A multiple resonance thermally activated delayed fluorescence (MR‐TADF) molecule with a fused, planar architecture tends to aggregate at high doping ratios, resulting in broad full width at half ...maximum (FWHM), redshifting electroluminescence peaks, and low device efficiency. Herein, we propose a mono‐substituted design strategy by introducing spiro‐9,9′‐bifluorene (SBF) units with different substituted sites into the MR‐TADF system for the first time. As a classic steric group, SBF can hinder interchromophore interactions, leading to high device efficiency (32.2–35.9 %) and narrow‐band emission (≈27 nm). Particularly, the shield‐like molecule, SF1BN, seldom exhibits a broadened FWHM as the doping ratio rises, which differs from the C3‐substituted isomer and unhindered parent emitter. These results manifest an effective method for constructing highly efficient MR‐TADF emitters through a spiro strategy and elucidate the feasibility for steric modulation of the spiro structure in π‐framework.
By incorporating a three‐dimensional spiro unit into multiple resonance thermally activated delayed fluorescence emitters, the device efficiency is increased to nearly 1.5 times that of the unhindered emitter. Notably, the linkage pattern with spatial interaction and hindrance can maintain the narrow FWHM and curb unfavorable redshifts at a high doping ratio.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal ...carcinogenesis (NPC) are largely unknown. Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, of which,
was one of the most upregulated lncRNAs in NPC.
significantly associated with poor survival in NPC. N(6)-Methyladenosine (m6A) was highly enriched within
and enhanced its RNA stability.
functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically,
functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target
(
), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In summary, our study reveals a potential ceRNA regulatory pathway in which
modulates
expression by binding to miR-590-3p and miR-1275, ultimately promoting tumorigenesis and metastasis in NPC. SIGNIFICANCE: These findings demonstrate the clinical significance of the lncRNA
in nasopharyngeal carcinoma (NPC) and the regulatory mechanism involved in NPC development and progression, providing a novel prognostic indicator and promising therapeutic target.
A series of novel Ln-MOFs were synthesized. The Eu based Ln-MOFs shows highly luminescence quantum yield, further investigation indicates it is a bifunctional sensor for detecting Ni2+ and Val at the ...same time. Interestingly, the LOD for sensing Ni2+ is an ultrahigh sensitive value of 1.0×10−9M, it is the most sensitive chemosensor for detecting Ni2+.
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•A series of novel Ln-MOFs are synthesized under mild hydrothermal conditions by introducing flexible ligand of 1,3-adamantanediacetic acid.•Eu based Ln-MOFs shows highly luminescent QYs.•Investigation reveals that the Eu based Ln-MOFs is a bifunctional sensor for probing Ni2+ and Val.•Eu based Ln-MOFs is the most sensitive chemosensor for detecting Ni2+.
A series of lanthanide metal-organic-frameworks (Ln-MOFs) are synthesized under mild hydrothermal condition by introducing the ligand of 1,3-adamantanediacetic acid (H2ADA). They are three dimentional (3D) structures and have the formula of Ln(ADA)1.5(phen)n (Ln3+=Eu3+1a, Gd3+1b, Tb3+1c, La3+1d, Ce3+1e, Pr3+1f, Nd3+1g, Y3+1h; phen=1,10-phenanthroline). These Ln-MOFs are fully characterized by single-crystal X-ray diffraction, PXRD, TGA, EA and FT-IR. Luminescence properties, including luminescence spectra, luminescence decay lifetimes and luminescence quantum yields (QYs) are analyzed in detail. Eu3+ complex of 1a shows highly luminescence QYs of 58.61%, which due to that the triplet state of phen competes well with the excited emission state of Eu3+. Further investigation reveals that 1a is a bifunctional sensor, which can be used as a turn-off luminescence sensor for detecting Ni2+ and turn-on luminescence sensor for probing Val at the same time. Interestingly, the limit of detect (LOD) for sensing Ni2+ is an ultrahigh sensitive value of 1.0×10−9M (5.9×10−5mg/L), which is lower than the Chinese environmental quality standard (0.5mg/L of total Ni2+ content, GB25467-2010), and it is the most sensitive chemosensor for detecting Ni2+, to the best of our knowledge. Investigation also reveals there is a good linear relationship between luminescence intensity and the concentration of Ni2+ in 0.2–0.6μM. The sensing mechanism for detecting Ni2+ and Val are also discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Superhydrophilic materials have attracted extensive attention as promising candidates for effective oil/water separation and water purification, however, realizing environmentally friendly and ...multifunctional materials with superhydrophilicity and underwater superoleophobicity is still a great challenge and urgently desired. In this work, we develop a controllable approach to achieve the superhydrophilicity of biodegradable electrospun stereocomplex polylactide (sc-PLA) membranes via the titanium carboxylate coordination bonding of gallic acid (GA) and tetrabutyl titanate (Ti(OBu)4) in aqueous solution, i.e. GA-modified TiO2 (GA-TiO2) coating. The GA-TiO2 coated sc-PLA (GT-sc) membranes show superhydrophilicity and underwater superoleophobicity in various harsh working conditions including corrosive organic solvents, saturated NaCl solution and acid solution at pH = 1, exhibiting effective and efficient separation property for a wide range of oil/water mixtures and oil-in-water emulsions. The GT-sc membranes can remove water-soluble contaminants such as methylene blue driven by gravity, leading to multifunctional water purification. Moreover, the GT-sc membranes possess splendid antifouling and self-cleaning performance resulting from the photocatalytic property of TiO2 under UV irradiation. Thus, this work provides an easily controlled route for fabricating green and durable membranes for multifunctional oil/water separation.
