Mercury (Hg), and its organic forms, are some of the most hazardous elements, with strong toxicity, persistence, and biological accumulation in marine organisms. Hg accumulation in continuous trophic ...levels (TL) in marine food chains remains unclear. In this study, individual invertebrate and fish samples collected from the Yellow River Estuary adjacent sea were grouped into continuous TL ranges, and the bioaccumulations of total Hg (THg) and methylmercury (MeHg) were analyzed. The trophic magnification factor in invertebrates and fish was 1.40 and 1.72 for THg, and 2.56 and 2.17 for MeHg, indicating that both THg and MeHg were significantly biomagnified with increasing TL in both invertebrates and fish through trophic transfer. To evaluate the health risk of seafood consumption, the target hazard quotient (THQ) was calculated. Increasing THQ values indicated that the health risks of invertebrate and fish consumption in humans, especially children, were both elevated with increasing TL. THQ values > 1 indicated that consumption of invertebrates at a TL above 4.0 and fish above 4.5 may pose a relatively higher risk for children. Therefore, the consumption of both individual invertebrates and fish at high trophic positions may present greater health risk, especially in young children.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Radiotherapy is the standard adjuvant treatment for esophageal squamous cell carcinoma (ESCC), yet radioresistance remains a major obstacle leading to treatment failure and unfavorable prognosis. ...Previous reports have demonstrated the involvement of astrocyte elevated gene-1 (AEG-1) in tumorigenesis and progression of multiple malignancies. Nevertheless, the precise role of AEG-1 in the radioresistance of ESCC remains elusive. Here, we unveiled a strong correlation between aberrant AEG-1 gene overexpression and malignant progression as well as adverse prognosis in ESCC patients. Moreover, both in vitro and in vivo investigations revealed that AEG-1 significantly alleviated irradiation-induced DNA damage and enhanced radiation resistance in ESCC cells. Mechanistically, AEG-1 recruited the deubiquitinase USP10 to remove the K48-linked polyubiquitin chains at the Lys425 of PARP1, thus preventing its proteasomal degradation. This orchestrated process facilitated homologous recombination-mediated DNA double-strand breaks (DSBs) repair, culminating in mitigated DNA damage and acquired radioresistance in ESCC cells. Notably, PARP1 overexpression reversed the radiosensitizing effect caused by AEG-1 deficiency. Collectively, these findings shed new light on the mechanism of ESCC radioresistance, providing potential therapeutic targets to enhance the efficacy of radiotherapy in ESCC.
•High expression level of AEG-1 is associated with poor prognosis in ESCC.•AEG-1 alleviates irradiation-induced DNA damage and confers radioresistance in ESCC cells both in vitro and in vivo.•AEG-1 promotes the homologous recombination-mediated repair of irradiation-induced DNA double-strand breaks.•AEG-1 recruits USP10 to remove the K48-linked polyubiquitin chains at the Lys425 site of PARP1 to prevent its degradation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The quality of poultry eggshells is closely related to the profitability of egg production. Eggshell speckles reflect an important quality trait that influences egg appearance and customer ...preference. However, the mechanism of speckle formation remains poorly understood. In this study, we systematically compared serum immune and antioxidant indices of hens laying speckled and normal eggs. Transcriptome and methylome analyses were used to elucidate the mechanism of eggshell speckle formation.
The results showed that seven differentially expressed genes (DEGs) were identified between the normal and speckle groups. Gene set enrichment analysis (GSEA) revealed that the expressed genes were mainly enriched in the calcium signaling pathway, focal adhesion, and MAPK signaling pathway. Additionally, 282 differentially methylated genes (DMGs) were detected, of which 15 genes were associated with aging, including ARNTL, CAV1, and GCLC. Pathway analysis showed that the DMGs were associated with T cell-mediated immunity, response to oxidative stress, and cellular response to DNA damage stimulus. Integrative analysis of transcriptome and DNA methylation data identified BFSP2 as the only overlapping gene, which was expressed at low levels and hypomethylated in the speckle group.
