Adolescence is a vulnerable period for psychological distress. This study aimed to comprehensively investigate the distribution of major stress-causing factors and their correlates in a large ...population of adolescents. A computerized self-report questionnaire was completed by 291,110 participating adolescents over a 4-year period using a cross-sectional study design. The questionnaire included items assessing demographic variables, major stressors, severity of perceived stress, and mental health outcomes such as depressed mood, suicidal ideation, and attempts. Among the major stressors, schoolwork/career was the most predominant (54.7%). However, the odds ratios for depressed mood and suicidal ideation were the highest in the stressor of conflict with peers (OR = 1.97 for depressed mood and OR = 2.00 for suicidal ideation), followed by family circumstances (OR = 1.77 and 1.94 for depressed mood and suicidal ideation, respectively). Conversely, schoolwork/career presented significantly lower odds ratios of 0.87 and 0.87 for depressed mood and suicidal ideation, respectively. This study provides important information on psychological distress related to adolescents’ mental health. Although school/career was the most prevalent source of psychological stress, the odds ratios for negative health outcomes of adolescents were higher in interpersonal problems such as conflicts with parents and peers and family circumstances. The present findings might help parents and clinicians understand the psychological distress of adolescents and improve their mental health.
Full text
Available for:
DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, ODKLJ, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, VSZLJ, ZAGLJ
Purpose
The factors affecting the anatomical and functional outcomes of arthroscopic superior capsular reconstruction (ASCR) were investigated in this study. Continuity between the posterior remnant ...tissue and graft, as well as medial-to-lateral anatomical graft continuity, might play a vital role in shoulder stability and functional recovery, which could be correlated with postoperative factors such as the acromiohumeral distance (AHD).
Methods
Thirty-two patients (36 shoulders) who underwent ASCR were included. The follow-up period was 24.8 ± 6.9 months. The relationship between graft continuity and preoperative, intraoperative, and postoperative factors that could affect the clinical and radiological outcomes of ASCR were investigated.
Results
The American Shoulder and Elbow Surgeons score increased from 50.3 ± 9.1 points preoperatively to 84.0 ± 5.0 points postoperatively (
p
< 0.01), and the Constant score increased from 56.3 ± 9.0 to 82.8 ± 5.6 points (
p
= 0.02). Re-tearing occurred in 13 patients during the postoperative follow-up period. The re-tear rate was relatively high (36.1%). The gap between the immediate postoperative and preoperative AHDs was 1.6 ± 2.2 mm in the re-tear (+) group and 3.8 ± 2.8 mm in the re-tear (−) group (
p
= 0.02). The integrity of the posterior remnant tissue had a statistically significant and different re-tear rate (
p
< 0.01).
Conclusion
Care should be taken in patients with inadequate AHD improvement and poor posterior remnant tissue immediately postoperatively, because the possibility of re-tearing is high. Therefore, better results can be predicted when considering these factors at the time of surgery.
Level of evidence
IV.
Full text
Available for:
EMUNI, FSPLJ, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Outdoor light at night (LAN) is an increasingly prevalent type of environmental pollution. Studies have demonstrated that outdoor LAN can disrupt circadian rhythms, potentially contributing to ...insomnia, cancer, cardiovascular disease, and metabolic changes in humans. We investigated the association of outdoor LAN with depressive symptoms and suicidal behaviors in South Korean adults.
This study used data from the 2009 Korean Community Health Survey, a representative sample dataset. Study population consisted of 113,119 participants for the assessment of depressive symptoms and 152,159 participants for the assessment of suicidal behavior. Depressive symptoms were measured using the Korean version of the Center for Epidemiologic Studies Depression Scale (depressive symptoms, score of > 16). Suicidal behaviors were defined as the experience of suicidal ideation or attempt. Outdoor LAN was estimated by satellite data from the National Centers for Environmental Information.
Participants with depressive symptoms or history of suicidal behaviors were more likely to have exposure to outdoor LAN than those without depressive symptoms or suicidal behaviors. Compared with adults living in areas exposed to the lowest outdoor LAN, those living in areas exposed to the highest levels had higher likelihood depressive symptoms (OR = 1.29; 95% CI: 1.15–1.46) or suicidal behaviors (OR = 1.27; 95% CI: 1.16–1.39). Significant dose-response relationships were observed between outdoor LAN and the odds of depressive symptoms and suicidal behaviors.
Outdoor LAN was found to be significantly associated with depressive symptoms and suicidal behaviors, suggesting that it may be an environmental contributor to mental health problems.
•Light pollution is increasingly prevalent type of environmental pollution.•Night-time light disrupts circadian rhythms, contributing to human health.•We investigated the association of light pollution with depression and suicidal behaviors.•High night-time light was associated with increased odds for depression or suicide.•Light pollution may be an environmental contributor to mental health problems.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Aims
We investigated the clinical features, predictors, and long‐term prognosis of pacing‐induced cardiomyopathy (PiCM).
