The “time-space compression” effect of high-speed rail (HSR) has effectively improved the accessibility of the cities and has had a profound impact on tourism. This study explores the impact of HSR ...on tourism development in cities along HSR lines from the perspective of transfer of transport advantages, then evaluates the impact of HSR on tourism development using panel data of 286 cities in China from 2005 to 2013 by the difference-in-differences (DID) method. The empirical results show that the opening of HSR has significantly increased the tourism revenue and tourist arrivals. These results are still holds after considering endogenous HSR lines placement, and by various robustness checks. Further analysis of nodal effect shows that node cities experienced greater growth in tourism revenue than non-node cities. The analysis of mechanism found that tourism development in node cities relied on hotel industry, while tourism development in non-node cities relied on scenic spots industry. The findings of this study validate the role of HSR as a catalyst for urban tourism development, and reveal the comparative advantages of tourism in different cities under the influence of HSR. This study has important reference value for the development of tourism industry policies in cities along and around HSR lines.
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Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a ...meta-analysis to evaluate the prognostic and clinicopathological value of PD-L1 expressed in tumor cells of patients with diffuse large B-cell lymphoma (DLBCL).
Relevant studies were identified from PubMed, EMBASE, Web of Science and the Cochrane Library. The hazard ratio (HR) and 95% confidence interval (95% CI) were used for analyzing survival outcomes, and the odds ratio (OR) was used for analyzing clinicopathological parameters.
Pooled results showed that tumor cell PD-L1 expression is associated with poor overall survival (OS) (HR = 2.128, 95% CI: 1.341-3.378, P = 0.001), the non-germinal center B-cell-like subtype (OR = 2.891, 95% CI: 2.087-4.003, P < 0.000), high international prognostic index score (3-5) (OR = 1.552, 95% CI: 1.111-2.169, P = 0.010), B symptoms (OR = 1.495, 95% Cl: 1.109-2.015, P = 0.008), positive MUM1 expression (OR = 3.365, 95% Cl: 1.578-7.175, P = 0.002) and negative BCL6 expression (OR = 0.414, 95% Cl: 0.217-0.792, P = 0.008). Sensitivity analysis showed that there was no publication bias among these studies.
Our meta-analysis supported the idea that tumor cell PD-L1 expression may represent a promising biomarker for predicting poor prognosis and is associated with adverse clinicopathologic features in DLBCL patients.
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Epithelial-mesenchymal transition (EMT) plays a crucial role in the progression and aggressiveness of colorectal carcinoma. E-cadherin is the best-characterized molecular marker of EMT, but its ...prognostic significance for patients with CRC remains inconclusive.
Eligible studies were searched from the PubMed, Embase and Web of Science databases. Correlation between E-cadherin expression and clinicopathological features and prognosis was analyzed. Subgroup analysis was also performed according to study location, number of patients, quality score of studies and cut-off value.
A total of 27 studies comprising 4244 cases met the inclusion criteria. Meta-analysis suggested that downregulated E-cadherin expression had an unfavorable impact on overall survival (OS) of CRC (n = 2730 in 14 studies; HR = 2.27, 95%CI: 1.63-3.17; Z = 4.83; P = 0.000). Subgroup analysis indicated that low E-cadherin expression was significantly associated with worse OS in Asian patients (n = 1054 in 9 studies; HR = 2.86, 95%CI: 2.13-3.7, Z = 7.11; P = 0.000) but not in European patients (n = 1552 in 4 studies; HR = 1.14, 95%CI: 0.95-1.35, Z = 1.39; P = 0.165). In addition, reduced E-cadherin expression indicated an unfavorable OS only when the cut off value of low E-cadherin expression was >50% (n = 512 in 4 studies; HR = 2.08, 95%CI 1.45-2.94, Z = 4.05; P = 0.000). Downregulated E-cadherin expression was greatly related with differentiation grade, Dukes' stages, lymphnode status and metastasis. The pooled OR was 0.36(95%CI: 0.19-0.7, Z = 3.03, P = 0.002), 0.34(95%CI: 0.21-0.55, Z = 6.61, P = 0.000), 0.49(95%CI: 0.32-0.74, Z = 3.02, P = 0.002) and 0.45(95%CI: 0.22-0.91, Z = 3.43, P = 0.001), respectively.
This study showed that low or absent E-cadherin expression detected by immunohistochemistry served as a valuable prognostic factor of CRC. However, downregulated E-cadherin expression seemed to be associated with worse prognosis in Asian CRC patients but not in European CRC patients. Additionally, this meta-analysis suggested that the negative threshold of E-cadherin should be >50% when we detected its expression in the immunohistochemistry stain.
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In this paper, we aim to address the limited capacity of compensation devices by enhancing their utilization rate by applying the currents’ physical component (CPC) theory for reactive power ...optimization in three-phase four-wire systems. When reactive currents cannot be fully compensated for, we propose using CPC theory to generate reference currents for the compensation devices. Weight coefficients associated with different reactive current components are introduced, enabling flexible combinations of these independent current components. The maximum output amplitude of the three-phase current from the compensation device serves as a constraint condition, allowing for the calculation of reference currents under various compensation targets. Additionally, a reactive current optimization compensation scheme focusing on loss reduction is selected. The simulated annealing–particle swarm optimization (SA-PSO) hybrid algorithm is employed to solve the optimization mathematical model. The discussed calculations, current waveforms, and voltage waveforms are generated using the constructed mathematical model and then used for a theoretical explanation. The simulation verifies the feasibility of the proposed method.
