Women in films are portrayed as the “ Others”, the victims of a patriarchal society and a vulnerable group, and since the 1970s, the image of women in Chinese films has shifted from the traditional ...“virtuous wife and mother” to the “Others”. This paper analyses the images of women in minority films in the new period from three perspectives: ethnic consciousness, traditional and modern factors, and social transformation.
Aiming at the problems of low pickup rate of residual film recycling machine, low recognition of background soil and residual film left in farmland under complex farmland environment, and mutual ...occlusion between classes, we propose a method combining YOLOv7-SPD target detection and Deeplabv3+ image segmentation. YOLOv7-SPD was first introduced to recognize and locate the residual film left in the farmland, and the detected residual film image was passed to the image segmentation algorithm, and the segmented image was processed to calculate the area of the residual film in the farmland. By improving the loss function, fusing the Coordinate Attention (CA) mechanism, and introducing the Space-to-Depth (SPD) module and Atrous Separable Convolution (ASConv) to improve the accuracy of the leftover film detection of farmland residual film. The experimental results show that the average detection precision of the final improved model recall is 87.62% and the average precision is 93.72%, which are 4.93% and 2.53%; The mIOU and F1 of the image segmentation model reached 91.55% and 94.77%, respectively, which is more significant. This research result demonstrates the potential of this algorithm in practical applications related to agricultural residue management and field cleanliness assessment, providing certain technical support to improve the recovery rate of residual film recycling machines and realizing the accuracy and efficiency of detection.
5-Hydroxymethylcytosine (5hmC) is an epigenetic DNA modification that is highly abundant in central nervous system. It has been reported that DNA 5hmC dysregulation play a critical role in ...Alzheimer's disease (AD) pathology. Changes in 5hmC signatures can be detected in circulating cell-free DNA (cfDNA), which has shown potential as a non-invasive liquid biopsy material.
However, the genome-wide profiling of 5hmC in cfDNA and its potential for the diagnosis of AD has not been reported to date.
We carried out a case-control study and used a genome-wide chemical capture followed by high-throughput sequencing to detect the genome-wide profiles of 5hmC in human cfDNA and identified differentially hydroxymethylated regions (DhMRs) in late-onset AD patients and the control.
We discovered significant differences of 5hmC enrichment in gene bodies which were linked to multiple AD pathogenesis-associated signaling pathways in AD patients compared with cognitively normal controls, indicating they can be well distinguished from normal controls by DhMRs in cfDNA. Specially, we identified 7 distinct genes (RABEP1, CPNE4, DNAJC15, REEP3, ROR1, CAMK1D, and RBFOX1) with predicting diagnostic potential based on their significant correlations with MMSE and MoCA scores of subjects.
The present results suggest that 5hmC markers derived from plasma cfDNA can served as an effective, minimally invasive biomarkers for clinical auxiliary diagnosis of late-onset AD.
Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the ...joint effects of VDD and SHS on hypertension in this population. We evaluated whether exposure to SHS modified the association between VDD and hypertension.
Data from National Health and Nutrition Examination Surveys (NHANES) 2007-2014 were analyzed. Our research subjects were 2826 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The directed acyclic graphs (DAG) and the back-door criterion were used to select a minimal sufficient adjustment set of variables (MSAs) that would identify the unconfounded effect of 25(OH)D and hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses.
The prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 41.0%, P = 0.008), as well as the exposure rate of SHS (39.1% vs 33.8%, P = 0.017). VDD was independently associated with nearly 50% increased risk of hypertension adjusted odds ratio (aOR) = 1.43, 95% confidence interval (CI): 1.01, 2.04, while no significant association was observed between SHS and hypertension. However, SHS showed a significant synergistic effect on VDD with a higher aOR of 1.79 (95% CI: 1.14, 2.80) (P
= 0.011). This synergistic effect was more obvious when stratified by BMI (in overweight women, aOR, 95% CI =4.74, 1.65-13.60 for interaction vs 2.33, 1.01-5.38 for VDD only) and race (in Non-Hispanic Black women, aOR, 95% CI =5.11, 1.58-16.54 for interaction vs 2.69, 1.10-6.62 for VDD only).
There exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in women who were overweight or Non-Hispanic Black. Further studies are warranted to verify this finding in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This research provides a comprehensive overview of micro-influence marketing, analyzing the characteristics of influencers and the mechanisms of their impact. A systematic review was conducted, ...encompassing 2091 citing articles and references across 74 studies involving 95 research institutions and over 12,000 samples. Employing an interdisciplinary approach that integrates insights from computer science, information science, communication, culture, psychology, sociology, education, business, and management, this study outlines the distinct features of micro-influencers. These features include performable authenticity, affinity expressed through consistency and transparency, musical and artistic media talent, and competitive individual traits. The research synthesizes antecedents of trust and attachment mechanisms commonly employed in influencer theory, taking an objective standpoint and minimizing emphasis on audience engagement and perception to trigger influence. The findings highlight that followers' pursuit of self-branding, driven by self-consciousness, social consciousness, credibility, and social presence, significantly influences the impact of self-expressive products on the audience's purchase intention. The research contributes to micro-influence marketing theory by integrating mechanics, offering practical implications for micro-influencers, and suggesting future research agendas.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
(Rosaceae, Prunoideae) serves as an excellent ornamental woody plant with a large-temperature-range cultivation scope. Its flower buds require a certain low temperature to achieve flowering ...circulation. Thus, it is important to delve into the processes of flower bud differentiation and dormancy, which affected its continuous flowering. These processes are generally considered as regulation by the MADS-box homologs,
(
), and
(
). However, a precise model on their interdependence and specific function, when acting as a complex in the flower development of
, is needed. Therefore, this study highlighted the integral roles of
and
in flower organ development and dormancy cycle. The segregation of
and
in a different cluster suggested distinct functions and neofunctionalization. The expression pattern and yeast two-hybrid assays jointly revealed that eight genes were involved in the floral organ development stages, with
and
specifically related to prolificated flower formation.