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•Superhydrophilic biodegradable membrane has been fabricated via a green gallic acid-modified TiO2 coating.•The membranes exhibit multifunctional oil/water separation with high separation efficiency under gravity driven.•The membranes possess outstanding chemical and mechanical stability in various harsh working conditions.•The membranes show excellent anti-fouling and self-cleaning performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The origins of Cenozoic granites in the Himalaya are key to understanding the evolution of the Himalayan orogen. However, it is unclear whether these granites represent primary melts, and the nature ...of their magma source is controversial. Here, we present a systematic element and Sr–Nd–B–Mo isotope study of Cenozoic granites from the Yardoi area in the eastern Tethyan Himalaya, China. These granites can be divided into two groups: mid‐Eocene porphyritic two‐mica granites with low SiO2 contents (65.9−69.6 wt.%) and adakitic geochemical signatures, and mid‐Eocene to Miocene equigranular granites with high SiO2 contents (71.6−75.5 wt.%). The high‐SiO2 granites (HSG) have similar Sr−Nd isotope compositions to the low‐SiO2 granites (LSG), but they have distinct δ11B values of −19.4‰ to −11.4‰ and −10.6‰ to −6.89‰. This indicates that the two groups have different sources, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metasedimentary rocks with less enriched Nd isotope compositions. The δ98/95Mo of the LSG and HSG are highly variable with values of −0.68‰ to 0.12‰ and −1.13‰ to 0.46‰, respectively. δ11B values of the HSG correlate positively with δ98/95Mo and Sr/Y values and correlate negatively with K2O, Rb, Zr, and Rb/Sr, reflecting the addition of external metamorphic fluids during anatexis of the metapelites. The B–Mo isotope data robustly suggest source‐controlled compositional diversity of the Himalayan granites, which could provide clues to the physical and geochemical responses during the evolution of a large orogen.
Plain Language Summary
Partial melts derived from crustal anatexis exhibit large compositional diversity. The relative influence of source compositions and magmatic differentiation on such heterogeneity is a subject of ongoing debate. B−Mo isotopes have the potential to trace the source compositions of crustal magmas. In this study, we present whole‐rock geochemical and B–Mo isotopic compositions of Cenozoic granites in the eastern Tethyan Himalaya. Samples with diverse mineralogical and geochemical features and ages (mid‐Eocene, early Oligocene, and Miocene) were investigated and can be divided into low‐SiO2 granites (LSG) and high‐SiO2 granites (HSG). Boron isotopes reveal different source compositions for the two groups, with the LSG derived by partial melting dominantly of metamafic rocks at thickened lower crustal conditions, and the HSG generated by partial melting of the mid‐crust metapelites. B–Mo isotopes combined with the variations in element contents/ratios provide evidence for the involvement of external fluids during the formation of the HSG. Our new data suggest that the geochemical diversity of anatectic melts is dominated by the nature of the source, including source lithology and fluid effects. This implies that the Himalayan granites could be potentially in tracing the thermal and tectonic evolution of the Himalayan orogen.
Key Points
Boron isotopes reveal different source compositions for the Himalayan Cenozoic granites
B–Mo isotopes provide evidence for the involvement of external fluids during crustal anatexis
Himalayan Cenozoic granites can potentially trace the evolution of a large orogen
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Background
The current study was performed to investigate whether circulating cell‐free Epstein‐Barr virus DNA (cfEBV DNA) would be useful for posttreatment surveillance in patients with ...nasopharyngeal carcinoma (NPC).
Methods
The authors identified a total of 1984 nondisseminated NPC patients from an institutional big‐data research platform. Blood samples were collected within 3 months of the completion of radiotherapy and every 3 to 12 months thereafter for cfEBV DNA analysis. Patients were followed until disease recurrence was detected or for a median of 60 months. Diagnostic performance was assessed by calculating the sensitivity, specificity, and accuracy based on the clinical detection of disease recurrence by conventional surveillance modalities (imaging scans and pathological examination).
