Bone marrow transplantation for the treatment of leukemia is increasingly successful in rendering patients disease free. However, it has become evident that the associated severe immunosuppression ...predisposes this population to an increased risk for other neoplastic disorders. We report on six patients in whom non-Hodgkin's lymphoma of the tonsillar region developed within 5 months after T-cell-depleted bone marrow transplantation for the treatment of leukemia at Memorial Sloan-Kettering Cancer Center from October 1990 to October 1992. These patients initially had what appeared to be infectious exudative pharyngitis/tonsillitis; however, they did not improve with medical therapy. Because of the persistence of pharyngitis/tonsillitis in association with cervical lymphadenopathy and odynophagia, the patients underwent definitive biopsy in the form of tonsillectomy, cervical lymph node biopsy, or both. Histopathologic review revealed non-Hodgkin's lymphoma. An association with Epstein-Barr virus has been noted in five of these patients. This article is aimed at alerting the clinician to consider the diagnosis of lymphoma in a patient with persistent pharyngitis/tonsillitis despite adequate medical therapy after bone marrow transplantation.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBJE, SBMB, UL, UM, UPUK
Factors controlling glutathione metabolism may govern sensitivity to chemotherapeutic agents such as cisplatin. Using a battery of cell lines derived from previously untreated head and neck squamous ...cell carcinomas, we examined cisplatin resistance relative to (a) glutathione-S-transferase (GST)-pi gene amplification and expression, (b) basal and inducible GST-total and GST-pi enzymatic activity, and (c) cellular levels of reduced glutathione (GSH). Using Southern blot analysis and northern blot hybridization, no relationship between GST-pi gene amplification, mRNA expression and drug resistance could be identified. Despite the capacity of cisplatin to induce GST enzyme activity, the response was variable and unrelated to cisplatin responsiveness. However, an inverse relationship between GSH levels and cisplatin sensitivity was identified. To further clarify these effects, cells were treated with S-allyl cysteine (SAC), a thioallyl derivative isolated from garlic (Allium sativum), which altered cellular GSH in a biphasic manner. Pretreatment with SAC to lower cellular GSH levels followed by exposure to cisplatin significantly enhanced the cytotoxic effects of cisplatin, while SAC alone had no effect on cell growth.
The Abolitionist Sisterhood Jean Fagan Yellin, John C. Van Horne / Jean Fagan Yellin, John C. Van Horne
05/2018
eBook
A small group of black and white American women who banded together in the 1830s and 1840s to remedy the evils of slavery and racism, the "antislavery females" included many who ultimately struggled ...for equal rights for women as well. Organizing fundraising fairs, writing pamphlets and giftbooks, circulating petitions, even speaking before "promiscuous" audiences including men and women—the antislavery women energetically created a diverse and dynamic political culture. A lively exploration of this nineteenth-century reform movement, The Abolitionist Sisterhood includes chapters on the principal female antislavery societies, discussions of black women's political culture in the antebellum North, articles on the strategies and tactics the antislavery women devised, a pictorial essay presenting rare graphics from both sides of abolitionist debates, and a final chapter comparing the experiences of the American and British women who attended the 1840 World Anti-Slavery Convention in London.
Between the 1880s and 1910s, thousands of African Americans passed civil service exams and became employed in the executive offices of the federal government. However, by 1920, promotions to ...well-paying federal jobs had nearly vanished for black workers. Eric S. Yellin argues that the Wilson administration's successful 1913 drive to segregate the federal government was a pivotal episode in the age of progressive politics. Yellin investigates how the enactment of this policy, based on progressives' demands for whiteness in government, imposed a color line on American opportunity and implicated Washington in the economic limitation of African Americans for decades to come.
SuperCDMS is an experiment designed to directly detect Weakly Interacting Massive Particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this paper, we present ...WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage- assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for 10 live days at the Soudan Underground Laboratory. A low energy threshold of 170 eVee (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV/c2.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
Democratic Fair Play ERIC S. YELLIN
Racism in the Nation's Service,
04/2013
Book Chapter
Swan Kendrick was ebullient on March 10, 1913. He had spent the week soaking up all the fanfare that accompanied Woodrow Wilson’s inauguration. He was elated by the presence of black women in the ...suffragette parade and by “the colored soldiers (National Guards) and high school cadets, in the inaugural parade.” Howard University, too, had entered its students in the parade’s college section. Black Washington was well represented in the city’s most important political celebration, a reflection of both the prominence of African Americans in the capital and the new administration’s desire to appear egalitarian. The politics of it all
Creating Normalcy ERIC S. YELLIN
Racism in the Nation's Service,
04/2013
Book Chapter
On May 30, 1922, the Lincoln Memorial in Washington, D.C., was officially dedicated. Gleaming white, the enormous neoclassical marble temple housed a larger-than-life statue of Abraham Lincoln, ...seated, with huge hands to symbolize the generosity he insisted upon and the bigness of his message. Stretching up to the ceiling along the inner walls were the words of Lincoln’s Gettysburg Address, his pithy paean to American democracy, union, and sacrifice. It was supposed to be a moment of national pride and sectional reconciliation: “Emancipation was a means to the great end—maintained union and nationality,” said President Warren G. Harding. To
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