Overall, these results indicate that aging- and immune-related genes and pathways play a crucial role in the formation of speckled eggshells, providing useful information for improving eggshell quality.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Metal‐free room‐temperature phosphorescence (RTP) materials are of great significance for many applications; however, they usually exhibit low efficiency and weak intensity. This article reports a ...new strategy for the preparation of a high‐efficiency and strong RTP materials from crystalline thermal‐annealed carbon dots (CDs) and boric acid (BA) composite (g‐t‐CD@BA) through grinding‐induced amorphous to crystallization transition. Amorphous thermal‐annealed CDs and BA composite (t‐CD@BA) is prepared following a thermal melting and super‐cooling route, where the CDs are fully dispersed in molten BA liquid and uniformly frozen in an amorphous thermal annealed BA matrix after super‐cooling to room temperature. Upon grinding treatment, the fracture and fragmentation caused by grinding promote the transformation of the high‐energy amorphous state to the lower energy crystalline counterparts. As a result, the CDs are uniformly in situ embedded in the BA crystal matrix. This method affords maximum uniform embedding of the CDs in the BA crystals, decreases nonradiative decay, and promotes intersystem crossing by restraining the free vibration of the CDs, thus producing strong RTP materials with the highest reported phosphorescence quantum yield (48%). Remarkably, RTP from g‐t‐CD@BA powder is strong enough to illuminate items with a delay time exceeding 9 s.
We present a new grinding‐induced amorphous‐to‐crystalline transition method for the preparation of crystalline carbon dots (CDs) and boric acid (BA) composite (g‐t‐CD@BA), that exhibits a world‐record phosphorescence efficiency of 48% and ultra‐strong RTP. Remarkably, the intense green phosphorescence of the g‐t‐CD@BA can illuminate items for more than 9 s to the unaided eye.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Amphiphilic nanosheets have gained great attraction in diverse applications owing to their unprecedented performance. In this paper, amphiphilic molybdenum disulfide (CTAB–MoS2) nanosheets were ...prepared through a one-step simple hydrothermal method, and the physicochemical properties were systematically investigated. The results showed that the CTAB–MoS2 nanosheets displayed a distinct ultrathin flakelike structure and a lateral size in the range of 95 nm. More specifically, the presence of defect sites over the surfaces of MoS2 nanosheets facilitated linkage with CTAB molecules, which made MoS2 amphiphilic. Because of the amphiphilic nature, the CTAB–MoS2 nanosheets could be steadily dispersed in water phase, reduce the oil–water interfacial tension, alter wettability of the solid surface, and stabilize emulsions at ultralow concentrations (50 mg/L). By observing and analyzing the interfacial behavior of CTAB–MoS2 nanosheets in a simulated oil/brine system, it was found that CTAB–MoS2 nanosheets could be adsorbed at the oil–water interface in the form of multilayer adsorption, and the adsorption layer (oil–water interfacial film) exhibited higher strength elasticity. This work provides a scalable method for preparing amphiphilic nanosheets and reveals the physicochemical properties of CTAB–MoS2 amphiphilic nanosheets.
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IJS, KILJ, NUK, PNG, UL, UM
White-light-emitting carbon dots (CDs) with fluorescence/phosphorescence dual-emission features are of great importance for single-phase white-light-emitting diodes (WLEDs), but so far rather limited ...due to weak phosphorescence. Herein, a highly efficient white-light emissive CD-based material is developed by one-step heat treatment of lycorine hydrochloride and boric acid (BA). The prepared CD@BA powders show prominent fluorescence/phosphorescence dual-emission with extraordinarily high overall quantum yield (QY) of 46%, phosphorescence QY of 30% and a broad full width at half maximum over 180 nm. Doping of N and B atoms as well as the strong interaction between CDs and the BA matrix not only effectively prevents aggregation-induced quenching in the solid state, but also greatly promotes phosphorescence emission, leading to the emergence of an ultrabroad-band emission spectrum. Based on the unique dual-emissive performance of CD@BA powders, they are successfully applied to single-component WLEDs. This work provides a new strategy for mass production of efficient white-light emissive CD-based materials, which have promising applications for single-phase WLEDs.
46% efficient white-light emissive carbon dot-based materials are successfully prepared by enhancing phosphorescence emission and are applied to single-component white-light-emitting diodes.
