To understand the mechanistic involvement of long non-coding RNA (lncRNA) SNHG3 in gastric cancer (GC), the relative abundance of SNHG3 was determined by real-time PCR. Overall and metastasis-free ...survival was analyzed by Kaplan-Meier's plot. The potential impact of SNHG3 on tumor progression was evaluated both in vitro and in vivo. The in vivo metastasis was monitored in the tail vein-injected mice. Our data suggested that high SNHG3 associated with unfavorable prognosis in respect to overall and metastasis-free survival. SNHG3-deficiency significantly suppressed cell proliferation and cell viability in vitro and xenograft progression in vivo. In addition, ectopic overexpression of SNHG3 promoted cell migration and invasion in vitro and lung metastasis in vivo. Mechanistically, we uncovered SNHG3 associated with EZH2 and negatively regulated MED18 expression through methylation modulation. Transient knockdown of MED18 in SNHG3-deficient cells completely rescued the tumor suppressive phenotypes in GC cells. Our data unraveled the oncogenic properties of high SNHG3 in GC, which predominantly depended on epigenetically regulated MED18.
In this article, we demonstrate transition-metal-catalyzed olefin metathesis as a simple, effective method for healing polymers via dynamic exchange of strong carbon–carbon double bonds. Upon ...introducing a very low level of the Grubbs’ second-generation Ru metathesis catalyst into cross-linked polybutadiene (PBD) network, the material self-heals effectively at various conditions under moderate pressures. In sharp contrast, catalyst-free control samples with identical network topology and cross-linking density show minimal healing. The healing efficiency of the materials was carefully investigated under different concentrations of the Ru catalyst, compression pressures, and temperatures. It is demonstrated for the first time that a bulk polymer could effectively heal via dynamic covalent bond formation at sub-ambient temperature. The Ru-loaded PBD samples not only heal well with themselves but also with control samples without any catalyst. Furthermore, a completely Ru-free PBD network can heal effectively upon simply applying a very small amount of Ru catalyst only at the fracture surface. The simplicity and effectiveness of this self-healing approach make it potentially applicable to a wide range of olefin-containing polymers.
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IJS, KILJ, NUK, PNG, UL, UM
As an emerging class of promising porous materials, the development of two‐dimensional conductive metal organic frameworks (2D c‐MOFs) is hampered by the few categories and tedious synthesis of the ...specific ligands. Herein, we developed a nonplanar hexahydroxyl‐functionalized Salphen ligand (6OH‐Salphen) through a facile two‐step synthesis, which was further applied to construct layered 2D c‐MOFs through in situ one pot synthesis based on the synergistic metal binding effect of the N2O2 pocket of Salphen. Interestingly, the C2v‐symmetry of ligand endows Cu‐Salphen‐MOF with periodically heterogeneous pore structures. Benefitting from the higher metal density and shorter in‐plane metal‐metal distance, Cu‐Salphen‐MOF showcased excellent NO2 sensing performance with good sensitivity, selectivity and reversibility. The current work opens up a new avenue to construct 2D c‐MOF directly from nonplanar ligands, which greatly simplifies the synthesis and provides new possibilities for preparing different topological 2D c‐MOF based functional materials.
A new nonplanar Salphen ligand (6OH‐Salphen) with C2v‐symmetry was developed to construct 2D Cu‐Salphen‐MOF via in situ one pot synthesis, featuring metal coordination induced planarization of the Salphen cores. The existence of N2O2 pocket of 6OH‐Salphen endows 2D Cu‐Salphen‐MOF with higher metal density, shorter metal‐metal distance and a narrower band gap, thus making it display a high response toward NO2 (766 % at 100 ppm).
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Tin diselenide (SnSe2) nanosheets as novel 2D layered materials have excellent optical properties with many promising application prospects, such as photoelectric detectors, nonlinear optics, ...infrared photoelectric devices, and ultrafast photonics. Among them, ultrafast photonics has attracted much attention due to its enormous advantages; for instance, extremely fast pulse, strong peak power, and narrow bandwidth. In this work, SnSe2 nanosheets are fabricated by using solvothermal treatment, and the characteristics of SnSe2 are systemically investigated. In addition, the solution of SnSe2 nanosheets is successfully prepared as a fiber‐based saturable absorber by utilizing the evanescent field effect, which can bear a high pump power. 31st‐order subpicosecond harmonic mode locking is generated in an Er‐doped fiber laser, corresponding to the maximum repetition rate of 257.3 MHz and pulse duration of 887 fs. The results show that SnSe2 can be used as an excellent nonlinear photonic device in many fields, such as frequency comb, lasers, photodetectors, etc.
Tin diselenide (SnSe2) nanosheets as novel 2D layered materials have excellent optical properties. SnSe2 nanosheets fabricated by using solvothermal treatment are successfully prepared as fiber‐based saturable absorbers by utilizing the evanescent field effect, which can bear a high pump power. 31st‐order subpicosecond harmonic mode‐locking is generated, corresponding to 257.3 MHz repetition rate.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Covalently cross-linked polymers have many technological applications for their excellent properties, but they suffer from the lack of processability and adaptive properties. We report a simple, ...efficient method of generating adaptive cross-linked polymers via olefin metathesis. By introducing a very low level of the Grubbs’ second-generation Ru metathesis catalyst, a chemically cross-linked polybutadiene network becomes malleable at room temperature while retaining its insolubility. The stress relaxation capability increases with increasing level of catalyst loading. In sharp contrast, catalyst-free control samples with identical network topology and cross-linking density do not show any adaptive properties. This chemistry should offer a possibility to combine the dimensional stability and solvent resistance of cross-linked polymers and the processability/adaptibility of thermoplastics.
