In this paper, we present an ambient light backscatter communication design that enables Internet of Things (IoT) devices to com-municate through the backscattering ambient light emitted from ...lighting infrastructure or sunlight. The device can selectively modulate ambient light by switching a liquid crystal display (LCD) shutter located on its surface, so that a nearby smart device, which includes a photodiode or a camera, can demodulate this backscattered light information. To verify the practicality of the proposed concept, we de-sign an IoT device equipped with a commercial LCD shutter and a microcontroller. Our device produces ambient light backscattered data at a speed of 100 bps, and these data are successfully decoded by a commercial photodiode module 10 cm away from the IoT device. We believe that our ambient light backscatter communication design is appropriate for implementation in various IoT applications KCI Citation Count: 1
Primary vaginal adenocarcinoma associated with human papillomavirus (HPV) infection is extremely rare. We report a case of primary adenocarcinoma of the vagina associated with human papilloma virus ...successfully treated with anterior pelvic exenteration and adjuvant concurrent chemoradiation therapy. A 51-year-old postmenopausal woman (gravida 1, para 1) presented with intermittent vaginal bleeding and pelvic pain. She was found to have a 5 × 5 cm necrotic tumor took up the vaginal. She had no previous history of antenatal exposure to diethylstilbestrol (DES). Pelvic magnetic resonance imaging (MRI) demonstrated a 4.8 × 6.0 cm mass in the vaginal canal, an 1.1 × 2.6 cm mass at the urinary bladder dome and a 1.1 cm irregular lymph node at the right external iliac chain with increased fluorodeoxyglucose (FDG) uptake from Fused whole-body positron emission tomography-computed tomography (PET-CT). Based on clinical investigations, the patient was diagnosed with a primary adenocarcinoma of vagina, staged International Fedestration of Gynecology and Obstetrics (FIGO) IVa. Anterior pelvic exenteration, simple vulvectomy, total vaginectomy, both pelvic lymph node dissection, and para-aortic lymph node dissection with ileal conduit urinary diversion (Bricker’s operation) was done. Histologically primary vaginal HPV type 16-associated adenocarcinoma was confirmed. Both obturator lymph node was positive for metastasis. Postoperatively, the patient received weekly cisplatin regimen administered with a dose of 40 mg/m2 on day 1 of external radiation therapy (RT), 1 to 4 hours before RT initiation. External beam pelvic RT dose prescription to the whole pelvis was 59.4 Gy in 33 fractions at the isocenter. But, after total dose of 43.2 Gy, patient complained severe bowel habit change and discontinued further treatment. The patient remains free from recurrence 8 months after initial surgery. In the lack of information and comparative analysis of management options for the more unusual and rare varieties of primary vaginal neoplasms in the literature, this suggests the possibility that surgical treatment may be preferentially selected on a case-by-case basis.
Purpose
Previously, an artificial neural network method was introduced to estimate quantitative myelin water fraction (MWF) using multi‐echo gradient‐echo data. However, the fiber orientation of ...white matter with respect to B0 could bias the quantification of MWF. Here, we developed an advanced workflow for MWF estimation that could improve the quantification of MWF.
Methods
To adopt fiber orientation effects, a complex‐valued neural network with complex‐valued operation was used. In addition, to compensate for the bias from different scan parameters, a signal model incorporating the T1 value was devised for training data generation. At the testing stage, a voxel‐spread function approach was utilized for spatial B0 artifact correction. Finally, dropout‐based variational inference was implemented for uncertainty estimates on the network model to provide a confidence interpretation of the output.
Results
According to simulation and in vivo analysis, the proposed method suggests improved quality of MWF estimation by correcting the bias and artifacts. The proposed complex‐valued neural network approach can alleviate the dependency of fiber orientation effects compared to previous artificial neural network method. Uncertainty estimates provides information different from fitting error that can be used as a confidence level of the resulting MWF values.
Conclusion
An improved MWF mapping using complex‐valued neural network analysis has been proposed.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Abstract
In this study, electrospun carbon nanofibers hybridized with silicon oxide (SiO
x
) are prepared by using a syringeless electrospinning system of polyacrylonitrile (PAN) solution containing ...tetraethylorthosilicate (TEOS) via a sequential pyrolysis process. The syringeless electrospinning system provides a large number of composite nanofibers in a short time, and the obtained composite nanofibers exhibit uniform diameter and morphology. The composite nanofiber is converted into a carbon nanofiber containing SiO
x
via a simple pyrolysis. The obtained SiO
x
‐carbon nanofiber mat exhibits higher charge/discharge capacity than a general carbon nanofiber, and it provides more stable retention than single crystalline silicon materials. Thus, the mass‐production of a SiO
x
‐carbon nanofiber from syringeless electrospinning is a promising method to produce anodic materials for Li‐ion batteries.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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•TRAP1 is overexpressed in many cancer cells and supports tumorigenesis by rewiring vital metabolic and cell death pathways.•Various phosphonium moieties that can deliver cargoes to ...mitochondria, are conjugated with TRAP1-selective inhibitors.•Triphenylphosphonium-conjugation dramatically improves the antiproliferative activities of the TRAP1 inhibitors.•Compound 6a suppresses tumor growth without noticeable toxicity in a mouse xenograft model with PC3 prostate cancer cells.