In this study, TiO2 photoanodes doped with samarium ions via a method of hydrothermal treatment were used to fabricate dye-sensitized solar cells (DSSCs). Different doping concentrations were ...investigated on the effects of the cell’s performance. Some techniques including XRD, scanning electron microscopy, HRTEM, XPS, UV-Vis, photoluminescence were used to characterize the morphology, structure, and optic properties of the prepared photoanodes. The photovoltaic performance of the fabricated cells was further evaluated by measuring the current density–voltage (J–V) curves. It was found that: (1) The down-conversion luminescence effect derived from samarium doping could enhance the light-harvesting ability. (2) Compared with the undoped sample, the samarium-doped cells exhibited enhanced photovoltaic performance. Among the cells with different doping concentrations, the cell TiO2:0.015 Sm showed the best power conversion efficiency of 6.08% with a high open-circuit voltage (V
oc) and a short-circuit current density (J
sc).
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CEKLJ, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The debate over the merits of centralized versus decentralized wastewater treatment plants (WWTPs) has gained prominence considering pressing sustainable development objectives and the need to reduce ...greenhouse gas (GHG) emissions. This highlights the importance of innovative analytical tools to shape forthcoming policies. Using causal machine learning, we evaluate the impact of WWTP scale on GHG emission intensities and investigate contributing factors. Results show GHG intensity typically decreases as WWTPs scale up. However, this trend varies based on regional environmental, economic, and infrastructure elements. Specifically, regions with fewer industrial wastewater contributions, increased rainwater composition, and elevated temperatures show smaller scale effects. This suggests limited GHG reductions from merely expanding WWTPs in such areas, as the benefits of handling fluctuating inflow volumes, tackling heavy pollution, and operating in cooler conditions offered by larger WWTPs are compromised. This research lays the foundation for comprehensive models promoting sustainable wastewater treatment strategies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A facile method is reported to develop glass-based analytical devices (GADs) based on immobilizing nanomaterials on a glass substrate with fluorescent glue. The fluorescent glue was first prepared by ...coupling bovine serum albumin (BSA)-protected Au nanoclusters (NCs) and sugars (i.e., ascorbic acid, AA). The glue was then used to immobilize carbon dots (C-dots) on glass substrates to fabricate the portable GADs. The liquid glue-C-dots mixture and probable GADs were developed for Hg
2+
detection. Under 365-nm excitation wavelength, the emission at 652 nm from the glue is gradually quenched with increasing concentrations of Hg
2+
. This quenching is explained in terms of the Stern-Volmer equation and is ascribed to static quenching. The fluorescent color of the glue and GADs gradually changes from pink to blue, with increasing concentrations of Hg
2+
. The limits of detection (LODs) for Hg
2+
determination by bare eyes are 1 nM both for the glue and GADs, suggesting an uncompromised sensing capability even after immobilization. The detection sensitivity of GADs shows a significant improvement compared with the same material-based papers (5 μM). A linear relationship is observed between the total Euclidean distances (EDs) and Hg
2+
concentration in the range 0–100 nM, providing the potential for Hg
2+
quantification using GADs. The LOD is estimated to be 0.84 nM. To show a potentially practical application, the GADs were used to detect Hg
2+
in certified reference material and lake water.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
This article provides a detailed review of capillary electrophoresis (CE) technology in 2022, summarizing a total of 881 CE technology-related articles searched from ISI Web of Science using the ...keywords "capillary electrophoresis mass spectrometry" or "capillary isoelectric focusing" or "micellar electrokinetic chromatography" or "capillary electrophoresis" (excluding "capillary electrochromatography""microchip" "microfluidic" "capillary monolithic column"). The review focuses on 16 articles published in
,
,
,
,
,
,
,
,
,
,
with impact factors (IFs) greater than 10.0, and 46 articles published in
,
,
, and
with IFs between 5.0 and 10.0. A comprehensive overview of representative CE works published in
,
, and important Chinese core journals (Peking University) with IFs<5.0 is also provided. Based on IFs, this review introduces representative works on CE to facilitate readers' understanding of important research advances in CE technology over the last year.
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