The fabrication of Co-Li2S nanocomposite thin film is reported by pulsed laser deposition (PLD) for the first time. Li2S-Co nanocomposite thin film is used as storing Li electrodes that have led to ...promising electrochemical activity and good electrochemical performance. The releasing Li process from the as-deposited Li2S-Co nanocomposite thin films is confirmed by the ex situ high resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED) measurements and may come from the decomposition of Li2S with and without the interaction of metal Co into CoS2 and S. The electrochemical reaction mechanism of Co-Li2S nanocomposite film electrode involving both the formation and decomposition of Li2S and the lithium extraction/insertion of CoS2 after the initial charging process is proposed. Our results demonstrate the advantages of using Co-Li2S nanocomposite in storage lithium materials.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Abstract We evaluated the incidence, age, gender, and anatomical distribution of gastric cancers in 65,284 cases of upper GI endoscopies. A total of 5253 gastric cancer cases were identified. Cancers ...of the cardia, fundus, body and antrum account for 33.6%, 2.7%, 23.6% and 34.0% of all cases, respectively. The mean age for gastric cancers was 56.9 ± 10.2 years and 69.7% of the cancer cases were found in the 50–69 year age group. Subjects with cardia cancer were slightly older than subjects with non-cardia cancer. Over the 12-year period, the incidence of the gastric antrum cancer had significantly declined, whereas the incidence of the gastric cancer in the cardia and body had risen steadily. Thus, there was a rising trend of cardia cancers and a decreasing trend of most non-cardia cancers.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Copper nitride (CuxN) films were prepared by plasma immersion ion implantation (PIII) as well as by reactive magnetron sputtering (RMS). Based on X-ray diffraction (XRD) analysis, a semiconductive ...phase Cu3N could be found in the films prepared by both methods. On the other hand, a copper-rich conductive phase Cu4N was observed only in the film prepared by PIII, in which gradually distributed nitrogen could be identified by secondary ion mass spectroscopy (SIMS) analysis. The resistive switching properties have been studied after depositing Ni as the top electrode. The Ni/CuxN/Cu memory devices prepared by PIII method showed a forming-free characteristic with a low operation voltage of ±0.2V, excellent DC and AC endurance performances at least longer than 600 times and 105 times with resistance window of 50 and 12 respectively. On the contrary, the resistive switching behavior for the device prepared by RMS needed a forming process and was unstable. The excellent performances in PIII prepared films were attributed to the coexistence of metallic Cu4N phase and gradually decreased nitrogen concentration. It was supposed that the Cu atoms bridge the small gaps between the bottom and top electrodes and form the conducting filaments.
► Two kinds of CuxN films were fabricated by PIII as well as RMS. ► The films showed different structure and composition by XRD and XPS analysis. ► The RRAM devices made by the films showed bipolar resistive switching property. ► Switching mechanism is due to the formation/rupture of Cu conducting filaments. ► The film preparing process strongly influences on the device electrical properties.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Background:
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease with the high rates of the morbidity and mortality due to the lack of the effective prognostic model for prediction.
Aim:
...To construct a risk model composed of the epithelial–mesenchymal transition (EMT)-related immune genes for the assessment of the prognosis, immune infiltration status, and chemosensitivity.
Methods:
We obtained the transcriptome and clinical data of the HCC samples from The Cancer Genome Atlas (TCGA) and The International Cancer Genome Consortium (ICGC) databases. The Pearson correlation analysis was applied to identify the differentially expressed EMT-related immune genes (DE-EMTri-genes). Subsequently, the univariate Cox regression was introduced to screen out the prognostic gene sets and a risk model was constructed based on the least absolute shrinkage and selection operator-penalized Cox regression. Additionally, the receiver operating characteristic (ROC) curves were plotted to compare the prognostic value of the newly established model compared with the previous model. Furthermore, the correlation between the risk model and survival probability, immune characteristic, and efficacy of the chemotherapeutics were analyzed by the bioinformatics methods.