Tumor-necrosis-factor-receptor associated protein 1 (TRAP1), a mitochondrial paralog of heat shock protein 90 family proteins, is overexpressed in many cancer cells and supports tumorigenesis by rewiring vital metabolic and cell death pathways. The triphenylphosphonium moiety is used to deliver therapeutic cargo to increase drug uptake into mitochondria. Various aryl- or alkyl-substituted phosphonium analogs were conjugated with TRAP1-selective inhibitors 4a-c to optimize anticancer activity. Among these various phosphonium-conjugated compounds, (6-(2-amino-9-(4-bromo-2-fluorobenzyl)-6-chloro-8-oxo-8,9-dihydro-7H-purin-7-yl)hexyl)triphenylphosphornium (6a) was identified as a potential anticancer agent. Compound 6a had IC50 values of 0.30–3.24 μM in seven different cancer cell lines and potently suppressed tumor growth without any noticeable in vivo toxicity in a nude mouse model xenografted with PC3 prostate cancer cells.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In this study, electrospun carbon nanofibers hybridized with silicon oxide (SiOx) are prepared by using a syringeless electrospinning system of polyacrylonitrile (PAN) solution containing ...tetraethylorthosilicate (TEOS) via a sequential pyrolysis process. The syringeless electrospinning system provides a large number of composite nanofibers in a short time, and the obtained composite nanofibers exhibit uniform diameter and morphology. The composite nanofiber is converted into a carbon nanofiber containing SiOx via a simple pyrolysis. The obtained SiOx‐carbon nanofiber mat exhibits higher charge/discharge capacity than a general carbon nanofiber, and it provides more stable retention than single crystalline silicon materials. Thus, the mass‐production of a SiOx‐carbon nanofiber from syringeless electrospinning is a promising method to produce anodic materials for Li‐ion batteries.
A silicon oxide (SiOx)‐carbon nanofiber for anode material of a lithium‐ion battery is prepared via a syringeless electrospinning system and simple pyrolysis. The anode material with the SiOx‐carbon nanofiber exhibits higher charging/discharging capacity when compared to that of carbon material and better retention capacity when compared with that of silicon materials.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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•Pyrazolo3,4-dpyrimidine derivatives were synthesized as mitochondria-permeable TRAP1 inhibitors.•Compounds 47 and 48 are potent TRAP1 inhibitor in the in vitro and in vivo assay with ...good ADME.•X-ray co-crystallization studies confirmed both 47 and 48 interact with the ATP binding pocket in the TRAP1 protein.•Compounds 47 and 48 demonstrated excellent anticancer efficiency in various cancer cells, with limited toxicity over normal hepatocyte and prostate cells.•Mouse PC3 xenograft studies showed 47 and 48 significantly reduced tumor growth.
TNF Receptor Associated Protein 1 (TRAP1) is a mitochondrial paralog of Hsp90 related to the promotion of tumorigenesis in various cancers via maintaining mitochondrial integrity, reducing the production of reactive oxygen species, and reprogramming cellular metabolism. Consequently, Hsp90 and TRAP1 have been targeted to develop cancer therapeutics. Herein, we report a series of pyrazolo3,4-dpyrimidine derivatives that are mitochondria-permeable TRAP1 inhibitors. Structure-based drug design guided the optimization of potency, leading to the identification of compounds 47 and 48 as potent TRAP1 and Hsp90 inhibitors with good metabolic and plasma stability as well as acceptable CYP and hERG inhibition. X-ray co-crystallization studies confirmed both 47 and 48 interact with the ATP binding pocket in the TRAP1 protein. Compounds 47 and 48 demonstrated excellent anticancer efficiency in various cancer cells, with limited toxicity over normal hepatocyte and prostate cells. Mouse PC3 xenograft studies showed 47 and 48 significantly reduced tumor growth.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In this paper, we present an ambient light backscatter communication design that enables Internet of Things (IoT) devices to communicate through the backscattering ambient light emitted from lighting ...infrastructure or sunlight. The device can selectively modulate ambient light by switching a liquid crystal display (LCD) shutter located on its surface, so that a nearby smart device, which includes a photodiode or a camera, can demodulate this backscattered light information. To verify the practicality of the proposed concept, we design an IoT device equipped with a commercial LCD shutter and a microcontroller. Our device produces ambient light backscattered data at a speed of 100 bps, and these data are successfully decoded by a commercial photodiode module 10 cm away from the IoT device. We believe that our ambient light backscatter communication design is appropriate for implementation in various IoT applications.
Cyclic α-aryl β-dicarbonyl derivatives are important scaffolds in medicinal chemistry. Palladium-catalyzed coupling reactions of haloarenes were conducted with diverse five- to seven-membered cyclic ...β-dicarbonyl derivatives including barbiturate, pyrazolidine-3,5-dione, and 1,4-diazepane-5,7-dione. The coupling reactions of various para- or meta-substituted aryl halides occurred efficiently when Pd(
-Bu
P)
, Xphos, and Cs
CO
were used under 1,4-dioxane reflux conditions. Although the couplings of ortho-substituted aryl halides with pyrazolidine-3,5-dione and 1,4-diazepane-5,7-dione were moderate, the coupling with barbiturate was limited. Using the optimized reaction conditions, we synthesized several 5-aryl barbiturates as new scaffolds of Ca
1.3 Ca
channel inhibitors. Among the synthesized molecules,
was the most potent Ca
1.3 inhibitor with an IC
of 1.42 μM.
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IJS, KILJ, NUK, PNG, UL, UM, UPUK
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