This study explores the role of the long noncoding RNA (LncRNA) CRNDE in cisplatin (CDDP) resistance of gastric cancer (GC) cells. Here, we show that LncRNA CRNDE is upregulated in carcinoma tissues ...and tumor‐associated macrophages (TAMs) of GC patients. In vitro experiments show that CRNDE is enriched in M2‐polarized macrophage‐derived exosomes (M2‐exo) and is transferred from M2 macrophages to GC cells via exosomes. Silencing CRNDE in M2‐exo reverses the promotional effect of M2‐exo on cell proliferation in CDDP‐treated GC cells and homograft tumor growth in CDDP‐treated nude mice. Mechanistically, CRNDE facilitates neural precursor cell expressed developmentally downregulated protein 4‐1 (NEDD4‐1)‐mediated phosphatase and tensin homolog (PTEN) ubiquitination. Silencing CRNDE in M2‐exo enhances the CDDP sensitivity of GC cells treated with M2‐exo, which is reduced by PTEN knockdown. Collectively, these data reveal a vital role for CRNDE in CDDP resistance of GC cells and suggest that the upregulation of CRNDE in GC cells may be attributed to the transfer of TAM‐derived exosomes.
SYNOPSIS
LncRNA CRNDE is transferred from M2‐polarized macrophages to GC cells via exosomes, suppressing PTEN expression in GC cells. The latter leads to a reduced sensitivity of GC cells to cisplatin.
LncRNA CRNDE is enriched in TAMs of GC patients.
LncRNA CRNDE is transferred from M2‐polarized macrophages to GC cells via exosomes in vitro.
CRNDE facilitates NEDD4‐1‐mediated PTEN ubiquitination in GC cells.
Exosomal transfer of LncRNA CRNDE is linked to cisplatin resistance in GC cells caused by reduced PTEN levels.
LncRNA CRNDE is transferred from M2‐polarized macrophages to GC cells via exosomes, suppressing PTEN expression in GC cells. The latter leads to a reduced sensitivity of GC cells to cisplatin.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Although persistent room‐temperature phosphorescence (RTP) emission has been observed for a few pure crystalline organic molecules, there is no consistent mechanism and no universal design strategy ...for organic persistent RTP (pRTP) materials. A new mechanism for pRTP is presented, based on combining the advantages of different excited‐state configurations in coupled intermolecular units, which may be applicable to a wide range of organic molecules. By following this mechanism, we have developed a successful design strategy to obtain bright pRTP by utilizing a heavy halogen atom to further increase the intersystem crossing rate of the coupled units. RTP with a remarkably long lifetime of 0.28 s and a very high quantum efficiency of 5 % was thus obtained under ambient conditions. This strategy represents an important step in the understanding of organic pRTP emission.
Persistence pays off: Bright persistent room‐temperature phosphorescence from pure organic molecules was achieved by intermolecular electronic coupling of selected units in crystals. The combined advantages of their different excited‐state configurations (i.e., the nπ* state with a high intersystem crossing rate and the ππ* state with a low radiative rate) results in a hybrid intersystem‐crossing process that leads to efficient persistent room‐temperature phosphorescence.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
In cellular networks, proximity users may communicate directly without going through the base station, which is called Device-to-device (D2D) communications and it can improve spectral efficiency. ...However, D2D communications may generate interference to the existing cellular networks if not designed properly. In this paper, we study a resource allocation problem to maximize the overall network throughput while guaranteeing the quality-of-service (QoS) requirements for both D2D users and regular cellular users (CUs). A three-step scheme is proposed. It first performs admission control and then allocates powers for each admissible D2D pair and its potential CU partners. Next, a maximum weight bipartite matching based scheme is developed to select a suitable CU partner for each admissible D2D pair to maximize the overall network throughput. Numerical results show that the proposed scheme can significantly improve the performance of the hybrid system in terms of D2D access rate and the overall network throughput. The performance of D2D communications depends on D2D user locations, cell radius, the numbers of active CUs and D2D pairs, and the maximum power constraint for the D2D pairs.
The North China Craton (NCC) was originally formed by the amalgamation of the eastern and western blocks along an orogenic belt at ∼1.9 Ga. After cratonization, the NCC was essentially stable until ...the Mesozoic, when intense felsic magmatism and related mineralization, deformation, pull-apart basins, and exhumation of the deep crust widely occurred, indicative of destruction or decratonization. Accompanying this destruction was significant removal of the cratonic keel and lithospheric transformation, whereby the thick (∼200 km) and refractory Archean lithosphere mantle was replaced by a thin (<80 km) juvenile one. The decratonization of the NCC was driven by flat slab subduction, followed by a rollback of the paleo-Pacific plate during the late Mesozoic. A global synthesis indicates that cratons are mainly destroyed by oceanic subduction, although mantle plumes might also trigger lithospheric thinning through thermal erosion. Widespread crust-derived felsic magmatism and large-scale ductile deformation can be regarded as petrological and structural indicators of craton destruction.
A craton, a kind of ancient continental block on Earth, was formed mostly in the early Precambrian (>1.8 Ga).
A craton is characterized by a rigid lithospheric root, which provides longevity and stability during its evolutionary history.
Some cratons, such as the North China Craton, can be destroyed by losing their stability, manifested by magmatism, deformation, earthquake, etc.
Photoaffinity labeling (PAL) in combination with a chemical probe to covalently bind its target upon UV irradiation has demonstrated considerable promise in drug discovery for identifying new drug ...targets and binding sites. In particular, carbene-mediated photoaffinity labeling (cmPAL) has been widely used in drug target identification owing to its excellent photolabeling efficiency, minimal steric interference and longer excitation wavelength. Specifically, diazirines, which are among the precursors of carbenes and have higher carbene yields and greater chemical stability than diazo compounds, have proved to be valuable photolabile reagents in a diverse range of biological systems. This review highlights current advances of cmPAL in medicinal chemistry, with a focus on structures and applications for identifying small molecule-protein and macromolecule-protein interactions and ligand-gated ion channels, coupled with advances in the discovery of targets and inhibitors using carbene precursor-based biological probes developed in recent decades.
Photoaffinity labeling (PAL) in combination with a chemical probe to covalently bind its target upon UV irradiation has demonstrated considerable promise in drug discovery for identifying new drug targets and binding sites.
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IJS, KILJ, NUK, UL, UM, UPUK
As renewable power generation becomes more prevalent, the problem of frequency stability has become a particular concern of transmission system operators, especially those of small power transmission ...systems. Traditional wind generation systems do not provide frequency regulation because they are decoupled from the power grid. Therefore, as conventional thermal generators are replaced by wind generators, the issue of frequency regulation for wind generation systems has become increasingly important. To release the kinetic energy stored in the rotating mass, inertia and droop control loops can be added into the controller of a wind turbine (WT). This work proposes an advanced control strategy with the time-varying gains of two control loops. In the proposed strategy, the gains are determined based on the desired frequency-response time. Moreover, the initial gain of the control loop is determined based on the wind speed, considering the operating condition of each WT in a wind farm. The effectiveness of the proposed method is verified by using an actual power system, revealing that it can be used to improve frequency regulation in a power grid.
During the past one to two decades, the probabilistic forecasting of a wind-power generation has been regarded as a necessary input to decisions made for the purpose of reliable and economic power ...systems operations, especially since the penetration of the renewable energy has begun to grow rapidly. Probabilistic forecasting differs from traditional deterministic forecasting in which it takes uncertainty into account. This paper proposes a modified nonparametric method for constructing reliable prediction intervals (PIs). The lower upper bound estimation (LUBE) method is adapted to construct PIs for the wind-power generation, based on the ensemble wind-speed data from the numerical weather prediction system of the Central Weather Bureau of Taiwan. The charged system search (CSS) is used to adjust parameters in LUBE. The performance of the proposed method is examined using datasets from several wind farms in Taiwan. Simulation results demonstrate that the quality of PIs output by the proposed model significantly exceeded that of those constructed using the persistence model with a 1-h-ahead time horizon.
