Background
High-velocity oxy-fuel (HVOF)-sprayed metallic coating can be used to create a surface layer that plays a significant role in enhancing the overall strength, stiffness, and fatigue life of ...the treated material. The micro-deformation around a single impacted particle is a critical factor that must be considered for the optimization of the HVOF process.
Objective
In this study, the micro-deformation field of stainless steel impacted by a ceramic particle was characterized at the micro-scale.
Method
A grid with a frequency of 1200 lines/mm was fabricated on the surface of stainless steel specimen. The microscopic deformation field formed on the substreate surface, induced by the impact of micro-particles with a diameter of 18 µm, was determined using the electron moiré method and numerical simulations.
Results
The in-plane plastic strain around the impacted particle was found to be as high as 9.1%, and the value sharply decreased with the increase of the distance to the edge of the impacted particle. The diameter of the plastic area was about 40 µm, which was approximately 2.2 times larger than the particle size. The experimental results were compared with numerical simulation results, and good agreement between the results was found.
Conclusions
The electron moiré technique can be a useful tool for the measurement of the deformation field induced by an impacted particle in a very local area with a size on the order of microns.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Phase space vortex merging in electron plasma waves is researched by applying a periodically changing electric field in plasma space with Maxwellian velocity distribution. The pump electric field ...excites the electron plasma wave with large amplitude and electron phase space vortices are formed. The electron plasma wave can be transited to longer wave modes through vortex merging processes. Excepting the fundamental mode of electron plasma waves, two or more modes appear and grow exponentially before vortex merging. After merging, another mode replaces the initial pumping wave as the strongest wave mode. It is verified that the growth of this new strong mode is related to trapping particle instability. Vortex merging is one of the saturation mechanisms of trapped particle instability.
An extractive fermentation process using an amine extractant and a hollow‐fiber membrane extractor to selectively remove propionic acid from the fermentation broth was developed to produce propionate ...from lactose. Compared to the conventional batch fermentation, the extractive fermentation had a much higher productivity (∼1 g/(L·h) or 5‐fold increase), higher propionate yield (up to 0.66 g/g or more than 20% increase), higher final product concentration (75 g/L or higher), and higher product purity (∼90%). Meanwhile, acetate and succinate productions in the extractive fermentation were significantly reduced. The improved fermentation performance can be attributed to the reduced product inhibition and a possible metabolic pathway shift to favor more propionic but less acetic and succinic acid production. The process was stable and gave consistent long‐term performance over the 1.5‐month period studied. The effects of propionate concentration, pH, and amine content in the solvent on the extractive fermentation were also studied and are discussed in this paper.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Metastases constitute the greatest causes of deaths from cancer. However, no effective therapeutic options currently exist for cancer patients with metastasis. Estrogen receptor β (ERβ), as a member ...of the nuclear receptor superfamily, shows potent tumor-suppressive activities in many cancers. To investigate whether modulation of ERβ could serve as a therapeutic strategy for cancer metastasis, we examined whether the selective ERβ agonist LY500307 could suppress lung metastasis of triple-negative breast cancer (TNBC) and melanoma. Mechanistically, while we observed that LY500307 potently induced cell death of cancer cells metastasized to lung in vivo, it does not mediate apoptosis of cancer cells in vitro, indicating that the cell death-inducing effects of LY500307 might be mediated by the tumor microenvironment. Pathological examination combined with flow cytometry assays indicated that LY500307 treatment induced significant infiltration of neutrophils in the metastatic niche. Functional experiments demonstrated that LY500307-treated cancer cells show chemotactic effects for neutrophils and that in vivo neutrophil depletion by Ly6G antibody administration could reverse the effects of LY500307-mediated metastasis suppression. RNA sequencing analysis showed that LY500307 could induce up-regulation of IL-1β in TNBC and melanoma cells, which further triggered antitumor neutrophil chemotaxis. However, the therapeutic effects of LY500307 treatment for suppression of lung metastasis was attenuated in IL1B
−/− murine models, due to failure to induce antitumor neutrophil infiltration in the metastatic niche. Collectively, our study demonstrated that pharmacological activation of ERβ could augment innate immunity to suppress cancer metastatic colonization to lung, thus providing alternative therapeutic options for cancer patients with metastasis.
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BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
Samples of polymeric materials generally have no intrinsic shape; rather their macroscopic form is determined by external forces such as surface tension and memory of shear (for example, during ...extrusion, moulding or embossing). Hence, in the molten state, the thermodynamically most stable form for polymer (nano)particles is spherical. Here, we present the first example of polymer nanoparticles that have an intrinsic non-spherical shape. We observe the formation of high-aspect-ratio ellipsoidal polymer nanoparticles, of controlled diameter, made from main-chain liquid crystalline polymers using a mini-emulsion technique. The ellipsoidal shape is shown to be an equilibrium (reversible) characteristic and a direct result of the material shape memory when a liquid crystal nanoparticle is in its monodomain form.
