The object of this paper was to explore the feasibility and advantages of endoscope-assisted parotid tumour resection. Three databases (PubMed, Web of Science, and Cochrane) were used to search for ...all related randomised controlled trials or controlled trials (up to November 2019). The key parameters for assessment included ‘Endoscope’, ‘Endoscopes’, ‘Cancer of Parotid’, and ‘Parotid Cancer’. To evaluate the feasibility and advantages of endoscope-assisted resection of parotid tumours, the data for each parameter were pooled, based on patients who received endoscope-assisted surgery and those who received conventional surgery. This meta-analysis included seven studies, involving 170 patients in the endoscopy group and 270 patients in the control group. The analysis using the pooled data showed that there were no significant differences in the operating times between the two groups; however, the endoscopy group had significantly shorter incisions and less intraoperative bleeding. In addition, the patients who received endoscope-assisted surgery had lower incidences of temporary facial paralysis and Frey’s syndrome after surgery. Patients in the endoscopy group had greater postoperative satisfaction. Endoscope-assisted parotid tumour resection results in only a small, concealed incision wound and fewer postoperative complications. Therefore, it is promising for the surgical treatment of parotid tumours.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Structural variations of the human brain are heritable and highly polygenic traits, with hundreds of associated genes identified in recent genome-wide association studies (GWAS). Transcriptome-wide ...association studies (TWAS) can both prioritize these GWAS findings and also identify additional gene-trait associations. Here we perform cross-tissue TWAS analysis of 211 structural neuroimaging and discover 278 associated genes exceeding Bonferroni significance threshold of 1.04 × 10
. The TWAS-significant genes for brain structures have been linked to a wide range of complex traits in different domains. Through TWAS gene-based polygenic risk scores (PRS) prediction, we find that TWAS PRS gains substantial power in association analysis compared to conventional variant-based GWAS PRS, and up to 6.97% of phenotypic variance (p-value = 7.56 × 10
) can be explained in independent testing data sets. In conclusion, our study illustrates that TWAS can be a powerful supplement to traditional GWAS in imaging genetics studies for gene discovery-validation, genetic co-architecture analysis, and polygenic risk prediction.
•Microstructures and elemental distributions of (VNbTiTa)100-xSix alloys were studied.•Nanoscale silicide precipitations form during high-temperature deformation processing.•Excellent combination of ...ductility and strength was obtained in (VNbTiTa)97.5Si2.5 alloy.
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(VNbTiTa)100-xSix (x = 0, 2.5, 5, 10) refractory high-entropy alloys (RHEAs) are investigated in this paper. The equal molar VNbTiTa RHEA exhibits a room-temperature yield strength of 704 MPa and good compressive ductility (fracture strain> 50%). Si additions can introduce BCC+M5Si3 eutectic formed at inter-dendrite areas, and when the Si content reaches 10% in mole, extra bulk M3Si phase was observed. The precipitated silicides greatly improve the yield strength up to 1671 MPa. As the temperature increases, the strengthening effect of silicide becomes weaker, and almost disappeared at 1200 ℃. Nanoscale silicides can precipitate during high-temperature deformations. (VNbTiTa)97.5Si2.5 RHEA possesses an excellent combination of room-temperature ductility 34% and yield strength 505 MPa at 1000 ℃.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Context. Thermonuclear bursts, also known as type I X-ray bursts, result from unstable nuclear burning of H/He accreted to the surface of neutron stars, lasting from tens to hundreds of seconds. ...Thermonuclear bursts have an important impact on accretion environments around the neutron stars, such as their disks and coronas, and are therefore a subject of extensive research. Thermonuclear bursts can be used as probes to gain a deeper understanding of the properties of their disks and coronas. Aims. By analyzing the data from Insight-HXMT and NICER, we can determine the evolution of the significance of the hard shortage in 4U 1636–536 with its spectral state, as well as the evolution of the fraction of deficit with energy. Additionally, we investigate the possible geometry and evolution of the corona in 4U 1636–536 by combining our findings with the results of spectral analysis. Methods. We extracted the light curves from the Insight-HXMT low-energy, medium-energy, and high-energy data and subtracted their pre-burst emission, which allowed us to estimate the significance of the hard shortages during the bursts. By fitting the spectra, the correlation between the persistent spectral parameters and the significance of the hard shortages could be established. The bursts were then grouped according to the spectral state in which they occurred, and the significance of the hard shortages was estimated. These in turn helped to investigate the evolution of the fraction of deficit with energy. Results. We find that during the soft state the significance of possible hard X-ray shortage in bursts is almost zero. However, in the hard state, some bursts exhibit significant shortages (> 3 σ ), while others do not. We attempt to establish a correlation between the significance of the hard X-ray shortage and the spectral parameters, but the data quality and the limited number of bursts prevent us from finding a strong correlation. For bursts with insignificant shortages in the soft state, the fraction of the deficit remains small. However, in the hard state the fraction of deficit for all bursts increases with energy, regardless of the significance of the shortage of individual bursts. For bursts during the hard state, we investigated the evolution of the fraction of deficit during the bursts by stacking the peaks and decays of the bursts, and find that as the flux of the bursts decreases, the energy corresponding to the maximum of the fraction of deficit becomes progressively higher. Conclusions. We explore the possible geometry and evolution of the corona suggested by the evolution of the fraction of deficit, which is obtained from the spectral and temporal analysis.