Controlling ferroic orders (ferroelectricity, ferromagnetism and ferroelasticity) by optical methods is a significant challenge due to the large mismatch in energy scales between the order parameter ...coupling strengths and the incident photons. Here, we demonstrate an approach to manipulate multiple ferroic orders in an epitaxial mixed-phase BiFeO3 thin film at ambient temperature via laser illumination. Phase-field simulations indicate that a light-driven flexoelectric effect allows the targeted formation of ordered domains. We also achieved precise sequential laser writing and erasure of different domain patterns, which demonstrates a deterministic optical control of multiferroicity at room temperature. As ferroic orders directly influence susceptibility and conductivity in complex materials, our results not only shed light on the optical control of multiple functionalities, but also suggest possible developments for optoelectronics and related applications.The remote, non-volatile and reversible optical control of ferroic orders is challenging. Here, using laser illumination, multiple orders in epitaxial mixed-phase BiFeO3 are manipulated deterministically using a thermally driven flexoelectric effect.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Mare volcanics on the Moon are the key record of thermo-chemical evolution throughout most of lunar history
. Young mare basalts-mainly distributed in a region rich in potassium, rare-earth elements ...and phosphorus (KREEP) in Oceanus Procellarum, called the Procellarum KREEP Terrane (PKT)
-were thought to be formed from KREEP-rich sources at depth
. However, this hypothesis has not been tested with young basalts from the PKT. Here we present a petrological and geochemical study of the basalt clasts from the PKT returned by the Chang'e-5 mission
. These two-billion-year-old basalts are the youngest lunar samples reported so far
. Bulk rock compositions have moderate titanium and high iron contents with KREEP-like rare-earth-element and high thorium concentrations. However, strontium-neodymium isotopes indicate that these basalts were derived from a non-KREEP mantle source. To produce the high abundances of rare-earth elements and thorium, low-degree partial melting and extensive fractional crystallization are required. Our results indicate that the KREEP association may not be a prerequisite for young mare volcanism. Absolving the need to invoke heat-producing elements in their source implies a more sustained cooling history of the lunar interior to generate the Moon's youngest melts.
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GEOZS, IJS, IMTLJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZAGLJ
A novel simple 1,3,4-oxadiazole-2-carbohydrazide was reported to discover low-cost and versatile antifungal agents. Bioassay results suggested that a majority of the designed compounds were extremely ...bioactive against four types of fungi and two kinds of oomycetes. This extreme bioactivity was highlighted by the applausive inhibitory effects of compounds 4b, 4h, 5c, 5g, 5h, 5i, 5m, 5p, 5t, and 5v against Gibberella zeae, affording EC50 values ranging from 0.486 to 0.799 μg/mL, which were superior to that of fluopyram (2.96 μg/mL) and comparable to those of carbendazim (0.947 μg/mL) and prochloraz (0.570 μg/mL). Meanwhile, compounds 4g, 5f, 5i, and 5t showed significant actions against Fusarium oxysporum with EC50 values of 0.652, 0.706, 0.813, and 0.925 μg/mL, respectively. Pharmacophore exploration suggested that the N′-phenyl-1,3,4-oxadiazole-2-carbohydrazide pattern is necessary for the bioactivity. Molecular docking of 5h with succinate dehydrogenase (SDH) indicated that it can completely locate the inside of the binding pocket via hydrogen-bonding and hydrophobic interactions, revealing that this novel framework might target SDH. This result was further verified by the significant inhibitory effect on SDH activity. In addition, scanning electron microscopy patterns were performed to elucidate the anti-G. zeae mechanism. Given these features, this type of framework is a suitable template for future exploration of alternative SDH inhibitors against plant microbial infections.
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IJS, KILJ, NUK, PNG, UL, UM, UPUK
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