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Core–shell or striped heteroatomic lanthanide metal–organic framework hierarchical single crystals were obtained by liquid‐phase anisotropic epitaxial growth, maintaining identical periodic ...organization while simultaneously exhibiting spatially segregated structure. Different types of domain and orientation‐controlled multicolor photophysical models are presented, which show either visually distinguishable or visible/near infrared (NIR) emissive colors. This provides a new bottom‐up strategy toward the design of hierarchical molecular systems, offering high‐throughput and multiplexed luminescence color tunability and readability. The unique capability of combining spectroscopic coding with 3D (three‐dimensional) microscale spatial coding is established, providing potential applications in anti‐counterfeiting, color barcoding, and other types of integrated and miniaturized optoelectronic materials and devices.
A colorful turn: Core–shell (see picture, left) or striped (right) heteroatomic lanthanide metal–organic framework hierarchical single crystals are assembled from solution‐mediated epitaxial growth. By manipulation of the domain and orientation, tunable multicolor to white light emissions can be achieved. Multiplexed and high‐throughput capabilities are provided through the combination of spectroscopy with 3D‐space operation.
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Lead zirconate titanate (PZT)‐based piezoelectric ceramics are important functional materials for various electromechanical applications, including sensors, actuators, and transducers. High ...piezoelectric coefficient and mechanical quality factor are essential for the resonant piezoelectric application. However, since these properties are often inversely proportional, simultaneously high performances are hard to achieve, consequently, a wide range of applications are strongly restricted. In the present study, exceptionally well‐balanced performances are achieved in PZT‐based ceramics via innovative defect engineering, which involves multi‐scale coordination among defect dipole, domain‐wall density, and grain boundary. These materials are superior to many state‐of‐the‐art commercial counterparts, which can potentially satisfy high‐end requirements for advanced electromechanical applications, such as energy harvesting, structural health monitoring, robotic sensors, and actuator.
Exceptionally well‐balanced piezoelectric performances are achieved in (Pb0.92Sr0.08)(Zr0.533Ti0.443Nb0.024)O3‐xwt%Mn (abbreviated as PSZTN‐Mn) ferroelectric ceramics (d33 = 510–460 pC N−1, Qm = 614–750), which is superior to many state‐of‐the‐art commercial piezoelectric ceramics. The high performance is proposed to originate from multi‐sale coordination among defect dipoles, domain wall, and grain boundary.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Intrinsically stretchable conductors play key roles in the dynamic interfacing of electronic devices with soft human tissues. However, it is difficult to simultaneously achieve high electrical ...conductivity and mechanical stretchability. Here, highly stretchable and conductive thin film electrodes are prepared by combining PEDOT:PSS and a mutually plasticized polymer dopant. Notably, harsh acid treatment for conductivity enhancement is avoided, and good solvent tolerance and high optical transparency are realized, all of which are essential to device fabrication. A transparent electrochromic display is further developed that can bear stretching up to 80% strain, demonstrating its promising application in next-generation optoelectronics.
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We describe a photoinduced copper‐catalyzed asymmetric radical decarboxylative alkynylation of bench‐stable N‐hydroxyphthalimide(NHP)‐type esters of racemic alkyl carboxylic acids with terminal ...alkynes, which provides a flexible platform for the construction of chiral C(sp3)−C(sp) bonds. Critical to the success of this process are not only the use of the copper catalyst as a dual photo‐ and cross‐coupling catalyst but also tuning of the NHP‐type esters to inhibit the facile homodimerization of the alkyl radical and terminal alkyne, respectively. Owing to the use of stable and easily available NHP‐type esters, the reaction features a broader substrate scope compared with reactions using the alkyl halide counterparts, covering (hetero)benzyl‐, allyl‐, and aminocarbonyl‐substituted carboxylic acid derivatives, and (hetero)aryl and alkyl as well as silyl alkynes, thus providing a vital complementary approach to the previously reported method.
Two in one: A photoinduced asymmetric radical decarboxylative alkynylation of bench‐stable racemic carboxylic acid derivatives with easily available terminal alkynes provides expedient access to diverse enantioenriched alkynes. The chiral copper catalyst serves as a dual photo‐ and cross‐coupling catalyst to achieve stereocontrol over the highly reactive prochiral alkyl radical intermediates.
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Abstract
Intrinsically and fully stretchable active-matrix-driven displays are an important element to skin electronics that can be applied to many emerging fields, such as wearable electronics, ...consumer electronics and biomedical devices. Here, we show for the first time a fully stretchable active-matrix-driven organic light-emitting electrochemical cell array. Briefly, it is comprised of a stretchable light-emitting electrochemical cell array driven by a solution-processed, vertically integrated stretchable organic thin-film transistor active-matrix, which is enabled by the development of chemically-orthogonal and intrinsically stretchable dielectric materials. Our resulting active-matrix-driven organic light-emitting electrochemical cell array can be readily bent, twisted and stretched without affecting its device performance. When mounted on skin, the array can tolerate to repeated cycles at 30% strain. This work demonstrates the feasibility of skin-applicable displays and lays the foundation for further materials development.
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