Abstract Objective To assess the associations between depression and incident cancer risk. Study design Systematic review and meta-analysis. Methods The Cochrane Library, Web of Science, MEDLINE, and ...PubMed databases were searched to identify studies. The quality of included studies was assessed using the Newcastle Ottawa Scale. Risk ratios (RRs) were used to measure effect size. A random-effects model was applied to synthesize the associations between depression and cancer risk. A forest plot was produced to visually assess RRs and 95% confidence intervals (CIs). Heterogeneity across studies was assessed using the I-squared statistic. A funnel plot was generated to assess potential publication bias, and Egger's regression was applied to test the symmetry of the funnel plot. Results In total, 1,469,179 participants and 89,716 incident cases of cancer from 25 studies were included. Depression was significantly associated with overall cancer risk (RR = 1.15, 95% CI: 1.09–1.22) and with liver cancer (RR = 1.20, 95% CI: 1.01–1.43) and lung cancer (RR = 1.33, 95% CI: 1.04–1.72). Subgroup analysis of studies in North America resulted in a significant summary relative risk (RR = 1.30, 95% CI: 1.15–1.48). No significant associations were found for breast, prostate, or colorectal/colon cancer. The average Newcastle Ottawa score was 7.56 for all included studies. Conclusion Our findings showed a small and positive association between depression and the overall occurrence risk of cancer, as well as liver cancer and lung cancer risks. However, multinational and larger sample studies are required to further research and support these associations. Moreover, confounding factors such as cigarette smoking and alcohol use/abuse should be considered in future studies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The decay
D
→
K
-
π
+
is studied in a sample of quantum-correlated
D
D
¯
pairs, based on a data set corresponding to an integrated luminosity of 2.93 fb
-
1
collected at the
ψ
(
3770
)
resonance by ...the BESIII experiment. The asymmetry between
C
P
-odd and
C
P
-even eigenstate decays into
K
-
π
+
is determined to be
A
K
π
=
0.132
±
0.011
±
0.007
, where the first uncertainty is statistical and the second is systematic. This measurement is an update of an earlier study exploiting additional tagging modes, including several decay modes involving a
K
L
0
meson. The branching fractions of the
K
L
0
modes are determined as input to the analysis in a manner that is independent of any strong phase uncertainty. Using the predominantly
C
P
-even tag
D
→
π
+
π
-
π
0
and the ensemble of
C
P
-odd eigenstate tags, the observable
A
K
π
π
π
π
0
is measured to be
0.130
±
0.012
±
0.008
. The two asymmetries are sensitive to
r
D
K
π
cos
δ
D
K
π
, where
r
D
K
π
and
δ
D
K
π
are the ratio of amplitudes and phase difference, respectively, between the doubly Cabibbo-suppressed and Cabibbo-favoured decays. In addition, events containing
D
→
K
-
π
+
tagged by
D
→
K
S
,
L
0
π
+
π
-
are studied in bins of phase space of the three-body decays. This analysis has sensitivity to both
r
D
K
π
cos
δ
D
K
π
and
r
D
K
π
sin
δ
D
K
π
. A fit to
A
K
π
,
A
K
π
π
π
π
0
and the phase-space distribution of the
D
→
K
S
,
L
0
π
+
π
-
tags yields
δ
D
K
π
=
187.6
-
9.7
+
8.9
-
6.4
+
5.4
∘
, where external constraints are applied for
r
D
K
π
and other relevant parameters. This is the most precise measurement of
δ
D
K
π
in quantum-correlated
D
D
¯
decays.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A
bstract
Based on
e
+
e
−
collision samples corresponding to an integrated luminosity of 4.4 fb
−
1
collected with the BESIII detector at center-of-mass energies between 4
.
6 GeV and 4
.
