Although pets existed in Europe long before the eighteenth century, the dominant belief was that pet keeping was at best frivolous and at worst downright dangerous. In Animal Companions , Ingrid ...Tague explores the eighteenth-century conversation about the presence of pets in British society and the ways in which that conversation both reflected and shaped broader cultural debates. Tague argues that pets, as neither human nor fully part of the natural world, offered a unique way for Britons of the eighteenth century to articulate what it meant to be human and what their society ought to look like.
Having emerged from the Malthusian cycle of dearth and famine at the end of the seventeenth century, England became the wealthiest nation in Europe, with unprecedented access to consumer goods of all kinds. And closely connected with these material changes was the Enlightenment, with its implications for contemporary understanding of religion, science, and non-European cultures. All these transformations generated both excitement and anxiety, and they were reflected in debates over the rights and wrongs of human-animal relationships. Looking at a wide variety of texts, Tague shows how pets became both increasingly visible indicators of spreading prosperity and catalysts for debates about the morality of the radically different society emerging in this period.
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3.
Global Trade in Exotic Pets 2006-2012 BUSH, EMMA R.; BAKER, SANDRA E.; MACDONALD, DAVID W.
Conservation biology,
June 2014, Volume:
28, Issue:
3
Journal Article
Peer reviewed
Open access
International trade in exotic pets is an important and increasing driver of biodiversity loss and often compromises the standards required for good animal welfare. We systematically reviewed the ...scientific and gray literature and used the United Nations Environment Programme - World Conservation Monitoring Centre (UNEP-WCMC) Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) trade database to establish temporal and geographical trade patterns of live exotic birds, mammals, and reptiles and to describe trends in research, taxonomic representation, and level of threat and legal protection of species traded. Birds were the most species-rich and abundant class reported in trade; reptiles were second most abundant but unusually the most studied in this context; and mammals were least abundant in trade. Mammalian and reptilian species traded as pets were more likely to be threatened than expected by random. There have been a substantial number of Appendix 1 listed captive-bred mammals and birds and wild-caught birds and reptiles reported in trade to CITES. We identified the Middle East's emerging role as a driver of demand for exotic pets of all taxa alongside the well-established and increasing role of South America and Southeast Asia in the market. Europe, North America, and the Middle East featured most heavily in trade reports to CITES, whereas trade involving South America and Southeast Asia were given most emphasis in the literature. For effective monitoring of and appropriate response to the international exotic pet trade, it is imperative that the reliability and detail of CITES trade reports improve and that scientific research be directed toward those taxa and locations that are most vulnerable. El mercado internacional de mascotas exóticas es un factor importante y creciente de pérdida de la biodiversidad y continuamente compromete los estándares requeridos para un buen bienestar animal. Sistemáticamente revisamos la literatura cientifica y gris y usamos la base de datos de mercados de UNEPWCMC CITES para establecer patrones temporales y geográficos del mercado de aves, mamíferos y reptiles exóticos vivos y describir las tendencias en la investigación, la representación taxonómica y el nivel de amenaza y la protección legal de las especies comercializadas. Las aves fueron la clase con mayor riqueza de especies y la más abundante; los reptiles fueron la segunda más abundante pero inusualmente la más estudiada en este contexto; los mamíferos fueron los menos abundantes en el mercado. Las especies de mamíferos y reptiles comercializadas como mascotas tuvieron mayor probabilidad de estar amenazadas que lo esperado por el azar. Ha babido un número sustancial de especies de mamíferos y aves criados en cautiverio y listados en el Apéndice-I de aves y reptiles capturados en vida silvestre reportados en el mercado a CITES. Identificamos el papel emergente del Oriente Medio como conductor de la demanda de mascotas exóticas de todos los taxones junto con el bien establecido y creciente papel de América del Sur y el Sureste Asiático en el mercado. Europa, América del Norte y el Oriente Medio figuraron más en los reportes de mercado bechos a CITES, mientras que al mercado en América del Sur y el Sureste Asiático se le dio más énfasis en la literatura. Para un monitoreo efectivo de y una respuesta apropiada al mercado internacional de mascotas exóticas, es imperativo que la confiabilidad y el detalle de los reportes de mercado de CITES mejoren y que la investigación científica sea dirigida hacia esos taxones y las localidades que sean más vulnerables.
