Barefoot shoes have recently become a popular alternative to conventional shoes among the parents of pre-school children. As the long-term effect of habitual shoe-wearing on the foot is still ...unclear, the aim of this study was to compare the arch index, dynamic foot anthropometry and gait parameters in toddlers who had been habitually wearing barefoot shoes or conventional shoes since their first steps. 30 toddlers- 15 habitually wearing barefoot shoes (BF group) and 15 habitually wearing conventional shoes (N-BF group)-participated in this study. Each child was measured twice during the study. The first data collection session occurred within one month after the first five consecutive unsupported steps were performed by the toddler. The second data collection session occurred seven months after this event. At each data collection session, the toddler was instructed to walk barefooted at its natural speed over an Emed.sup.® platform (Novel GmbH, Germany). The Emed .sup.® software generated data regarding the arch index, dynamic foot anthropometry, foot progression angle, contact area, contact time, peak pressure and maximum force. The Wilcoxon signed-rank test was used to compare the differences between the 1.sup.st and 2.sup.nd data collections. The Mann-Whitney U test was used to compare the differences between the BF and N-BF groups. The results of this study show a higher plantar arch and a smaller foot progression angle in the BF group. The forefoot width in both the BF and N-BF groups remained proportional to the foot length after seven months of independent walking. These findings may encourage parents and caregivers to introduce barefoot shoes or create a habitual barefoot time for their child.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
While the immunomodulation effects of per- and polyfluoroalkyl substances (PFASs) are described on the level of clinical signs in epidemiological studies (e.g., suppressed antibody response after ...vaccination), the underlying mechanism has still not been fully elucidated. To reveal mechanisms of PFAS exposure on immunity, we investigated the genome-wide transcriptomic changes of peripheral blood mononuclear cells (PBMCs) responding to PFAS exposure (specifically, exposure to PFPA, PFOA, PFNA, PFDA, PFUnDA, PFHxS, and PFOS). Blood samples and the chemical load in the blood were analyzed under the cross-sectional CELSPAC: Young Adults study. The overall aim of the study was to identify sensitive gene sets and cellular pathways conserved for multiple PFAS chemicals. Transcriptome networks related to adaptive immunity were perturbed by multiple PFAS exposure (i.e., blood levels of at least four PFASs). Specifically, processes tightly connected with late B cell development, such as B cell receptor signaling, germinal center reactions, and plasma cell development, were shown to be affected. Our comprehensive transcriptome analysis identified the disruption of B cell development, specifically the impact on the maturation of antibody-secreting cells, as a potential mechanism underlying PFAS immunotoxicity.
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IJS, KILJ, NUK, PNG, UL, UM
During pregnancy, an array of changes occurs in women body to enable the growth and development of the future baby and the consequent delivery. These changes are reflected in the range of motion of ...trunk, pelvis, lower limbs and other body segments, affect the locomotion and some of these changes may persist to the postpartum period. The aim of this study was to describe the changes affecting the gait during pregnancy and to determine the effect of tested footwear on kinematic gait characteristics during pregnancy as previous studies indicate that special orthopaedic insoles and footwear might be useful in prevention of the common musculoskeletal pain and discomfort related to pregnancy. Participants from the control group (n = 18), without any intervention, and the experimental group (n = 23), which was wearing the tested shoes, were measured at their 14, 28 and 37 gestational weeks and 28 weeks postpartum to capture the complete pregnancy-related changes in gait. The gait 3D kinematic data were obtained using Simi Motion System. The differences between the control and experimental group at the first data collection session in most of the analysed variables, as well as relatively high standard deviations of analysed variables indicate large individual differences in the gait pattern. The effect of tested footwear on kinematic gait pattern changes may be explained by its preventive effect against the foot arches falling. In the control group, changes associated previously with the foot arches falling and hindfoot hyperpronation were observed during advanced phases of pregnancy and postpartum, e.g. increase in knee flexion or increase in spinal curvature. For the comprehensive evaluation of the tested footwear on pregnancy gait pattern, future studies combining the kinematic and dynamic plantographic methods are needed.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Although it has been well-documented that older adults spend a significant amount of time being sedentary and have slower gait velocity, little is known of how physical fitness mediates the ...association between them. The main purpose of this study was to explore whether objectively measured physical fitness mediates the association between domain-specific and total sedentary behavior and gait velocity. We recruited 120 older adults aged ≥ 60 years. Sedentary behavior was assessed by the Measure of Older Adults' Sedentary Time questionnaire. We used a Zebris pressure platform to assess gait velocity. To assess the level of overall physical fitness, we summed the
-scores of seven tests: (1) waist circumference, (2) chair stand in 30 s, (3) arm curl in 30 s, (4) 2-min step test, (5) chair sit-and-reach test, (6) back scratch test, and (7) 8-foot up-and-go test. Overall physical fitness was obtained by summing up all physical test
-scores. Gait velocity was significantly associated with all domain-specific and total sedentary behavior (
= -0.04 to -0.35,
< 0.05). Overall physical fitness was significantly associated with all domain-specific and total sedentary behavior (
= -0.21 to -1.24,
< 0.001) and gait velocity (
= 0.23 to 0.24,
< 0.001). When physical fitness was put as the mediator, significant direct effects between sedentary behavior and gait velocity disappeared. Results indicate that physical fitness fully mediates the association between sedentary behavior and gait velocity in older adults.
