The Archean – Early Paleoproterozoic tectono-magmatic history of the Yangtze Block is inadequately constrained owing to the scarcity of coeval magmatic outcrops. Herein, we report on the Earliest ...Paleoproterozoic (2498 ± 17 Ma) meta-diabase dike in the Bajiaojing area of the western Yangtze Block, which may represent the oldest known mafic magmatism in the block. Whole-rock geochemical and mineral chemical proxies (e.g., U/Nb, Sc/Yb, and La/Yb) demonstrated that the Bajiaojing meta-diabase was likely emplaced in a continental arc setting. Positive zircon εHf(t) values (> 8) and incompatible elemental ratios (e.g., Gd/Yb, Sm/Yb, and Lu/Hf) further indicated that the mafic dike was derived from a depleted asthenospheric mantle source, which was modified by fluid and sediment from the subducting slab. The subduction-related modification also accounted for the compositional heterogeneity in the mantle source, which was observed in the wide range of Zr/Nb (1.05–4.38), Ce/Pb (6.11–81.59), and Nb/U (7.96–78.72) values. By combining the Precambrian evolutionary history of the Yangtze Block, we determined that an essential magmatic episode occurred in the Earliest Paleoproterozoic that was likely linked to crustal growth in the block. Therefore, the 2.5 Ga magmatism represented by the Bajiaojing meta-diabase was a potential provenance for the synchronous detrital zircons from Precambrian basement rocks.
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•The meta-diabases were the oldestknown mafic magmatism in the Yangtze Block.•They represented relicts of the continental arc in an active-type margin.•They originated from the asthenospheric mantle modified by subducted slabs.•This magmatism was related to the coeval crustal growth of the block.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Here new evidence of the isotope geochronology and the geochemistry from the Yuanmou-Miyi complexes reveal the Precambrian tectono-magmatism geodynamic process in the study area. The Yangtze Block ...basement with 1.81- ~1.77 Ga and negative ε
Hf
(t) values of −7.8 to −0.7 corresponded to the assembly of the Columbia-supercontinent. However, the rifting magmatic event of ~ 1.70 Ga, which caused the continental crust extension-thinning in the study area, may exert influence on the subduction-magmatism in the Grenvillian period. The Yuanmou-Miyi complexes of 1.19- ~1.00 Ga are characterized by (La/Sm)
N
＞1, depletion in HFSEs, negative anomalies of Nb-Ta, and enrichment of LILEs, which show a genetic link with the subduction-magmatism. The temporal tendency that the magmatism from Yuanmou to Miyi gradually became younger, may be responsible for the subducting direction. The subduction caused the reactivation of the Anninghe-Lvzhijiag fault zone, and created the rupture windows of the subduction slab, leading to upwelling of the deep magma. These granitoids were derived from the partial melting of the mantle wedge, while the small-scale gabbro dikes intruded into the granitoids were likely spillover products from the asthenosphere mantle melts through the rupture windows.
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BFBNIB, GIS, IJS, KISLJ, NUK, PNG, UL, UM, UPUK
With the increasing interest in nanodevices based on two-dimensional layered materials (2DLMs) after the birth of graphene, the mechanical and coupling properties of these materials, which play an ...important role in determining the performance and life of nanodevices, have drawn increasingly more attention. In this review, both experimental and simulation methods investigating the mechanical properties and behaviour of 2DLMs have been summarized, which is followed by the discussion of their elastic properties and failure mechanisms. For further understanding and tuning of their mechanical properties and behaviour, the influence factors on the mechanical properties and behaviour have been taken into consideration. In addition, the coupling properties between mechanical properties and other physical properties are summarized to help set up the theoretical blocks for their novel applications. Thus, the understanding of the mechanical and coupling properties paves the way to their applications in flexible electronics and novel electronics, which is demonstrated in the last part. This review is expected to provide in-depth and comprehensive understanding of mechanical and coupling properties of 2DLMs as well as direct guidance for obtaining satisfactory nanodevices from the aspects of material selection, fabrication processes and device design.
With the increasing interest in nanodevices based on two-dimensional layered materials (2DLMs) after the birth of graphene, the mechanical and coupling properties of these materials, which play an important role in determining the performance and life of nanodevices, have drawn increasingly more attention.
