Photothermal therapy (PTT) has emerged as a promising cancer therapeutic modality with high therapeutic specificity, however, its therapeutic effectiveness is limited by available high‐efficiency ...photothermal agents (PTAs), especially in the second near‐infrared (NIR‐II) biowindow. Here, based on facile liquid‐exfoliated FePS3 nanosheets, a highly efficient NIR‐II PTA with its photothermal conversion efficiency of up to 43.3% is demonstrated, which is among the highest reported levels in typical PTAs. More importantly, such Fe‐based 2D nanosheets also show superior Fenton catalytic activity facilitated by their ultrahigh specific surface area, simultaneously enabling cancer chemodynamic therapy (CDT). Impressively, the efficiency of CDT could be further remarkably enhanced by its photothermal effect, leading to cancer synergistic PTT/CDT. Both in vitro and in vivo studies reveal a highly efficient tumor ablation under NIR‐II light irradiation. This work provides a paradigm for cancer CDT and PTT in the NIR‐II biowindow via a single 2D nanoplatform with desired therapeutic effect. Furthermore, with additional possibilities for magnetic resonance imaging, photoacoustic tomography, as well as drug loading, this Fe‐based 2D material could potentially serve as a 2D “all‐in‐one” theranostic nanoplatform.
A highly efficient 2D NIR‐II photothermal agent (PTA) with a photothermal conversion efficiency of up to 43.3% is first developed based on facile liquid‐exfoliated FePS3 nanosheets, which is among the highest reported levels. More importantly, this novel PTA also shows remarkable Fenton catalytic activity, enabling superior synergistic photothermal–chemodynamic therapeutics along with excellent biocompatibility.
Full text
Available for:
FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
It is challenging to develop the synergistic intelligent therapeutic nanoplatform to cure cancer. In the present study, a novel nanotherapeutic platform was constructed for H2O2 self-supplying and ...multimodal breast cancer therapy. In which, copper peroxide nanoparticles (CP NPs) were adsorbed on the surface of mesoporous carbon nanospheres (MCN) through electrostatic attraction, followed by loading doxorubicin (DOX) into the nanocomposite (MCN-CP) and coating hyaluronic acid (HA) on the surface, the DOX/MCN-CP-HA nanoplatform was obtained. In the system, the MCN not only possessed a high DOX loading capacity, but produced excellent photothermal therapy (PTT) effect. Importantly, the ultra-small CP NPs as the Fenton agent not only could selectively self-supplying H2O2 in acidic condition, but simultaneously release Cu2+ to catalyze the production of ·OH in the presence of H2O2. Meantime, the resulting Cu2+ possessed GSH-elimination property, which afforded enhanced chemodynamic therapy (CDT). Furthermore, the outer layer HA targeted to CD44 and achieved breast cancer cell targeting. The elevated temperature from PTT and acidic tumor microenvironment accelerated the release of DOX, which enabled DOX/MCN-CP-HA as an intelligent CDT-PTT-chemotherapy synergistic nanoplatform. In vitro and in vivo pharmacodynamic evaluations confirmed the potential of the nanoplatform for CDT-PTT-chemotherapy synergistic oncotherapy of breast cancer.
Display omitted
•Surface engineered MCN was used as PTT-CDT-CT synergistic delivery nanoplatform.•H2O2 self-supply and highly efficient CDT effect was achieved by CuO2 NPs.•The HA provided targeting ability for breast cancer cells.•The novel nanoplatform could improve breast cancer oncotherapy efficacy.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
MoS2 has garnered considerable attention as an exceptional co-catalyst that is capable of significantly enhancing the efficiency of H2O2 decomposition in advanced oxidation processes (AOPs). This ...improvement allows for a reduction in the required amounts of H2O2 and Fe2+. In this study, we investigated the cyclic durability of photo-Fenton catalysts, focusing on the degradation of pollutants through the introduction of PPy into heterogeneous 1T-2H MoS2 units. The resulting photothermal-Fenton catalysts, comprising non-ferrous Fenton catalysts, demonstrated excellent degradation performance for simulated pollutants. In comparison with 1T-2H MoS2, the PPy@1T-2H MoS2 composite exhibited remarkable stability and photothermal enhancement in the photo-Fenton degradation of methylene blue (MB) under visible light irradiation. The photo-Fenton reaction efficiently degraded contaminants, achieving 99% removal within 5 min and 99.8% removal within 30 min. Moreover, the co-catalyst complex displayed enhanced cyclic stability during the photo-Fenton reaction, with a contaminant removal efficiency of 92%, even after the 13th cyclic test. The combined effects of PPy and 1T-2H MoS2 demonstrated improved efficiency in both photocatalytic and photo-Fenton catalytic reactions. Furthermore, PPy@1T-2H MoS2 exhibited outstanding performance in the photothermal evaporation of water, achieving an efficiency of 86.3% under one solar irradiation.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This paper investigated sulfadiazine oxidation by the Fenton process under various reaction conditions. The reaction conditions tested in the experiments included the initial pH value of reaction ...solutions, and the dosages of ferrous ions and hydrogen peroxide. Under the reaction conditions with pH 3, 0.25 mM of ferrous ion and 2 mM of hydrogen peroxide, a removal efficiency of nearly 100% was achieved for sulfadiazine. A series of intermediate products including 4-OH-sulfadiazine/or 5-OH-sulfadiazine, 2-aminopyrimidine, sulfanilamide, formic acid, and oxalic acid were identified. Based on these products, the possible oxidation pathway of sulfadiazine by Fenton's reagent was proposed. The toxicity evaluation of reaction solutions showed increased antimicrobial effects following the Fenton oxidation process. The results from this study suggest that the Fenton oxidation process could remove sulfadiazine, but also increase solution toxicity due to the presence of more toxic products.
Full text
Available for:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Load filters
No result was selected!
Please select the results that you wish to export.
The search was successfully saved.
Editing
The search could not be saved.
Saved searches can be viewed in the list My searches.
The changes made to the saved search were saved successfully.
Save search
Shelf entry
No result was selected!
Adding material to shelf was successful.
Adding material to shelf was partly successful.
Adding material to shelf failed completely.
It was not necessary to add the material to the shelf.
Please select the results that you want to put on shelf!
On shelf the following records have been successfully added:
On shelf the following records have been successfully added: