Fragmente Christine Hehle, Hanna Delf von Wolzogen / Theodor-Fontane-Archiv / Christine Hehle, Hanna Delf von Wolzogen
2016, 2016-10-24
eBook
Gegenstand dieser kritischen Edition sind ca. 170 erzählerische bzw. essayistische Texte Theodor Fontanes, die als Entwürfe überliefert sind. Etwa 80 Texte werden hier erstmals publiziert. Fontane, ...dessen Nachlass zu den größten Schriftstellernachlässen des 19. Jahrhunderts gehört, hat außerordentlich viele solcher unvollendeten Texte hinterlassen. Über viele Stoffe und Sujets parallel verfügen zu können, gehörte besonders für den Romancier zur conditio sine qua non seines Schaffensprozesses. Umfangreiche Roman-Manuskripte gehören ebenso dazu wie kurz notierte Gesprächsskizzen oder Figurenentwürfe. Die Edition, herausgegeben im Auftrag des Theodor-Fontane-Archivs, gibt erstmals eine Gesamtübersicht über diese von der Forschung bislang nur punktuell wahrgenommenen Texte. Eine digitale Präsentation der Handschriften auf der Website des Theodor-Fontane-Archivs ist in Vorbereitung.
Effi Briest Fontane, Theodor; Cooper, William A
2010, c2010., 2009-05-01
eBook
Effi Briest, the classic German realist novel, follows a young woman through her life and marriage. She is an innocent when she is married to the social climbing Instetten, and longs for wordly ...things. When she is left alone by her husband, who is pursuing his political career, she succumbs to the flattery of another man. Her adultery has wide and tragic consequences on the rest of her life.
Acute kidney injury (AKI) is a common and serious complication in hospitalized patients, which continues to pose a clinical challenge for treating physicians. The most recent Kidney Disease Improving ...Global Outcomes practice guidelines for AKI have restated the importance of earliest possible detection of AKI and adjusting treatment accordingly. Since the emergence of initial studies examining the use of neutrophil gelatinase-associated lipocalin (NGAL) and cycle arrest biomarkers, tissue inhibitor metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein (IGFBP7), for early diagnosis of AKI, a vast number of studies have investigated the accuracy and additional clinical benefits of these biomarkers. As proposed by the Acute Dialysis Quality Initiative, new AKI diagnostic criteria should equally utilize glomerular function and tubular injury markers for AKI diagnosis. In addition to refining our capabilities in kidney risk prediction with kidney injury biomarkers, structural disorder phenotypes referred to as "preclinical-" and "subclinical AKI" have been described and are increasingly recognized. Additionally, positive biomarker test findings were found to provide prognostic information regardless of an acute decline in renal function (positive serum creatinine criteria). We summarize and discuss the recent findings focusing on two of the most promising and clinically available kidney injury biomarkers, NGAL and cell cycle arrest markers, in the context of AKI phenotypes. Finally, we draw conclusions regarding the clinical implications for kidney risk prediction.
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