Methods and results
From a retrospective analysis of 1418 consecutive ...pacemaker patients, 618 were found to have a preserved baseline left ventricular ejection fraction (LVEF), follow‐up echocardiographic data, and no history of heart failure (HF). PiCM was defined as a reduction in LVEF (< 50%) along with either (i) a ≥ 10% decrease in LVEF, or (ii) new‐onset regional wall motion abnormality unrelated to coronary artery disease. PiCM occurred in 87 of 618 patients (14.1%), with a decrease in mean LVEF from 60.5% to 40.1%. The median time to PiCM was 4.7 years. Baseline left bundle branch block, wider paced QRS duration (≥ 155 ms), and higher ventricular pacing percentage (≥ 86%) were identified as independent predictors of PiCM in multivariate logistic regression analysis. The risk of PiCM increased gradually with the number of identified predictors, becoming more significant in the presence of two or more predictors (P < 0.001). During the entire follow‐up (median 7.2 years), the risk of all‐cause death or HF admission was significantly higher in patients with PiCM compared to those without PiCM (38.3% vs. 54.0%, adjusted hazard ratio 2.93; 95% confidence interval 1.82–4.72; P < 0.001).
Conclusion
Pacing‐induced cardiomyopathy patients showed a worse long‐term prognosis than those without PiCM. Therefore, patients with multiple risk factors of PiCM should be monitored carefully even if their left ventricular systolic function is preserved initially. A timely upgrade to a biventricular or His‐bundle pacing device needs to be considered in patients with PiCM.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
Many studies have examined the negative impact on smartphone addiction in adolescents. Recent concerns have focused on predictors of smartphone addiction. This study aimed to investigate the ...association of adolescents' smartphone addiction with family environment (specifically, domestic violence and parental addiction). We further investigated whether self-control and friendship quality, as predictors of smartphone addiction, may reduce the observed risk.
We used the 2013 national survey on internet usage and utilization data from the National Information Agency of Korea. Information on exposure and covariates included self-reported experience of domestic violence and parental addiction, sociodemographic variables, and other variables potentially related to smartphone addiction. Smartphone addiction was estimated using a smartphone addiction proneness scale, a standardized measure developed by national institutions in Korea.
Adolescents who had experienced domestic violence (OR = 1.74; 95% CI: 1.23-2.45) and parental addiction (OR = 2.01; 95% CI: 1.24-3.27) were found to be at an increased risk for smartphone addiction after controlling for all potential variables. Furthermore, on classifying adolescents according to their level of self-control and friendship quality the association between domestic violence and parental addiction, and smartphone addiction was found to be significant in the group with adolescents with lower levels of self-control (OR = 2.87; 95% CI: 1.68-4.90 and OR = 1.95; 95% CI: 1.34-2.83) and friendship quality (OR = 2.33; 95% CI: 1.41-3.85 and OR = 1.83; 95% CI: 1.26-2.64).
Our findings suggest that family dysfunction was significantly associated with smartphone addiction. We also observed that self-control and friendship quality act as protective factors against adolescents' smartphone addiction.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Advancement in metabolic engineering of microorganisms has enabled bio-based production of a range of chemicals, and such engineered microorganism can be used for sustainable production leading to ...reduced carbon dioxide emission there. One area that has attained much interest is microbial hydrocarbon biosynthesis, and in particular, alkanes and alkenes are important high-value chemicals as they can be utilized for a broad range of industrial purposes as well as ‘drop-in’ biofuels. Some microorganisms have the ability to biosynthesize alkanes and alkenes naturally, but their production level is extremely low. Therefore, there have been various attempts to recruit other microbial cell factories for production of alkanes and alkenes by applying metabolic engineering strategies. Here we review different pathways and involved enzymes for alkane and alkene production and discuss bottlenecks and possible solutions to accomplish industrial level production of these chemicals by microbial fermentation.
Full text
Available for:
CEKLJ, DOBA, FZAB, GEOZS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Mevalonate is an important platform compound for the biosynthesis of isoprenoids. It can be synthesized from acetyl‐CoA in the presence of nicotinamide adenine dinucleotide phosphate (NADPH) by the ...introduced mvaES operon in Escherichia coli. The influences of E. coli hosts, acetyl‐CoA supply, and NADPH availability were assessed and engineered to improve the production titer and yield of mevalonate from glycerol. As a result, E. coli DH5α was found to be the best host with high specific capability and titer of mevalonate from glycerol. Through the engineering of phosphoketolase‐phosphotransacetylase (xPK‐PTA) bypass and NADPH availability, a final titer of 7.21 g/L with a specific capability of 1.36 g/g dry cell weight was gained in flask culture. Our work could offer new information to metabolically engineer the mevalonate pathway for the efficient production of isoprenoids.