7 GeV, a ...partial wave analysis of the charmed baryon hadronic decay
Λ
c
+
→
Λ
π
+
π
0
is performed, and the decays
Λ
c
+
→
Λ
ρ
(770)
+
and
Λ
c
+
→
Σ(1385)
π
are studied for the first time. Making use of the world-average branching fraction
B
Λ
c
+
→
Λ
π
+
π
0
, their branching fractions are determined to be
B
Λ
c
+
→
Λ
ρ
770
+
=
4.06
±
0.30
±
0.35
±
0.23
×
10
−
2
,
B
Λ
c
+
→
Σ
1385
+
π
0
=
5.86
±
0.49
±
0.52
±
0.35
×
10
−
3
,
B
Λ
c
+
→
Σ
1385
0
π
+
=
6.47
±
0.59
±
0.66
±
0.38
×
10
−
3
,
where the first uncertainties are statistical, the second are systematic, and the third are from the uncertainties of the branching fractions
B
Λ
c
+
→
Λ
π
+
π
0
and
B
Σ
1385
→
Λ
π
. In addition, the decay asymmetry parameters are measured to be
α
Λ
ρ
(770)+
= − 0.763 ± 0.053 ± 0.045,
α
Σ
1385
+
π
0
=
−
0.917
±
0.069
±
0.056
, and
α
Σ
1385
0
π
+
=
−
0.789
±
0.098
±
0.056
.
Abstract
PSR J2150+3427 is a 0.654 s pulsar discovered by the Commensal Radio Astronomy FAST Survey. From the follow-up observations, we find that the pulsar is in a highly eccentric orbit (
e
= ...0.601) with an orbital period of 10.592 days and a projected semimajor axis of 25.488 lt-s. Using 2.7 yr of timing data, we also measured the rate of periastron advance
ω
̇
= 0.0115(4) deg yr
−1
. An estimate for the total mass of the system using the
ω
̇
gives
M
tot
= 2.59(13)
M
⊙
, which is consistent with most of the known double neutron star (DNS) systems and one neutron star (NS)–white dwarf (WD) system named B2303+46. Combining
ω
̇
with the mass function of the system gives the masses of
M
p
< 1.67 and
M
c
> 0.98
M
⊙
for the pulsar and the companion star, respectively. This constraint, along with the spin period and orbital parameters, suggests that it is possibly a DNS system, and we cannot entirely rule out the possibility of an NS–WD system. Future timing observations will vastly improve the uncertainty in
ω
̇
, and are likely to allow the detection of additional relativistic effects, which can be used to modify the values of
M
p
and
M
c
. With a spin-down luminosity of
E
̇
= 5.07(6) × 10
29
erg s
−1
, PSR J2150+3427 is a very low-luminosity pulsar, with only the binary pulsar J2208+4610 having a smaller
E
̇
.
Background
Acne vulgaris is a prevalent skin condition. We have found that some acromegaly patients have acne. However, no study has examined the relationship between acromegaly and acne.
Objective
...To explore prevalence and correlation of adult acne in patients with acromegaly.
Methods
For this cross-sectional study, we collected questionnaires, clinical information, and laboratory test results of acromegaly patients from January 2022 to December 2022 at Huashan Hospital. Of the 133 questionnaires returned, 123 had valid responses.
Results
Of the 123 patients with acromegaly enrolled in this study, 54.5% had adult acne. No statistically significant difference was found in prevalence between male and female patients. 61.2% of adult acne patients reported late-onset acne. Late-onset acne patients first developed acne years before acromegaly diagnosis (mean of 5.6 years for male and 4.5 years for female patients). Some acne patients have received traditional anti-acne treatment. Moreover, 31% of the patients reported no improvement, and only 3.5% of patients claimed complete resolution of acne after treatment. Before acromegaly treatment, the prevalence of adult acne was 51.2%, with mild acne accounting for 73.0%, moderate acne accounting for 23.8%, and severe acne accounting for 3.2%. After acromegaly treatment, the prevalence of adult acne was significantly decreased to 37.4% (
P
= 0.007). An overall decrease in acne severity was noted, with 93.5%, 6.5%, and 0% having mild, moderate, and severe acne, respectively. A total of 83.6% of the patients had self-assessed acne remission, and 33.3% of the patients reported complete acne resolution. However, 9.0% of patients reported that their condition had worsened after acromegaly treatment. After treatment, GH, IGF-1, IGF-1 index, insulin levels, and HOMA-IR decreased significantly in all patients with acromegaly (
P
< 0.05). Acne remission correlated positively with IGF-1 levels, but not with GH levels. The relationship between acromegaly and acne remains to be elucidated.