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FMFMET, NUK, UL, UM, UPUK
Using a low background data sample of 9.7×10^{5} J/ψ→γη^{'}, η^{'}→γπ^{+}π^{-} events, which are 2 orders of magnitude larger than those from the previous experiments, recorded with the BESIII ...detector at BEPCII, the decay dynamics of η^{'}→γπ^{+}π^{-} are studied with both model-dependent and model-independent approaches. The contributions of ω and the ρ(770)-ω interference are observed for the first time in the decays η^{'}→γπ^{+}π^{-} in both approaches. Additionally, a contribution from the box anomaly or the ρ(1450) resonance is required in the model-dependent approach, while the process specific part of the decay amplitude is determined in the model-independent approach.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
•The initial microstructure was considered in analyzing the deformation behavior.•The fine acicular microstructure and the duplex microstructure were employed.•Two different microstructures exhibit ...different deformation behavior.•Deformation characteristics considering initial microstructure were obtained.
Based on the stress–strain data from the isothermal compression test in a wide range of temperature and strain rate, the effect of initial microstructure on the deformation behavior of Ti60 titanium alloy at high temperature processing was analyzed. The beta heat treated specimen with fine acicular Widmanstätten microstructure and the alpha–beta forged specimen with duplex microstructure were tested. The constitutive equation and the processing map were established for this alloy with two different initial microstructures. The results show that the initial acicular and duplex microstructures of Ti60 alloy exhibit different deformation characteristics below beta transus and the similar deformation characteristics above beta transus. With the spheroidization of lamellar phase, the calculated activity energy of the Ti60 alloy with acicular microstructure is much larger than that duplex microstructure, and the processing map also exhibits a big difference. The research provides a basis for determination of the forging process of Ti60 alloy based on the different initial microstructures.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
For materials near the phase boundary between weak and strong topological insulators (TIs), their band topology depends on the band alignment, with the inverted (normal) band corresponding to the ...strong (weak) TI phase. Here, taking the anisotropic transition-metal pentatelluride ZrTe5 as an example, we show that the band inversion manifests itself as a second extremum (band gap) in the layer stacking direction, which can be probed experimentally via magnetoinfrared spectroscopy. Specifically, we find that the band anisotropy of ZrTe5 features a slow dispersion in the layer stacking direction, along with an additional set of optical transitions from a band gap next to the Brillouin zone center. Our work identifies ZrTe5 as a strong TI at liquid helium temperature and provides a new perspective in determining band inversion in layered topological materials.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
Refractory or relapsed B lymphoblastic leukemia (B-ALL) patients have a dismal outcome with current therapy. We treated 42 primary refractory/hematological relapsed (R/R) and 9 refractory minimal ...residual disease by flow cytometry (FCM-MRD
) B-ALL patients with optimized second generation CD19-directed CAR-T cells. The CAR-T-cell infusion dosages were initially ranged from 0.05 to 14 × 10
/kg and were eventually settled at 1 × 10
/kg for the most recent 20 cases. 36/40 (90%) evaluated R/R patients achieved complete remission (CR) or CR with incomplete count recovery (CRi), and 9/9 (100%) FCM-MRD
patients achieved MRD
. All of the most recent 20 patients achieved CR/CRi. Most cases only experienced mild to moderate CRS. 8/51 cases had seizures that were relieved by early intervention. Twenty three of twenty seven CR/CRi patients bridged to allogeneic hematopoietic stem cell transplantation (allo-HCT) remained in MRD
with a median follow-up time of 206 (45-427) days, whereas 9 of 18 CR/CRi patients without allo-HCT relapsed. Our results indicate that a low CAR-T-cell dosage of 1 × 10
/kg, is effective and safe for treating refractory or relapsed B-ALL, and subsequent allo-HCT could further reduce the relapse rate.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The effect of Ce and Ni contents on the glass-forming ability (GFA) of Mg–Ce–Ni system in the Mg-rich corner of Mg–Ce–Ni system is revealed. Ce is more advantageous for the GFA of Mg-rich Mg–Ce–Ni ...system than Ni, and the lowest Ce content is ∼5 at.% to obtain the fully amorphous alloy. Amorphous alloy with the highest Mg content, Mg90Ce5Ni5, was obtained by melt-spinning. With the amorphous alloy as precursor, nanostructure multi-phases compositae was prepared by crystallizing it in hydrogenation process. The compositae with reversible hydrogen storage capacity of 5.3 wt.% shows much faster kinetics and lower MgH2 desorption activation energy than those of induction-melt Mg90Ce5Ni5 alloy. Both in situ formed nanosized Mg2Ni and CeH2.73 act as effective catalysts and significantly improve the hydrogen storage properties of MgH2.
► The effect of Ce and Ni contents on GFA of Mg-rich Mg–Ce–Ni system is revealed. ► GFR of Mg-rich Mg–Ce–Ni system is pictured for H-storage materials design. ► Mg90Ce5Ni5 owns the highest Mg content in amorphous Mg–Ce–Ni system. ► The mechanism of improved H-storage property of amorphous precursor is explained.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Diamond-based semiconductor with high electrical conductivity is a key point in diamond device development. In this paper, a thin single crystal diamond layer of high quality was epitaxially grown on ...a commercial tool-grade diamond seed by incorporating active O atoms from the typical growth environment. Subsequently, the H-termination density was enhanced on the diamond surface by exposure to the pure hydrogen plasma, and the surface conductivity of H-terminated diamond was analyzed in detail. The thin epitaxial layers on the high-pressure high-temperature diamond seeds show lower resistance than the ones on the chemical vapor deposition diamond seeds, which could be comparable with the lowest values reported. After the thin diamond layers were grown with and without addition of O
2
, the carrier mobility in the conductive channel increased to almost 80 cm
2
V
−1
s
−1
under O
2
contained condition, much higher than those without O
2
incorporation. The ionization scattering is dominant to the carrier mobility compared with the surface scattering. The higher carrier mobility is attributed to the lower impurity density in the epitaxial layer, which is because the active O atoms could purify the epitaxial layer by removing or reducing Si- and N-related impurities.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
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