Results:
Six DE-EMTri-genes were ultimately selected to construct the prognostic model. The area under the curve (AUC) values for 1-, 2-, and 3- year were 0.773, 0.721, and 0.673, respectively. Stratified survival analysis suggested that the prognosis of the low-score group was superior to the high-score group. Moreover, the univariate and multivariate analysis indicated that risk score hazard ratio (HR) 5.071, 95% CI 3.050, 8.432; HR 4.396, 95% CI 2.624, 7.366;
p
< 0.001 and stage (HR 2.500, 95% CI 1.721, 3.632; HR 2.111, 95% CI 1.443, 3.089;
p
< 0.001) served as an independent predictive factors in HCC. In addition, the macrophages, natural killer (NK) cells, and regulatory T (Treg) cells were significantly enriched in the high-risk group. Finally, the patients with the high-risk score might be more sensitive to cisplatin, doxorubicin, etoposide, gemcitabine, and mitomycin C.
Conclusion:
We established a reliable EMTri-genes-based prognostic signature, which may hold promise for the clinical prediction.
The thin films of nanostructured In2O3 have been prepared by reactive pulsed laser deposition (PLD) method in oxygen ambient. The electrochemical properties have been investigated by charge/discharge ...measurement and cyclic voltammograms. A large reversible capacity of nanostructured In2O3 thin films was found to be 883mAhg-1, corresponding to 8.9 Li per In2O3. A new couple of reduction and oxidation peaks at 1.0 and 1.9V were observed from CV curves for the first time. The electrochemical reaction properties of In2O3 with lithium were examined by X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM) and selected area electron diffraction (SAED) measurements. Both alloying/dealloying processes and oxidation/reduction processes of In were revealed during the lithium electrochemical reaction of In2O3 thin film electrode instead of the classical alloying reaction between In2O3 and lithium.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Li‐rich layered oxides (LLOs) suffer from rapid voltage decay and capacity fading, greatly hindering their applications as high‐energy cathode materials for Li‐ion batteries (LIBs), which are closely ...associated with irreversible structural transformation and lattice oxygen loss upon electrochemical cycling. A strategy of Al/Ti synergistic bulk doping is proposed to stabilize LLOs against structural degradations, yielding remarkable electrochemical performance including a minor voltage decay of 0.34 mV cycle−1 and a superior capacity retention of 89.7% over 500 cycles at 1C. The improved structural stability of Al/Ti codoped LLOs is well maintained after not only initial but also long cycles. This effect can be attributed to the cooperation of Al and Ti, with the former stabilizing the lattice oxygen by strong Al–O bonds and the latter improving the Li+ conductivity by expanding the lattice. The facile bulk synergistic doping of LLOs paves avenues toward their application for high‐energy LIBs.
With the Al/Ti synergistic doping, Li‐rich layered oxide (LLO) delivers a minor voltage decay of 0.34 mV cycle−1 and a superior capacity retention of 89.7% over 500 cycles at 1C, which is attributed to the stabilization of the lattice oxygen by strong Al–O bonds and the improvement of Li+ conductivity by Ti‐induced lattice expansion.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The development of environment‐friendly and high‐performance carbon materials for energy applications has remained a great challenge. Here, a novel and facile method for synthesis of olive‐like ...nitrogen‐doped carbon embedded with germanium (Ge) nanoparticles using widespread and nontoxic dopamine as carbon and nitrogen precursors is demonstrated, especially by understanding the tendency of pure GeO2 nanoparticles forming ellipsoidal aggregation, and the chelating reaction of the catechol structure in dopamine with metal ions. The as‐synthesized Ge/N‐C composites show an olive‐like porous carbon structure with a loading weight of as high as 68.5% Ge nanoparticles. A lithium ion battery using Ge/N‐C as the anode shows 1042 mAh g−1 charge capacity after 2000 cycles (125 d) charge/discharge at C/2 (1C = 1600 mA g−1) with a capacity maintaining efficiency of 99.6%, significantly exceeding those of the previously reported Ge/C‐based anode materials. This prominent cyclic charge/discharge performance of the Ge/N‐C anode is attributed to the well‐dispersed Ge nanoparticles in graphitic N‐doped carbon matrix, which facilitates high rates (0.5–15 C) of charge/discharge and increases the anode structure integrity. The synthesis strategy presented here may be a very promising approach to prepare a series of active nanoparticle–carbon hybrid materials with nitrogen doping for more and important applications.