The effective acetyl‐CoA supply and nicotinamide adenine dinucleotide phosphate availability boost mevalonate biosynthesis from glycerol in Escherichia coli.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Peptides show tremendous promise in synthesizing metal–peptide superstructures with tailored shapes and functions. However, bottom‐up control of the polymorphs of these superstructures using a single ...short peptide without molecular modification has not been mechanistically clarified. Therefore, an approach to constructing gold–peptide superstructures with unprecedented structural diversity using a tyrosine‐rich short peptide is developed, based on the assembling and mineralizing attributes of tyrosine. One‐step UV irradiation of peptide/gold‐salt systems enables on‐site mineralization of gold ions, permitting controlled solvent‐dependent fabrication of various superstructures. 0D colloids, 2D sheets, 3D superspheres, and 3D hollow capsules are produced via one‐pot reactions in a pH‐10 buffer, at the interface of a toluene–water biphasic system, in water, and in toluene‐in‐water emulsions, respectively, whereas 1D rod/fibril structures are produced using rapidly assembling peptides (A, F, I, L, N, V, Y, and D as X in YY‐X‐YY) in a two‐step process. Several peptide derivatives, which also exhibit assembling and biomineralizing abilities and form various superstructures, validate the functionality of the tyrosine‐rich peptide. This study sheds light on the design and development of diverse gold‐peptide superstructures for applications including catalysis, sensing, imaging, and photothermal therapy.
Unprecedented structural polymorphism of gold@peptide superstructures from the nanoscale to the macroscale is achieved using a newly designed tyrosine‐rich short peptide. The facile assembly‐and‐mineralization method reported herein enables elaborate control of the gold@peptide superstructure, yielding diverse configurations such as 0D colloids, 1D rods/fibrils, 2D nanosheets, 3D superspheres, and 3D hollow capsules.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
•Strain acceleration and geometry of a specimen lead to inertia effects in SHPB test.•Concrete SHPB tests were performed.•DIF considering the pure rate effect was proposed.•Proposed DIF provided an ...accurate prediction for the apparent dynamic strength.
The dynamic increase factor (DIF) has been widely used to consider the rate effect in the analysis and design of concrete structures that are subject to impact loads. A variety of DIFs have been proposed by many researchers based on the results of dynamic material tests such as the split Hopkinson pressure bar (SHPB) test. These DIFs have been adopted in authoritative design guidelines and model codes such as the ACI 349–13, ACI 370R-14, fib MC2010, and UFC 3-340-02. However, previous studies did not properly consider the strain acceleration and the geometrical characteristics of the test specimens that cause the axial and radial inertia forces which influence the test results. For this reason, predictions can become non conservative when these DIFs are used in the analysis and design of concrete structures that are subject to impact or impulsive loads. In this study, to overcome the limitations of existing DIFs, a new concrete DIF that excludes inertia effects by considering the strain acceleration and geometry of the specimens has been proposed based on SHPB test results. The proposed DIF was numerically validated using finite element analyses. Compared with other existing DIFs, the results show improved predictions of the enhancement of the concrete compressive strength due to rate effect.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
•rDOI measured by US, CT, and MRI demonstrated excellent correlations with pDOI.•MRI-based DOI measurement would provide more consistent rDOI.•rDOI was useful in predicting cervical LN metastasis.
To ...comprehensively assess the correlation between radiologic depth of invasion (rDOI) and pathologic depth of invasion (pDOI) in oral cavity squamous cell carcinoma (OSCC) by meta-analysis.
PubMed and Embase databases were searched to find pertinent articles reporting rDOI of OSCC. Studies evaluating the correlations and mean differences (MDs) between rDOI and pDOI were included. The rDOI was measured based on ultrasound (US), computed tomography (CT), or magnetic resonance imaging (MRI). The correlation coefficients and MDs between rDOI and pDOI were meta-analytically pooled. Between-study heterogeneity was assessed using Higgins’ inconsistency index (I2). Subgroup analysis was performed based on imaging modality.
Twenty-three studies with 1787 patients were included. The pooled correlation coefficient and MD were 0.86 (95 % confidence interval CI, 0.82–0.90; I2 = 66.9 %) and 1.84 mm (95 % CI, 1.02–2.65 mm; I2 = 88.2 %), respectively. In subgroup analysis, MRI showed the largest MD (n = 12, 2.61 mm), followed by US (n = 2, –0.41 mm) and CT (n = 2, 0.12 mm). US showed the highest correlation coefficient (n = 3, 0.91), followed by MRI (n = 12, 0.85) and CT (n = 3, 0.82).
rDOI measured by US, CT, and MRI demonstrated excellent correlations with pDOI.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PDF
