In the setting of nonparametric multivariate regression with unknown error variance σ², we study asymptotic properties of a Bayesian method for estimating a regression function f and its mixed ...partial derivatives. We use a random series of tensor product of B-splines with normal basis coefficients as a prior for f, and σ is either estimated using the empirical Bayes approach or is endowed with a suitable prior in a hierarchical Bayes approach. We establish pointwise, L₂ and L∞-posterior contraction rates for f and its mixed partial derivatives, and show that they coincide with the minimax rates. Our results cover even the anisotropic situation, where the true regression function may have different smoothness in different directions. Using the convergence bounds, we show that pointwise, L₂ and L∞-credible sets for f and its mixed partial derivatives have guaranteed frequentisi coverage with optimal size. New results on tensor products of B-splines are also obtained in the course.
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BFBNIB, INZLJ, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK, ZRSKP
Inflammasomes are multiprotein signaling complexes that activate the innate immune system. Canonical inflammasomes recruit and activate caspase-1, which then cleaves and activates IL-1β and IL-18, as ...well as gasdermin D (GSDMD) to induce pyroptosis. In contrast, non-canonical inflammasomes, caspases-4/-5 (CASP4/5) in humans and caspase-11 (CASP11) in mice, are known to cleave GSDMD, but their role in direct processing of other substrates besides GSDMD has remained unknown. Here, we show that CASP4/5 but not CASP11 can directly cleave and activate IL-18. However, CASP4/5/11 can all cleave IL-1β to generate a 27-kDa fragment that deactivates IL-1β signaling. Mechanistically, we demonstrate that the sequence identity of the tetrapeptide sequence adjacent to the caspase cleavage site regulates IL-18 and IL-1β recruitment and activation. Altogether, we have identified new substrates of the non-canonical inflammasomes and reveal key mechanistic details regulating inflammation that may aid in developing new therapeutics for immune-related disorders.
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•Human CASP4/5 directly process IL-18 at D36 to generate the activated cytokine•CASP4/5 cleave IL-1β at D27 into a p27 species that inactivates downstream IL-1R signaling•The tetrapeptide sequence of IL-18 and IL-1β regulates their processing by caspases•CASP11 can process IL-1β into the deactivating p27 species but does not process IL-18
Exconde et al. report that the non-canonical inflammasomes directly process IL-18 and IL-1β. The tetrapeptide sequence regulates IL-18 and IL-1β processing to generate an active or inactive cytokine respectively. These results suggest that the non-canonical inflammasomes directly modulate inflammation and may have a broader substrate repertoire than previously known.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This article traces the evolving attitudes and relationships of Korean Protestants and American missionaries after 1945 through an investigation of the rise of one Korean Presbyterian pastor, ...Kyung-Chik Han, as a renowned religious leader at home and abroad during the escalation of the Cold War in the 1950s, and the uneasy transitions within the American Presbyterian missions in Korea. The analysis of Han's sermons and addresses in Korea and the West, popular American Protestant magazines, and American missionary documents illumines the creation of new transnational Christian partnerships, the presence of ongoing cross-cultural tensions, and the emergence of new challenges between Korean Protestants and American missionaries as the positions of authority started to shift. This study concludes with broader observations connecting the history of the relationships between Han and American Protestants to some of the problems with contemporary interpretations of the changing dynamics and mission flows in world Christianity.
本文追溯1945年后南韩基督徒和美国宣教士不断改变的态度及关系。这是透过对一位长老会牧者坤赤翰的升起的研究调查，以及在韩国的美国长老会宣教会经历的不易的转折而达成的。坤赤翰是五十年代逐渐升级的冷战期间在国内外著名的宗教领袖，对他的讲章，及其在韩国和西方，美国的基督教杂志及宣教文件里的发言的分析，我们可以发现新的跨国基督徒合作的开始，持续的跨文化张力的存在，以及当权力开始转移时韩国基督徒及美国宣教士所面临的新的挑战。这个研究得出更广义的结论，即是翰与美国基督徒之间关系的这段历史，可以联系到世界基督教不断改变的宣教流所面临的当代诠释问题。
Este artículo describe la relación y las actitudes que van surgiendo entre protestantes coreanos y misioneros estadounidenses desde1945 en adelante. Investiga el surgimiento del pastor coreano presbiteriano, Kyung-Chik Han, como líder religioso de renombre tanto en su país como en el extranjero durante la escalada de la Guerra Fría en la década de 1950. Trata, además, sobre las incómodas transiciones dentro de las misiones de presbiterianos americanos en Corea. El análisis de sermones y discursos de Han en Corea y occidente, de revistas populares norteamericanas, y documentos misioneros estadounidenses explica la creación de nuevas asociaciones cristianas transnacionales, la presencia de tensiones interculturales en curso, y la aparición de nuevos retos entre protestantes coreanos y misioneros estadounidenses cuando los lugares de autoridad empiezan a cambiar. Este estudio concluye con observaciones más amplias que relacionan la historia entre Han y los protestantes norteamericanos a algunos de los problemas con interpretaciones contemporáneas sobre la dinámica cambiante y los flujos de la misión en el cristianismo mundial.
This article is in English.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Bayesian model averaging is flawed in the M-open setting in which the true data-generating process is not one of the candidate models being fit. We take the idea of stacking from the point estimation ...literature and generalize to the combination of predictive distributions. We extend the utility function to any proper scoring rule and use Pareto smoothed importance sampling to efficiently compute the required leave-one-out posterior distributions. We compare stacking of predictive distributions to several alternatives: stacking of means, Bayesian model averaging (BMA), Pseudo-BMA, and a variant of Pseudo-BMA that is stabilized using the Bayesian bootstrap. Based on simulations and real-data applications, we recommend stacking of predictive distributions, with bootstrapped-Pseudo-BMA as an approximate alternative when computation cost is an issue.
Admissibility of propensity and relationship evidence under section 31A of the Evidence Act (WA) - application - principles - determining the fact in issue and whether the section 31A evidence has ...the required connection with it - whether the section 31A evidence only complements already suspect evidence - analysis of case law on sexual assault, violence and drug matters.
I begin my discussion by giving an overview of the main results. Then I proceed to touch upon issues about whether the credible ball constructed can be interpreted as a confidence ball, suggestions ...on reducing computational costs, and posterior consistency or contraction rates.
I begin by summarizing key ideas of the paper under discussion. Then I will talk about a graphical modeling perspective, posterior contraction rates and alternative methods of aggregation. Moreover, ...I will also discuss possible applications of the stacking method to other problems, in particular, aggregating (sub)posterior distributions in distributed computing.
Impact of Section 126 of the Young Offender's Act 1984 (WA) (YOA) - uniqueness Of Section 126 and the sentencing aims for children - history and application of the provision in light of the ...complicated sentencing process.
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