The main objective of our study was to determine whether constant and variable practice conditions lead to the development of different memory representations (GMP) and as a result, they benefit ...performance of a skill differently. We compared one of the Generalized Motor Program (GMP) invariant features, i.e., relative timing, of the same variation of skill developed in constant and variable practice conditions. In two experiments, participants, naïve to the basketball, were practicing free throws, receiving the same amount of practice. In constant conditions they practiced at one distance only (4.57 m), whereas in variable conditions they practiced at seven (2.74, 3.35, 3.96, 4.57, 5.18, 5.79, and 6.4 m) and five (3.35, 3.96, 4.57, 5.18, and 5.79 m) distances, in Experiments 1 and 2, respectively. We found that relative timing of skills developed in constant and variable practice conditions is the same, confirming that these practice conditions form the same memory representation. However, we also observed that constant practice (CP) conditions resulted in overall shorter movement time as compared to the skill practiced in variable conditions. We hypothesized that it may be due to the facilitation of parameters assignment as it takes place in especial skill.
Although obesity has been consistently correlated with higher plantar pressure during the lifespan, to date little evidence has been provided regarding of how domain-specific and total sedentary ...behaviors may be correlated with plantar pressures. Moreover, high peak plantar pressures have been consistently associated with foot pain and discomfort, which prevent individuals from being physically active. Therefore, the main purpose of the study was to explore the correlations between time spent in sedentary behaviors and plantar pressures.
We recruited 120 older women aged ≥60 years. To assess the time spent in different domains of sedentary behavior, we used the Measure of Older Adults' Sedentary Time (MOST) questionnaire. Peak pressures beneath forefoot, midfoot and hindfoot were measured with a Zebris pressure platform.
In the unadjusted model, peak pressures were significantly correlated with almost all domain-specific sedentary behaviors (
= 0.15-0.41). Total time spent in sedentary behaviors was significantly correlated with forefoot (
= 0.40,
< 0.001), hindfoot (
= 0.31,
< 0.001) and total peak plantar pressure (
= 0.40,
< 0.001). In a model adjusted for age, the risk of falls, foot pain and gait velocity, similar significant correlations between sedentary behaviors and plantar pressures remained.
: Our study shows moderate correlation between domain-specific and total time spent in sedentary behaviors and plantar pressure beneath different foot regions in a sample of older women.
Humans are widely exposed to phthalates and their novel substitutes, and considering the negative health effects associated with some phthalates, it is crucial to understand population levels and ...exposure determinants. This study is focused on 300 urine samples from teenagers (aged 12–17) and 300 from young adults (aged 18–37) living in Czechia collected in 2019 and 2020 to assess 17 plasticizer metabolites as biomarkers of exposure. We identified widespread phthalate exposure in the study population. The diethyl phthalate metabolite monoethyl phthalate (MEP) and three di (2-ethylhexyl) phthalate metabolites were detected in the urine of >99% of study participants. The highest median concentrations were found for metabolites of low-molecular-weight (LMW) phthalates: mono-n-butyl phthalate (MnBP), monoisobutyl phthalate (MiBP) and MEP (60.7; 52.6 and 17.6 μg/L in young adults). 1,2-cyclohexanedicarboxylic acid diisononyl ester (DINCH) metabolites were present in 68.2% of the samples with a median of 1.24 μg/L for both cohorts. Concentrations of MnBP and MiBP were similar to other European populations, but 5–6 times higher than in populations in North America. We also observed large variability in phthalate exposures within the study population, with 2–3 orders of magnitude differences in urinary metabolites between high and low exposed individuals. The concentrations varied with season, gender, age, and lifestyle factors. A relationship was found between high levels of MEP and high overall use of personal care products (PCPs). Cluster analysis suggested that phthalate exposures depend on season and multiple lifestyle factors, like time spent indoors and use of PCPs, which combine to lead to the observed widespread presence of phthalate metabolites in both study populations. Participants who spent more time indoors, particularly noticeably during colder months, had higher levels of high-molecular weight phthalate metabolites, whereas participants with higher PCP use, particularly women, tended to have higher concentration of LMW phthalate metabolites.
