The dense ceramic oxygen-permeable membrane has attracted much attention due to its potential applications in production of oxygen from air and manipulation of oxygen-consuming industrial chemical ...processes. In the present study, Gd0.1Ce0.9O2–δ-La0.6Sr0.4FeO3–δ（GDC-LSF） dual-phase composite membrane was prepared using the phase-inversion tape casting/lamination/sintering method. The as-prepared membrane consisted of an 80 μm thick dense oxygen separation layer sandwiched between two 420 μm thick finger-like porous support layers. The inner surface of the support layers was further modified with Nd2NiO4+δ（NNO） nanoparticles using the impregnation method. An oxygen permeation flux of 1.53 mL·cm-2·min-1 was measured at 900 ℃ by exposing one side of the membrane to a flowing air stream and the other side to a flowing He stream. When CO2 was used as sweep gas, an oxygen permeation flux of 0.6 mL·cm-2·min-1 was obtained, and no decrease in the flux was observed during 90 h of testing. The membrane remained intact a
(
) is a key pathogen of periodontitis. Increasing evidence shows that
signals to mitochondria in periodontal cells, including gingival epithelial cells, gingival fibroblast cells, immune cells, etc. ...Mitochondrial dysfunction affects the cellular state and participates in periodontal inflammatory response through the aberrant release of mitochondrial contents. In the current review, it was summarized that
induced mitochondrial dysfunction by altering the mitochondrial metabolic state, unbalancing mitochondrial quality control, prompting mitochondrial reactive oxygen species (ROS) production, and regulating mitochondria-mediated apoptosis. This review outlines the impacts of
and its virulence factors on the mitochondrial function of periodontal cells and their role in periodontitis.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Glioblastoma (GBM) is one of the most lethal brain tumors with a short survival time. EGFR amplification and mutation is the most significant genetic signature in GBM. About half of the GBMs with ...EGFR amplification express a constitutively autophosphorylated variant of EGFR, known as EGFRvIII. Our in vitro data demonstrated further enhanced EGFRvIII activity and tumor cell invasion in the tumor microenvironment of hypoxia plus extracellular matrix (ECM) vitronectin, in which EGFRvIII and integrin β3 tended to form complexes. The treatment with ITGB3 siRNA or the integrin antagonist cilengetide preferentially interrupted the EGFRvIII/integrin β3 complex, effectively reduced tumor cell invasion and activation of downstream signaling effectors. Cilengitide is recently failed in Phase III CENTRIC trial in unselected patients with GBM. However, we found that cilengitide demonstrated efficacious tumor regression via inhibition of tumor growth and angiogenesis in EGFRvIII orthotopic xenografts. Bioinformatics analysis emphasized key roles of integrin β3, hypoxia and vitronectin and their strong correlations with EGFRvIII expression in malignant glioma patient samples in vivo. In conclusion, we demonstrate that EGFRvIII/integrin β3 complexes promote GBM progression and metastasis in the environment of hypoxia and vitronectin-enrichment, and cilengitide may serve as a promising therapeutics for EGFRvIII-positive GBMs.
We demonstrate a thermoreflectance-based thermometry technique with an ultimate temperature resolution of 60 µK in a 2.6 mHz bandwidth. This temperature resolution was achieved using a 532 ...nm-wavelength probe laser and a ∼1 µm-thick silicon transducer film with a thermoreflectance coefficient of -4.7 × 10
K
at room temperature. The thermoreflectance sensitivity reported here is over an order-of-magnitude greater than that of metal transducers, and is comparable to the sensitivity of traditional resistance thermometers. Supporting calculations reveal that the enhancement in sensitivity is due to optical interference in the thin film.
CaF2, BaF2, and MgF2 are low-index, infrared-transparent materials that are extensively used in optical systems. Despite their technological importance, a systematic investigation into the ...temperature dependence of their optical properties is lacking. In this study, spectroscopic ellipsometry was used to obtain the refractive index of monocrystalline CaF2, BaF2, and MgF2 for wavelengths between 220 nm and 1700 nm, and for temperatures between 21 °C and 368 °C. The raw ellipsometric data was fit to a Sellmeier model with temperature-dependent oscillator terms to extract the real part of the refractive index of each material. The refractive index of CaF2 and BaF2 was observed to decrease linearly with increasing temperature, which can be largely attributed to a reduction in the mass density due to thermal expansion. In contrast, the refractive index of MgF2 was found to vary nonlinearly with temperature, which suggests competing effects from the material's electronic polarizability. The temperature-dependent refractive index data reported here provide a finely-resolved mapping of the thermo-optic coefficient for these three materials, which could inform the development of optical devices operating at elevated or unsteady temperatures.
