Influenza virus has continuously spread around the globe for more than 100 years since the first influenza epidemic in 1918. The rapid and unpredictable gene variation of the influenza virus could ...possibly bring about another pandemic in future, which might threaten to overwhelm us without adequate preparation. Consequently, it is extremely urgent to identify effective broad-spectrum antiviral treatments for a variety of influenza virus variants. As essential body components, trace elements are great potential candidates with an as yet poorly understood ability to protect the host from influenza infection. Herein, we have summarized the present state of knowledge concerning the function of trace elements in influenza virus replication along with an analysis of their potential molecular mechanisms. Modulation of host immune responses to the influenza virus is one of the most common modes to achieve the anti-influenza activity of trace elements, such as selenium and zinc. Simultaneously, some antioxidant and antiviral signal pathways can be altered with the participation of trace elements. More interestingly, some micro-elements including selenium, zinc, copper and manganese, directly target viral proteins and regulate their stability and activity to influence the life cycle of the influenza virus. Further verification of the antiviral effect and the mechanism will promote the application of trace elements as adjuvants in the clinic.
Alismataceae is one of the early diverged families of monocotyledonous plants. We report the complete chloroplast genomes of three
species, including
(Sam.) Juzep. 1934,
Raf. 1908, and
Pursh 1813, of ...which
is a traditional Chinese medical plant used widely to treat diuretics, diabetes, hepatitis, and inflammation. We sequenced the complete chloroplast genomes with the Illumina Nova-Seq 6000 platform using herbarium collections. The chloroplast genomes of
,
and
are 159,861 bp, 160,180 bp, and 159,727 bp in length, respectively. The three chloroplast genomes each contain 113 genes, including four rRNAs, 30 tRNAs genes, and 79 protein-coding genes, and the average GC content is 36.0%. Based on the whole chloroplast genomes of 19 species of Alismataceae and the close allies, the medicinally important
was found to be closely related to another medicinal plant
L. 1753 in the phylogenetic analysis. The genus
was supported to be monophyletic.
In order to improve air quality and reduce haze, Chongqing has raised the nitrogen oxide emission requirements of gas industrial boilers, reduced the emission limits, and promoted a large number of ...low-nitrogen transformations of industrial boilers in Chongqing. In this paper, the main generation mechanism of nitrogen oxides and different technical schemes of low nitrogen transformation were introduced. Six representative industrial boilers were selected to carry out low nitrogen transformation based on FGR technology, and nitrogen oxide emission under the reference oxygen content, smoke exhaust temperature, thermal efficiency and actual output of boilers before and after the transformation were compared and tested. The test results show that the actual output of industrial boilers can be reduced and the energy consumption of boilers can be increased by using FGR low nitrogen technology.
The volume fracturing technique has been widely used to improve the productivity of ultralow-permeability reservoirs. This paper presents a new semianalytical model to simulate the pressure transient ...and production behaviour of finite conductivity vertical fractured wells with stimulated reservoir volume (SRV) in heterogeneous reservoirs. The model is based on the five-linear flow model, the Warren-Root model, and fracture conductivity influence function. The model is validated by comparing its results with a numerical model. One novelty of this model is its consideration of three different kinds of production prediction models. Constant rate, constant pressure, and compound working systems are taken into account. This paper illustrates the effects of the SRV size and shape, mobility ratio, initial flow rate, limiting wellbore pressure, and hydraulic fracture parameters under different working systems. Results show that the SRV and parameters of fractures have a significant influence on long-term well performance. Moreover, the initial rate can extend the constant rate period by 418%, and limiting wellbore pressure can effectively improve the cumulative recovery rate by 23%. Therefore, this model can predict long-term wells’ behaviour and provide practical guiding significance for hydraulic fracturing design.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Pyrogenic biomass carbon has been deemed a promising alternative to Pt/C for the oxygen reduction reaction (ORR) owing to its low cost, excellent activity, and eco-friendly properties. Herein, a ...porous carbon tube material derived from kapok fibres was prepared by combining activation with pyrolysis. Electrochemical measurements demonstrated that the kapok fibre-derived material prepared at 900°C had excellent ORR performance with a half-wave potential −0.14 V (vs. Ag/AgCl) close to that of commercial Pt/C (−0.13 V vs. Ag/AgCl) in 0.1 mol L
−1
KOH. The prepared material also displayed remarkable methanol tolerance and durability. Furthermore, the maximum power density output of the microbial fuel cell using the prepared material was (801±40) mW m
−2
, comparable to that of the Pt/C cathode ((778±31) mW m
−2
). The present work provides a facile way of using economical and renewable biomass to develop a porous structure and high-activity cathode ORR catalyst for fuel cell applications.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
This study aimed to investigate the effect of the oral processing of vegetables induced by texture modification on acute postprandial glycemic response (GR) and insulin response (IR) when co-ingested ...and ingested prior to a rice meal. In a randomized crossover trial, 14 healthy female subjects consumed (1) co-ingestion of soft broccoli and rice (SR); (2) co-ingestion of hard broccoli and rice (HR); (3) soft broccoli prior to rice (S+R); (4) hard broccoli prior to rice (H+R); (5) rice (R). Postprandial GR and IR was compared between test meals over a period of 180-min, and the oral processing behaviors were measured for each test food samples. Hard broccoli was observed to have a higher mastication time and chews than soft broccoli. All the broccoli meals resulted in reduced incremental peak glucose (IPG) and an increased incremental area under the insulin curve in 180 min (iAUC
) compared with R. The S+R curbed the IPG by 40% with comparable HOMA-IR AUC
compared with R, while the H+R elevated the HOMA-IR AUC
by 62% more than that of R. In conclusion, the soft broccoli intake prior to a rice meal effectively attenuated postprandial GR, without lowering insulin sensitivity as its hard counterpart did.
