Breast cancer has been suggested to potentially have prenatal origins. We examined associations between birth weight, body mass index (BMI) at four‐time points over 25 years of adulthood, and risk of ...postmenopausal breast cancer, with emphasis on whether the association between birth weight and risk of breast cancer was mediated by weight and height changes over the adult life course. Postmenopausal women (n = 70,397) aged 50–79 years without breast cancer at enrollment (1993–1998) were followed up to 25 years. Weight and height were measured at baseline. Birth weight, and weights at ages 18, 35 and 50 were self‐reported. Breast cancer cases were centrally adjudicated. Compared to women with birth weight of 6–8 pounds, women with birth weight of <6 pounds had lower risk of breast cancer (HR = 0.88 95% CI: 0.79–0.99). 44% and 21% of the relationship between birth weight and breast cancer risk was mediated by adult height and weight at baseline, respectively. Birth weight of 8 pounds or more was not associated with risk of postmenopausal breast cancer. Weight gain in adulthood was associated with increased risk of breast cancer regardless of time periods. In conclusion, lower birthweight was associated with lower risk of postmenopausal breast cancer, and this reduction in risk was significantly mediated by childhood or adolescent growth, especially by adult height. Our data suggest that reaching and maintaining a healthy weight during adulthood is key in the prevention of breast cancer.
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Higher birthweight is associated with increased risk of breast cancer, especially in premenopausal women. In this study, the authors analyzed the effect of adult weight and height on the association between birthweight and postmenopausal breast cancer. They enrolled 70,397 postmenopausal women and monitored their breast cancer incidence over a 25‐year follow up. Women under 6 pounds at birth had reduced cancer risk, but more than 40% of this effect was mediated by adult height. High birthweight was not associated with postmenopausal breast cancer risk. Adult weight gain was associated with increased risk, regardless of birthweight.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The circadian timing system synchronizes cellular function by coordinating rhythmic transcription via a transcription-translational feedback loop. How the circadian system regulates gene expression ...at the translational level remains a mystery. Here, we show that the key circadian transcription factor BMAL1 associates with the translational machinery in the cytosol and promotes protein synthesis. The mTOR-effector kinase, ribosomal S6 protein kinase 1 (S6K1), an important regulator of translation, rhythmically phosphorylates BMAL1 at an evolutionarily conserved site. S6K1-mediated phosphorylation is critical for BMAL1 to both associate with the translational machinery and stimulate protein synthesis. Protein synthesis rates demonstrate circadian oscillations dependent on BMAL1. Thus, in addition to its critical role in circadian transcription, BMAL1 is a translation factor that links circadian timing and the mTOR signaling pathway. More broadly, these results expand the role of the circadian clock to the regulation of protein synthesis.
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•The circadian protein BMAL1 rhythmically interacts with the translational machinery•BMAL1 is a substrate of the mTOR-effector kinase S6K1•BMAL1 regulates circadian rhythms of protein synthesis
BMAL1 rhythmically interacts with translational machinery, promoting protein synthesis in response to mTOR signaling. These findings connect circadian timing to the control of protein production.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Regulator-, and ...vacuolar adenosine triphosphatase–dependent fashion, the translocation of mTORC1 to the lysosomal surface, where it interacts with its activator Rheb. Here, we identify SLC38A9, an uncharacterized protein with sequence similarity to amino acid transporters, as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases (GTPases) and Regulator in an amino acid–sensitive fashion. SLC38A9 transports arginine with a high Michaelis constant, and loss of SLC38A9 represses mTORC1 activation by amino acids, particularly arginine. Overexpression of SLC38A9 or just its Regulator-binding domain makes mTORC1 signaling insensitive to amino acid starvation but not to Rag activity. Thus, SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.
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BFBNIB, NMLJ, NUK, PNG, SAZU, UL, UM, UPUK
The phenomenon of quasi-periodic pulsations (QPPs) in solar and stellar flares has been known for over 50 years and significant progress has been made in this research area. It has become clear that ...QPPs are not rare—they are found in many flares and, therefore, robust flare models should reproduce their properties in a natural way. At least fifteen mechanisms/models have been developed to explain QPPs in solar flares, which mainly assume the presence of magnetohydrodynamic (MHD) oscillations in coronal structures (magnetic loops and current sheets) or quasi-periodic regimes of magnetic reconnection. We review the most important and interesting results on flare QPPs, with an emphasis on the results of recent years, and we present the predicted and prominent observational signatures of each of the fifteen mechanisms. However, it is not yet possible to draw an unambiguous conclusion as to the correct underlying QPP mechanism because of the qualitative, rather than quantitative, nature of most of the models and also due to insufficient observational information on the physical properties of the flare region, in particular the spatial structure of the QPP source. We also review QPPs in stellar flares, where progress is largely based on solar-stellar analogies, suggesting similarities in the physical processes in flare regions on the Sun and magnetoactive stars. The presence of QPPs with similar properties in solar and stellar flares is, in itself, a strong additional argument in favor of the likelihood of solar-stellar analogies. Hence, advancing our understanding of QPPs in solar flares provides an important additional channel of information about stellar flares. However, further work in both theory/simulations and in observations is needed.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The gel-like and fractal structures of activated sludge (AS) before and after extracellular polymeric substances (EPS) extraction as well as different EPS fractions were investigated. The ...contributions of individual components in different EPS fractions to the gel-like behavior of sludge samples by enzyme treatment were examined as well. The centrifugation and ultrasound method was employed to stratify the EPS into slime, loosely and tightly bound EPS (LB- and TB-EPS). It was observed that all samples behaved as weak gels with weak-link. TB-EPS and AS after LB-EPS extraction showed the strongest elasticity in higher concentrations and highest mass fractal dimension, which may indicate the key role of TB-EPS in the gel-like and fractal structures of the sludge. Effects of protease or amylase on the gel-like property of sludge samples differed in the presence of different EPS fractions.