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IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This paper discusses the design, fabrication and testing of a novel thermoelectric device comprised of arrays of silicon nanowires embedded in a polymer matrix. By exploiting the low-thermal ...conductivity of the composite and presumably high-power factor of the nanowires, a thermoelectric figure of merit, higher than the corresponding bulk value, should result. Arrays were first synthesized using a vapor-liquid-solid (VLS) process leading to one-dimensional (1-D) growth of single-crystalline nanowires. To provide structural support while maintaining thermal isolation between nanowires, parylene, a low thermal conductivity and extremely conformal polymer, was embedded within the arrays. Mechanical polishing and oxygen plasma etching techniques were used to expose the nanowire tips and a metal contact was deposited on the top surface. Scanning electron micrographs (SEMs) illustrate the results of the fabrication processes. Using a modification of the 3/spl omega/ technique, the effective thermal conductivity of the nanowire matrix was measured and 1 V characteristics were also demonstrated. An assessment of the suitability of this nanocomposite for high thermoelectric performance devices is given.
A series of poly(ethylene oxide) (PEO)/organoclay nanocomposites have been prepared via a solvent casting method. Using three different organoclays modified with the alkylammonium salts, the effect ...of surfactants on organoclay surfaces in polymer/organoclay nanocomposites was investigated by focusing on two major aspects: internal structure analysis and rheological measurement of the nanocomposites. The d spacings of both the pure PEO and intercalated organoclay were examined via X-ray diffraction analysis, and the microstructure of these nanocomposites was examined by transmission electron microscopy. Rheological properties of these nanocomposites exhibited different behavior with different modifier concentrations and surfactant sizes (chain lengths). To analyze the non-Newtonian flow behavior, we fitted shear viscosity data via the Carreau model, showing that steady shear viscosity and power-law behavior increase with organoclay content. Hysteresis phenomenon was also enhanced with organoclay content, and the increase in the storage/loss moduli and interactions among organoclay platelets were observed with organoclay content. The enhanced thermal stability of the nanocomposites by organoclay was also observed.
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IJS, KILJ, NUK, PNG, UL, UM
Hard coatings have been adopted in cutting and forming applications for nearly two decades. The major purpose of using hard coatings is to reduce the friction coefficient between contact surfaces, to ...increase strength, toughness and anti-wear performance of working tools and molds, and then to obtain a smooth work surface and an increase in service life of tools and molds. In this report, we deposited a composite CrTiSiN hard coating, and a traditional single-layered TiAlN coating as a reference. Then, the coatings were comparatively studied by a series of tests. A field emission SEM was used to characterize the microstructure. Hardness was measured using a nano-indentation tester. Adhesion of coatings was evaluated using a Rockwell C hardness indentation tester. A pin-on-disk wear tester with WC balls as sliding counterparts was used to determine the wear properties. A self-designed compression and friction tester, by combining a Universal Testing Machine and a wear tester, was used to evaluate the contact behavior of composite CrTiSiN coated dies in compressing of Mg alloy sheets under high pressure. The results indicated that the hardness of composite CrTiSiN coating was lower than that of the TiAlN coating. However, the CrTiSiN coating showed better anti-wear performance. The CrTiSiN coated dies achieved smooth surfaces on the Mg alloy sheet in the compressing test and lower friction coefficient in the friction test, as compared with the TiAlN coating.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Air pollutants have, and continue to be, major contributing factors to chronic diseases and mortality, subsequently impacting public health. Chronic diseases include: chronic obstructive pulmonary ...diseases (COPD), cardiovascular diseases (CVD), asthma, and cancer. Byproducts of oxidative stress found in air pollutants are common initiators or promoters of the damage produced in such chronic diseases. Such air pollutants include: ozone, sulfur oxides, carbon monoxide, nitrogen oxides, and particulate matter. Interaction between oxidative stress byproducts and certain genes within our population may modulate the expression of specific chronic diseases. In this brief review we attempt to provide some insight into what we currently know about the health problems associated with various air pollutants and their relationship in promoting chronic diseases through changes in oxidative stress and modulation of gene expression. Such insight eventually may direct the means for effective public health prevention and treatment of diseases associated with air pollution and treatment of diseases associated with air pollution.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The low-mass X-ray binary (LMXB) system FIRST J102347.6+003841 hosts a newly born millisecond pulsar (MSP) PSR J1023+0038 that was revealed as the first and only known rotation-powered MSP in a ...quiescent LMXB. While the system is shown to have an accretion disk before 2002, it remains unclear how the accretion disk has been removed in order to reveal the radio pulsation in 2007. In this Letter, we report the discovery of Delta *g-rays spatially consistent with FIRST J102347.6+003841, at a significance of seven standard deviations, using data obtained by the Fermi Gamma-ray Space Telescope. The Delta *g-ray spectrum can be described by a power law (PL) with a photon index of 2.9 ? 0.2, resulting in an energy flux above 200 MeV of (5.5 ? 0.9) X 10--12 erg cm--2 s--1. The Delta *g-rays likely originate from the MSP PSR J1023+0038, but also possibly from an intrabinary shock between the pulsar and its companion star. To complement the Delta *g-ray study, we also re-investigate the XMM-Newton data taken in 2004 and 2008. Our X-ray spectral analysis suggests that a broken PL with two distinct photon indices describes the X-ray data significantly better than a single PL. This indicates that there exists two components and that both components appear to vary with the orbital phase. The evidence for Delta *g-ray emission conforms with a recent suggestion that Delta *g-rays from PSR J1023+0038 may be responsible for ejecting the disk material out of the system.
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