CaF
2
, BaF
2
, and MgF
2
are low-index, infrared-transparent materials that are extensively used in optical systems. Despite their technological importance, a systematic investigation into the ...temperature dependence of their optical properties is lacking. In this study, spectroscopic ellipsometry was used to obtain the refractive index of monocrystalline CaF
2
, BaF
2
, and MgF
2
for wavelengths between 220 nm and 1700 nm, and for temperatures between 21 °C and 368 °C. The raw ellipsometric data was fit to a Sellmeier model with temperature-dependent oscillator terms to extract the real part of the refractive index of each material. The refractive index of CaF
2
and BaF
2
was observed to decrease linearly with increasing temperature, which can be largely attributed to a reduction in the mass density due to thermal expansion. In contrast, the refractive index of MgF
2
was found to vary nonlinearly with temperature, which suggests competing effects from the material’s electronic polarizability. The temperature-dependent refractive index data reported here provide a finely-resolved mapping of the thermo-optic coefficient for these three materials, which could inform the development of optical devices operating at elevated or unsteady temperatures.
This study was to investigate direct electrolysis of CO2via solid oxide cells with thin Y0.16Zr0.84O1.92 (YSZ) electrolytes and (La0.8Sr0.2)0.95MnO3−δ (LSM)-YSZ air electrodes supported on ...La0.8Sr0.2Cr0.5Fe0.5O3−δ (LSCrF)-YSZ fuel electrodes. The fuel electrode with straight open pores was prepared using the phase-inversion tape casting method, modified with nano-scaled Sr2Fe1.5Mo0.5O6−δ (SFM) catalysts using the impregnation method. Substantially larger maximum power densities were observed in the fuel cell mode for single cells with the SFM catalysts than without, e.g., 423 vs. 51 mW·cm−2 at 800 °C. Impedance analysis showed an order magnitude drop in the pure ohmic resistances and the interfacial polarization resistances in the presence of electronically conductive and catalytically active SFM nanoparticulates. Electrolysis measurements indicated that these nano-scaled SFM catalysts also helped to promote CO2 reduction reactions. The electrolysis current densities at 1.5 V were 0.48, 0.64 and 1.02 A·cm−2 for the SFM-infiltrated cells at 700, 750, 800 °C, respectively. In contrast, the blank cells displayed much smaller current densities of 0.22, 0.35 and 0.41 A·cm−2 under the similar conditions. Apparently, the modification of the LSCrF-YSZ electrode with SFM nanoparticulates provided extended electrochemically active sites with sufficient interconnected paths to transfer electrons and oxygen ions, which led to a significant increase in the electrochemical performance. The reduced polarization resistance and high current density show that the nano-scaled SFM-modified LSCrF-YSZ fuel electrode is highly effective for pure CO2 electrolysis without using the safe gas.
•La0.8Sr0.2Cr0.5Fe0.5O3−δ-based fuel electrode was prepared by phase inversion tape casting.•The electrode possessed straight open pores, allowing modification with Sr2Fe1.5Mo0.5O6−δ.•The electrode-supported solid oxide cell showed improved CO2 electrolysis performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPUK, ZAGLJ, ZRSKP
Graphene oxide and zirconia powders were mixed using a colloidal coating route. In situ reduced graphene oxide‐toughened zirconia ceramics were prepared by spark plasma sintering. Their ...microstructure, mechanical properties, and toughening mechanisms were investigated. The results show that graphene oxide can be easily reduced in situ during sintering and that it disperses homogeneously within the zirconia substrate. Compared with the toughness of 3 mol.% yttria‐stabilized zirconia, the fracture toughness of in situ reduced graphene oxide‐toughened zirconia increased by up to 175% (from ~6.07 to ~10.64 MPa·m1/2) at 0.09 wt.% graphene oxide with a small increase in hardness. The improvement is more significant than that of prereduced graphene oxide‐toughened cases, and it is associated with the formation of a C‐O‐Zr bond at the interface in addition to conventional toughening mechanisms.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
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