The classification of states of matter and their corresponding phase transitions is a special kind of machine-learning task, where physical data allow for the analysis of new algorithms, which have ...not been considered in the general computer-science setting so far. Here we introduce an unsupervised machine-learning scheme for detecting phase transitions with a pair of discriminative cooperative networks (DCNs). In this scheme, a guesser network and a learner network cooperate to detect phase transitions from fully unlabeled data. The new scheme is efficient enough for dealing with phase diagrams in two-dimensional parameter spaces, where we can utilize an active contour model-the snake-from computer vision to host the two networks. The snake, with a DCN "brain," moves and learns actively in the parameter space, and locates phase boundaries automatically.
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Learning phase transitions by confusion van Nieuwenburg, Evert P. L.; Liu, Ye-Hua; Huber, Sebastian D.
Nature physics,
05/2017, Volume:
13, Issue:
5
Journal Article
Peer reviewed
Open access
Classifying phases of matter is key to our understanding of many problems in physics. For quantum-mechanical systems in particular, the task can be daunting due to the exponentially large Hilbert ...space. With modern computing power and access to ever-larger data sets, classication problems are now routinely solved using machine-learning techniques1. Here, we propose a neural-network approach to finding phase transitions, based on the performance of a neural network after it is trained with data that are deliberately labelled incorrectly. We demonstrate the success of this method on the topological phase transition in the Kitaev chain2, the thermal phase transition in the classical Ising model3, and the many-body-localization transition in a disordered quantum spin chain4. Our method does not depend on order parameters, knowledge of the topological content of the phases,or any other specics of the transition at hand. It therefore paves the way to the development of a generic tool for identifying unexplored phase transitions.
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Chitin deacetylases (CDAs) are enzymes required for one of the pathways of chitin degradation, in which chitosan is produced by the deacetylation of chitin. Bioinformatic investigations with genomic ...and transcriptomic databases identified four genes encoding CDAs in Nilaparvata lugens (NlCDAs). Phylogenetic analysis showed that insect CDAs were clustered into five major groups. Group I, III and IV CDAs are found in all insect species, whereas the pupa‐specific group II and gut‐specific group V CDAs are not found in the plant‐sap/blood‐sucking hemimetabolous species from Hemiptera and Anoplura. The developmental and tissue‐specific expression patterns of four NlCDAs revealed that NlCDA3 was a gut‐specific CDA, with high expression at all developmental stages; NlCDA1, NlCDA2 and NlCDA4 were highly expressed in the integument and peaked periodically during every moulting, which suggests their roles in chitin turnover of the insect old cuticle. Lethal phenotypes of cuticle shedding failure and high mortality after the injection of double‐stranded RNAs (dsRNAs) for NlCDA1, NlCDA2 and NlCDA4 provide further evidence for their functions associated with moulting. No observable morphological and internal structural abnormality was obtained in insects treated with dsRNA for gut‐specific NlCDA3.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Chitinases are important enzymes required for chitin degradation and reconstruction in insects. Based on a bioinformatics investigation, we identified 12 genes encoding putative chitinase‐like ...proteins, including 10 chitinases (Cht), one imaginal disc growth factor (IDGF) and one endo‐β‐N‐acetylglucosaminidase (ENGase) in the genome of the brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae). These 12 genes were clustered into nine different groups, with 11 in glycoside hydrolase family 18 groups (groups I‐VIII) and one in the ENGase group. Developmental and tissue‐specific expression pattern analysis revealed that the transcript levels of eight genes peaked periodically during moulting and were mainly expressed in the integument, except NlCht2, NlCht4, NlIDGF and NlENGase. NlCht2, NlIDGF and NlENGase were expressed at all stages with slight periodical changes and mainly expressed in the female reproductive organs in adults, whereas NlCht4 was highly expressed only at the adult stage in the male reproductive organs. Lethal phenotypes were observed in insects challenged by double‐stranded RNAs for NlCht1, NlCht5, NlCht7, NlCht9 and NlCht10 during moulting, suggesting their significant roles in old cuticle degradation. NlCht1 was the most sensitive gene, inducing 50% mortality even at 0.01 ng per insect. Our results illustrate the structural and functional differences of chitinase‐like family genes and provide potential targets for RNA interference‐based rice planthopper management.
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In this study, an integrated model (PORO-WSSI II) for wave–seabed–structure interactions (WSSI) is developed by combining (i) the Volume-Averaged Reynolds-Averaged Navier–Stokes (VARANS) equations ...for wave motions in a fluid domain and the porous media flows in porous structures, and (ii) the dynamic Biot's equations for a porous elastic seabed. The effects of the porous flow in seabed and marine structures, and the fluid exchange at the interface between the fluid domain and solid domain on wave characteristics are considered. The finite difference two-step projection method and the forward time difference method are adopted to solve the VARANS equations. The volume of fluid (VOF) method is applied to track water free-surface. The finite element method and the Generalized Newmark method are respectively adopted for the space discretization and time discretization of the dynamic Biot's equations. A one-way integrating method is developed to integrate the VARANS equations with the dynamic Biot's equations. Several experimental data available in the literature are used to validate the integrated model. An overall agreement between the numerical results and the experiment data indicates that the integrated model developed for the WSSI problem is highly reliable. The integrated model is then applied to investigate the dynamic response of a large-scale composite breakwater on a seabed, and the mechanism of WSSI. Numerical results indicate that there are intensive fluid exchanges between the water body and the seabed and strong seepage forces in the seabed under the ocean wave loading. The excessive upward seepage force leads to the liquefaction of the seabed in the region under wave trough. There is a liquefaction zone in the seabed close to the bottom corner of the rubble mound, which may lead to foundation instability of the composite breakwater. The parametric study indicates that the wave characteristics have a significant impact on the liquefaction properties (depth, width and area).