This study aimed to develop a value-added bio-based polymer product for food packaging. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a promising bioplastic with limitations in ...processability and brittleness, which our group previously addressed by incorporating high-molecular-weight natural rubber (NR) compatibilized with peroxide and coagent. Yet, processability in an industrial setting proved difficult. Coffee oil epoxide (COE), a waste-derived plasticizer, was incorporated into the PHBV/NR/peroxide/coagent matrix via extrusion, and properties of resulting sheets were evaluated. COE incorporation significantly decreased the oxygen and water permeability of the PHBV/NR sheets. Maximum degradation temperature Tpeak (°C) increased by ~4.6 °C, and degree of crystallinity decreased by ~15.5% relative to pristine PHBV, indicating good thermal stability. Melting (Tm) and glass transition temperatures (Tg) of the PHBV/NR blend remained unchanged with COE incorporation. X-ray diffraction (XRD) revealed ~10.36% decrease in crystal size for the plasticized blend. Energy-dispersive X-ray analysis (EDAX) and scanning electron microscopy (SEM) confirmed good dispersion with no phase separation. The water uptake capacity of the plasticized blend was reduced by 61.02%, while surface contact angle measurements showed improved water resistance. The plasticized PHBV sheet shows promise for environmentally friendly packaging films due to its high thermal stability, effective barrier properties, and industrial scalability.
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From a social psychology perspective, this study explored the personal and social psychological motivation of Retaliatory Justice. This study constructed a four-dimensional model of the psychological ...motivation of Retaliatory Justice from the two dimensions of "Self vs. Society" and "Identity vs. Resource." They were Identity-Based Self-Oriented Motivation (Pacifying Outrage), Resource-Based Self-Oriented Motivation (Occupying Resource), Identity-Based Society-Oriented Motivation (Value Confirmation), and Resource-Based Society-Oriented Motivation (Deterrence and Control). In this study, 497 sets of valid data were extracted from 6 universities in Xi'an, Shaanxi Province, China, using 3 sets of situational experiments and the "Questionnaire Star" online survey platform as a vehicle to explore the personal motivations and psychosocial motivations of Retaliatory Justice. The empirical results showed that the situational experiment significantly verified the existence of Pacifying Outrage and Value Confirmation, and partially verified the existence of Deterrence and Control and Occupying Resource. Multiple linear regression analysis showed that only the effect of Pacifying Outrage on Retaliatory Justice showed a main effect, and the interaction between Pacifying Outrage and Deterrence and Control was not significant. Pacifying Outrage significantly affects Retaliatory Justice, while Occupying Resource significantly affects Retaliatory Justice, but the interaction between the two was not significant. Value Confirmation significantly affects Retaliatory Justice. Value Confirmation and Deterrence and Control synergistically affect Retaliatory Justice, but Deterrence and Control had no significant effect on Retaliatory Justice. Taking emotions as clues, this paper discussed the realistic value of the rheological paths of the psychological motivation of Retaliatory Justice, which brought enlightenment to the improvement of social morality, the cultivation of judicial trust, and the construction of psychological service system.
The systemic immune-inflammation index (SII) based on neutrophil, platelet and lymphocyte counts, is a prognostic biomarker in some solid cancers. However, the prognostic value of SII has not yet ...been validated. This study was to evaluate the role of SII in predicting survival for patients with diffuse large B cell lymphoma (DLBCL).
We retrospectively investigated 224 patients with DLBCL between August 2005 and October 2018. Kaplan-Meier analysis and Cox proportional hazard models were used to assess the prognostic value of SII.
In the ROC curve analysis, SII had the highest AUC and was more accurate as a prognostic factor. Patients with higher SII tended to have higher level of LDH, more advanced stage, poor PS, and high IPI score compared with low SII group. In univariate analyses, SII, PLR and NLR were all prognostic for progression-free survival and overall survival. Moreover, only SII, older age, HBSAg-positive and IPI were the independent prognostic factors for patients in multivariate analysis. The nomogram based on SII, older age, HBSAg status and IPI showed accurate prognostic ability for predicting 3-years and 5-years survival rates (c-index, 0.791) compared to the IPI alone (c-index, 0.716).
SII was a powerful tool for predicting outcome in patients with DLBCL. It might assist the separation of high-risk patients among patients with the same IPI.
Small (< 4 cm) clear cell renal cell carcinoma (ccRCC) is the most common type of small renal cancer and its prognosis is poor. However, conventional radiological characteristics obtained by computed ...tomography (CT) are not sufficient to predict the nuclear grade of small ccRCC before surgery. A total of 113 patients with histologically confirmed ccRCC were randomly assigned to the training set (n = 67) and the testing set (n = 46). The baseline and CT imaging data of the patients were evaluated statistically to develop a clinical model. A radiomics model was created, and the radiomics score (Rad-score) was calculated by extracting radiomics features from the CT images. Then, a clinical radiomics nomogram was developed using multivariate logistic regression analysis by combining the Rad-score and critical clinical characteristics. The receiver operating characteristic (ROC) curve was used to evaluate the discrimination of small ccRCC in both the training and testing sets. The radiomics model was constructed using six features obtained from the CT images. The shape and relative enhancement value of the nephrographic phase (REV of the NP) were found to be independent risk factors in the clinical model. The area under the curve (AUC) values for the training and testing sets for the clinical radiomics nomogram were 0.940 and 0.902, respectively. Decision curve analysis (DCA) revealed that the radiomics nomogram model was a better predictor, with the highest degree of coincidence. The CT-based radiomics nomogram has the potential to be a noninvasive and preoperative method for predicting the WHO/ISUP grade of small ccRCC.
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