Hydrogenation and nanocrystallization of Ti6Al4V alloy were achieved by electrolytic hydrogenation and SMAT processing. The hydride δ phase appeared when the hydrogenation time reached 4 h. The grain ...size of Ti6Al4V alloy after surface nanocrystallization reached below 35 nm when the SMAT processing time was 2 h. Surface morphology and roughness were characterized by AFM. The diffusion bonding between Ti6Al4V alloys at low temperature was achieved under different parameters. It is demonstrated that the porosity at the interface decreased correspondingly when the hydrogenation time or nanocrystallization time was extended. The porosity of the joint reached 0 when the hydrogenation time was 24 h or the nanocrystallization time was 4 h. Then hydrogenation and nanocrystallization treatments were combined. It is found that there are more bonding defects in both hydrogenation-nanocrystallization and nanocrystallization-hydrogenation joints than in joints with single hydrogenation or nanocrystallization treatment. It can be concluded that the porosity of the joints with nanocrystallization first is lower than that with hydrogenation first.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In this study, the distribution patterns of P2X1 to P2X7 receptors in the anterior pituitary cells of rat were studied with single-, double-, and triple-labeling immunofluorescence, combined method ...of immunofluorescence and in situ hybridization, and Western blot. The results showed that the expression level of the P2X4 receptor protein was highest, followed by P2X5, P2X3, P2X2, P2X6, and P2X7 receptor proteins, but no P2X1 receptor protein was detected. Strong P2X4 receptor-immunoreactivity was detected in almost all the anterior pituitary cells. Different combinations of P2X receptors were detected in each individual cell type of the rat anterior pituitary. Gonadotrophs express P2X4, P2X5, and P2X6 receptors. Corticotrophs express P2X3 and P2X4 receptors. Folliculo-stellate cells express P2X2 and P2X4 receptors, and somatotrophs, lactotrophs, and thyrotrophs express only P2X4 receptors. The macrophages with Iba-1-ir expressed P2X7 receptors. The possible functions of these P2X receptors in each individual cell type of the rat anterior pituitary are discussed.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Acid fracturing has been widely used as an industry practice in explored and developed carbonate reservoirs. It is very important to understand responses of reservoirs and improve production ...performance of a well due to the presence of fracture networks by stimulation treatments. Pressure transient analysis is one of the most effective diagnostic techniques available to enhance our understanding of natural and artificial-etched fracture behavior. This work presented a novel mathematical model for unsteady state flow of naturally fractured porous medium into multiple etched fractures intersecting a vertical well, and three different geometric shapes of matrix blocks containing slabs, cylinders and spheres were considered. The new solution was derived by using the Laplace transformation and the point source function integral approach. The polar coordinate transformation was used to deal with the radial distribution of arbitrary fracture number and angle. Then the model was validated by comparison with three published cases. Finally, type curves were plotted to identify flow regimes: linear flow, transitional flow, pseudoradial flow, and boundary dominant flow if the closed or constant pressure boundary exists. Furthermore, sensitivity analysis was investigated. The results showed that the acid-etched fracture parameters containing fracture number, fracture distribution and conductivity had a significant impact on pressure behavior at early times. However, natural fracture storativity coefficient and interporosity flow parameter mainly affected the transitional flow at intermediate times. Moreover, the shape of matrix blocks had a little influence on transient responses at intermediate times. It is found that multiple etched fractures existing near the wellbore consume less pressure drop and increase the productivity of a well as a whole.
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Reorientation fractures may be formed in soft and shallow formations during fracturing stimulation and then affect well productivity. The principal focus of this study is on the productivity analysis ...for a horizontal well with multiple reorientation fractures in an anisotropic reservoir. Combining the nodal analysis technique and fracture-wing method, a semi-analytical model for a horizontal well with multiple finite-conductivity reorientation fractures was established to calculate its dimensionless productivity index and derivative for production evaluation. A classic case in the literature was selected to verify the accuracy of our semi-analytical solution and the verification indicates this new solution is reliable. Results show that for a fixed fracture configuration the dimensionless productivity index of the proposed model first goes up and then remains constant with the increase of fracture conductivity, and optimal fracture conductivity can be determined on derivative curves. Strong permeability anisotropy is a negative factor for well production and the productivity index gradually decreases with the increase of anisotropic factor. As principal fracture angle goes up, horizontal well’s productivity index increases correspondingly. However, the effect of reoriented fracture angle on the productivity index is not as strong as that of principal fracture angle. When reoriented fracture angle is smaller than principal fracture angle, reoriented factor should be as low as possible to achieve optimal productivity index. Meanwhile, well productivity index rises up with the increase of fracture number and fracture spacing, but the horizontal well has optimal reorientation fracture number and fracture spacing to get the economical productivity. Furthermore, the influence of the rotation of one central reorientation fracture on productivity index is weaker than that caused by the rotation of one external reorientation fracture. In addition, the asymmetrical distribution of one or more reorientation fractures slightly affects the productivity index when fracture conductivity is high enough.
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