induced power corrections are taken into account. Assuming 2-quark bound states for ... and ..., the observed large rates of and modes can be explained in QCDF with the ... mixing angle in the vicinity of 20degrees. However, this does not necessarily imply that a 4-quark assignment for is ruled out because of extra diagrams contributing to ... Irrespective of the mixing angle theta, the predicted branching fraction of ... is far below the Belle measurement, and this needs to be clarified in the future.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Arsenic is an environmental contaminant, and accumulating evidence has indicated that exposure to arsenic can cause various diseases, especially cardiotoxicity. Selenium (Se) exerts a vital role in ...the regulation of multiple physiological activities. Recently, several studies highlighted that Se treatment can effectively antagonize the toxic effects induced by arsenic. However, the exact underlying effect and mechanism of Se on Arsenic-induced cardiotoxicity has not been explored. In the current study, the arsenic trioxide (ATO)-triggered heart damage mice model was used to explore whether Se exerts protective roles in ATO-related cardiotoxicity and its potential mechanism. Our data showed that Se treatment significantly alleviated ATO-mediated cardiotoxicity evidenced by increased weight, decreased myocardial damage markers, and improved heart functions in mice. Furthermore, we demonstrated that Se remarkably inhibited ATO-mediated oxidative stress and inflammatory responses in heart tissues. Mechanistically, we showed that Se upregulated the levels of NAD
+
in cardiomyocytes of the mice challenged by ATO, and this effect involved in the activation of the NAD
+
biosynthesis through the salvage pathway. Collectively, our findings demonstrated that Se protected against ATO-mediated cardiotoxicity by antioxidant and anti-inflammatory effects via increasing the NAD
+
pool in mice.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Aerobic granular sludge is one promising biotechnology in wastewater treatment. Despite intensive researches on granular architecture and strategies to improve treatment efficiency, there are still ...some elusive material parameters needed to stimulate the granulation process. The main aim of this study was to evaluate aerobic granular sludge innovatively using the universal rheology methodology, in terms of processability or quality and texture. Steady shear and oscillatory measurements were performed. Basic rheological characterization showed that aerobic granular sludge was a shear-thinning Herschel–Bulkley fluid with yield pseudoplasticity. Meanwhile, granular sludge presented characterized viscoelastic behaviors in dynamic sweeps highlighting its superiority to flocculent sludge. Furthermore, a Wagner-type constitutive model incorporating a relaxation and damping function was introduced and able to describe the time-dependent and non-linear viscoelastic behaviors. This study could make a further step on predicting rheological properties, helping improve the actual sludge treatment process and the operation of sludge dewatering.
Display omitted
•Rheology was successfully applied to analyze flow behavior of aerobic granular sludge.•Rheological properties can reflect internal microstructure of granule.•Aerobic granular sludge is a Herschel–Bulkley fluid with pseudoplasticity.•Viscoelastical definition differentiates aerobic granules from flocculent sludge.•Wagner-type model can predict fluid viscoelasticity in sludge flow.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Studies have shown that integrating anlotinib with programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors enhances survival rates among progressive non-small-cell lung cancer (NSCLC) ...patients lacking driver mutations. However, not all individuals experience clinical benefits from this therapy. As a result, it is critical to investigate the factors that contribute to the inconsistent response of patients. Recent investigations have emphasized the importance of lipid metabolic reprogramming in the development and progression of NSCLC.
The objective of this investigation was to examine the correlation between lipid variations and observed treatment outcomes in advanced NSCLC patients who were administered PD-1/PD-L1 inhibitors alongside anlotinib. A cohort composed of 30 individuals diagnosed with advanced NSCLC without any driver mutations was divided into three distinct groups based on the clinical response to the combination treatment, namely, a group exhibiting partial responses, a group manifesting progressive disease, and a group demonstrating stable disease. The lipid composition of patients in these groups was assessed both before and after treatment.
Significant differences in lipid composition among the three groups were observed. Further analysis revealed 19 differential lipids, including 2 phosphatidylglycerols and 17 phosphoinositides.
This preliminary study aimed to explore the specific impact of anlotinib in combination with PD-1/PD-L1 inhibitors on lipid metabolism in patients with advanced NSCLC. By investigating the effects of using both anlotinib and PD-1/PD-L1 inhibitors, this study enhances our understanding of lipid metabolism in lung cancer treatment. The findings from this research provide valuable insights into potential therapeutic approaches and the identification of new therapeutic biomarkers.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Lymph node metastasis (LNM) is the prominent route of gastric cancer dissemination, and usually leads to tumor progression and a dismal prognosis of gastric cancer. Although exosomal lncRNAs have ...been reported to be involved in tumor development, whether secreted lncRNAs can encode peptides in recipient cells remains unknown. Here, we identified an exosomal lncRNA (lncAKR1C2) that was clinically correlated with lymph node metastasis in gastric cancer in a VEGFC-independent manner. Exo-lncAKR1C2 secreted from gastric cancer cells was demonstrated to enhance tube formation and migration of lymphatic endothelial cells, and facilitate lymphangiogenesis and lymphatic metastasis in vivo. By comparing the metabolic characteristics of LN metastases and primary focuses, we found that LN metastases of gastric cancer displayed higher lipid metabolic activity. Moreover, exo-lncAKR1C2 encodes a microprotein (pep-AKR1C2) in lymphatic endothelial cells and promotes CPT1A expression by regulating YAP phosphorylation, leading to enhanced fatty acid oxidation (FAO) and ATP production. These findings highlight a novel mechanism of LNM and suggest that the microprotein encoded by exosomal lncAKR1C2 serves as a therapeutic target for advanced gastric cancer.
Four group 10 metal nanoclusters, Ni
10
(4-MePhS)
20
, Ni
11
(PhS)
22
, Pd
9
(PhS)
18
and Pd
10
(PhS)
20
were synthesized from disulfides based on a photochemical reduction-oxidation cascade process, ...which proceeds
via
a different mechanism to that of the conventional two-step reduction process. The as-obtained nanoclusters possess oxidative resistance and structural robustness under different conditions. Their atomically precise structures are determined to be nickel or palladium rings in which the metal atoms are bridged by Ar-S groups. Their catalytic performance in oxygen reduction reaction was compared, and the ring size-dependent catalytic activity of the group 10 metal nanoclusters was revealed. This work provides an efficient route to atomically precise and structurally stable group 10 metal nanoclusters, and sheds light on their further applications in electrocatalysis.
Photochemical synthesis and electrochemical catalysis
: Group 10 metal nanoclusters were synthesized by a photochemical reduction-oxidation cascade method and showed structural stability, catalytic durability, and ring size-dependent activity to ORR.
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