Results
During follow‐up, a total of 767 patients (38.7%) had detectable cfEBV DNA. The recurrence rate among these patients was 63.8% (489 of 767 patients), which was significantly higher than that in patients with undetectable cfEBV DNA (8.6%; 105 of 1217 patients). cfEBV DNA sensitivity, specificity, and accuracy were 68.8%, 80.0%, and 78.2%, respectively, for local recurrence; 80.2%, 80.0%, and 85.9%, respectively, for regional recurrence; and 91.1%, 80.0%, and 92.8%, respectively, for distant metastasis. cfEBV DNA was found to have higher sensitivity for the detection of extrapulmonary metastases (94.9%‐96.5%) compared with pulmonary metastases (78.4%). It is interesting to note that among the patients with disease recurrence with detectable cfEBV DNA, positive cfEBV DNA results preceded radiological and/or clinical evidence of disease recurrence by a median of 2.3 months (interquartile range, 0.1‐9.5 months). In addition, of the 278 cfEBV DNA‐positive patients who did not develop disease recurrence, 227 (81.7%) had transiently positive cfEBV DNA that fell to undetectable levels during long‐term monitoring.
Conclusions
Plasma cfEBV DNA in patients with NPC appears to be an early sign of tumor recurrence, especially extrapulmonary metastases.
Circulating cell‐free Epstein‐Barr virus (EBV) DNA levels in the plasma can be useful for detecting tumor recurrence early after treatment in patients with nasopharyngeal carcinoma, particularly those with extrapulmonary metastases. Positive circulating cell‐free EBV DNA can be detected at a median of 2.3 months before radiological or clinical evidence of disease recurrence is noted.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
A narrowband blue CP-TADF emitter with a rigid hetero-helicene structure (QAO-PhCz) was synthesized and characterized. QAO-PhCz exhibits good electroluminescence performance (EQE = 14.0%) and narrow ...FWHM. The enantiomers of QAO-PhCz display CPL and CPEL properties with |
g
lum
| and |
g
EL
|values of up to 1.1 × 10
−3
and 1.5 × 10
−3
, respectively.
A narrowband blue CP-TADF emitter with a rigid hetero-helicene structure (QAO-PhCz) was synthesized and characterized.
This work describes the first hot exciton fluorescent material based on benzoc1,2,5thiadiazole and chiral binaphthol enabling circularly polarized luminescence (CPL) through a chiral perturbation ...strategy. The new molecular architecture displays CPL, hybridized local and charge transfer (HLCT) properties concurrently. Utilizing it as the emitter, circularly polarized organic light‐emitting diodes (CP‐OLEDs) achieve an external quantum efficiency (EQE) of 7.2% with a good exciton utilization (36%) and a moderate circularly polarized electroluminescence (CPEL) dissymmetry factor (gEL, 2.1 × 10−3). In addition, the CP‐HLCT molecule is sensitized by a thermally activated delayed fluorescence material, significantly ameliorating the efficiency of HLCT fluorescent CP‐OLEDs. Excellent performances of twofold maximum EQE (EQEmax) of 15.3% and 82% exciton utilization are obtained in the sensitized device, regarding an extremely low‐efficiency roll‐off of 2.6% at 1000 cd m−2 as well as CPEL with a gEL value of 2.0 × 10−3.
This work proposes the circularly polarized luminescence molecule based on a hybridized local and charge‐transfer (HLCT) chromophore through chiral perturbation, achieving excellent device performances of high exciton utilization and low‐efficiency roll‐off with a thermally activated delayed fluorescence sensitizer, which could pave the way to develop the novel CP‐HLCT materials and highly efficient circularly polarized organic light‐emitting diodes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
The optimal post-treatment surveillance strategy that can detect early recurrence of a cancer within limited visits remains unexplored. Here we adopt nasopharyngeal carcinoma as the study model to ...establish an approach to surveillance that balances the effectiveness of disease detection versus costs. A total of 7,043 newly-diagnosed patients are grouped according to a clinic-molecular risk grouping system. We use a random survival forest model to simulate the monthly probability of disease recurrence, and thereby establish risk-based surveillance arrangements that can maximize the efficacy of recurrence detection per visit. Markov decision-analytic models further validate that the risk-based surveillance outperforms the control strategies and is the most cost-effective. These results are confirmed in an external validation cohort. Finally, we recommend the risk-based surveillance arrangement which requires 10, 11, 13 and 14 visits for group I to IV. Our surveillance strategies might pave the way for individualized and economic surveillance for cancer survivors.
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies ...showed that
, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this study, fractured mice intragastrically administrated with
were found to display better fracture healing than mice treated with vehicle. Notably, more preosteclasts positive for platelet-derived growth factor-BB (PDGF-BB) were induced by
at 2 weeks post fracture, coinciding with increased formation of type H vessels, a specific vessel subtype that couples angiogenesis and osteogenesis, and can be stimulated by PDGF-BB. Moreover,
treatment significantly reduced gut permeability and inflammation at the early stage. Dextran sulfate sodium (DSS) was used to disrupt the gut barrier to determine its role in fracture healing and whether
still can stimulate bone fracture healing. As expected,
evidently improved gut barrier, reduced inflammation and restored the impaired bone healing and angiogenesis in DSS-treated mice. Our results suggest that
reduces intestinal permeability and alleviates inflammation, which probably induces more PDGF-BB
preosteoclasts and type H vessel formation in callus, thereby promoting fracture healing. This study provides the evidence for the involvement of type H vessels in fracture healing and suggests the potential of
as a promising strategy for bone healing.This article has an associated First Person interview with the first author of the paper.
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