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•All samples behaved as weak gels.•G0′ values of all samples increased exponentially with an increase of TSS content.•AS after LB-EPS extraction had the highest G0′ and Df.•TB-EPS showed the highest Df.•TB-EPS may be the key fraction to the gel-like and drying properties of AS.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
6.
Kink Oscillations of Coronal Loops Nakariakov, V. M.; Anfinogentov, S. A.; Antolin, P. ...
Space science reviews,
09/2021, Volume:
217, Issue:
6
Journal Article
Peer reviewed
Open access
Kink oscillations of coronal loops, i.e., standing kink waves, is one of the most studied dynamic phenomena in the solar corona. The oscillations are excited by impulsive energy releases, such as low ...coronal eruptions. Typical periods of the oscillations are from a few to several minutes, and are found to increase linearly with the increase in the major radius of the oscillating loops. It clearly demonstrates that kink oscillations are natural modes of the loops, and can be described as standing fast magnetoacoustic waves with the wavelength determined by the length of the loop. Kink oscillations are observed in two different regimes. In the rapidly decaying regime, the apparent displacement amplitude reaches several minor radii of the loop. The damping time which is about several oscillation periods decreases with the increase in the oscillation amplitude, suggesting a nonlinear nature of the damping. In the decayless regime, the amplitudes are smaller than a minor radius, and the driver is still debated. The review summarises major findings obtained during the last decade, and covers both observational and theoretical results. Observational results include creation and analysis of comprehensive catalogues of the oscillation events, and detection of kink oscillations with imaging and spectral instruments in the EUV and microwave bands. Theoretical results include various approaches to modelling in terms of the magnetohydrodynamic wave theory. Properties of kink oscillations are found to depend on parameters of the oscillating loop, such as the magnetic twist, stratification, steady flows, temperature variations and so on, which make kink oscillations a natural probe of these parameters by the method of magnetohydrodynamic seismology.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Loss of muscle mass and waning in muscle strength are common in older adults, and inflammation may play a key role in pathogenesis. This study aimed to examine associations of C-reactive protein ...(CRP) and systemic immune-inflammation index (SII) with sarcopenia and sarcopenic obesity in older adults with chronic comorbidities. Cross-sectional data from the National Health and Nutrition Examination Survey (1999–2006) were obtained for participants aged ≥60 years. Sarcopenia was defined by a lean mass and body height (males < 7.26 kg/m2, females < 5.45 kg/m2). Sarcopenic obesity was defined by the concurrent presence of sarcopenia and obesity (defined by relative fat mass). Logistic regression was used to assess the associations of CRP and SII with sarcopenia and sarcopenic obesity. The dose–response relationship was examined via restricted cubic splines. Of the participants (n = 2483), 23.1% (n = 574) and 7.7% (n = 190) had sarcopenia and sarcopenic obesity, respectively. The multivariable logistic regression models suggested a positive association of SII with sarcopenia and sarcopenic obesity, but a positive statistically significant association was not consistently observed for CRP. Dose–response curves suggested similar association patterns for these biomarkers. In clinical practice, measures to prevent sarcopenia and sarcopenic obesity are needed for older vulnerable people with high systemic inflammation.