The potential applications of 2D layered materials (2DLMs) as the functional membranes in flexible electronics and nano‐electromechanical systems emphasize the role of the mechanical properties of ...these materials. Interlayer interactions play critical roles in affecting the mechanical properties of 2DLMs, and nevertheless the understanding of their relationship remains incomplete. In the present work, it is reported that the fracture strength of few‐layer (FL) WS2 can be weakened by the interlayer friction among individual layers with the assistance of finite element simulations and density functional theory (DFT) calculations. The reduced fracture strength can be also observed in FL WSe2 but with a lesser extent, which is attributed to the difference in the interlayer sliding energies of WS2 and WSe2 as confirmed by DFT calculations. Moreover, the tip‐membrane friction can give rise to the underestimation of the Young's modulus except for the membrane nonlinearity. These results give deep insights into the influence of interfacial interactions on the mechanical properties of 2DLMs, and suggest that importance should be also attached to the interlayer interactions during the design of nanodevices with 2DLMs as the functional materials.
Interlayer interactions associated interlayer friction can weaken the mechanical properties of 2D materials. The reduction of the fracture strength in mechanically exfoliated WS2 and WSe2 is different due to their different interlayer sliding energy. A reduction of even ≈13.71% of the fracture strength is found in trilayer WS2 than monolayer WS2.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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•The dodecyl-sulfate-intercalated Mg-Al-LDH nanosheets with ultrathin morphology are synthesized for solving dye pollution.•This simple one-step surfactant-assisted synthetic method ...avoids the strict conditions to prevent CO32− pollution.•The LDH adsorbs methyl orange from aqueous solution effectively and rapidly.•The surface-interlayer-adsorption mechanism is proposed for its high dye-removal performance.
A high-performance dye adsorbent of ultrathin dodecyl-sulfate (DS−) intercalated Mg-Al layered double hydroxide nanosheets (DI-LDH Ns) were controllably synthesized by a simple one-step surfactant-assisted hydrothermal method. The unique intercalated structure with week interlayer interaction and high accessible surface of DI-LDH Ns provide efficient adsorption of methyl orange (MO), leading to its superior performance with much higher uptake capability (846.6 mg/g at 298 K) and less adsorbing equilibrium time (5 min) than those of ultrathin DS−-surface-modified Mg-Al-LDH nanosheets (DM-LDH Ns, 327.4 mg/g at 298 K, 120 min) and original Mg-Al-LDH (O-LDH, 208.2 mg/g at 298 K, 120 min). The composition and structure of these LDHs were investigated by systematic physicochemical characterization, such as XRD, TEM, FT-IR, BET and TGA. The adsorption behavior of DI-LDH Ns follows the Langmuir isotherm equation. A plausible mechanism is proposed to explain the adsorption process of such DI-LDH Ns, in which the synergistic contributions of surface and interlayer adsorption between DI-LDH Ns and MO play an important role. This study puts forward a new thought for the development of high-performance LDH adsorbents with an ultrathin intercalated structure for the efficient and rapid removal of dyes.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Background Radiotherapy (RT) is one of the major therapeutic approaches to hepatocellular carcinoma (HCC). Ionizing radiation (IR) inducing the generation of reactive oxygen species (ROS) leads to a ...promising antitumor effect. However, the dysregulation of the redox system often causes radioresistance and impairs the efficacy of RT. Increasing evidence indicates that nuclear protein 1 (NUPR1) plays a critical role in redox reactions. In this study, we aim to explore the role of NUPR1 in maintaining ROS homeostasis and radioresistance in HCC. Methods The radioresistant role of NUPR1 was determined by colony formation assay, comet assay in vitro, and xenograft tumor models in vivo. Probes for ROS, apoptosis assay, and lipid peroxidation assay were used to investigate the functional effect of NUPR1 on ROS homeostasis and oxidative stress. RNA sequencing and co-immunoprecipitation assay were performed to clarify the mechanism of NUPR1 inhibiting the AhR/CYP signal axis. Finally, we analyzed clinical specimens to assess the predictive value of NUPR1 and AhR in the radiotherapeutic efficacy of HCC. Results We demonstrated that NUPR1 was upregulated in HCC tissues and verified that NUPR1 increased the radioresistance of HCC in vitro and in vivo. NUPR1 alleviated the generation of ROS and suppressed oxidative stress, including apoptosis and lipid peroxidation by downregulating cytochrome P450 (CYP) upon IR. ROS scavenger N-acetyl-L-cysteine (NAC) and CYP inhibitor alizarin restored the viability of NUPR1-knockdown cells during IR. Mechanistically, the interaction between NUPR1 and aryl hydrocarbon receptor (AhR) promoted the degradation and decreased nuclear translation of AhR via the autophagy-lysosome pathway, followed by being incapable of CYP's transcription. Furthermore, genetically and pharmacologically activating AhR abrogated the radioresistant role of NUPR1. Clinical data suggested that NUPR1 and AhR could serve as novel biomarkers for predicting the radiation response of HCC. Conclusions Our findings revealed the role of NUPR1 in regulating ROS homeostasis and oxidative stress via the AhR/CYP signal axis upon IR. Strategies targeting the NUPR1/AhR/CYP pathway may have important clinical applications for improving the radiotherapeutic efficacy of HCC. Keywords: NUPR1, Reactive oxygen species, Hepatocellular carcinoma, Radioresistance, Oxidative stress, Aryl hydrocarbon receptor
