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  • A novel protein encoded by ... A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis
    Zhang, Maolei; Huang, Nunu; Yang, Xuesong ... Oncogene, 03/2018, Volume: 37, Issue: 13
    Journal Article
    Peer reviewed

    Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated that even though circRNAs are generally expressed at low levels, they ...
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  • Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling
    Gao, Xinya; Xia, Xin; Li, Fanying ... Nature cell biology, 03/2021, Volume: 23, Issue: 3
    Journal Article
    Peer reviewed

    Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However, EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that there is redundant ...
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  • A peptide encoded by circul... A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
    Zhang, Maolei; Zhao, Kun; Xu, Xiaoping ... Nature communications, 10/2018, Volume: 9, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding circRNAs and the functions of their translated ...
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  • A novel tumor suppressor pr... A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
    Xia, Xin; Li, Xixi; Li, Fanying ... Molecular cancer, 08/2019, Volume: 18, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been ...
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  • A novel protein encoded by ... A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity
    Wu, Xujia; Xiao, Songhua; Zhang, Maolei ... Genome Biology, 01/2021, Volume: 22, Issue: 1
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    Open access

    Aberrant activation of the Hedgehog pathway drives tumorigenesis of many cancers, including glioblastoma. However, the sensitization mechanism of the G protein-coupled-like receptor smoothened (SMO), ...
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  • Circular HER2 RNA positive ... Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab
    Li, Jie; Ma, Maoguang; Yang, Xuesong ... Molecular cancer, 09/2020, Volume: 19, Issue: 1
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    Open access

    Abstract Background Triple negative breast cancer (TNBC) remains the most challenging breast cancer subtype so far. Specific therapeutic approaches have rarely achieved clinical improvements in ...
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  • Whole-genome sequencing of ... Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization
    Qin, Cheng; Yu, Changshui; Shen, Yaou ... Proceedings of the National Academy of Sciences - PNAS, 04/2014, Volume: 111, Issue: 14
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    As an economic crop, pepper satisfies people's spicy taste and has medicinal uses worldwide. To gain a better understanding of Capsicum evolution, domestication, and specialization, we present here ...
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  • Whole-genome sequencing of ... Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits
    Wang, Xiaolong; Liu, Jing; Zhou, Guangxian ... Scientific reports, 12/2016, Volume: 6, Issue: 1
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    The goat (Capra hircus) is one of the first farm animals that have undergone domestication and extensive natural and artificial selection by adapting to various environments, which in turn has ...
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  • Circular RNA encoded MET va... Circular RNA encoded MET variant promotes glioblastoma tumorigenesis
    Zhong, Jian; Wu, Xujia; Gao, Yixin ... Nature communications, 07/2023, Volume: 14, Issue: 1
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    Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and tumorigenicity. ...
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  • GmNAP1 is essential for tri... GmNAP1 is essential for trichome and leaf epidermal cell development in soybean
    Tang, Kuanqiang; Yang, Suxin; Feng, Xingxing ... Plant molecular biology, 08/2020, Volume: 103, Issue: 6
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    Key message Map-based cloning revealed that two novel soybean distorted trichome mutants were due to loss function of GmNAP1 gene, which affected the trichome morphology and pavement cell ploidy by ...
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