Cardiac-specific troponins are elevated in blood following cardiac injury and are the preferred diagnostic biomarkers when acute myocardial infarction is suspected clinically. Cardiac troponin (cTn) ...elevations are also observed in clinical conditions without obvious connection to cardiac injury. Irrespective of the underlying condition, cTn elevation is linked to a poor prognosis, even if the elevation is stable over time. Here, we explore mechanisms that may lead to cTn elevations, including necrosis, apoptosis, necroptosis, cell wounds and decreased clearance. The aim is to broaden the perspective of how we interpret unexpected cTn elevations in patients. The cTn elevations may not be able to serve as direct proof of myocardial necrosis especially in the absence of a clear-cut reason for its release.
AMI: acute myocardial infarction; cTn: cardiac troponin; cTnI: cardiac troponin I; cTnT: cardiac troponin T; MLKL: mixed lineage kinase domain-like; TUNEL: terminal deoxynucleotidyl transferase nick end labeling
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
La resolución contractual Vidal Ramírez, Fernando
Lex (Lima),
11/2019, Volume:
17, Issue:
24
Journal Article
Open access
El presente artículo resume los medios mediante los cuales un contrato válidamente celebradopuede quedar sin efecto. La causa resolutoria es única y la genera el incumplimiento de una de laspartes, ...la inejecución de sus obligaciones, aunque el Código Civil ha establecido vías resolutoriasprevistas en los artículos 1428, 1429 y 1430.
A childhood intervention to improve the social skills and self-control of at-risk kindergarten boys in the 1980s had positive impacts over the life course: higher trust and self-control as ...adolescents; increased social group membership, education, and reduced criminality as young adults; and increased marriage and employment as adults. Using administrative data, we find this intervention increased average yearly employment income by about 20 percent and decreased average yearly social transfers by almost 40 percent. We estimate that $1 invested in this program around age 8 yields about $11 in benefits by age 39, with an internal rate of return of around 17 percent. (JEL I21, I26, I28, J13, J24, J31, Z13)
Nowadays, the transformation between coordinate systems is the major interested problems especially in Iraq. There are many coordinate systems used to produce maps and documentations due to different ...datums and spheroids. These coordinate systems are preferable to be unified in local countries. Thus, this paper deals with the transformation of coordinate systems of Karbala 1979 Polservice and World Geodetic System (WGS) 1984 to Iraqi Geospatial Reference System (IGRS). Accurate and well distributed control points are selected to cover the study area in Baghdad city, Iraq. Coordinate transformations are implemented using ArcGIS application mainly. Also, MATLAB software is used to convert geographic to map coordinates and vice versa by designing two MATLAB programs. The differences between the coordinate systems have been calculated. The results found that the discrepancies between Karbala 1979 Polservice and IGRS are about 278.6 m, -287.6 m, 0.01 second, and -11.2 second in northing, easting, latitude, and longitude, respectively. The WGS 1984 is superposed to IGRS and the distinction between them is negligible. The map coordinate differences between ArcGIS and MATLAB results are about -16 to 14 mm in northing and about -13 to 12 mm in easting, while the latitude and longitude differences are zero.
Nowadays, the transformation between coordinate systems is the major interested problems especially in Iraq. There are many coordinate systems used to produce maps and documentations due to different ...datums and spheroids. These coordinate systems are preferable to be unified in local countries. Thus, this paper deals with the transformation of coordinate systems of Karbala 1979 Polservice and World Geodetic System (WGS) 1984 to Iraqi Geospatial Reference System (IGRS). Accurate and well distributed control points are selected to cover the study area in Baghdad city, Iraq. Coordinate transformations are implemented using ArcGIS application mainly. Also, MATLAB software is used to convert geographic to map coordinates and vice versa by designing two MATLAB programs. The differences between the coordinate systems have been calculated. The results found that the discrepancies between Karbala 1979 Polservice and IGRS are about 278.6 m, -287.6 m, 0.01 second, and -11.2 second in northing, easting, latitude, and longitude, respectively. The WGS 1984 is superposed to IGRS and the distinction between them is negligible. The map coordinate differences between ArcGIS and MATLAB results are about -16 to 14 mm in northing and about -13 to 12 mm in easting, while the latitude and longitude differences are zero.
Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and ...synaptic pathology are closely related to the cognitive dysfunction. Brain imaging methods that are tuned to assess degeneration of myelinated nerve fibers in the brain (collectively called white matter) include diffusion tensor imaging (DTI) and related techniques, and are expected to shed light on disease-related loss of structural connectivity. Participants (N = 70, ages 47-76 years) from the Wisconsin Registry for Alzheimer's Prevention study underwent DTI and hybrid diffusion imaging to determine a free-water elimination (FWE-DTI) model. The study assessed the extent to which preclinical AD pathology affects brain white matter. Preclinical AD pathology was determined using cerebrospinal fluid (CSF) biomarkers. The sample was enriched for AD risk (APOE ε4 and parental history of AD). AD pathology assessed by CSF analyses was significantly associated with altered microstructure on both DTI and FWE-DTI. Affected regions included frontal, parietal, and especially temporal white matter. The f-value derived from the FWE-DTI model appeared to be the most sensitive to the relationship between the CSF AD biomarkers and microstructural alterations in white matter. These findings suggest that white matter degeneration is an early pathological feature of AD that may have utility both for early disease detection and as outcome measures for clinical trials. More complex models of microstructural diffusion properties including FWE-DTI may provide increased sensitivity to early brain changes associated with AD over standard DTI.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Nel febbraio scorso è stato presentato nelle sedi deputate il Piano nazionale denominato Proteggitalia (Piano nazionale per la mitigazione del rischio idrogeologico, il ripristino e la tutela della ...risorsa ambientale, adottato con DPCM 20 febbraio 2019, con successiva approvazione, con Delibera CIPE 24 luglio 2019, del Piano stralcio degli interventi immediatamente cantierabili individuati dal Ministero dell’Ambiente), Piano la cui continuità dovrebbe essere garantita dal nuovo governo. Il Piano si prefigge di mitigare e prevenire il dissesto idrogeologico mediante azioni atte a favorire la messa in sicurezza del nostro Paese, ovvero la realizzazione di opere di manutenzione del territorio e di prevenzione del rischio. Particolare attenzione, oltre agli interventi riconducibili alla gestione delle emergenze e alle azioni di prevenzione dei rischi e manutenzione del territorio, viene dedicata alla semplificazione e rafforzamento della governance. Il piano si configura, dunque, come un riordino, una combinazione e un’integrazione dei vari aspetti, norme, interventi e risorse che nel tempo si sono avvicendate in tema di sicurezza del territorio ....
Using comparative cases from Guinea, Uganda, and the Democratic Republic of Congo, this study explains why some refugee-hosting communities launch large-scale attacks on civilian refugees whereas ...others refrain from such attacks even when encouraged to do so by state officials. Ato Kwamena Onoma argues that such outbreaks only happen when states instigate them because of links between a few refugees and opposition groups. Locals embrace these attacks when refugees are settled in areas that privilege residence over indigeneity in the distribution of rights, ensuring that they live autonomously of local elites. The resulting opacity of their lives leads locals to buy into their demonization by the state. Locals do not buy into state denunciation of refugees in areas that privilege indigeneity over residence in the distribution of rights because refugees in such areas are subjugated to locals who come to know them very well. Onoma reorients the study of refugees back to a focus on the disempowered civilian refugees that constitute the majority of refugees even in cases of severe refugee militarization.
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