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The tip-membrane interface plays a critical role in characterizing the mechanical properties of ultrathin 2D materials by commonly employed nanoindentation based on atomic force microscopy (AFM). ...However, the reliability of the assumption that the tip-membrane interface remains pinned during nanoindentation remains unclear, which may introduce unignorable uncertainty in evaluating their true mechanical properties. In this work, it is reported that load-dependent frictional behavior would occur on the tip-membrane interface during nanoindentation tests on monolayer and multilayer suspended WS
2
and graphene, and the curve hysteresis could be well explained by the stick-slip behavior. Further analyses and finite element simulations demonstrated that the frictional energy dissipation should be mainly attributed to the frictional behavior along the direction parallel to the cantilever beam. Meanwhile, the in-plane membrane stiffness was mainly responsible for the different frictional behavior on monolayer and multilayer 2D materials. Based on these analyses, some suggestions were proposed to help reduce the uncertainty when extracting the mechanical properties of 2D materials. These findings not only facilitate the deep understanding of the origin of the curve hysteresis during nanoindentation, but also help to evaluate the mechanical properties of 2D materials in a more reliable way.
The stick-slip behavior on the tip-membrane interface could result in load-dependent curve hysteresis during AFM nanoindentation on 2D materials.
Abstract
Understanding the relationship between interlayer interactions and the mechanical properties and behaviors of two-dimensional layered materials is critical in the development of related ...nanodevices. Nevertheless, it is still challenging due to difficulties in experiments. In this work, nanoindentation simulations on few-layer WS
2
were conducted by varying the tip radius, suspended membrane radius, and membrane size using a molecular dynamics simulation. Consistent with our previous experimental results, few-layer WS
2
exhibited a layer-dependent reduction in fracture strength owing to the uneven stress distribution among individual layers induced by interlayer sliding under out-of-plane deformation. Furthermore, apparent curve hysteresis was observed due to interlayer sliding in the supported region when a large tip radius and membrane radius were employed. However, instead of the supported part, the interlayer sliding within the suspended part resulted in reduced fracture strength with the increase of layer number. These findings not only provide an in-depth comprehension of the influence of interlayer sliding on fracture strength of few-layer WS
2
, but also suggest that the role of interlayer interactions should be seriously considered during nanodevice design.
Abstract
A phenotype may be associated with multiple genes that interact with each other in the form of a gene module or network. How to identify these relationships is one important aspect of ...comparative transcriptomics. However, it is still a challenge to align gene modules associated with different phenotypes. Although several studies attempted to address this issue in different aspects, a general framework is still needed. In this study, we introduce Module Alignment of TranscripTomE (MATTE), a novel approach to analyze transcriptomics data and identify differences in a modular manner. MATTE assumes that gene interactions modulate a phenotype and models phenotype differences as gene location changes. Specifically, we first represented genes by a relative differential expression to reduce the influence of noise in omics data. Meanwhile, clustering and aligning are combined to depict gene differences in a modular way robustly. The results show that MATTE outperformed state-of-the-art methods in identifying differentially expressed genes under noise in gene expression. In particular, MATTE could also deal with single-cell ribonucleic acid-seq data to extract the best cell-type marker genes compared to other methods. Additionally, we demonstrate how MATTE supports the discovery of biologically significant genes and modules, and facilitates downstream analyses to gain insight into breast cancer. The source code of MATTE and case analysis are available at https://github.com/zjupgx/MATTE.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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