Conclusions
Our findings provide preliminary evidence of the high prevalence of adult acne in acromegaly patients, and a high rate of late-onset acne as well. Traditional anti-acne treatments are less effective. Acne could be considerably relieved by treating acromegaly. Acne remission positively correlated with IGF-1 decline as well, which revealed the correlation between acne and IGF-1.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We study the process e+e−→π+π−ψ(3686) using 5.1 fb−1 of data collected at 16 center-of-mass energy (s) points from 4.008 to 4.600 GeV by the BESIII detector operating at the BEPCII collider. The ...measured Born cross sections for e+e−→π+π−ψ(3686) are consistent with previous results, but with much improved precision. A fit to the cross section shows contributions from two structures: the first has M=4209.5±7.4±1.4 MeV/c2 and Γ=80.1±24.6±2.9 MeV, and the second has M=4383.8±4.2±0.8 MeV/c2 and Γ=84.2±12.5±2.1 MeV, where the first errors are statistical and the second systematic. The lower-mass resonance is observed in the process e+e−→π+π−ψ(3686) for the first time with a statistical significance of 5.8σ. A charged charmoniumlike structure is observed in the π±ψ(3686) invariant mass spectrum for data at s=4.416 GeV. A fit with an S-wave Breit-Wigner function yields a mass M=4032.1±2.4 MeV/c2, where the errors are statistical only. However, there are still unresolved discrepancies between the fit model and data. The width of the intermediate state varies in a wide range for different kinematic regions within the data set. Therefore, no simple interpretation of the data has been found, and a future data sample with larger statistics and more theoretical input will be required to better understand this issue.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
We report a new measurement of electron antineutrino disappearance using the fully constructed Daya Bay Reactor Neutrino Experiment. The final two of eight antineutrino detectors were installed in ...the summer of 2012. Including the 404 days of data collected from October 2012 to November 2013 resulted in a total exposure of 6.9×10^{5} GW_{th} ton days, a 3.6 times increase over our previous results. Improvements in energy calibration limited variations between detectors to 0.2%. Removal of six ^{241}Am-^{13}C radioactive calibration sources reduced the background by a factor of 2 for the detectors in the experimental hall furthest from the reactors. Direct prediction of the antineutrino signal in the far detectors based on the measurements in the near detectors explicitly minimized the dependence of the measurement on models of reactor antineutrino emission. The uncertainties in our estimates of sin^{2}2θ_{13} and |Δm_{ee}^{2}| were halved as a result of these improvements. An analysis of the relative antineutrino rates and energy spectra between detectors gave sin^{2}2θ_{13}=0.084±0.005 and |Δm_{ee}^{2}|=(2.42±0.11)×10^{-3} eV^{2} in the three-neutrino framework.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
High-performance and long-pulse operation is a crucial goal of current magnetic fusion research. Here, we demonstrate a high-connement plasma regime known as an H-mode with a record pulse length of ...over 30 s in the Experimental Advanced Superconducting Tokamak sustained by lower hybrid wave current drive (LHCD) with advanced lithium wall conditioning. We nd that LHCD provides a exible boundary control for a ubiquitous edge instability in H-mode plasmas known as an edge-localized mode, which leads to a marked reduction in the heat load on the vessel wall compared with standard edge-localized modes. LHCD also induces edge plasma ergodization that broadens the heat deposition footprint. The heat transport caused by this ergodization can be actively controlled by regulating the edge plasma conditions. This potentially offers a new means for heat-ux control, which is a key issue for next-step fusion development. PUBLICATION ABSTRACT
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IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
A
bstract
Using (10087 ± 44) × 10
6
J
/
ψ
events collected with the BESIII detector at the BEPCII
e
+
e
−
storage ring at the center-of-mass energy of
s
= 3.097 GeV, we present a search for the rare ...semi-muonic charmonium decay
J
/
ψ
→
D
−
μ
+
ν
μ
+ c.c.. Since no significant signal is observed, we set an upper limit of the branching fraction to be
B
(
J
/
ψ
→
D
−
μ
+
ν
μ
+ c.c.) < 5.6 × 10
−
7
at 90% confidence level. This is the first search for the weak decay of charmonium with a muon in the final state.
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