► We proposed an integrated model for wave–seabed–structure interactions. ► Pre-consolidation is considered in the new model, which is important for prediction of liquefaction. ► Numerical results show the applicability of Biot's dynamic poro-elastic model in the rubble mound.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
An accurate local bond–slip model is of fundamental importance in the modelling of FRP-strengthened RC structures. In this paper, a review of existing bond strength models and bond–slip models is ...first presented. These models are then assessed using the results of 253 pull tests on simple FRP-to-concrete bonded joints, leading to the conclusion that a more accurate model is required. In the second half of the paper, a set of three new bond–slip models of different levels of sophistication is proposed. A unique feature of the present work is that the new bond–slip models are not based on axial strain measurements on the FRP plate; instead, they are based on the predictions of a meso-scale finite element model, with appropriate adjustment to match their predictions with the experimental results for a few key parameters. Through comparisons with the large test database, all three bond–slip models are shown to provide accurate predictions of both the bond strength (i.e. ultimate load) and the strain distribution in the FRP plate.
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SUMMARY
Submucosal tunneling endoscopic resection (STER) of subepithelial tumors (SETs) originating from the muscularis propria (MP) layer in the cardia is rarely performed due to the difficulty of ...creating a submucosal tunnel for resection. The aim of this study is to evaluate the feasibility of STER using methylene-blue guidance for SETs originating from the MP layer in the cardia. From January 2012 to December 2014, 56 patients with SETs originating from the MP layer in the cardia were treated with STER using methylene-blue guidance. The complete resection rate and adverse event rate were the main outcome measurements. Successful complete resection by STER was achieved in all 56 cases (100%). The median size of the tumor was 1.8 cm. Nine patients (15.3%) had adverse events including subcutaneous emphysema, pneumoperitoneum, pneumothorax, and pleural effusion. These nine patients recovered successfully after conservative treatment without endoscopic or surgical intervention. No residual or recurrent tumors were detected in any patient during the follow-up period (median, 25 months). The adverse event rate was significantly higher for tumors originating in the deeper MP layers (46.7%) than in the superficial MP layers (4.9%) (P < 0.05), differed significantly according to tumor size (5.4% for tumors < 2.0 cm vs. 36.8% for tumors ≥ 2.0 cm; P < 0.05), and also differed significantly in relation to the tumor growth pattern (4.1% for the intraluminal growth vs. 100% for the extraluminal growth; P < 0.001). STER using methylene-blue guidance appears to be a feasible method for removing SETs originating from the MP layer in the cardia.
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In insect eggs, the chorion has the essential function of protecting the embryo from external agents during development while allowing gas exchange for respiration. In this study, we found a novel ...gene, Nilaparvata lugens chorion protein (NlChP), that is involved in chorion formation in the brown planthopper, Nilaparvata lugens. NlChP was highly expressed in the follicular cells of female adult brown planthoppers. Knockdown of NlChP resulted in oocyte malformation and the inability to perform oviposition, and electron microscopy showed that the malformed oocytes had thin and rough endochorion layers compared to the control group. Liquid chromatography with tandem mass spectrometry analysis of the eggshell components revealed four unique peptides that were matched to NlChP. Our results demonstrate that NlChP is a novel chorion protein essential for egg maturation in N. lugens, a hemipteran insect with telotrophic meroistic ovaries. NlChP may be a potential target in RNA interference‐based insect pest management.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
Soluble aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that ...sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3β or stress activated protein kinase 4 enabled recombinant wild-type tau of isoform 0N4R to spontaneously polymerize into small amorphous aggregates in vitro. We employed tandem mass spectrometry to determine the phosphorylation sites, high-resolution native mass spectrometry to measure the degree of phosphorylation, and super-resolution microscopy and electron microscopy to characterize the morphology of aggregates formed. Functionally, compared with the unmodified aggregates, which require heparin induction to assemble, these self-assembled hyperphosphorylated tau aggregates more efficiently disrupt membrane bilayers and induce Toll-like receptor 4-dependent responses in human macrophages. Together, our results demonstrate that hyperphosphorylated tau aggregates are potentially damaging to cells, suggesting a mechanism for how hyperphosphorylation could drive neuroinflammation in tauopathies.
Fiber-reinforced polymer (FRP) composites have found increasingly wide applications in civil engineering due to their high strength-to-weight ratio and high corrosion resistance. One important ...application of FRP composites is as a confining material for concrete, particularly in the strengthening or seismic retrofit of existing reinforced concrete columns by the provision of a FRP jacket. FRP confinement can enhance both the compressive strength and the ultimate strain of concrete significantly. This paper presents a new stress–strain model for FRP-confined concrete in which the responses of the concrete core and the FRP jacket as well as their interaction are explicitly considered. Such a model is often referred to as an analysis-oriented model. The key novel feature of the proposed analysis-oriented model, compared to existing models of the same kind, is a more accurate and more widely applicable lateral strain equation based on a careful interpretation of the lateral deformation characteristics of unconfined, actively confined, and FRP-confined concrete. Through comparisons with independent test data, the proposed model is shown to be accurate not only for FRP-confined concrete but also for concrete confined with a steel tube, demonstrating the wide applicability of the model to concrete confined with different confining materials. The accuracy of the proposed model is also shown to be superior to existing analysis-oriented stress-strain models through comparisons with test data.
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