An olive‐like nitrogen‐doped carbon with embedded Ge nanoparticles is synthesized and characterized. The novel structure endows high charge capacity and stable cycle performance for the anode of a lithium ion battery.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
It is still debatable whether serum ferritin is a potential prognostic marker in patients with decompensated cirrhosis. In this meta-analysis, we hope to investigate the relationship between elevated ...serum ferritin and the risk of death in patients with decompensated cirrhosis. We systematically searched PubMed, Embase, Web of Science, Cochrane Library, CNKI, SinoMed, WAN FANG, and ClinicalTrials.gov without language restrictions from inception to 3 October 2022, and finally identified a total of eight eligible studies with 1829 patients. The pooled prevalence of elevated serum ferritin in decompensated cirrhosis was 40.6% 95% confidence interval (CI) 32.1-49.2%, and it was higher in males, patients with alcohol-associated liver disease, those with Child-Pugh grade C, those with hepatic encephalopathy, and nonsurvivors. Nonsurvivors had significantly higher serum ferritin levels than survivors mean difference 247.90; 95% CI, 130.97-364.84. With a pooled unadjusted hazard ratio of 2.38 (95% CI, 1.78-3.18), high serum ferritin was associated with an increased risk of death in patients with decompensated cirrhosis, with low heterogeneity among the included studies. In conclusion, high serum ferritin levels were associated with mortality in patients with decompensated cirrhosis. More prospective and homogeneous clinical studies are required to validate our findings.
Environmental tobacco smoke (ETS) exposure has been proven to induce digestive diseases such as hepatic steatosis, cirrhosis, and gastrointestinal cancer, yet little is known about the link between ...ETS exposure and constipation. This study aimed to investigate the impact of ETS exposure on the risk of chronic constipation in adults aged 20 years or older. This is a cross-sectional study based on population. A total number of 7705 participants from the National Health and Nutrition Examination Survey (NHANES) 2005–2010 were included. Cotinine, an alkaloid found in tobacco, serves as a reliable and precise biomarker for measuring exposure to ETS. Hence, the categorization of exposure to ETS was conducted based on serum cotinine levels, resulting in four distinct categories. The association between ETS exposure and the risk of constipation was assessed using multivariable restricted cubic spline and logistic regression with odds ratio (OR) and 95% confidence interval (CI). The weighted prevalence of constipation in this study was estimated to be 7.51% based on stool consistency, or 3.11% based on stool frequency. The fully adjusted models indicated a positive correlation between exposure to ETS and constipation as measured by stool frequency, among adults with poor dietary quality (OR (95% CI): moderate exposure: 2.49 (1.05, 5.94); high exposure: 2.36(1.13, 4.95),
P
for trend = 0.03), while no significant difference was observed in the subgroup with a higher healthy eating index. Furthermore, the log10-transformed serum cotinine level exhibited a non-linear inverted U-shaped association with constipation in individuals with poor dietary quality (
P
overall = 0.0207,
P
non-linear = 0.0427). Conversely, a J-shaped non-linear relationship was observed in the subgroup with a higher healthy eating index (
P
overall = 0.0028,
P
non-linear = 0.0036). Our results show that ETS exposure appears to be positively associated with stool frequency-related chronic constipation in adults with poor dietary quality.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Considerable controversy exists on the association between serum vitamin D concentrations and Alzheimer disease (AD) risk. This study aimed to synthesize the association of serum vitamin D ...concentrations with AD in adults.
PubMed, Embase, and Cochrane library databases were searched for prospective cohort studies with data on serum vitamin D concentrations and AD risk.
The studies that reported the adjusted relative risks (RRs) with 95% confidence intervals (CIs) of AD associated with serum vitamin D concentrations were included and subjected to subgroup analyses. Six prospective cohort studies with 1607 AD cases and 21,692 individuals were included in the meta-analysis. In 4 cohort studies with information about serum vitamin D concentrations <25 and 25 to 50 nmol/L, the random effects summary estimate did not show an increased risk of AD after adjustment for the established risk factors, while 3 cohort studies reported the RRs for incident AD per standard deviation (SD) decrease in serum vitamin D concentration and the random effects summary estimate did not show an increased risk of AD after adjustment for the established risk factors.
The current meta-analysis indicated that serum vitamin D deficiency (<25 nmol/L) or insufficiency (25-50 nmol/L) was not statistically significant and associated with the risk of AD.