Pulmonary hypertension (PH) is a progressive and severe disorder in pulmonary hemodynamics. PH can be fatal if not well managed. Fibrosing mediastinitis (FM) is a rare and benign fibroproliferative ...disease in the mediastinum, which may lead to pulmonary vessel compression and PH. PH caused by FM (PH-FM) is a pathologic condition belonging to group 5 in the World Health Organization PH classification. PH-FM has a poor prognosis because of a lack of effective therapeutic modalities and inappropriate diagnosis. With the development of percutaneous pulmonary vascular interventional therapy, the prognosis of PH-FM has been greatly improved in recent years. This article provides a comprehensive review on the epidemiology, pathophysiologic characteristics, clinical manifestations, diagnostic approaches, and treatment modalities of PH-FM based on data from published reports and our medical center with the goal of facilitating the diagnosis and treatment of this fatal disease.
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•PH-FM, as a type of rare condition in group 5 PH, has a poor prognosis because of a lack of effective therapeutic modalities and frequent misdiagnosis and underdiagnosis.•The most prevalent trigger of FM is H-FM in the United States and TB-FM in China.•Imaging findings, including mismatched perfusion defects in the V/Q scan, FM dyad, and FM triad are important diagnostic clues, and clinical classification facilitates decision making in diagnosis and therapeutics.•Because of the limited efficacy of drug therapy as well as the uncertain effectiveness and high risk of surgical treatment, endovascular interventional modality is currently the preferred therapeutic option, although procedure-related complications and intrastent restenosis after PV intervention need to be addressed.
The rapid developments of globalization promote interaction among countries and people around the globe through the fast mode of information and telecommunication technology (ICT). ICT development ...also contributes to economic growth through various channels, but it may influence the environment on the other hand. Considering this concern, the present study focuses on examining the relationship between ICT developments and carbon emissions through the globalization channel. The study employs robust panel data estimation methods, continuously updated fully modified, and continuously updated bias corrected estimators, for the data set of Brazil, Russia, India, China, and South Africa (BRICS) economies spanning from 1990 to 2015. Findings of the study are robust against heteroskedasticity, endogeneity, and cross‐sectional dependence issues. The robust panel data estimators reveal that ICT has a favourable effect on carbon emissions in BRICS countries. Also, globalization leads to environmental pollution by contributing to an increase in CO2 emissions. These findings provide new insights to the policymakers in combatting environmental challenges.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Successful implementation of FM-enabled BIM can be achieved with 1) a clear definition of what FM-enabled BIM constitutes, 2) a seamless and practical process of collecting the FM-enabled BIM data ...throughout project development phases, and 3) a well-executed interoperability plan for exchanging data between BIM tools and facility management systems, such as Computerized Maintenance Management System (CMMS). This research contributes to the body of knowledge by first defining, and examining one of the first few pilots implementation of FM-enabled BIM, and discussing the challenges encountered and the lessons learned, and then by proposing a research framework for future researchers to systematically and strategically build the knowledge foundation on BIM for FM field. The implementation process described and the lessons learned captured in this pilot project provide valuable insights into the successful implementation of FM-enabled BIM.
•Theoretical applications of BIM for facilities management are discussed.•A proposed FM-enabled BIM implementation is examined in a real-world pilot project, describing in detail the process of planning and developing BIM for its later use during the handover and operations phases.•State-of-the-art BIM-enabled strategies and tools are applied on the project to achieve the successful handover of FM-enabled BIM.•Lessons learned from the pilot project are discussed, and a framework for future studies in BIM for FM is proposed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
While BIM processes are established for new buildings, the majority of existing buildings is not maintained, refurbished or deconstructed with BIM yet. Promising benefits of efficient resource ...management motivate research to overcome uncertainties of building condition and deficient documentation prevalent in existing buildings.
Due to rapid developments in BIM research, involved stakeholders demand a state-of-the-art overview of BIM implementation and research in existing buildings. This paper presents a review of over 180 recent publications on the topic. Results show scarce BIM implementation in existing buildings yet, due to challenges of (1) high modeling/conversion effort from captured building data into semantic BIM objects, (2) updating of information in BIM and (3) handling of uncertain data, objects and relations in BIM occurring in existing buildings.
Despite fast developments and spreading standards, challenging research opportunities arise from process automation and BIM adaption to existing buildings' requirements.
•In existing buildings, BIM application and stakeholder involvement is seldom.•Challenges are automated BIM creation, BIM update and handling uncertain BIM data.•Cost-benefit analyses of FM and deconstruction functionalities in BIM lack yet.•Organizational and legal frames need adaption to existing buildings’ BIM processes.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Summary
Remarkable progress in various techniques of in vivo fluorescence microscopy has brought an urgent need for reliable markers for tracking cellular structures and processes. The goal of this ...manuscript is to describe unexplored effects of the FM (Fei Mao) styryl dyes, which are widely used probes that label processes of endocytosis and vesicle trafficking in eukaryotic cells. Although there are few reports on the effect of styryl dyes on membrane fluidity and the activity of mammalian receptors, FM dyes have been considered as reliable tools for tracking of plant endocytosis. Using plasma membrane‐localized transporters for the plant hormone auxin in tobacco BY‐2 and Arabidopsis thaliana cell suspensions, we show that routinely used concentrations of FM 4‐64 and FM 5‐95 trigger transient re‐localization of these proteins, and FM 1‐43 affects their activity. The active process of re‐localization is blocked neither by inhibitors of endocytosis nor by cytoskeletal drugs. It does not occur in A. thaliana roots and depends on the degree of hydrophobicity (lipophilicity) of a particular FM dye. Our results emphasize the need for circumspection during in vivo studies of membrane proteins performed using simultaneous labelling with FM dyes.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
In the blind reception of non‐cooperative signals in short‐time burst communication, signal time domain detection is the premise and key of signal modulation parameter estimation, signal ...demodulation, decoding, interpretation, information acquisition and interference guidance. In this paper, the semi‐blind demodulation method of short‐time burst FM‐MFSK signal is studied under the condition of low signal‐to‐noise ratio. A short‐time burst FM‐MFSK semi‐blind demodulation method based on STFT is proposed. When SNR is higher than 3 dB, the correct demodulation probability for FM‐MFSK signal can reach 90%.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
This paper is concerned with the problem of two-dimensional (2-D) stochastic peak-to-peak filter design for Fornasini-Marchesini local state-space (FM LSS) systems with state-multiplicative noise. ...First, a novel sufficient condition is established, which guarantees that the underlying FM LSS system is stochastically mean-square stable with 2-D stochastic peak-to-peak performance. A deterministic FM LSS system case is also discussed. Subsequently, based on the result, a new 2-D stochastic peak-to-peak filter of general form is designed for FM LSS systems with state-multiplicative noise. Finally, a numerical example is presented to show the effectiveness of the proposed 2-D stochastic peak-to-peak filter.
This paper puts forward a generalization of the short-time Fourier-based synchrosqueezing transform using a new local estimate of instantaneous frequency. Such a technique enables not only to achieve ...a highly concentrated time-frequency representation for a wide variety of amplitude- and frequency-modulated multicomponent signals but also to reconstruct their modes with a high accuracy. Numerical investigation on synthetic and gravitational-wave signals shows the efficiency of this new approach.
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