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We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-O-(2-sup.18Ffluoroethyl)-6-O-desmethyl-diprenorphine (sup.18FFE-DPN) from ...the novel precursor 6-O-(2-tosyloxyethyl)-6-O-desmethyl- 3-O-trityl-diprenorphine (TE-TDDPN), which we designate as the Henriksen precursor. We undertook an optimization of the synthesis conditions, aiming to enhance the accessibility of sup.18FFE-DPN for positron emission tomography (PET) studies of μ-opioid receptors. Herein, we report an optimized direct nucleophilic sup.18F-fluorination and the deprotection conditions for a fully automated radiosynthesis of sup.18FFE-DPN on a modified GE Tracerlab FX FE synthesis panel. Starting from 1–1.5 GBq of sup.18Ffluoride and applying an Oasis Max 1cc cartridge for fluorine-18 trapping with a reduced amount of Ksub.2COsub.3 (5.06 μmol Ksup.+ ion), sup.18FFE-DPN (sup.18F11) was produced with 44.5 ± 10.6 RCY (decay-corrected), high radiochemical purity (>99%), and a molar activity of 32.2 ± 11.8 GBq/μmol in 60–65 min.
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Background
We evaluated the ability of different (18F)fluoro‐deoxy‐d‐glucose (FDG)‐positron emission tomography (PET)‐based and magnetic resonance (MR)‐based parameters to identify prevertebral space ...(PVS) infiltration by hypopharyngeal carcinoma.
Methods
Retrospective study on 59 patients with advanced hypopharyngeal squamous cell carcinoma undergoing cross‐sectional imaging and triple endoscopy for staging.
Results
Obliteration of retropharyngeal fat plane on T1‐weighted MR images was found more often (P < .001) in tumors fixated to the PVS. Complete fat plane obliteration best predicted tumor fixation to PVS (accuracy 99%; CI: 97%‐100%; P < .001). With similar accuracy, PET‐based models predicted PVS fixation (combination of standardized uptake value SUVmax of the primary tumor and presence of focal FDG‐uptake in prevertebral muscles accuracy 98%; CI 94%‐100%; P < .001; metabolic tumor volume MTV accuracy 98%; CI 95%‐100%; P < .001).
Conclusion
Both the MR‐based parameter of complete fat plane obliteration and PET‐based models (increased SUVmax in combination with presence of focal FDG‐uptake of prevertebral muscles; increased MTV) predict PVS involvement independently with high accuracy.
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Most petroleum-derived plastics, as exemplified by poly(ethylene terephthalate) (PET), are chemically inactive and highly resistant to microbial attack. The accumulation of plastic waste results in ...environmental pollution and threatens ecosystems, referred to as the “microplastic issue”. Recently, PET hydrolytic enzymes (PHEs) have been identified and we reported PET degradation by a microbial consortium and its bacterial resident, Ideonella sakaiensis. Bioremediation may thus provide an alternative solution to recycling plastic waste. The mechanism of PET degradation into benign monomers by PET hydrolase and mono(2-hydroxyethyl) terephthalic acid (MHET) hydrolase from I. sakaiensis has been elucidated; nevertheless, biodegradation may require additional development for commercialization owing to the low catalytic activity of these enzymes. Here, we introduce PET degrading microorganisms and the enzymes involved, along with the evolution of PHEs to address the issues that hamper microbial and enzymatic PET degradation. Potential applications of PET degradation are also discussed.
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The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been ...limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively followed for 22 years.
Two brothers (A and B), both carriers of the H163Y mutation, were followed between 1995 and 2017. They underwent repeated clinical evaluations, neuropsychological assessments, and cerebrospinal fluid analyses, as well as brain imaging examinations with structural magnetic resonance,
Ffluorodeoxyglucose positron emission tomography, and
CPittsburgh compound B positron emission tomography.
Brother A was followed between 44 and 64 years of age. Cognitive symptoms due to Alzheimer's disease set in at the age of 54. Gradual worsening of symptoms resulted in admittance to a nursing home owing to dependence on others for all activities of daily living. He showed a curvilinear decline in cognitive function on neuropsychological tests, and changes on magnetic resonance imaging, positron emission tomography, and biomarkers in the cerebrospinal fluid supported a clinical diagnosis of Alzheimer's disease. Brother A died at the age of 64 and fulfilled the criteria for definitive Alzheimer's disease according to neuropathological examination results. Brother B was followed between the ages of 43 and 65 and showed no cognitive deterioration on repeated neuropsychological test occasions. In addition, no biomarker evidence of Alzheimer's disease pathology was detected, either on imaging examinations or in cerebrospinal fluid.
The average (SD) age of symptom onset for PSEN1 H163Y is 51 ± 7 years according to previous studies. However, we present a case of a biomarker-verified reduction in penetrance in a mutation carrier who was still symptom-free at the age of 65. This suggests that other genetic, epigenetic, and/or environmental factors modify the onset age.
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Head motion is a major source of image artefacts in neuroimaging studies and can lead to degradation of the quantitative accuracy of reconstructed PET images. Simultaneous magnetic resonance‐positron ...emission tomography (MR‐PET) makes it possible to estimate head motion information from high‐resolution MR images and then correct motion artefacts in PET images. In this article, we introduce a fully automated PET motion correction method, MR‐guided MAF, based on the co‐registration of multicontrast MR images. The performance of the MR‐guided MAF method was evaluated using MR‐PET data acquired from a cohort of ten healthy participants who received a slow infusion of fluorodeoxyglucose (18‐FFDG). Compared with conventional methods, MR‐guided PET image reconstruction can reduce head motion introduced artefacts and improve the image sharpness and quantitative accuracy of PET images acquired using simultaneous MR‐PET scanners. The fully automated motion estimation method has been implemented as a publicly available web‐service.
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The role of hybrid imaging using
F-fluoro-2-deoxy-D-glucose positron-emission tomography (FDG-PET), computed tomography (CT) and magnetic resonance imaging (MRI) to improve preoperative evaluation of ...rectal cancer is largely unknown. To investigate this, the RECTOPET (REctal Cancer Trial on PET/MRI/CT) study has been launched with the aim to assess staging and restaging of primary rectal cancer. This report presents the study workflow and the initial experiences of the impact of PET/CT on staging and management of the first patients included in the RECTOPET study.
This prospective cohort study, initiated in September 2016, is actively recruiting patients from Region Västerbotten in Sweden. This pilot study includes patients recruited and followed up until December 2017. All patients had a biopsy-verified rectal adenocarcinoma and underwent a minimum of one preoperative FDG-PET/CT and FDG-PET/MRI examination. These patients were referred to the colorectal cancer multidisciplinary team meeting at Umeå University Hospital. All available data were evaluated when making management recommendations. The clinical course was noted and changes consequent to PET imaging were described; surgical specimens underwent dedicated MRI for anatomical matching between imaging and histopathology.
Twenty-four patients have so far been included in the study. Four patients were deemed unresectable, while 19 patients underwent or were scheduled for surgery; one patient was enrolled in a watch-and-wait programme after restaging. Consequent to taking part in the study, two patients were upstaged to M1 disease: one patient was diagnosed with a solitary hepatic metastasis detected using PET/CT and underwent metastasectomy prior to rectal cancer surgery, while one patient with a small, but metabolically active, lung nodulus experienced no change of management. PET/MRI did not contribute to any recorded change in patient management.
The RECTOPET study investigating the role of PET/CT and PET/MRI for preoperative staging of primary rectal cancer patients will provide novel data that clarify the value of adding hybrid to conventional imaging, and the role of PET/CT versus PET/MRI.
NCT03846882 .
Astrocytes are highly efficient homeostatic glial cells playing a crucial role in optimal brain functioning and homeostasis. Astrocytes respond to changes in brain homoeostasis following central ...nervous system (CNS) injury/diseased state by a specific defence mechanism called reactive astrogliosis. Recent studies have implicated and placed reactive astrogliosis in the centre of pathophysiology of Alzheimer's disease (AD) and other neurodegenerative disorders. The AD biomarker field is evolving rapidly with new findings providing strong evidence which supports the notion that a reactive astrogliosis is an early event in the time course of AD progression which may precede other pathological hallmarks of AD. Clinical/translational in vivo PET and in vitro postmortem brain imaging studies demonstrated ‘a first and second wave’ of reactive astrogliosis in AD with distinct close‐loop relationships with other pathological biomarkers at different stages of the disease. At the end stages, reactive astrocytes are found to be associated, or in proximity, with amyloid plaque and tau pathological deposits in postmortem AD brains. Several new PET‐tracers, which are being in pipeline and validated at a very fast pace for mapping and visualising reactive astrogliosis in the brain, will provide further invaluable mechanistic insights into AD and other non‐AD dementia pathologies. The complementary roles of microglia and astrocyte activation in AD progression, along with the clinical value of new fluid astrocytes biomarkers in the context of existing biomarkers, are the latest avenue that needs further exploration.
Astrocytes are the key homeostatic cells in the human CNS, which responds to CNS injuries/diseased state by a specific defence mechanism called reactive astrogliosis. In Alzheimer's disease (AD), the role of astrocytes is still unclear and with new findings providing strong evidence that reactive astrogliosis is an early event in the time course of AD progression preceding some other pathological hallmarks. Based on clinical in vivo PET and post‐mortem brain imaging studies we propose ‘a first and second wave model’ of reactive astrogliosis in AD with distinct close loop relationships with soluble Aβ species and Aβ plaques as well as other hallmarks at different stages of the disease.
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