Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20 pathogenic species of Leishmania sp. Due to the limitations of the current treatments available, chalcone ...moiety has been drawn with a lot of attention due to the simple chemistry and synthesis, being reported with antileishmanial activity in particular against amastigote form. This review aims to provide an overview towards antileishmanial activity of chalcones derivatives against amastigote form for Leishmania major, L. amazonensis, L. panamensis, L. donovani and L. infantum as well as their structure-activity relationship (SAR), molecular targets and in silico ADMET evaluation. In this way, it is expected that this review may support the research and development of new promising chalcones candidates a leishmanicidal drugs.
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•Chalcones derivatives against Leishmania sp.•Different patterns of substitutions on chalcone rings.•Application of medicinal chemistry strategies.•In silico ADMET were performed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
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•Chronic alcoholism interferes with the bone repair process.•The use of biomaterial based on beta-tricalcium phosphate did not improve the neoformation process.•Alcoholism associated ...with the alloplastic graft for bone repair results in the formation of fibrous connective tissue.
This study evaluated the effect of ethanol on the repair in calvaria treated with beta-tricalcium phosphate (β-TCP). Forty rats were distributed into 2 groups: Water group (CG, n = 20) and Alcohol Group (AG, n = 20), which received 25% ethanol ad libitum after an adaptation period of 3 weeks. After 90 days of liquid diet, the rats were submitted to a 5.0 mm bilateral craniotomy in the parietal bones; the left parietal was filled with β-TCP (CG-TCP and AG-TCP) and the contralateral only with blood clot (CG-Clot and AG-Clot). The animals were killed after 10, 20, 40 and 60 days. The groups CG-Clot and AG-Clot showed similar pattern of bone formation with a gradual and significant increase in the amount of bone in CG-Clot (22.17 ± 3.18 and 34.81 ± 5.49) in relation to AG-Clot (9.35 ± 5.98 and 21.65 ± 6.70) in periods of 20–40 days, respectively. However, in the other periods there was no statistically significant difference. Alcohol ingestion had a negative influence on bone formation, even with the use of β-TCP, exhibiting slow resorption and replacement by fibrous tissue, with 16% of bone formation within 60 days in AG-TCP, exhibiting immature bone tissue with predominance of disorganized collagen fibers. Defects in CG-TCP showed bone tissue with predominance of lamellar arrangement filling 39% of the original defect. It can be concluded that chronic ethanol consumption impairs the ability to repair bone defects, even with the use of a β-TCP biomaterial.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Autogenous bone grafts are used to repair bone defects, and the stabilization is needed for bone regeneration. Laser photobiomodulation is a modality of treatment in clinical practice for tissue ...regeneration, and it has therapeutic effects as an anti-inflammatory, analgesic and modulating cellular activity. The aim of the present study was to evaluate the effects of low-level laser therapy (LLLT) on an autogenous bone graft integration process stabilized with a new heterologous fibrin sealant. Forty rats were divided into two groups: Autogenous Fibrin Graft (AFG, n=20), in which a 5mm dome osteotomy was conducted in the right parietal bone and the graft was adhered to the left side using fibrin sealant; and Autogenous Fibrin Graft Laser (AFGL, n=20), which was subjected to the same procedures as AFG with the addition of LLLT. The treatment was performed immediately following surgery and then three times a week until euthanasia, using an 830nm laser (30mW, 6J/cm2, 0.116cm2, 258.6mW/cm2, 2.9J). Five animals from each group were euthanized at 10, 20, 30 and 40days postoperative, and the samples were submitted to histomorphological and histomorphometric analysis. Partial bone regeneration occurred, with new bone tissue integrating the graft to the recipient bed and small areas of connective tissue. Comparative analysis of the groups at the same intervals revealed minor interfaces in group AFGL, with statistically significant differences (p<0.05) at all of the analyzed intervals (10days p=0.0087, 20days p=0.0012, 30days p<0.0001, 40days p=0.0142). In conclusion, low-level laser therapy stimulated bone regeneration and accelerated the process of integration of autogenous bone grafts.