•600 urine samples from teenagers and young adults analysed for phthalate metabolites.•Highest median concentrations found for MnBP, MiBP and MEP in young adults.•DINCH metabolites were present in urine for 68% of the study population.•MnBP and MiBP were 5–6 times higher than in similar populations in North America.•Phthalate metabolite levels vary with season, gender, age, and cosmetics use.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Developmental dysplasia of the hip (DDH) is recognized as a leading cause of significant long-term complications, including inaccurate gait patterns, persistent pain, and early regressive joint ...disorder, and it can influence families functionally, socially, and psychologically.
This study aimed to determine foot posture and gait analysis across patients with developmental hip dysplasia. We retrospectively reviewed participants referred to the pediatric rehabilitation department of KASCH from the orthopedic clinic between 2016 and 2022 (patients born 2016-2022) with DDH for conservative brace treatment.
The foot postural index for the right foot showed a mean of 5.89 (
= 203, SD 4.15) and the left food showed a mean of 5.94 (
= 203, SD 4.19). The gait analysis mean was 6.44 (
= 406, SD 3.84). The right lower limb mean was 6.41 (
= 203, SD 3.78), and the left lower limb mean was 6.47 (
= 203, SD 3.91). The correlation for general gait analysis was r = 0.93, presenting the very high impact of DDH on gait. Significant correlation results were found between the right (r = 0.97) and left (r = 0.25) lower limbs. Variation between the right and left lower limb
-values was 0.88 (
< 0.05). DDH affects the left lower limb more than the right during gait.
We conclude that there is a higher risk of developing foot pronation on the left side, which is altered by DDH. Gait analysis has shown that DDH affects the right lower limb more than the left. The results of the gait analysis showed gait deviation in the sagittal mid- and late stance phases.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The main purpose of the study was to explore the effects of carrying police equipment on spatiotemporal and kinetic gait parameters. Two-hundred and seventy-five healthy men and women attending ...police academy (32% women) were randomly recruited. Gait analysis without and with a police equipment load (≈3.5 kg) was analyzed using the Zebris pressure platform. Differences and effect sizes were calculated using a Student t-test and Wilcoxon test for dependent samples and Cohen’s D statistics. In both men and women, carrying police equipment significantly increased the foot rotation (effect size 0.13–0.25), step width (0.13–0.33), step time (0.25), stride time (0.13–0.25) and peak plantar pressure beneath the forefoot (0.16–0.30), midfoot (0.15–0.32) and hindfoot (0.13–0.25) region of the foot. Significant reductions in the step length (0.12–0.25), stride length (0.14–0.23), cadence (0.15–0.28) and walking speed (0.20–0.22) were observed in both sexes. Although significant, the effect sizes were mostly trivial in men and small in women. Our study shows significant changes in the spatiotemporal and kinetic gait parameters when carrying police equipment for both men and women. Although the effect sizes are trivial to small, carrying police equipment of ≈3.5 kg may have a negative impact on gait characteristics in first-year police officers.
This study aimed to analyse the kinematic differences in gait between three groups of toddlers who differed in their weeks of independent walking (IW) experience, but not in anthropometrical ...characteristics, to determine the relationship between walking experience without the side effect of morphological differences on gait parameters. Twenty-six toddlers participated in this study. Depending on the week of their IW, toddlers were divided into three groups: Group 1 (1-5 weeks of IW), Group 2 (6-10 weeks of IW), and Group 3 (11-15 weeks of IW). Each toddler walked barefooted over a 2-m long pathway, and 3D kinematic data were obtained. A decrease in the upper limb position, hip flexion, and step width, i.e., changes towards the adult gait pattern, were observed in Group 3. Less experienced walkers exhibited a wider step width despite no statistically significant difference in body mass and height between groups. Results of this study show no statistically significant difference in step length between groups, suggesting that step length is more related to height than to the walking experience. The increased step length in more experienced walkers reported in previous studies may therefore be a result of different heights and not walking experience.
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