-
mingled in the protein complex in bud dormancy stages with
. Finally, we proposed the hypothesis that PmSVP1 and PmSVP2 could combine with PmDAM1 to have an effect on flower organogenesis and interact with PmDAM5 and PmDAM6 to regulate flower bud dormancy. These findings could help expand the current molecular mechanism based on MADS-box genes during flower bud development and dormancy.
The PEBP gene family is involved in many biological processes in plants, including plant growth and development, flowering regulation, light response, and abiotic stress response. But there is little ...information about the role of the PEBP gene family in Cymbidium species. In this study, we identified 11, 9, and 7 PEBP genes in C. ensifolium, C. sinense, and C. goeringii, respectively, and mapped them to the chromosomes. We also studied the physicochemical characteristics of the proteins encoded by these PEBPs and analyzed their intra-species collinearity, gene structure, conserved motifs, and cis-acting elements. Furthermore, a total of forty PEBP genes from C. sinense, C. ensifolium, C. goeringii, Phalaenopsis, and Arabidopsis were divided into three clades based on the phylogenetic tree. The expression patterns of 11 PEBP genes in different tissues and organs of C. ensifolium were analyzed based on transcriptome data, indicating that the CePEBPs might play an important role in the growth and development, especially in the flower bud organs (1–5 mm). CePEBP5 plays an indispensable role in both the vegetative and reproductive growth cycles of C. ensifolium. CePEBP1 is essential for root development, while CePEBP1, CePEBP3, CePEBP5, and CePEBP10 regulate the growth and development of different floral organ tissues at various stages. The findings of this study can do a great deal to understand the roles of the PEBP gene family in Cymbidium.
Background
The relationship between a single food or nutrient and pulmonary tuberculosis (TB) has been explored in many studies; however, the relationship between dietary patterns and TB is still ...lacking.
Objective
Our study aims to investigate the association between dietary patterns and the initial clinical manifestations in patients with TB.
Materials and methods
A cross-sectional study including 1,661 patients with active TB was conducted in Qingdao, China, from 2011 to 2019. A semiquantitative food frequency questionnaire was used to collect dietary data. Dietary patterns were determined by principal component factor analysis. Initial clinical manifestations were assessed using a combination of the patient self-reported clinical symptoms and the admission results indicated by the TB score. The associations between dietary patterns and TB scores in patients with TB were examined by the logistics regression model.
Results
The analysis identified four dietary patterns: meat-fruit-seafood pattern; dairy-egg pattern; beans and their products-whole grain pattern; and refined grain-vegetable pattern. In a multiple-adjusted model, higher adherence to the meat-fruit-seafood pattern showed a protective effect on the TB score (OR 0.53, 95% CI 0.39, 0.84,
P
for trend = 0.010) and the association was stronger in patients older than 45 years (OR 0.32, 95% CI 0.16, 0.64,
P
for trend < 0.001). The higher adherence to beans and their products-whole grain pattern was a protective factor for TB score (OR 0.57, 95% CI 0.37, 0.87,
P
for trend = 0.025), and the association was also observed in patients with concurrent TB and diabetes mellitus (DM) with a more significant effect (OR 0.33, 95% CI 0.14, 0.80,
P
for trend = 0.025). No significant association was found between dairy-egg pattern and refined grain–vegetable dietary pattern with TB score.
Conclusion
Dietary patterns characterized by a balanced diet rich in high-quality protein, sufficient energy, as well as marine n-3 PUFA, phytochemicals, B vitamins, and fiber are associated with mild initial clinical manifestations, and the association is stronger in patients older than 45 years and those with concurrent TB and DM.
Phalaenopsis malipoensis Z.J. Liu et S.C. Chen, 2005 is a valuable species of Orchidaceae with significant ornamental value. This study reports the first complete chloroplast genome of P.malipoensis ...was collected integrally and clarified further. The genome was 144,528 bp in length and comprised four regions, including a pair of inverted repeats each 24,710 bp, a large single-copy region of 83,475 bp, and a small single-copy region of 11,633 bp. The whole genome contained 125 genes, including 8 rRNAs, and 39 tRNAs. Phylogenetic analysis indicated that P. malipoensis was closely related to Phalaenopsis lobbii. The analysis of P. malipoensis chloroplast genome will provide significant data for the identification and further improvement of P. malipoensis.
Cortical activation and network interaction, two characterizations of the cortical states, are separately studied in most previous studies. To further clarify the underlying mechanism, the ...association between these two indicators during sleep was investigated in this study. Twenty healthy individuals were enrolled and all of them underwent overnight polysomnography (PSG) recording. The relative spectral powers and the phase transfer entropy (PTE) of various frequency components were extracted from 6 electroencephalographic (EEG) channels, to assess the cortical activation and network interaction, respectively. Pearson correlation coefficient was employed to estimate their associations. The results suggested that there was a negative correlation between spectral power and phase transfer entropy in δ and α frequency bands during sleep. As the sleep deepened, an increased negative correlation in the δ frequency band was noted, but the negative correlation became less extreme in the α frequency band. The extremum of the correlation coefficient was noted in δ of N3, and α of Wake. Overall, this study provides a connection between these two cortical activity assessments, especially reveals the variable characteristics of different frequency components, which is conducive to better understand sleep state.
•Associations between cortical activation and network interaction was studied using rPSD and PTE.•The coupling of cortical activation and network interaction varied in different frequency band.•As sleep deepens, negative correlation increased in the δ, and vice versa for α frequency band.•The negative correlation peaked in the N3 of δ and Wake of α.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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