•Stabilizing grafts with heterologous fibrin sealant is proposed.•Combination of fibrin sealant and LLLT demonstrated potential for bone repair process.•Low-level laser therapy improved the process of integration of bone grafts.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
This research evaluated the influence of Photobiomodulation Therapy (PBMT) on lesions of the facial nerve repaired with the end-to-side technique or coaptation with a new heterologous fibrin sealant. ...Thirty-two Wistar rats were separated into 5 groups: Control group (CG), where the buccal branch of the facial nerve was collected; Experimental Suture Group (ESG) and Experimental Fibrin Group (EFG), in which the buccal branch was end-to-side sutured to the zygomatic branch on the right side of the face or coaptated with fibrin sealant on the left side; Experimental Suture Laser Group (ESLG) and Experimental Fibrin Laser Group (EFLG), in which the same procedures were performed as the ESG and EFG, associated with PBMT (wavelength of 830nm, energy density 6.2J/cm2, power output 30mW, beam area of 0.116cm2, power density 0.26W/cm2, total energy per session 2.16J, cumulative dose of 34.56J). The laser was applied for 24s/site at 3 points on the skin's surface, for a total application time of 72s, performed immediately after surgery and 3 times a week for 5weeks. A statistically significant difference was observed in the fiber nerve area between the EFG and EFLG (57.49±3.13 and 62.52±3.56μm2, respectively). For the area of the axon, fiber diameter, axon diameter, myelin sheath area and myelin sheath thickness no statistically significant differences were found (p<0.05). The functional recovery of whisker movement occurred faster in the ESLG and EFLG, which were associated with PBMT, with results closer to the CG. Therefore, PBMT accelerated morphological and functional nerve repair in both techniques.
•End-to-side neurorrhaphy or new heterologous fibrin sealant+PBMT were evaluated.•Experimental groups with PBMT obtained the highest morphometric means in nerve fibers.•PBMT accelerated histological and functional nerve repair in both techniques.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The purpose of the Dental Sculpture and Anatomy discipline is to introduce undergraduate students to the study of the anatomic and morphological characteristics of permanent and primary human ...dentition, through classes, books and cognitive and psychomotor activities. This discipline supports the teaching of specific knowledge necessary for a more extensive education, involving interdisciplinarity as a means of knowledge exchange among several areas of dentistry, to achieve comprehensive professional education. Students must recognize the dental morphology from samples of preserved teeth, and reproduce the morphology through three-dimensional models made of stone or wax blocks. In this article, the authors describe the process for producing teeth collars and macro dental models made of stone, their importance and benefits of utilization. The purpose of the study was to encourage the teaching of Dental Sculpture and Anatomy toundergraduate students of the Bauru School of Dentistry, University of São Paulo, through activities that would associate theory, practice and the development of manual skills.
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10IJAERS-02202139-TheImpact.pdf Cunha Souza, Fernanda Karolyne; Menezes, Fabia Matos; Farias da Silva, Fernanda ...
International Journal of Advanced Engineering Research and Science,
2021, Volume:
8, Issue:
3
Journal Article
Ozone Therapy in Dentistry: A Systematic Review German, Iris Jasmin Santos; Rodrigues, Antonio de Castro; Andreo, Jesus Carlos ...
International journal of odontostomatology,
08/2013, Volume:
7, Issue:
2
Journal Article
Open access
The purpose of this systematic review was to verify the literature available regarding the effectiveness and the biological effects of ozone therapy in periodontics, orthodontics and dental implants. ...Studies were searched in September 2012. Analyzed sources included the databases PubMed, Lilacs and SciELO, through a combination of key words, dental implants, periodontics, orthodontics, therapeutics. Studies between 2002 and 2012 were included. In vitro and in vivo studies English and Spanish language publications, excluding posters, letters to the editors and conferences. In Vitro and in Vivo studies showed the inactivation of the major periodontal pathogens by ozone. There were divergent results and lack of evidence for the activity of ozone on adhesion of orthodontic brackets, in implantology and orthodontics. Ozone could be considered as a promissory alternative therapy in dentistry. However, well-designed studies are needed to assess the application of ozone in order to evaluate its clinical effectiveness in the field of dentistry.
O presente estudo possui como objetivo investigar o efeito das soluções irrigadoras utilizadas em endodontia regenerativa sobre as células-tronco de origem dental. Realizou-se uma extensa revisão da ...literatura para identificar estudos relevantes acerca da proposta do presente estudo. Bases de dados eletrônicas, como PubMed, Scielo e Google Acadêmico, foram consultadas para obter artigos publicados. A clorexidina e o EDTA emergem como alternativas promissoras ao hipoclorito de sódio, apresentando menor toxicidade e preservando melhor a viabilidade e função das células-tronco. No entanto, é necessário realizar mais pesquisas para validar esses achados e determinar as melhores práticas clínicas para a utilização dessas soluções irrigadoras em endodontia regenerativa. Em última análise, este estudo contribui para o avanço do conhecimento científico na área da endodontia regenerativa, fornecendo uma base sólida para o desenvolvimento de protocolos clínicos mais eficazes e personalizados. Esperamos que essas descobertas inspirem futuras pesquisas e promovam melhorias significativas na prática clínica, com o objetivo final de proporcionar aos pacientes tratamentos mais seguros, previsíveis e eficazes para a regeneração tecidual dentária.
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