We present a continuous record of the Asian monsoon over the last 16 ka from δ
18O measurements of stalagmite calcite. Over 900 oxygen isotopic measurements providing information on shifts in monsoon ...precipitation are combined with a chronology from 45 precise
230Th dates. δ
18O and therefore Asian monsoon intensity generally follows changes in insolation, although changes in δ
18O are generally accommodated in abrupt shifts in contrast to smoothly varying insolation, indicating that threshold effects may be important. δ
18O decreased dramatically (∼3‰) at the start of the Holocene (∼11.5 ka) and remained low for ∼6 ka. Four positive δ
18O events centered at 11225±97 yr BP (1.05‰), 10880±117 yr BP (1.15‰), 9165±75 yr BP (1.4‰), and a double event centered at 8260±64 yr BP (1.1‰) and 8080±74 yr BP (1.0‰) punctuated this period of high monsoon intensity. All four events correlate within error with climate changes in Greenland ice cores. Thus, the relationship between the Asian monsoon and the North Atlantic observed during the glacial period appears to continue into the early Holocene. In addition, three of the four events correlate within error with outburst events from Lake Agassiz. The decline of monsoon intensity in the mid-late Holocene is characterized by an abrupt positive shift in δ
18O which occurs at 3550±59 yr BP (1.1‰ in ∼100 yr). In addition, the Holocene is punctuated by numerous centennial- and multi-decadal-scale events (amplitudes 0.5 to 1‰) up to half the amplitude of the glacial interstadial events seen in the last glacial period. Thus, Holocene centennial- and multi-decadal-scale monsoon variability is significant, although not as large as glacial millennial-scale variability. The monsoon shows a strong connection with northern South American hydrological changes related by changes in ITCZ position. Spectral analysis of the δ
18O record shows significant peaks at solar periodicities of 208 yr and 86 yr suggesting variation is influenced by solar forcing. However, there are numerous other significant peaks including peaks at El Niño frequencies (observed for high-resolution portions of the record between 8110 and 8250 yr) which suggest that changes in oceanic and atmospheric circulation patterns in addition to those forced by solar changes are important in controlling Holocene monsoon climate. In addition, for this high-resolution portion, we observe a distinctive biennial oscillation of the Asian monsoon, which has been associated with the Tropospheric Biennial Oscillation (TBO).
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity is associated with increased ...risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.
To investigate the association between body fat and breast cancer risk in women with normal BMI.
This ad hoc secondary analysis of the Women's Health Initiative (WHI) clinical trial and observational study cohorts was restricted to postmenopausal participants with a BMI ranging from 18.5 to 24.9. Women aged 50 to 79 years were enrolled from October 1, 1993, through December 31, 1998. Of these, 3460 participants underwent body fat measurement with dual-energy x-ray absorptiometry (DXA) at 3 US designated centers with follow-up. At a median follow-up of 16 years (range, 9-20 years), 182 incident breast cancers had been ascertained, and 146 were ER positive. Follow-up was complete on September 30, 2016, and data from October 1, 1993, through September 30, 2016, was analyzed August 2, 2017, through August 21, 2018.
Body fat levels were measured at baseline and years 1, 3, 6, and 9 using DXA. Information on demographic data, medical history, and lifestyle factors was collected at baseline. Invasive breast cancers were confirmed via central review of medical records by physician adjudicators. Blood analyte levels were measured in subsets of participants.
Among the 3460 women included in the analysis (mean SD age, 63.6 7.6 years), multivariable-adjusted hazard ratios for the risk of invasive breast cancer were 1.89 (95% CI, 1.21-2.95) for the highest quartile of whole-body fat and 1.88 (95% CI, 1.18-2.98) for the highest quartile of trunk fat mass. The corresponding adjusted hazard ratios for ER-positive breast cancer were 2.21 (95% CI, 1.23-3.67) and 1.98 (95% CI, 1.18-3.31), respectively. Similar positive associations were observed for serial DXA measurements in time-dependent covariate analyses. Circulating levels of insulin, C-reactive protein, interleukin 6, leptin, and triglycerides were higher, whereas levels of high-density lipoprotein cholesterol and sex hormone-binding globulin were lower in those in the uppermost vs lowest quartiles of trunk fat mass.
In postmenopausal women with normal BMI, relatively high body fat levels were associated with an elevated risk of invasive breast cancer and altered levels of circulating metabolic and inflammatory factors. Normal BMI categorization may be an inadequate proxy for the risk of breast cancer in postmenopausal women.
ClinicalTrials.gov identifier: NCT00000611.
Using first-principles methods, we investigated the reaction pathways of the formic acid oxidation on Pd(111) and PdAu(111) surfaces. The dehydrogenation of formic acid can simultaneously occur via ...C–H and O–H activation on different Pd ensembles. However, on the contiguous ensembles without threefold Pd hollow, the reaction of COOH → CO + OH proceeds with a high activation energy (∼1.00 eV), and the direct pathway is predominant for H production from formic acid. Our results indicates that the proper arrangement of Au and Pd sites can significantly improve electrocatalytic activity of PdAu catalyst for formic acid oxidation attributed to the reduction of poisoning species of COad.
► First-principles calculations and NEB simulations for HCOOH's decomposition on PdAu(111) surfaces. ► Ensemble effects on formic acid oxidation on Pd-decorated Au(111) surface. ► H production from formic acid through the direct pathway on Pd-decorated Au(111) surface.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
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